PL375344A1 - Novel carboxamide compounds having an mch-antagonistic effect, medicaments containing said compounds, and methods for the production thereof - Google Patents
Novel carboxamide compounds having an mch-antagonistic effect, medicaments containing said compounds, and methods for the production thereofInfo
- Publication number
- PL375344A1 PL375344A1 PL03375344A PL37534403A PL375344A1 PL 375344 A1 PL375344 A1 PL 375344A1 PL 03375344 A PL03375344 A PL 03375344A PL 37534403 A PL37534403 A PL 37534403A PL 375344 A1 PL375344 A1 PL 375344A1
- Authority
- PL
- Poland
- Prior art keywords
- compounds
- mch
- production
- methods
- antagonistic effect
- Prior art date
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- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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- C07D487/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
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DE10238865A DE10238865A1 (en) | 2002-08-24 | 2002-08-24 | New carboxamides are melanin-concentrating hormone receptor antagonists, useful for treating e.g. metabolic diseases, diabetes, eating disorders, cardiovascular disease, emotional disorders, reproductive and memory disorders |
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PL375344A1 true PL375344A1 (en) | 2005-11-28 |
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EP (1) | EP1534689A1 (en) |
JP (1) | JP2006507246A (en) |
KR (1) | KR20050040928A (en) |
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NO (1) | NO20050068L (en) |
PE (1) | PE20040974A1 (en) |
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UA (1) | UA82853C2 (en) |
WO (1) | WO2004024702A1 (en) |
ZA (1) | ZA200500086B (en) |
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WO2004072018A1 (en) | 2003-02-12 | 2004-08-26 | Takeda Pharmaceutical Company Limited | Amine derivative |
CA2540826A1 (en) | 2003-10-01 | 2005-04-14 | The Procter & Gamble Company | Melanin concentrating hormone antagonists |
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US7605176B2 (en) | 2004-03-06 | 2009-10-20 | Boehringer Ingelheim International Gmbh | β-ketoamide compounds with MCH antagonistic activity |
US7524862B2 (en) | 2004-04-14 | 2009-04-28 | Boehringer Ingelheim International Gmbh | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
DE102004017934A1 (en) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New alkyne compounds having MCH antagonist activity and medicaments containing these compounds |
CN1956719A (en) * | 2004-05-25 | 2007-05-02 | 辉瑞产品公司 | Specific ppar excitant for treating negative energy equilibrium |
TW200613272A (en) * | 2004-08-13 | 2006-05-01 | Astrazeneca Ab | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
DE102004039789A1 (en) | 2004-08-16 | 2006-03-02 | Sanofi-Aventis Deutschland Gmbh | Aryl-substituted polycyclic amines, process for their preparation and their use as pharmaceuticals |
US7300931B2 (en) * | 2004-12-28 | 2007-11-27 | Kinex Pharmaceuticals, Llc | Compositions for treating cell proliferation disorders |
US7968574B2 (en) | 2004-12-28 | 2011-06-28 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
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TW200804347A (en) | 2006-01-10 | 2008-01-16 | Janssen Pharmaceutica Nv | Urotensin II receptor antagonists |
KR20080095879A (en) * | 2006-02-15 | 2008-10-29 | 사노피-아벤티스 | Novel azacyclyl-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments |
JP2009526794A (en) * | 2006-02-15 | 2009-07-23 | サノフィ−アベンティス | Novel amino alcohol-substituted arylthienopyrimidinones, methods for their preparation and their use as pharmaceuticals |
EP1987006B1 (en) | 2006-02-15 | 2011-01-12 | Sanofi-Aventis | Novel aminoalcohol-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments |
RU2008136898A (en) * | 2006-02-15 | 2010-03-20 | Санофи-Авентис (Fr) | AZACYCLYL-SUBSTITUTED ARYLDIGIDROISOCHINOLINONES, METHOD FOR PRODUCING THEM AND THEIR USE AS MEDICINES |
TWI398440B (en) * | 2006-06-29 | 2013-06-11 | Kinex Pharmaceuticals Llc | Biaryl compositions and methods for modulating a kinase cascade |
EP2041071B1 (en) * | 2006-06-29 | 2014-06-18 | Kinex Pharmaceuticals, LLC | Biaryl compositions and methods for modulating a kinase cascade |
CA2659412A1 (en) | 2006-07-31 | 2008-02-07 | Janssen Pharmaceutica N.V. | Urotensin ii receptor antagonists |
EP2383259A1 (en) | 2006-08-25 | 2011-11-02 | Boehringer Ingelheim International GmbH | New pyridone derivatives with MCH antagonistic activity and medicaments comprising these compounds |
MX2009005908A (en) | 2006-12-05 | 2009-06-16 | Janssen Pharmaceutica Nv | Novel substituted diaza spiro pyridinone derivatives for use in mch-1 mediated diseases. |
TW200831485A (en) | 2006-12-11 | 2008-08-01 | Boehringer Ingelheim Int | New pyridazine derivatives with MCH antagonistic activity and medicaments comprising these compounds |
US7935697B2 (en) | 2006-12-28 | 2011-05-03 | Kinex Pharmaceuticals, Llc | Compositions for modulating a kinase cascade and methods of use thereof |
EA200900937A1 (en) * | 2007-01-03 | 2009-12-30 | Кортекс Фармасеутикалс, Инк. | COMPOUNDS OF 3-SUBSTITUTED- [1,2,3] BENZOTRIAZINONE FOR STRENGTHENING GLUTAMATERGIC SYNAPTIC RESPONSES |
CA2680275C (en) | 2007-03-09 | 2016-08-23 | Renovis, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
TWI417100B (en) | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | Oxadiazole derivatives and their use as metabotropic glutamate receptor potentiators-842 |
EP2025674A1 (en) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs |
CN101412682B (en) * | 2007-10-19 | 2012-06-27 | 上海药明康德新药开发有限公司 | Process for synthesizing aryl anthranilic acid and derivatives thereof |
ES2552549T3 (en) * | 2008-04-23 | 2015-11-30 | Rigel Pharmaceuticals, Inc. | Carboxamide compounds for the treatment of metabolic disorders |
SA109300358B1 (en) | 2008-06-06 | 2012-11-03 | استرازينيكا ايه بي | Isoindolone Metabotropic Glutamate receptor Potentiators |
ATE546448T1 (en) | 2008-08-02 | 2012-03-15 | Janssen Pharmaceutica Nv | UROTENSIN II RECEPTOR ANTAGONISTS |
UY32443A (en) | 2009-02-13 | 2010-09-30 | Sanofi Aventis | NEW TETRAHYDRONAFTALENES, PROCESSES FOR THE PREPARATION AND USE OF THE SAME AS A MEDICINAL PRODUCT. |
UY32442A (en) | 2009-02-13 | 2010-09-30 | Sanofi Aventis | NEW SUBSTITUTED INDANS, PROCESSES FOR THEIR PREPARATION AND USE OF THE SAME AS A MEDICINAL PRODUCT |
WO2011129936A2 (en) | 2010-04-16 | 2011-10-20 | Kinex Pharmaceuticals, Llc | Compositions and methods for the prevention and treatment of cancer |
GB201009853D0 (en) | 2010-06-11 | 2010-07-21 | Chroma Therapeutics Ltd | HSP90 inhibitors |
TWI577670B (en) * | 2011-05-10 | 2017-04-11 | 基利科學股份有限公司 | Fused heterocyclic compounds as ion channel modulators |
NO3175985T3 (en) | 2011-07-01 | 2018-04-28 | ||
TWI549944B (en) | 2011-07-01 | 2016-09-21 | 吉李德科學股份有限公司 | Fused heterocyclic compounds as ion channel modulators |
UY34194A (en) * | 2011-07-15 | 2013-02-28 | Astrazeneca Ab | ? (3- (4- (SPIROHETEROCYCLIC) METHYL) PHENOXI) AZETIDIN-1-IL) (5- (PHENYL) -1,3,4-OXADIAZOL-2-IL) METHANONE IN THE TREATMENT OF OBESITY? |
US8933079B2 (en) * | 2012-03-07 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Pyridone and pyridazinone derivatives as anti-obesity agents |
HUE037637T2 (en) | 2012-08-30 | 2018-09-28 | Athenex Inc | N-(3-fluorobenzyl)-2-(5-(4-morpholinophenyl)pyridin-2-yl) acetamide as protein tyrosine kinase modulators |
FR3000491B1 (en) * | 2012-09-27 | 2015-08-28 | Univ Lille Ii Droit & Sante | COMPOUNDS FOR USE IN THE TREATMENT OF MYCOBACTERIAL INFECTIONS |
CN110407824B (en) * | 2019-08-08 | 2021-07-02 | 安徽医科大学 | Aryl formamide compound and preparation method, pharmaceutical composition and application thereof |
JP2022549227A (en) * | 2019-09-17 | 2022-11-24 | バイアル-アールアンドディー インベストメンツ ソシエダッド アノニマ | Substituted saturated and unsaturated N-heterocyclic carboxamides and related compounds for use in treating medical disorders |
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EP1218336A2 (en) * | 1999-09-20 | 2002-07-03 | Takeda Chemical Industries, Ltd. | Melanin concentrating hormone antagonist |
AU2001256733A1 (en) * | 2000-05-16 | 2001-11-26 | Takeda Chemical Industries Ltd. | Melanin-concentrating hormone antagonist |
EP1299362A4 (en) * | 2000-07-05 | 2004-11-03 | Synaptic Pharma Corp | Selective melanin concentrating hormone-1 (mch1) receptor antagonists and uses thereof |
US20030022891A1 (en) * | 2000-12-01 | 2003-01-30 | Anandan Palani | MCH antagonists and their use in the treatment of obesity |
ES2243588T3 (en) * | 2000-12-22 | 2005-12-01 | Schering Corporation | PCHERIDINIC ANTAGONISTS OF THE MCH AND ITS USE IN THE TREATMENT OF OBESITY. |
GB0124627D0 (en) * | 2001-10-15 | 2001-12-05 | Smithkline Beecham Plc | Novel compounds |
GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
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TW200413332A (en) | 2004-08-01 |
UA82853C2 (en) | 2008-05-26 |
RS20050173A (en) | 2007-09-21 |
MXPA05002158A (en) | 2005-05-23 |
ECSP055615A (en) | 2005-05-30 |
AR043046A1 (en) | 2005-07-13 |
CN1678591A (en) | 2005-10-05 |
DE10238865A1 (en) | 2004-03-11 |
HRP20050179A2 (en) | 2006-05-31 |
WO2004024702A1 (en) | 2004-03-25 |
EA200500301A1 (en) | 2006-02-24 |
KR20050040928A (en) | 2005-05-03 |
PE20040974A1 (en) | 2005-01-12 |
CA2496563A1 (en) | 2004-03-25 |
JP2006507246A (en) | 2006-03-02 |
BR0313790A (en) | 2005-07-12 |
ZA200500086B (en) | 2006-07-26 |
NO20050068L (en) | 2005-03-04 |
AU2003258620A1 (en) | 2004-04-30 |
EP1534689A1 (en) | 2005-06-01 |
EA012834B1 (en) | 2009-12-30 |
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