JP2006507246A - Mch拮抗活性を有する新規カルボキサミド化合物、これらの化合物を含む医薬組成物及びそれらの製造方法 - Google Patents
Mch拮抗活性を有する新規カルボキサミド化合物、これらの化合物を含む医薬組成物及びそれらの製造方法 Download PDFInfo
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- JP2006507246A JP2006507246A JP2004535098A JP2004535098A JP2006507246A JP 2006507246 A JP2006507246 A JP 2006507246A JP 2004535098 A JP2004535098 A JP 2004535098A JP 2004535098 A JP2004535098 A JP 2004535098A JP 2006507246 A JP2006507246 A JP 2006507246A
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- phenyl
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- ethyl
- ylmethyl
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- 0 C*C1/C(/C)=C/C(C)(*)/C=C(/C(N(C)C(**)=N2)=O)\*2=C1 Chemical compound C*C1/C(/C)=C/C(C)(*)/C=C(/C(N(C)C(**)=N2)=O)\*2=C1 0.000 description 27
- ACYFWRHALJTSCF-UHFFFAOYSA-N CC(C)(C)NC(C)=O Chemical compound CC(C)(C)NC(C)=O ACYFWRHALJTSCF-UHFFFAOYSA-N 0.000 description 1
- KALBEHZGFMLOKH-UHFFFAOYSA-N CC(c1ccc(CCNC(c(cc2)ccc2-c(cc2)ccc2Cl)=O)cc1)N1CCCC1 Chemical compound CC(c1ccc(CCNC(c(cc2)ccc2-c(cc2)ccc2Cl)=O)cc1)N1CCCC1 KALBEHZGFMLOKH-UHFFFAOYSA-N 0.000 description 1
- LIGOINHGXGBEGR-UHFFFAOYSA-N CCN(CC)C1CN(Cc2ccc(CCNC(c(cc3)ccc3-c(cc3)ccc3Cl)=O)cc2)C1 Chemical compound CCN(CC)C1CN(Cc2ccc(CCNC(c(cc3)ccc3-c(cc3)ccc3Cl)=O)cc2)C1 LIGOINHGXGBEGR-UHFFFAOYSA-N 0.000 description 1
- UCCLCBSFBWDJQI-UHFFFAOYSA-N CCN(CC)Cc1ccc(CCNC(c(cc2)ccc2-c(cc2)ccc2Cl)=O)cc1 Chemical compound CCN(CC)Cc1ccc(CCNC(c(cc2)ccc2-c(cc2)ccc2Cl)=O)cc1 UCCLCBSFBWDJQI-UHFFFAOYSA-N 0.000 description 1
- FMEYCZUSBBLZDQ-UHFFFAOYSA-N CCOC(CN(C)Cc1ccc(CCNC(c(cc2)ccc2-c(cc2)ccc2Cl)=O)cc1)=O Chemical compound CCOC(CN(C)Cc1ccc(CCNC(c(cc2)ccc2-c(cc2)ccc2Cl)=O)cc1)=O FMEYCZUSBBLZDQ-UHFFFAOYSA-N 0.000 description 1
- VBHMLASMUWPBRI-UHFFFAOYSA-N CN(CC1)CC11CN(Cc2ccc(CCNC(c(cc3)ccc3-c(cc3)ccc3Cl)=O)cc2)CC1 Chemical compound CN(CC1)CC11CN(Cc2ccc(CCNC(c(cc3)ccc3-c(cc3)ccc3Cl)=O)cc2)CC1 VBHMLASMUWPBRI-UHFFFAOYSA-N 0.000 description 1
- SNUHVJGTLPAEGW-UHFFFAOYSA-N O=C(c(c(F)c1)ccc1-c(cc1)ccc1Br)NCCc1cc(Br)c(CN2CC=CC2)cc1 Chemical compound O=C(c(c(F)c1)ccc1-c(cc1)ccc1Br)NCCc1cc(Br)c(CN2CC=CC2)cc1 SNUHVJGTLPAEGW-UHFFFAOYSA-N 0.000 description 1
- ZRGMUJWUOLQWRK-UHFFFAOYSA-N O=C(c(c(F)c1)ccc1-c(cc1)ccc1Cl)NCCc1ccc(CN2CCCC2)cc1 Chemical compound O=C(c(c(F)c1)ccc1-c(cc1)ccc1Cl)NCCc1ccc(CN2CCCC2)cc1 ZRGMUJWUOLQWRK-UHFFFAOYSA-N 0.000 description 1
- MLAJSOTVMCVZRD-UHFFFAOYSA-N O=C(c(cc1)ccc1-c(cc1)ccc1Cl)NCCc1ccc(CN2CC=CC2)cn1 Chemical compound O=C(c(cc1)ccc1-c(cc1)ccc1Cl)NCCc1ccc(CN2CC=CC2)cn1 MLAJSOTVMCVZRD-UHFFFAOYSA-N 0.000 description 1
- OADFNLMXSVHXEZ-UHFFFAOYSA-N O=C(c(cc1)ccc1-c(cc1Cl)ccc1Cl)NCCc1ccc(CN2CCCC2)cc1 Chemical compound O=C(c(cc1)ccc1-c(cc1Cl)ccc1Cl)NCCc1ccc(CN2CCCC2)cc1 OADFNLMXSVHXEZ-UHFFFAOYSA-N 0.000 description 1
- MBDVXEPJQWFCPA-UHFFFAOYSA-N O=C(c1cc(Cl)c(C2CCCCC2)cc1)NCCc1ccc(CN2CCCC2)cc1 Chemical compound O=C(c1cc(Cl)c(C2CCCCC2)cc1)NCCc1ccc(CN2CCCC2)cc1 MBDVXEPJQWFCPA-UHFFFAOYSA-N 0.000 description 1
- JZGDBPYGQVLLBI-UHFFFAOYSA-N O=C(c1ccc(-c(cc2)ccc2Cl)c(F)c1)NCCc1ccc(CN2CCCC2)cc1 Chemical compound O=C(c1ccc(-c(cc2)ccc2Cl)c(F)c1)NCCc1ccc(CN2CCCC2)cc1 JZGDBPYGQVLLBI-UHFFFAOYSA-N 0.000 description 1
- JKPOEURLDWJJDS-UHFFFAOYSA-N OC1(CCN(Cc2ccc(CCN(C=Nc3c4ccc(-c(cc5)ccc5Cl)c3)C4=O)cc2)CC1)c1ccccc1 Chemical compound OC1(CCN(Cc2ccc(CCN(C=Nc3c4ccc(-c(cc5)ccc5Cl)c3)C4=O)cc2)CC1)c1ccccc1 JKPOEURLDWJJDS-UHFFFAOYSA-N 0.000 description 1
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- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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DE10238865A DE10238865A1 (de) | 2002-08-24 | 2002-08-24 | Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
PCT/EP2003/009099 WO2004024702A1 (de) | 2002-08-24 | 2003-08-16 | Neue carbonsäureamid-verbindungen mit mch-antagonistischer wirkung, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
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JP2010514837A (ja) * | 2007-01-03 | 2010-05-06 | コーテックス ファーマシューティカルズ, インコーポレイテッド | グルタミン酸作動性シナプス反応を強化するための3−置換−[1,2,3]ベンゾトリアジノン化合物 |
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ATE546448T1 (de) | 2008-08-02 | 2012-03-15 | Janssen Pharmaceutica Nv | Urotensin-ii-rezeptorantagonisten |
UY32443A (es) | 2009-02-13 | 2010-09-30 | Sanofi Aventis | Nuevos tetrahidronaftalenos, procesos para su preparación y uso de los mismos como medicamento. |
AR075401A1 (es) | 2009-02-13 | 2011-03-30 | Sanofi Aventis | Indanos sustituidos, procesos para su preparacion y uso de los mismos como un medicamento |
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GB0124627D0 (en) * | 2001-10-15 | 2001-12-05 | Smithkline Beecham Plc | Novel compounds |
GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
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2002
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2003
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- 2003-08-16 WO PCT/EP2003/009099 patent/WO2004024702A1/de active Application Filing
- 2003-08-16 KR KR1020057003110A patent/KR20050040928A/ko not_active Application Discontinuation
- 2003-08-16 EP EP03794886A patent/EP1534689A1/de not_active Withdrawn
- 2003-08-16 PL PL03375344A patent/PL375344A1/xx not_active Application Discontinuation
- 2003-08-16 UA UAA200502601A patent/UA82853C2/uk unknown
- 2003-08-16 RS YUP-2005/0173A patent/RS20050173A/sr unknown
- 2003-08-16 AU AU2003258620A patent/AU2003258620A1/en not_active Abandoned
- 2003-08-16 CN CNA038200767A patent/CN1678591A/zh active Pending
- 2003-08-16 CA CA002496563A patent/CA2496563A1/en not_active Abandoned
- 2003-08-16 EA EA200500301A patent/EA012834B1/ru not_active IP Right Cessation
- 2003-08-16 JP JP2004535098A patent/JP2006507246A/ja active Pending
- 2003-08-21 PE PE2003000849A patent/PE20040974A1/es not_active Application Discontinuation
- 2003-08-22 TW TW092123197A patent/TW200413332A/zh unknown
- 2003-08-22 AR ARP030103034A patent/AR043046A1/es unknown
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2005
- 2005-01-05 ZA ZA200500086A patent/ZA200500086B/xx unknown
- 2005-01-06 NO NO20050068A patent/NO20050068L/no not_active Application Discontinuation
- 2005-02-18 EC EC2005005615A patent/ECSP055615A/es unknown
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US8598169B2 (en) | 2004-12-28 | 2013-12-03 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
US9580387B2 (en) | 2004-12-28 | 2017-02-28 | Athenex, Inc. | Biaryl compositions and methods for modulating a kinase cascade |
US9655903B2 (en) | 2004-12-28 | 2017-05-23 | Athenex, Inc. | Compositions and methods of treating cell proliferation disorders |
JP2009542680A (ja) * | 2006-06-29 | 2009-12-03 | キネックス ファーマシューティカルズ, エルエルシー | キナーゼカスケードを調節するためのビアリル組成物および方法 |
US9556120B2 (en) | 2006-12-28 | 2017-01-31 | Athenex, Inc. | Compositions for modulating a kinase cascade and methods of use thereof |
US10323001B2 (en) | 2006-12-28 | 2019-06-18 | Athenex, Inc. | Compositions for modulating a kinase cascade and methods of use thereof |
JP2010514837A (ja) * | 2007-01-03 | 2010-05-06 | コーテックス ファーマシューティカルズ, インコーポレイテッド | グルタミン酸作動性シナプス反応を強化するための3−置換−[1,2,3]ベンゾトリアジノン化合物 |
US10196357B2 (en) | 2007-04-13 | 2019-02-05 | Athenex, Inc. | Biaryl compositions and methods for modulating a kinase cascade |
JP2014520839A (ja) * | 2011-07-15 | 2014-08-25 | アストラゼネカ アクチボラグ | 療法薬 |
US9926273B2 (en) | 2012-08-30 | 2018-03-27 | Athenex, Inc. | Composition and methods for modulating a kinase cascade |
US10106505B2 (en) | 2012-08-30 | 2018-10-23 | Athenex, Inc. | Composition and methods for modulating a kinase cascade |
Also Published As
Publication number | Publication date |
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NO20050068L (no) | 2005-03-04 |
CN1678591A (zh) | 2005-10-05 |
ECSP055615A (es) | 2005-05-30 |
MXPA05002158A (es) | 2005-05-23 |
RS20050173A (en) | 2007-09-21 |
PL375344A1 (en) | 2005-11-28 |
WO2004024702A1 (de) | 2004-03-25 |
KR20050040928A (ko) | 2005-05-03 |
EA012834B1 (ru) | 2009-12-30 |
BR0313790A (pt) | 2005-07-12 |
TW200413332A (en) | 2004-08-01 |
PE20040974A1 (es) | 2005-01-12 |
EA200500301A1 (ru) | 2006-02-24 |
AU2003258620A1 (en) | 2004-04-30 |
AR043046A1 (es) | 2005-07-13 |
ZA200500086B (en) | 2006-07-26 |
HRP20050179A2 (en) | 2006-05-31 |
UA82853C2 (en) | 2008-05-26 |
CA2496563A1 (en) | 2004-03-25 |
DE10238865A1 (de) | 2004-03-11 |
EP1534689A1 (de) | 2005-06-01 |
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