AR037008A1 - El uso del antagonista del receptor nk-1 para la elaboracion de un medicamento para el tratamiento y/o prevencion de lesiones cerebrales, espinales o neuronales y una composicion farmaceutica que comprende uno o mas de dicho antagonista. - Google Patents
El uso del antagonista del receptor nk-1 para la elaboracion de un medicamento para el tratamiento y/o prevencion de lesiones cerebrales, espinales o neuronales y una composicion farmaceutica que comprende uno o mas de dicho antagonista.Info
- Publication number
- AR037008A1 AR037008A1 ARP020102546A ARP020102546A AR037008A1 AR 037008 A1 AR037008 A1 AR 037008A1 AR P020102546 A ARP020102546 A AR P020102546A AR P020102546 A ARP020102546 A AR P020102546A AR 037008 A1 AR037008 A1 AR 037008A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- halogen
- hydrogen
- trifluoromethyl
- cyano
- Prior art date
Links
- 210000004556 brain Anatomy 0.000 title abstract 3
- 230000001537 neural effect Effects 0.000 title abstract 3
- 230000002265 prevention Effects 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 2
- 230000006378 damage Effects 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 24
- -1 cyclic tertiary amine Chemical class 0.000 abstract 18
- 229910052736 halogen Inorganic materials 0.000 abstract 13
- 150000002367 halogens Chemical class 0.000 abstract 13
- 229910052739 hydrogen Inorganic materials 0.000 abstract 13
- 239000001257 hydrogen Substances 0.000 abstract 13
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 11
- 125000003545 alkoxy group Chemical group 0.000 abstract 10
- 150000002431 hydrogen Chemical group 0.000 abstract 10
- 125000001424 substituent group Chemical group 0.000 abstract 8
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 7
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000005842 heteroatom Chemical group 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 abstract 3
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 159000000003 magnesium salts Chemical class 0.000 abstract 3
- 239000002464 receptor antagonist Substances 0.000 abstract 3
- 229940044551 receptor antagonist Drugs 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 230000003902 lesion Effects 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- HCNNJLLLMSVTFH-UHFFFAOYSA-N n-[[3,5-bis(trifluoromethyl)phenyl]methyl]-n-methyl-4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridine-3-carboxamide Chemical compound C=1N=C(N2CCN(C)CC2)C=C(C=2C(=CC=CC=2)C)C=1C(=O)N(C)CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 HCNNJLLLMSVTFH-UHFFFAOYSA-N 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
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- Pain & Pain Management (AREA)
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- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
El uso de un antagonista del receptor NK-1, en combinación opcionalmente con una sal de magnesio, para el tratamiento y/o prevención de lesiones cerebrales, espinales o neuronales, en donde dicho antagonista del receptor NK-1 es un compuesto de fórmula general (1), en donde: R es hidrógeno, alquilo inferior, alcoxilo inferior, halógeno o trifluorometilo; R1 es hidrógeno o halógeno; o R y R1, pueden estar juntos -CH=CH-CH=CH-; R2 y R2' son independientemente uno del otro hidrógeno, halógeno, trifluorometilo, alquilo inferior, alcoxilo inferior o ciano; o R2 y R2' pueden estar juntos -CH=CH-CH=CH-, sustituidos opcionalmente por uno o dos sustituyentes seleccionados de alquilo inferior, halógeno o alcoxilo inferior; R3 es, independientemente uno del otro si aparecen dos veces, hidrógeno, alquilo inferior o puede, si aparecen dos veces, formar juntos con el átomo de carbono al que están unidos un grupo cicloalquilo; R4 es hidrógeno, -N(R5)2, -N(R5)(CH2)nOH, alquilo-N(R5)S(O)2-inferior, -N(R5)S(O)2-fenilo, -N=CH-N(R5)2, -N(R5)C(O)R5, una amina terciaria cíclica del grupo de fórmulas (2) o R4 es -(CsC)mR7 o -(CR'=CR'')mR7 en donde R7 es: a) halógeno, b) ciano, o los grupos siguientes; c) (CR'R'')m-R8 d) -C(O)NR'R'', e) -C(O)O(CH2)nR8, f) -C(O)R8, g) -N(OH)-(CH2)nR8, h)-NR'C(O)-(CH2)nR8, i) -N[C(O)-R']2, j) -OR9, k) -(CH2)n-SR9, -(CH2)n-S(O)R9, o -(CH2)n-S(O)2R9, l) arilo, opcionalmente sustituido con uno o más sustituyentes, seleccionados de halógeno, trifluorometilo, alquilo inferior, alcoxilo inferior, ciano, hidroxilo, -NR'R'', nitro,-(CH2)mOR', -C(O)NR'R'', -C(O)OR' o -C(O)R', m) es un grupo heteroarilo de cinco o seis miembros, que contienen de uno a cuatro heteroátomos, seleccionados de N, O, o S y pueden estar opcionalmente sustituidos por uno o más sustituyentes, seleccionados de halógeno, trifluorometilo, alquilo inferior, alcoxilo inferior, ciano, hidroxilo, -NR'R'', nitro, -(CH2)mOR', -C(O)OR', C(O)NR'R'' o -C(O)R', n) es una amina terciaria cíclica saturada de cinco o seis miembros del grupo de fórmula (3) que puede contener un heteroátomo adicional, seleccionado de N, O, ó S, R'/R'' son independientemente uno del otro hidrógeno, hidroxilo, alquilo inferior, cicloalquilo o arilo, en donde el grupo alquilo inferior, cicloalquilo o arilo puede estar sustituido opcionalmente con uno o más sustituyentes seleccionados de halógeno, trifluorometilo, alquilo inferior, alcoxilo inferior, ciano, hidroxilo, -NR'''R'''', nitro, -(CH2)mOR''', -C(O)NR'''R'''', -C(O)OR''' o -C(O)R''', R'''/R'''' son independientemente uno del otro hidrógeno, alquilo inferior, cicloalquilo o arilo, R8 es hidrógeno, ciano, hidroxilo, halógeno, trifluorometilo, -C(O)OR', -OC(O)R' o arilo, opcionalmente sustituido por uno o más sustituyentes, seleccionados de halógeno, trifluorometilo, alquilo inferior, alcoxilo inferior, ciano, hidroxilo, -NR'R'', nitro,-(CH2)mOR', -C(O)NR'R'', -C(O)OR', -C(O)R', o es un grupo heteroarilo de cinco o seis miembros, que contienen de uno a cuatro heteroátomos, seleccionados de N, O ó S y pueden estar opcionalmente sustituidos por uno o más sustituyentes, seleccionados de halógeno, trifluorometilo, alquilo inferior, alcoxilo inferior, ciano, hidroxilo, -NR'R'', nitro, -(CH2)mOR', -C(O)NR'R'', -C(O)OR' o -C(O)R', R9 es hidrógeno, alquilo inferior, trifluorometilo, o arilo, en donde el grupo alquilo inferior o arilo puede estar sustituido por uno o más sustituyentes, seleccionados de halógeno, trifluorometilo, alquilo inferior, alcoxilo inferior, ciano, hidroxilo, -NR'R'', nitro, -C(O)NR'R'', -(CH2)mOR', -C(O)OR', -C(O)R', o es un grupo heteroarilo de cinco o seis miembros, que contiene de uno a cuatro heteroátomos, seleccionados de N, O ó S ,y pueden estar opcionalmente sustituidos por uno o más sustituyentes seleccionados de halógeno, trifluorometilo, alquilo inferior, alcoxilo inferior, ciano, hidroxilo, -NR'R'', nitro, -(CH2)mOR', -C(O)NR'R'', -C(O)OR' o -C(O)R', R10 es -C(O)-(CH2)mOH o un grupo oxo; o R4 es un N-óxido de fórmula general como fórmula (4) en donde R11 Y R11' son independientemente uno del otro -(CH2)pOR12 o alquilo inferior, en donde R12 es hidrógeno, alquilo inferior o fenilo; o R11 y R11' forman junto con el átomo de N al que están unidos una amina terciaria cíclica del grupo de fórmula (5) en donde R13 es hidrógeno, hidroxilo, alquilo inferior, alcoxilo inferior, -(CH2)pOH, -COOR3, -CON(R3)2, -N(R3)CO-alquilo inferior o -C(O)R3; R5 es, independientemente uno del otro, hidrógeno, cicloalquilo- C3-6, bencilo, fenilo, o alquilo inferior; R6 es hidrógeno, hidroxilo, alquilo inferior, -(CH2)nCOO-alquilo inferior, -N(R5)CO-alquilo inferior, hidroxi-alquilo inferior, ciano, -(CH2)nO(CH2)nOH, -CO o un grupo heterocíclico de 5 o 6 miembros, unido opcionalmente mediante un grupo alquileno; X es -C(O)N(R5)-, -(CH2)mO-, -O(CH2)m-, -(CH2)mN(R5)-, -N(R5)C(O)- ó -N(R5)(CH2)m-, n es 0, 1, 2, 3 ó 4; m es 1 ó 2; y p es 1, 2 ó 3; y las sales de adición ácida farmacéuticamente aceptables y los pro-fármacos de las mismas, tanto solos o en combinación con una sal de magnesio. Se ejemplifica el uso de N-(3,5-bis-trifluorometil-bencil)-N-metil-6-(4-metil-piperazin-1-il)-4-o-tolil-nicotinamida. La presente también se refiere a una composición farmacéutica que comprende uno o más. de tales antagonistas del receptor NK-1, en combinación opcionalmente con una sal de magnesio, y un excipiente farmacéuticamente aceptable para el tratamiento y/o prevención de lesiones cerebrales, espinales o neuronales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01116812 | 2001-07-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR037008A1 true AR037008A1 (es) | 2004-10-20 |
Family
ID=8178001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020102546A AR037008A1 (es) | 2001-07-10 | 2002-07-08 | El uso del antagonista del receptor nk-1 para la elaboracion de un medicamento para el tratamiento y/o prevencion de lesiones cerebrales, espinales o neuronales y una composicion farmaceutica que comprende uno o mas de dicho antagonista. |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US20030083345A1 (es) |
| EP (2) | EP1406618A2 (es) |
| JP (1) | JP2004536119A (es) |
| KR (1) | KR100589106B1 (es) |
| CN (1) | CN100346789C (es) |
| AR (1) | AR037008A1 (es) |
| AU (1) | AU2002328837B2 (es) |
| BR (1) | BR0210893A (es) |
| CA (1) | CA2451566C (es) |
| GT (1) | GT200200143A (es) |
| HK (1) | HK1068266A1 (es) |
| HR (1) | HRP20031071A2 (es) |
| HU (1) | HUP0401210A3 (es) |
| IL (1) | IL159350A0 (es) |
| MX (1) | MXPA04000278A (es) |
| NO (1) | NO332847B1 (es) |
| NZ (1) | NZ530107A (es) |
| PA (1) | PA8549901A1 (es) |
| PE (1) | PE20030238A1 (es) |
| PL (1) | PL211246B1 (es) |
| RU (1) | RU2304435C2 (es) |
| UY (1) | UY27374A1 (es) |
| WO (1) | WO2003006016A2 (es) |
| ZA (1) | ZA200400138B (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS50932B (sr) * | 2000-07-14 | 2010-08-31 | F. Hoffmann-La Roche Ag. | N-oksidi kao prolekovi 4-fenil-piridinskih derivata koji su antagonisti nk1 receptora |
| NZ544244A (en) * | 2003-07-03 | 2008-10-31 | Hoffmann La Roche | Dual NK1/NK3 antagonists for treating schizophrenia |
| GB0410215D0 (en) * | 2004-05-07 | 2004-06-09 | Lescroart Pol | Nerve damage |
| JP4580426B2 (ja) | 2004-07-06 | 2010-11-10 | エフ．ホフマン−ラ ロシュ アーゲー | Ｎｋ−１受容体拮抗薬の合成において中間体として使用されるカルボキサミド誘導体の製造方法 |
| US20060030600A1 (en) * | 2004-08-06 | 2006-02-09 | Patrick Schnider | Dual NK1/NK3 receptor antagonists for the treatment of schizophrenia |
| CA2601935C (en) * | 2005-02-22 | 2013-04-09 | F. Hoffmann-La Roche Ag | Nk1 antagonists |
| KR20070094666A (ko) | 2005-02-25 | 2007-09-20 | 에프. 호프만-라 로슈 아게 | 약제 물질 분산성이 향상된 정제 |
| PL1863767T3 (pl) * | 2005-03-23 | 2009-08-31 | Helsinn Healthcare Sa | Metabolity antagonistów NK-1 do leczenia wymiotów |
| ES2439736T3 (es) | 2005-11-08 | 2014-01-24 | Vertex Pharmaceuticals Incorporated | Moduladores heterocíclicos de transportadores de casete de unión a ATP |
| US7671221B2 (en) | 2005-12-28 | 2010-03-02 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| US7754739B2 (en) | 2007-05-09 | 2010-07-13 | Vertex Pharmaceuticals Incorporated | Modulators of CFTR |
| DE102007018151A1 (de) * | 2007-04-16 | 2008-10-23 | Günenthal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
| CN104447716A (zh) | 2007-05-09 | 2015-03-25 | 沃泰克斯药物股份有限公司 | Cftr调节剂 |
| AU2008278273A1 (en) * | 2007-07-19 | 2009-01-22 | Adelaide Research & Innovation Pty Ltd | Method for reducing intracranial pressure |
| CN101910156B (zh) | 2007-12-07 | 2013-12-04 | 沃泰克斯药物股份有限公司 | 3-(6-(1-(2,2-二氟苯并[d][1,3]间二氧杂环戊烯-5-基)环丙烷甲酰氨基)-3-甲基吡啶-2-基)苯甲酸的固体形式 |
| CA2989620C (en) | 2007-12-07 | 2022-05-03 | Vertex Pharmaceuticals Incorporated | Processes for producing cycloalkylcarboxamido-pyridine benzoic acids |
| EP2271622B1 (en) | 2008-02-28 | 2017-10-04 | Vertex Pharmaceuticals Incorporated | Heteroaryl derivatives as CFTR Modulators |
| GB0808747D0 (en) * | 2008-05-14 | 2008-06-18 | Glaxo Wellcome Mfg Pte Ltd | Novel compounds |
| DK3150198T3 (da) | 2010-04-07 | 2021-11-01 | Vertex Pharma | Farmaceutiske sammensætninger af 3-(6-(1-(2,2-difluorbenzo[d][1,3]dioxol-5-yl)-cyclopropancarboxamido)-3-methylpyriodin-2-yl)benzoesyre og indgivelse deraf |
| US20160129007A1 (en) * | 2013-07-02 | 2016-05-12 | Eustralis Pharmaceuticals Limited (Trading As Pressura Neuro) | Method for Preventing and/or Treating Chronic Traumatic Encephalopathy - IV |
| CA2914515C (en) * | 2013-07-02 | 2018-12-11 | Eustralis Pharmaceuticals Limited (Trading As Pressura Neuro) | Method for preventing and/or treating chronic traumatic encephalopathy-i |
| KR101903713B1 (ko) * | 2013-07-02 | 2018-10-04 | 유스트랄리스 파마슈티칼스 리미티드 (트레이딩 애즈 프레스수라 뉴로) | 만성 외상성 뇌병증-ii를 예방 및/또는 치료하는 방법 |
| KR20160078997A (ko) | 2013-11-08 | 2016-07-05 | 깃세이 야쿠힌 고교 가부시키가이샤 | 카복시메틸피페리딘 유도체 |
| US10231932B2 (en) | 2013-11-12 | 2019-03-19 | Vertex Pharmaceuticals Incorporated | Process of preparing pharmaceutical compositions for the treatment of CFTR mediated diseases |
| TWI649307B (zh) | 2014-05-07 | 2019-02-01 | 日商橘生藥品工業股份有限公司 | Cyclohexylpyridine derivative |
| JP6494757B2 (ja) | 2014-11-18 | 2019-04-03 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | ハイスループット試験高速液体クロマトグラフィーを行うプロセス |
| CN111741755B (zh) * | 2018-02-02 | 2024-04-16 | 尤斯特拉里斯制药有限公司（以普雷舒拉纽罗作为商号） | 肠胃外制剂及其用途 |
| KR101970099B1 (ko) * | 2018-02-07 | 2019-04-17 | 한국과학기술연구원 | 척수 손상의 예방 및 치료용 조성물 |
| KR102005019B1 (ko) * | 2018-04-04 | 2019-07-31 | 한국과학기술연구원 | 뇌졸중의 예방 및 치료용 조성물 |
| US20230124548A1 (en) * | 2019-08-23 | 2023-04-20 | Eustralis Pharmaceuticals Limited (Trading As Pressura Neuro) | Therapeutic Methods And Uses Thereof |
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| US4745123A (en) * | 1986-02-18 | 1988-05-17 | Warner-Lambert Company | Substituted tetrahydro-3-pyridine-carboxylic acid, ester, and amide cholinergic agents |
| IS4208A (is) * | 1993-09-22 | 1995-03-23 | Glaxo Group Limited | 3-(tetrazólýl-benzyl)amínó-piperadidín afleiður |
| US6175013B1 (en) * | 1994-06-10 | 2001-01-16 | Eli Lilly And Company | Imidazolinyl tachykinin receptor antagonists |
| US5607947A (en) * | 1995-02-21 | 1997-03-04 | Eli Lilly And Company | Pyrrolidinyl tachykinin receptor antagonists |
| IL116249A (en) * | 1994-12-12 | 2003-07-06 | Pfizer | Nk-1 receptor antagonists for the treatment of neuronal damage and stroke |
| TW382017B (en) * | 1995-12-27 | 2000-02-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives |
| CA2291734A1 (en) * | 1997-06-27 | 1999-01-07 | Merck Sharp & Dohme Limited | Substituted 3-(benzylamino)piperidine derivatives and their use as therapeutic agents |
| US5972938A (en) * | 1997-12-01 | 1999-10-26 | Merck & Co., Inc. | Method for treating or preventing psychoimmunological disorders |
| DK1157005T3 (da) * | 1999-02-24 | 2005-02-14 | Hoffmann La Roche | 3-phenylpyridinderivater og anvendelsen deraf som NK-1-receptorantagonister |
| ATE496032T1 (de) * | 1999-02-24 | 2011-02-15 | Hoffmann La Roche | 4-phenylpyridinderivate und deren verwendung als nk-1 rezeptorantagonisten |
| GB9923748D0 (en) * | 1999-10-07 | 1999-12-08 | Glaxo Group Ltd | Chemical compounds |
| US6303790B1 (en) * | 1999-11-29 | 2001-10-16 | Hoffman-La Roche Inc. | Process for the preparation of pyridine derivatives |
| DE60006340T2 (de) * | 1999-11-29 | 2004-09-09 | F. Hoffmann-La Roche Ag | 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramid |
| AUPQ514600A0 (en) * | 2000-01-18 | 2000-02-10 | James Cook University | Brain injury treatment |
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