AU2007307324B2 - Culture method for obtaining a clonal population of antigen-specific B cells - Google Patents

Culture method for obtaining a clonal population of antigen-specific B cells Download PDF

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Publication number
AU2007307324B2
AU2007307324B2 AU2007307324A AU2007307324A AU2007307324B2 AU 2007307324 B2 AU2007307324 B2 AU 2007307324B2 AU 2007307324 A AU2007307324 A AU 2007307324A AU 2007307324 A AU2007307324 A AU 2007307324A AU 2007307324 B2 AU2007307324 B2 AU 2007307324B2
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AU
Australia
Prior art keywords
antigen
antibody
cell
cells
specific
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Ceased
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AU2007307324A
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English (en)
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AU2007307324A1 (en
Inventor
Leon Garcia
Anne Elisabeth Carvalho Jensen
John Latham
Ethan Ojala
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Lundbeck Seattle Biopharmaceuticals Inc
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Alder Biopharmaceuticals Inc
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Application filed by Alder Biopharmaceuticals Inc filed Critical Alder Biopharmaceuticals Inc
Publication of AU2007307324A1 publication Critical patent/AU2007307324A1/en
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Publication of AU2007307324B2 publication Critical patent/AU2007307324B2/en
Ceased legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0635—B lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2007307324A 2006-05-19 2007-05-21 Culture method for obtaining a clonal population of antigen-specific B cells Ceased AU2007307324B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80141206P 2006-05-19 2006-05-19
US60/801,412 2006-05-19
PCT/US2007/011980 WO2008045140A1 (en) 2006-05-19 2007-05-21 Culture method for obtaining a clonal population of antigen-specific b cells

Publications (2)

Publication Number Publication Date
AU2007307324A1 AU2007307324A1 (en) 2008-04-17
AU2007307324B2 true AU2007307324B2 (en) 2013-08-15

Family

ID=39283142

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007307324A Ceased AU2007307324B2 (en) 2006-05-19 2007-05-21 Culture method for obtaining a clonal population of antigen-specific B cells

Country Status (12)

Country Link
US (3) US20070269868A1 (enExample)
EP (1) EP2021463B1 (enExample)
JP (1) JP5607357B2 (enExample)
CN (1) CN101600793B (enExample)
AU (1) AU2007307324B2 (enExample)
CA (1) CA2652392C (enExample)
DK (1) DK2021463T3 (enExample)
IL (1) IL195285A (enExample)
MX (1) MX2008014692A (enExample)
NO (1) NO20084835L (enExample)
NZ (1) NZ572807A (enExample)
WO (1) WO2008045140A1 (enExample)

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US7906117B2 (en) 2007-05-21 2011-03-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
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US9701747B2 (en) 2007-05-21 2017-07-11 Alderbio Holdings Llc Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
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US9212223B2 (en) 2008-11-25 2015-12-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
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Also Published As

Publication number Publication date
US20120141982A1 (en) 2012-06-07
EP2021463B1 (en) 2016-11-23
WO2008045140A1 (en) 2008-04-17
CA2652392C (en) 2017-10-10
NO20084835L (no) 2009-02-16
NZ572807A (en) 2011-10-28
AU2007307324A1 (en) 2008-04-17
US20130316353A1 (en) 2013-11-28
EP2021463A1 (en) 2009-02-11
IL195285A (en) 2012-07-31
IL195285A0 (en) 2011-08-01
JP2009537176A (ja) 2009-10-29
EP2021463A4 (en) 2009-09-02
US20070269868A1 (en) 2007-11-22
CN101600793A (zh) 2009-12-09
CN101600793B (zh) 2013-06-26
MX2008014692A (es) 2009-08-18
CA2652392A1 (en) 2008-04-17
DK2021463T3 (en) 2017-01-16
JP5607357B2 (ja) 2014-10-15

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