JP2009537176A5 - - Google Patents
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- Publication number
- JP2009537176A5 JP2009537176A5 JP2009512060A JP2009512060A JP2009537176A5 JP 2009537176 A5 JP2009537176 A5 JP 2009537176A5 JP 2009512060 A JP2009512060 A JP 2009512060A JP 2009512060 A JP2009512060 A JP 2009512060A JP 2009537176 A5 JP2009537176 A5 JP 2009537176A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- cells
- subpopulation
- antibody
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 41
- 102000036639 antigens Human genes 0.000 claims 41
- 108091007433 antigens Proteins 0.000 claims 41
- 238000000034 method Methods 0.000 claims 39
- 210000003719 b-lymphocyte Anatomy 0.000 claims 24
- 210000004027 cell Anatomy 0.000 claims 11
- 210000000628 antibody-producing cell Anatomy 0.000 claims 10
- 230000006698 induction Effects 0.000 claims 6
- 230000001629 suppression Effects 0.000 claims 6
- 239000011159 matrix material Substances 0.000 claims 5
- 239000007787 solid Substances 0.000 claims 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 3
- 239000011324 bead Substances 0.000 claims 3
- 241000282414 Homo sapiens Species 0.000 claims 2
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 230000008484 agonism Effects 0.000 claims 2
- 230000008485 antagonism Effects 0.000 claims 2
- 230000008236 biological pathway Effects 0.000 claims 2
- 210000002798 bone marrow cell Anatomy 0.000 claims 2
- 230000006037 cell lysis Effects 0.000 claims 2
- 210000001165 lymph node Anatomy 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 210000000952 spleen Anatomy 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 241000700199 Cavia porcellus Species 0.000 claims 1
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241000699666 Mus <mouse, genus> Species 0.000 claims 1
- 241000235648 Pichia Species 0.000 claims 1
- 241000700159 Rattus Species 0.000 claims 1
- 241000283984 Rodentia Species 0.000 claims 1
- 238000001261 affinity purification Methods 0.000 claims 1
- 239000003636 conditioned culture medium Substances 0.000 claims 1
- 230000001143 conditioned effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80141206P | 2006-05-19 | 2006-05-19 | |
| US60/801,412 | 2006-05-19 | ||
| PCT/US2007/011980 WO2008045140A1 (en) | 2006-05-19 | 2007-05-21 | Culture method for obtaining a clonal population of antigen-specific b cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009537176A JP2009537176A (ja) | 2009-10-29 |
| JP2009537176A5 true JP2009537176A5 (enExample) | 2010-07-08 |
| JP5607357B2 JP5607357B2 (ja) | 2014-10-15 |
Family
ID=39283142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009512060A Expired - Fee Related JP5607357B2 (ja) | 2006-05-19 | 2007-05-21 | 抗原特異的ｂ細胞のクローン集団を獲得するための培養方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20070269868A1 (enExample) |
| EP (1) | EP2021463B1 (enExample) |
| JP (1) | JP5607357B2 (enExample) |
| CN (1) | CN101600793B (enExample) |
| AU (1) | AU2007307324B2 (enExample) |
| CA (1) | CA2652392C (enExample) |
| DK (1) | DK2021463T3 (enExample) |
| IL (1) | IL195285A (enExample) |
| MX (1) | MX2008014692A (enExample) |
| NO (1) | NO20084835L (enExample) |
| NZ (1) | NZ572807A (enExample) |
| WO (1) | WO2008045140A1 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
| US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
| US7906117B2 (en) | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
| US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| CN105001332B (zh) | 2007-05-21 | 2018-12-04 | 奥尔德生物控股有限责任公司 | 针对il-6的抗体及其用途 |
| US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
| KR20110112307A (ko) * | 2008-11-25 | 2011-10-12 | 앨더 바이오파마슈티컬즈, 인코포레이티드 | 알부민을 상승시키고 및／또는 ｃｒｐ를 낮추는 ｉｌ６의 길항제 |
| US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
| US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US9452227B2 (en) | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
| US8323649B2 (en) | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
| US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
| US9079942B2 (en) * | 2009-02-09 | 2015-07-14 | Epitomics, Inc. | CDR-anchored amplification method |
| US20100317539A1 (en) * | 2009-06-12 | 2010-12-16 | Guo-Liang Yu | Library of Engineered-Antibody Producing Cells |
| US8709424B2 (en) | 2009-09-03 | 2014-04-29 | Merck Sharp & Dohme Corp. | Anti-GITR antibodies |
| US8293483B2 (en) | 2009-09-11 | 2012-10-23 | Epitomics, Inc. | Method for identifying lineage-related antibodies |
| US20120294852A1 (en) | 2009-11-24 | 2012-11-22 | Smith Jeffrey T L | Antagonists of il-6 to raise albumin and/or lower crp |
| US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
| TWI667346B (zh) | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | 促進抗原消失之具有經修飾的FcRn親和力之抗體 |
| DK2400298T3 (da) * | 2010-05-28 | 2013-09-02 | Hoffmann La Roche | Enkelt B-celle-dyrkningsfremgangsmåde og specifik antistoffremstilling |
| CA2818813C (en) | 2010-11-23 | 2020-10-06 | Alder Biopharmaceuticals, Inc. | Anti-il-6 antibodies for the treatment of oral mucositis |
| MX359070B (es) | 2010-12-01 | 2018-09-13 | Alderbio Holdings Llc | Composiciones anti-ngf y uso de las mismas. |
| JP5963746B2 (ja) * | 2011-03-30 | 2016-08-03 | 国立大学法人富山大学 | 形質細胞または形質芽細胞の選択方法、目的抗原特異的な抗体の製造方法、新規モノクローナル抗体 |
| TWI692485B (zh) | 2011-05-20 | 2020-05-01 | 美商艾爾德生物控股有限責任公司 | 抗降血鈣素基因相關胜肽（ａｎｔｉ-ｃｇｒｐ）組成物及其用途 |
| CN103702685B (zh) | 2011-05-20 | 2017-12-15 | 奥尔德生物控股有限责任公司 | 抗cgrp抗体和抗体片段用于在有需要的受试者、尤其是偏头痛患者中预防或抑制畏光或厌光的用途 |
| KR102128628B1 (ko) | 2011-05-20 | 2020-06-30 | 앨더바이오 홀딩스 엘엘씨 | 설사의 만성 및 급성 형태를 치료 또는 예방하기 위한 항-cgrp 또는 항-cgrp-r 항체 또는 항체 단편의 용도 |
| WO2013000982A1 (en) * | 2011-06-27 | 2013-01-03 | Vivalis | Method for screening cells |
| CN103987853A (zh) | 2011-09-28 | 2014-08-13 | Cb生物技术公司 | 使用Arm-PCR和高通量测序鉴定抗原特异的适应性免疫应答 |
| CN103946236B (zh) | 2011-11-23 | 2018-02-16 | 弗·哈夫曼-拉罗切有限公司 | 表达cd40l的哺乳动物细胞及其用途 |
| JP2015500655A (ja) | 2011-12-21 | 2015-01-08 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 同起源の抗体可変領域遺伝子セグメントをクローニングおよび発現させるための迅速な方法 |
| EP2727941A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Method for the production of multispecific antibodies |
| EP2727942A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Bispecific antibodies against human EGFR, HER2, and HER3 |
| EP2727943A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Trispecific antibodies against human EGFR, HER2 and HER3 |
| WO2014067642A1 (en) | 2012-11-05 | 2014-05-08 | Mab Discovery Gmbh | Method for the production of multispecific antibodies |
| CN104903349B (zh) | 2012-11-08 | 2018-10-19 | 十一生物治疗股份有限公司 | Il-6拮抗剂及其应用 |
| SG11201503706TA (en) * | 2012-11-13 | 2015-06-29 | Genentech Inc | Enrichment of antigen-specific plasmablasts |
| JP2016506974A (ja) * | 2013-02-15 | 2016-03-07 | エスバテック − ア ノバルティスカンパニー エルエルシー | Ｃｄｒグラフトのためのアクセプターフレームワーク |
| TW201444868A (zh) * | 2013-03-14 | 2014-12-01 | Alder Biopharmaceuticals Inc | Ｈｇｆ抗體及其組成物 |
| US20160033504A1 (en) * | 2013-03-15 | 2016-02-04 | Alder Biopharmaceuticals, Inc. | Protocol for identifying and isolating antigen-specific b cells and producing antibodies to desired antigens |
| WO2014145744A1 (en) | 2013-03-15 | 2014-09-18 | Alder Biopharmaceuticals, Inc. | Antibody purification and purity monitoring |
| DK2971037T3 (da) | 2013-03-15 | 2019-10-14 | Alder Biopharmaceuticals Inc | Temperaturændring til ekspression med højt udbytte af polypeptider i gær og andre transformerede celler |
| US20160075766A1 (en) | 2013-05-21 | 2016-03-17 | Roche Diagnostics Operations, Inc. | Method for producing antibodies using ovine b-cells and uses thereof |
| CN104232577B (zh) * | 2013-06-20 | 2017-12-01 | 中国人民解放军军事医学科学院基础医学研究所 | 一种获得自身反应性b细胞的方法 |
| WO2015003122A2 (en) | 2013-07-03 | 2015-01-08 | Alder Biopharmaceuticals, Inc. | Regulation of glucose metabolism using anti-cgrp antibodies |
| DK4268843T3 (da) | 2014-11-07 | 2025-11-10 | F Hoffmann La Roche Ltd | Forbedrede IL-6-antistoffer |
| CN107428827A (zh) * | 2015-03-18 | 2017-12-01 | 宜康公司 | 通过b细胞淘选和增殖高通量产生单克隆抗体 |
| US11174317B2 (en) | 2015-06-04 | 2021-11-16 | National Center Of Neurology And Psychiatry | Therapeutic agent for mental illness comprising IL-6 inhibitor as active ingredient |
| EP3960765A1 (en) | 2015-06-26 | 2022-03-02 | Sanofi Biotechnology SAS | Monoclonal anti-il-1racp antibodies |
| WO2017147293A1 (en) | 2016-02-23 | 2017-08-31 | Eleven Biotherapeutics, Inc. | Il-6 antagonist formulations and uses thereof |
| ES2951698T3 (es) | 2016-03-30 | 2023-10-24 | Hoffmann La Roche | Procedimiento de cultivo de linfocitos B |
| SG10202109691UA (en) | 2016-04-15 | 2021-10-28 | Alder Biopharmaceuticals Inc | Anti-pacap antibodies and uses thereof |
| EP3241845A1 (en) | 2016-05-06 | 2017-11-08 | MAB Discovery GmbH | Humanized anti-il-1r3 antibodies |
| CN106350485B (zh) * | 2016-08-24 | 2020-02-21 | 杭州百凌生物科技有限公司 | 一种快速高效分离单个抗原特异性b细胞的方法 |
| JP6916884B2 (ja) | 2017-01-02 | 2021-08-11 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｂ細胞培養法 |
| EP3401332A1 (en) | 2017-05-08 | 2018-11-14 | MAB Discovery GmbH | Anti-il-1r3 antibodies for use in inflammatory conditions |
| CN110621773B (zh) | 2017-05-19 | 2023-06-09 | 豪夫迈·罗氏有限公司 | 用于产生胸腺细胞上清液的方法 |
| US11125757B2 (en) * | 2017-05-26 | 2021-09-21 | Emory University | Methods of culturing and characterizing antibody secreting cells |
| CN111417719B (zh) | 2017-11-30 | 2023-08-29 | 豪夫迈·罗氏有限公司 | B细胞培养方法 |
| EP3794026A4 (en) * | 2018-05-18 | 2022-06-22 | Chan Zuckerberg Biohub, Inc. | METHODS FOR ISOLATION OF ALLERGEN-SPECIFIC ANTIBODIES FROM HUMANS AND THEIR USES |
| WO2021014389A1 (en) | 2019-07-24 | 2021-01-28 | H. Lundbeck A/S | Anti-mglur5 antibodies and uses thereof |
| JP2023106635A (ja) | 2020-04-17 | 2023-08-02 | 中外製薬株式会社 | 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法 |
| WO2022004620A1 (ja) * | 2020-06-29 | 2022-01-06 | 株式会社Npt | 抗原特異的抗体産生細胞を含む組成物の製造方法、ワクチン組成物の製造方法、細胞分離キットおよびワクチン組成物 |
| EP4305190A4 (en) | 2021-03-11 | 2025-03-26 | Iggenix, Inc. | METHODS AND SYSTEMS FOR PREDICTING AN ALLERGIC REACTION |
| US20240228595A1 (en) * | 2021-05-11 | 2024-07-11 | Yale University | Methods for Monoclonal Antibody Generation |
| WO2024062074A1 (en) | 2022-09-21 | 2024-03-28 | Sanofi Biotechnology | Humanized anti-il-1r3 antibody and methods of use |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6657103B1 (en) * | 1990-01-12 | 2003-12-02 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| AU7796291A (en) * | 1990-05-04 | 1991-11-27 | Baxter Diagnostics Inc. | High affinity antibodies to small peptides |
| EP0542810A1 (en) | 1990-08-02 | 1993-05-26 | B.R. Centre Limited | Methods for the production of proteins with a desired function |
| ATE153695T1 (de) * | 1990-11-26 | 1997-06-15 | Akzo Nobel Nv | Verfahren zur herstellung von antikörpern |
| US6277969B1 (en) * | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| US5256542A (en) * | 1992-03-09 | 1993-10-26 | Tanox Biosystems, Inc. | Selecting low frequency antigen-specific single B lymphocytes with correction for background noise |
| US6972125B2 (en) * | 1999-02-12 | 2005-12-06 | Genetics Institute, Llc | Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith |
| DK1562968T3 (da) * | 2001-11-14 | 2013-10-28 | Janssen Biotech Inc | Anti-il-6-antistoffer, sammensætninger, fremgangsmåder og anvendelser |
| US20040185040A1 (en) * | 2001-11-21 | 2004-09-23 | Celltech R & D Limited | Modulating immune responses |
| US8188231B2 (en) * | 2002-09-27 | 2012-05-29 | Xencor, Inc. | Optimized FC variants |
| JP4603894B2 (ja) | 2002-12-03 | 2010-12-22 | ユセベ ファルマ ソシエテ アノニム | 抗体産生細胞を同定するためのアッセイ |
| GB0312481D0 (en) | 2003-05-30 | 2003-07-09 | Celltech R&D Ltd | Antibodies |
| CA2533830A1 (en) * | 2003-08-07 | 2005-02-24 | Epitomics, Inc. | Methods for humanizing rabbit monoclonal antibodies |
| US7771969B2 (en) | 2003-08-20 | 2010-08-10 | Celltech R&D Limited | Methods for obtaining antibodies |
| ES2385829T3 (es) | 2003-08-20 | 2012-08-01 | Ucb Pharma, S.A. | Métodos para obtener anticuerpos |
| CN1871259A (zh) * | 2003-08-22 | 2006-11-29 | 比奥根艾迪克Ma公司 | 具有改变的效应物功能的经改进的抗体和制备它的方法 |
| EP1664774A4 (en) * | 2003-08-29 | 2007-06-27 | Centocor Inc | RAPID MEANS FOR OBTAINING HIGH-EXPRESSION CLONES OF MAMMALIAN CELLS, ACCORDING TO A METHYLCELLULOSE SCREENING METHOD AND IMMUNOPRECIPITATION |
| EP2330201B1 (en) * | 2003-10-22 | 2017-04-05 | Keck Graduate Institute | Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy |
| GB0412973D0 (en) | 2004-06-10 | 2004-07-14 | Celltech R&D Ltd | Identification of antibody producing cells |
| US20060051348A1 (en) * | 2004-09-09 | 2006-03-09 | Jorn Gorlach | Method of producing a plurality of isolated antibodies to a plurality of cognate antigens |
| JP2008517914A (ja) * | 2004-10-22 | 2008-05-29 | ジェネンコー・インターナショナル・インク | ヒトの抗体の分離方法 |
| US7462697B2 (en) * | 2004-11-08 | 2008-12-09 | Epitomics, Inc. | Methods for antibody engineering |
| GB0425972D0 (en) | 2004-11-25 | 2004-12-29 | Celltech R&D Ltd | Biological products |
| PA8672101A1 (es) * | 2005-04-29 | 2006-12-07 | Centocor Inc | Anticuerpos anti-il-6, composiciones, métodos y usos |
| WO2007038746A2 (en) * | 2005-09-28 | 2007-04-05 | The University Of Chicago | Versatile vectors for expression of foreign proteins in photosynthetic bacteria |
-
2007
- 2007-05-21 MX MX2008014692A patent/MX2008014692A/es active IP Right Grant
- 2007-05-21 NZ NZ572807A patent/NZ572807A/en not_active IP Right Cessation
- 2007-05-21 DK DK07861311.4T patent/DK2021463T3/en active
- 2007-05-21 JP JP2009512060A patent/JP5607357B2/ja not_active Expired - Fee Related
- 2007-05-21 CN CN200780027028.2A patent/CN101600793B/zh not_active Expired - Fee Related
- 2007-05-21 EP EP07861311.4A patent/EP2021463B1/en not_active Revoked
- 2007-05-21 US US11/802,235 patent/US20070269868A1/en not_active Abandoned
- 2007-05-21 CA CA2652392A patent/CA2652392C/en not_active Expired - Fee Related
- 2007-05-21 WO PCT/US2007/011980 patent/WO2008045140A1/en not_active Ceased
- 2007-05-21 AU AU2007307324A patent/AU2007307324B2/en not_active Ceased
-
2008
- 2008-11-13 IL IL195285A patent/IL195285A/en active IP Right Grant
- 2008-11-18 NO NO20084835A patent/NO20084835L/no unknown
-
2011
- 2011-08-08 US US13/204,915 patent/US20120141982A1/en not_active Abandoned
-
2013
- 2013-04-12 US US13/861,518 patent/US20130316353A1/en not_active Abandoned
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