ZA200500086B - Novel carboxamide compounds having an MCH-antagonistic effect, medicaments containing said compounds, and method for the production thereof - Google Patents
Novel carboxamide compounds having an MCH-antagonistic effect, medicaments containing said compounds, and method for the production thereofInfo
- Publication number
- ZA200500086B ZA200500086B ZA200500086A ZA200500086A ZA200500086B ZA 200500086 B ZA200500086 B ZA 200500086B ZA 200500086 A ZA200500086 A ZA 200500086A ZA 200500086 A ZA200500086 A ZA 200500086A ZA 200500086 B ZA200500086 B ZA 200500086B
- Authority
- ZA
- South Africa
- Prior art keywords
- compounds
- mch
- production
- antagonistic effect
- medicaments containing
- Prior art date
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- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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DE10238865A DE10238865A1 (de) | 2002-08-24 | 2002-08-24 | Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
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UA (1) | UA82853C2 (xx) |
WO (1) | WO2004024702A1 (xx) |
ZA (1) | ZA200500086B (xx) |
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US7351719B2 (en) | 2002-10-31 | 2008-04-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds |
EP1593667A4 (en) * | 2003-02-12 | 2009-03-04 | Takeda Pharmaceutical | AMINE DERIVATIVE |
CN101068773A (zh) | 2003-10-01 | 2007-11-07 | 宝洁公司 | 黑素聚集激素拮抗剂 |
EP1680109A4 (en) * | 2003-10-07 | 2009-05-06 | Renovis Inc | AMIDE DERIVATIVES AS ION CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE DERIVATIVES |
US7592373B2 (en) | 2003-12-23 | 2009-09-22 | Boehringer Ingelheim International Gmbh | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds |
US7605176B2 (en) | 2004-03-06 | 2009-10-20 | Boehringer Ingelheim International Gmbh | β-ketoamide compounds with MCH antagonistic activity |
DE102004017934A1 (de) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
US7524862B2 (en) | 2004-04-14 | 2009-04-28 | Boehringer Ingelheim International Gmbh | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
WO2005115389A2 (en) * | 2004-05-25 | 2005-12-08 | Pfizer Products Inc. | Specific ppar agonists for treating negative energy balance |
TW200613272A (en) | 2004-08-13 | 2006-05-01 | Astrazeneca Ab | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
DE102004039789A1 (de) | 2004-08-16 | 2006-03-02 | Sanofi-Aventis Deutschland Gmbh | Arylsubstituierte polycyclische Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
CN101184734B (zh) * | 2004-12-28 | 2013-05-29 | 金克斯医药品有限公司 | 治疗细胞增殖紊乱的化合物和方法 |
US7968574B2 (en) | 2004-12-28 | 2011-06-28 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
WO2007021309A1 (en) * | 2005-08-12 | 2007-02-22 | Astrazeneca Ab | Substituted isoindolones and their use as metabotropic glutamate receptor potentiators |
US7807706B2 (en) | 2005-08-12 | 2010-10-05 | Astrazeneca Ab | Metabotropic glutamate-receptor-potentiating isoindolones |
US8329704B2 (en) | 2005-12-21 | 2012-12-11 | Janssen Pharmaceutica, N.V. | Substituted pyrazinone derivatives for use in MCH-1 mediated diseases |
TW200804347A (en) | 2006-01-10 | 2008-01-16 | Janssen Pharmaceutica Nv | Urotensin II receptor antagonists |
CN101370501A (zh) * | 2006-02-15 | 2009-02-18 | 塞诺菲-安万特股份有限公司 | 新的氮杂环基取代的芳基噻吩并嘧啶酮类、其制备方法以及其作为药物的用途 |
EP1987042B1 (en) * | 2006-02-15 | 2015-01-21 | Sanofi | Novel amino alcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments |
EP1987020B1 (en) * | 2006-02-15 | 2012-10-03 | Sanofi | Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments |
MY149854A (en) | 2006-02-15 | 2013-10-31 | Sanofi Aventis | Novel aminoalcohol-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments |
TWI398440B (zh) * | 2006-06-29 | 2013-06-11 | Kinex Pharmaceuticals Llc | 雙芳基組成物與調節激酶級聯之方法 |
CA2656564C (en) * | 2006-06-29 | 2015-06-16 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
WO2008016534A1 (en) | 2006-07-31 | 2008-02-07 | Janssen Pharmaceutica, N.V. | Urotensin ii receptor antagonists |
WO2008022979A1 (en) | 2006-08-25 | 2008-02-28 | Boehringer Ingelheim International Gmbh | New pyridone derivatives with mch antagonistic activity and medicaments comprising these compounds |
CA2664112C (en) | 2006-12-05 | 2015-02-17 | Janssen Pharmaceutica N.V. | Novel substituted diaza-spiro-pyridinone derivatives for use in mch-1 mediated diseases |
WO2008071646A1 (en) | 2006-12-11 | 2008-06-19 | Boehringer Ingelheim International Gmbh | New pyridazine derivatives with mch antagonistic activity and medicaments comprising these compounds |
US7935697B2 (en) | 2006-12-28 | 2011-05-03 | Kinex Pharmaceuticals, Llc | Compositions for modulating a kinase cascade and methods of use thereof |
EA200900937A1 (ru) * | 2007-01-03 | 2009-12-30 | Кортекс Фармасеутикалс, Инк. | Соединения 3-замещенного-[1,2,3]бензотриазинона для усиления глутаматергических синаптических ответов |
CN101686680B (zh) | 2007-03-09 | 2015-12-09 | 伊沃泰克美国股份有限公司 | 作为p2x7调节剂的双环杂芳基化合物及其用途 |
TWI417100B (zh) | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | 二唑衍生物及其作為代謝型麩胺酸受體增效劑-842之用途 |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
CN101412682B (zh) * | 2007-10-19 | 2012-06-27 | 上海药明康德新药开发有限公司 | 芳基氨茴酸及其衍生物的合成方法 |
US8314107B2 (en) * | 2008-04-23 | 2012-11-20 | Rigel Pharmaceuticals, Inc. | Carboxamide compounds and methods for using the same |
US7790760B2 (en) | 2008-06-06 | 2010-09-07 | Astrazeneca Ab | Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286 |
ATE546448T1 (de) | 2008-08-02 | 2012-03-15 | Janssen Pharmaceutica Nv | Urotensin-ii-rezeptorantagonisten |
AR075402A1 (es) | 2009-02-13 | 2011-03-30 | Sanofi Aventis | Derivados heterociclicos oxigenados y/o nitrogenados de tetrahidronaftaleno, medicamentos que los contienen y uso de los mismos en el tratamiento de trastornos metabolicos, tales como obesidad,entre otros. |
UY32442A (es) | 2009-02-13 | 2010-09-30 | Sanofi Aventis | Nuevos indanos sustituidos, procesos para su preparacion y uso de los mismos como un medicamento |
WO2011129936A2 (en) | 2010-04-16 | 2011-10-20 | Kinex Pharmaceuticals, Llc | Compositions and methods for the prevention and treatment of cancer |
GB201009853D0 (en) | 2010-06-11 | 2010-07-21 | Chroma Therapeutics Ltd | HSP90 inhibitors |
CN105693645B (zh) * | 2011-05-10 | 2018-10-09 | 吉利德科学公司 | 作为离子通道调节剂的稠合杂环化合物 |
TWI478908B (zh) | 2011-07-01 | 2015-04-01 | Gilead Sciences Inc | 作為離子通道調節劑之稠合雜環化合物 |
NO3175985T3 (xx) | 2011-07-01 | 2018-04-28 | ||
UY34194A (es) * | 2011-07-15 | 2013-02-28 | Astrazeneca Ab | ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad? |
US8933079B2 (en) * | 2012-03-07 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Pyridone and pyridazinone derivatives as anti-obesity agents |
JP6499076B2 (ja) | 2012-08-30 | 2019-04-10 | アセネックス インコーポレイテッド | タンパク質チロシンキナーゼ調節因子としてのn−(3−フルオロベンジル)−2−(5−(4−モルホリノフェニル)ピリジン−2−イル)アセトアミド |
FR3000491B1 (fr) * | 2012-09-27 | 2015-08-28 | Univ Lille Ii Droit & Sante | Composes utilisables dans le traitement des infections mycobacteriennes |
CN110407824B (zh) * | 2019-08-08 | 2021-07-02 | 安徽医科大学 | 芳基甲酰胺类化合物及其制备方法、药物组合物及用途 |
KR20220100860A (ko) * | 2019-09-17 | 2022-07-18 | 비알 - 알&디 인베스트먼츠, 에스.에이. | 질병의 치료에 사용하기 위한 치환된, 포화 및 불포화 n-헤테로시클릭 카르복사미드 및 관련 화합물 |
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US7115750B1 (en) * | 1999-09-20 | 2006-10-03 | Takeda Pharmaceutical Company Limited | Melanin concentrating hormone antagonist |
WO2001087834A1 (fr) * | 2000-05-16 | 2001-11-22 | Takeda Chemical Industries, Ltd. | Antagoniste de l'hormone de concentration de la melanine |
AU783403B2 (en) * | 2000-07-05 | 2005-10-20 | H. Lundbeck A/S | Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof |
US20030022891A1 (en) * | 2000-12-01 | 2003-01-30 | Anandan Palani | MCH antagonists and their use in the treatment of obesity |
DE60112791T2 (de) * | 2000-12-22 | 2006-06-08 | Schering Corp. | Piperidin mch antagonisten und ihre verwendung in der behandlung von obesität |
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GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
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- 2003-08-16 EP EP03794886A patent/EP1534689A1/de not_active Withdrawn
- 2003-08-16 EA EA200500301A patent/EA012834B1/ru not_active IP Right Cessation
- 2003-08-16 RS YUP-2005/0173A patent/RS20050173A/sr unknown
- 2003-08-16 PL PL03375344A patent/PL375344A1/xx not_active Application Discontinuation
- 2003-08-16 MX MXPA05002158A patent/MXPA05002158A/es unknown
- 2003-08-16 BR BR0313790-2A patent/BR0313790A/pt not_active Expired - Fee Related
- 2003-08-16 CN CNA038200767A patent/CN1678591A/zh active Pending
- 2003-08-16 KR KR1020057003110A patent/KR20050040928A/ko not_active Application Discontinuation
- 2003-08-16 CA CA002496563A patent/CA2496563A1/en not_active Abandoned
- 2003-08-16 WO PCT/EP2003/009099 patent/WO2004024702A1/de active Application Filing
- 2003-08-21 PE PE2003000849A patent/PE20040974A1/es not_active Application Discontinuation
- 2003-08-22 TW TW092123197A patent/TW200413332A/zh unknown
- 2003-08-22 AR ARP030103034A patent/AR043046A1/es unknown
-
2005
- 2005-01-05 ZA ZA200500086A patent/ZA200500086B/xx unknown
- 2005-01-06 NO NO20050068A patent/NO20050068L/no not_active Application Discontinuation
- 2005-02-18 EC EC2005005615A patent/ECSP055615A/es unknown
- 2005-02-23 HR HR20050179A patent/HRP20050179A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20050040928A (ko) | 2005-05-03 |
EA200500301A1 (ru) | 2006-02-24 |
PL375344A1 (en) | 2005-11-28 |
RS20050173A (xx) | 2007-09-21 |
WO2004024702A1 (de) | 2004-03-25 |
UA82853C2 (en) | 2008-05-26 |
BR0313790A (pt) | 2005-07-12 |
ECSP055615A (es) | 2005-05-30 |
CA2496563A1 (en) | 2004-03-25 |
MXPA05002158A (es) | 2005-05-23 |
JP2006507246A (ja) | 2006-03-02 |
TW200413332A (en) | 2004-08-01 |
AU2003258620A1 (en) | 2004-04-30 |
EP1534689A1 (de) | 2005-06-01 |
PE20040974A1 (es) | 2005-01-12 |
AR043046A1 (es) | 2005-07-13 |
HRP20050179A2 (en) | 2006-05-31 |
EA012834B1 (ru) | 2009-12-30 |
DE10238865A1 (de) | 2004-03-11 |
NO20050068L (no) | 2005-03-04 |
CN1678591A (zh) | 2005-10-05 |
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