NO20084835L - Dyrkingsmetode for a oppna en klonpopulasjon av antigen-spesifikke B celler - Google Patents

Dyrkingsmetode for a oppna en klonpopulasjon av antigen-spesifikke B celler

Info

Publication number
NO20084835L
NO20084835L NO20084835A NO20084835A NO20084835L NO 20084835 L NO20084835 L NO 20084835L NO 20084835 A NO20084835 A NO 20084835A NO 20084835 A NO20084835 A NO 20084835A NO 20084835 L NO20084835 L NO 20084835L
Authority
NO
Norway
Prior art keywords
antigen
cells
obtaining
specific
culture method
Prior art date
Application number
NO20084835A
Other languages
English (en)
Norwegian (no)
Inventor
John Latham
Leon Garcia
Anne Elisabeth Carvalho Jensen
Ethan Ojala
Original Assignee
Alder Biopharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39283142&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20084835(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alder Biopharmaceuticals Inc filed Critical Alder Biopharmaceuticals Inc
Publication of NO20084835L publication Critical patent/NO20084835L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • C07K16/248IL-6
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0635B lymphocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/11Coculture with; Conditioned medium produced by blood or immune system cells

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
NO20084835A 2006-05-19 2008-11-18 Dyrkingsmetode for a oppna en klonpopulasjon av antigen-spesifikke B celler NO20084835L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80141206P 2006-05-19 2006-05-19
PCT/US2007/011980 WO2008045140A1 (en) 2006-05-19 2007-05-21 Culture method for obtaining a clonal population of antigen-specific b cells

Publications (1)

Publication Number Publication Date
NO20084835L true NO20084835L (no) 2009-02-16

Family

ID=39283142

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084835A NO20084835L (no) 2006-05-19 2008-11-18 Dyrkingsmetode for a oppna en klonpopulasjon av antigen-spesifikke B celler

Country Status (12)

Country Link
US (3) US20070269868A1 (enExample)
EP (1) EP2021463B1 (enExample)
JP (1) JP5607357B2 (enExample)
CN (1) CN101600793B (enExample)
AU (1) AU2007307324B2 (enExample)
CA (1) CA2652392C (enExample)
DK (1) DK2021463T3 (enExample)
IL (1) IL195285A (enExample)
MX (1) MX2008014692A (enExample)
NO (1) NO20084835L (enExample)
NZ (1) NZ572807A (enExample)
WO (1) WO2008045140A1 (enExample)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8252286B2 (en) 2007-05-21 2012-08-28 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US8178101B2 (en) 2007-05-21 2012-05-15 Alderbio Holdings Inc. Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
US8062864B2 (en) 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US8404235B2 (en) 2007-05-21 2013-03-26 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
KR101829776B1 (ko) 2007-05-21 2018-02-19 앨더바이오 홀딩스 엘엘씨 Il-6에 대한 항체 및 이의 용도
US9701747B2 (en) 2007-05-21 2017-07-11 Alderbio Holdings Llc Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
US7906117B2 (en) 2007-05-21 2011-03-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
US8420089B2 (en) 2008-11-25 2013-04-16 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US8992920B2 (en) 2008-11-25 2015-03-31 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of arthritis
US9452227B2 (en) 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
US8337847B2 (en) 2008-11-25 2012-12-25 Alderbio Holdings Llc Methods of treating anemia using anti-IL-6 antibodies
US8323649B2 (en) 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
WO2010065077A2 (en) * 2008-11-25 2010-06-10 Alder Biopharmaceuticals, Inc. Antagonists of il-6 to prevent or treat thrombosis
US9212223B2 (en) 2008-11-25 2015-12-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US9079942B2 (en) * 2009-02-09 2015-07-14 Epitomics, Inc. CDR-anchored amplification method
US20100317539A1 (en) * 2009-06-12 2010-12-16 Guo-Liang Yu Library of Engineered-Antibody Producing Cells
IN2012DN01920A (enExample) 2009-09-03 2015-07-24 Schering Corp
US8293483B2 (en) 2009-09-11 2012-10-23 Epitomics, Inc. Method for identifying lineage-related antibodies
US9775921B2 (en) 2009-11-24 2017-10-03 Alderbio Holdings Llc Subcutaneously administrable composition containing anti-IL-6 antibody
EP2504030A4 (en) 2009-11-24 2013-06-26 Alderbio Holdings Llc IL-6 ANTAGONISTS FOR INCREASING ALBUMIN AND / OR REDUCING CRP
TWI667346B (zh) 2010-03-30 2019-08-01 中外製藥股份有限公司 促進抗原消失之具有經修飾的FcRn親和力之抗體
SI2400298T1 (sl) 2010-05-28 2013-11-29 F. Hoffmann-La Roche Ag Postopek kultivacije posamezne B-celice in izdelava specifičnih protiteles
AU2011332817A1 (en) 2010-11-23 2013-06-13 Alder Biopharmaceuticals, Inc. Anti-IL-6 antibodies for the treatment of anemia
NZ611076A (en) 2010-12-01 2015-09-25 Alderbio Holdings Llc Anti-ngf compositions and use thereof
JP5963746B2 (ja) * 2011-03-30 2016-08-03 国立大学法人富山大学 形質細胞または形質芽細胞の選択方法、目的抗原特異的な抗体の製造方法、新規モノクローナル抗体
JP6374789B2 (ja) 2011-05-20 2018-08-15 アルダーバイオ・ホールディングズ・エルエルシー 羞明または光嫌悪症を予防または抑制する抗cgrp抗体および抗体断片のそれを必要とする対象、特に片頭痛患者における使用
SG10201604040PA (en) 2011-05-20 2016-07-28 Alderbio Holdings Llc Anti-cgrp compositions and use thereof
CN103957935B (zh) 2011-05-20 2018-04-03 奥尔德生物控股有限责任公司 抗cgrp或抗cgrp‑r抗体或抗体片段用于治疗或预防慢性和急性形式的腹泻的用途
EP2724157B1 (en) * 2011-06-27 2017-03-08 Valneva Method for screening cells
US11782053B2 (en) * 2011-09-28 2023-10-10 iRepertoire, Inc. Identification of antigen-specific adaptive immune responses using ARM-PCR and high-throughput sequencing
JP6374791B2 (ja) 2011-11-23 2018-08-15 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Cd40l発現哺乳動物細胞およびその使用
MX354049B (es) 2011-12-21 2018-02-09 Hoffmann La Roche Método rápido para la clonación y expresión de segmentos génicos de regiones variables de anticuerpos cognados.
EP2727942A1 (en) 2012-11-05 2014-05-07 MAB Discovery GmbH Bispecific antibodies against human EGFR, HER2, and HER3
EP2727941A1 (en) 2012-11-05 2014-05-07 MAB Discovery GmbH Method for the production of multispecific antibodies
WO2014067642A1 (en) 2012-11-05 2014-05-08 Mab Discovery Gmbh Method for the production of multispecific antibodies
EP2727943A1 (en) 2012-11-05 2014-05-07 MAB Discovery GmbH Trispecific antibodies against human EGFR, HER2 and HER3
BR112015010360A8 (pt) 2012-11-08 2018-01-16 Eleven Biotherapeutics Inc antagonistas de il-6 e utilização dos mesmos.
CN104822828A (zh) * 2012-11-13 2015-08-05 弗·哈夫曼-拉罗切有限公司 抗原特异性浆母细胞的富集
EP2956478A1 (en) * 2013-02-15 2015-12-23 ESBATech - a Novartis Company LLC Acceptor framework for cdr grafting
WO2014153166A2 (en) * 2013-03-14 2014-09-25 Alder Biopharmaceuticals, Inc. Therapeutic use of antibodies to hgf
CA2907570A1 (en) * 2013-03-15 2014-09-18 Alder Biopharmaceuticals, Inc. Protocol for identifying and isolating antigen-specific b cells and producing antibodies to desired antigens
EP3754012A1 (en) 2013-03-15 2020-12-23 Alder Biopharmaceuticals, Inc. Antibody purification and purity monitoring
JP6412552B2 (ja) 2013-03-15 2018-10-24 アルダー・バイオファーマシューティカルズ・インコーポレーテッド 酵母及び他の形質転換細胞中のポリペプチドの高収率発現のための温度シフト
US20160075766A1 (en) 2013-05-21 2016-03-17 Roche Diagnostics Operations, Inc. Method for producing antibodies using ovine b-cells and uses thereof
CN104232577B (zh) * 2013-06-20 2017-12-01 中国人民解放军军事医学科学院基础医学研究所 一种获得自身反应性b细胞的方法
MX374612B (es) 2013-07-03 2025-03-06 H Lundbeck As Star Regulacion del metabolismo de glucosa usando anticuerpos anti-cgrp.
UA122673C2 (uk) 2014-11-07 2020-12-28 Елевен Байотерапьютікс, Інк. Антитіло, що специфічно зв'язується з людським il-6
WO2016149137A1 (en) * 2015-03-18 2016-09-22 Epitomics, Inc. High throughput monoclonal antibody generation by b cell panning and proliferation
EP3305325B1 (en) 2015-06-04 2025-07-30 National Center of Neurology and Psychiatry Mental illness therapeutic agent having il-6 inhibitor as active ingredient
US10906971B2 (en) 2015-06-26 2021-02-02 Sanofi Biotechnology SAS Monoclonal anti-IL-1RAcP antibodies
JP2019510078A (ja) 2016-02-23 2019-04-11 セセン バイオ, インコーポレイテッド Il−6アンタゴニスト製剤およびその使用
EP4273232A3 (en) 2016-03-30 2024-01-03 F. Hoffmann-La Roche AG B-cell cultivation method
JP2019515671A (ja) 2016-04-15 2019-06-13 アルダー バイオファーマシューティカルズ、インコーポレイテッド 抗pacap抗体及びそれらの使用
EP3241845A1 (en) 2016-05-06 2017-11-08 MAB Discovery GmbH Humanized anti-il-1r3 antibodies
CN106350485B (zh) * 2016-08-24 2020-02-21 杭州百凌生物科技有限公司 一种快速高效分离单个抗原特异性b细胞的方法
CN110121554B (zh) 2017-01-02 2023-08-15 豪夫迈·罗氏有限公司 B细胞培养方法
EP3401332A1 (en) 2017-05-08 2018-11-14 MAB Discovery GmbH Anti-il-1r3 antibodies for use in inflammatory conditions
EP3625332B1 (en) 2017-05-19 2022-02-02 F. Hoffmann-La Roche AG Method for the production of thymocyte supernatant
US11125757B2 (en) * 2017-05-26 2021-09-21 Emory University Methods of culturing and characterizing antibody secreting cells
EP3717632B1 (en) 2017-11-30 2022-10-26 F. Hoffmann-La Roche AG B-cell cultivation method
AU2019270181B2 (en) * 2018-05-18 2023-06-01 Cz Biohub Sf, Llc Methods of isolating allergen-specific antibodies from humans and uses thereof
CN114144436A (zh) 2019-07-24 2022-03-04 H.隆德贝克有限公司 抗mGluR5抗体及其用途
JP2023106635A (ja) 2020-04-17 2023-08-02 中外製薬株式会社 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法
WO2022004620A1 (ja) * 2020-06-29 2022-01-06 株式会社Npt 抗原特異的抗体産生細胞を含む組成物の製造方法、ワクチン組成物の製造方法、細胞分離キットおよびワクチン組成物
WO2022192625A1 (en) 2021-03-11 2022-09-15 IgGenix, Inc. Methods and systems for predicting allergic response
WO2022241415A1 (en) * 2021-05-11 2022-11-17 Yale University Methods for monoclonal antibody generation
KR20250060305A (ko) 2022-09-21 2025-05-07 사노피 바이오테크놀로지 인간화 항-il-1r3 항체 및 사용 방법

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6657103B1 (en) * 1990-01-12 2003-12-02 Abgenix, Inc. Human antibodies derived from immunized xenomice
AU7796291A (en) * 1990-05-04 1991-11-27 Baxter Diagnostics Inc. High affinity antibodies to small peptides
WO1992002551A1 (en) 1990-08-02 1992-02-20 B.R. Centre Limited Methods for the production of proteins with a desired function
ZA919299B (en) * 1990-11-26 1992-08-26 Akzo Nv Method for the production of antibodies
US6277969B1 (en) * 1991-03-18 2001-08-21 New York University Anti-TNF antibodies and peptides of human tumor necrosis factor
US5256542A (en) * 1992-03-09 1993-10-26 Tanox Biosystems, Inc. Selecting low frequency antigen-specific single B lymphocytes with correction for background noise
US6972125B2 (en) * 1999-02-12 2005-12-06 Genetics Institute, Llc Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith
RU2318829C2 (ru) * 2001-11-14 2008-03-10 Сентокор, Инк. Антитела против il-6, композиции, способы и применение
US20040185040A1 (en) * 2001-11-21 2004-09-23 Celltech R & D Limited Modulating immune responses
US8188231B2 (en) * 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
CA2507004A1 (en) 2002-12-03 2004-06-17 Celltech R & D Limited Assay for identifying antibody producing cells
GB0312481D0 (en) * 2003-05-30 2003-07-09 Celltech R&D Ltd Antibodies
WO2005016950A1 (en) * 2003-08-07 2005-02-24 Epitomics, Inc. Methods for humanizing rabbit monoclonal antibodies
EP1658498A1 (en) 2003-08-20 2006-05-24 Celltech R & D Limited Methods for obtaining antibodies
EP1658500B1 (en) 2003-08-20 2012-04-18 UCB Pharma, S.A. Methods for obtaining antibodies
CN1871259A (zh) * 2003-08-22 2006-11-29 比奥根艾迪克Ma公司 具有改变的效应物功能的经改进的抗体和制备它的方法
WO2005020924A2 (en) * 2003-08-29 2005-03-10 Centocor, Inc. A rapid way to obtain high expression clones of mammalian cells using a methylcellulose and immunoprecipitation screening method
ES2630224T3 (es) * 2003-10-22 2017-08-18 Keck Graduate Institute Métodos para sintetizar polipéptidos heteromultiméricos en levadura con el uso de una estrategia de apareamiento haploide
GB0412973D0 (en) 2004-06-10 2004-07-14 Celltech R&D Ltd Identification of antibody producing cells
US20060051348A1 (en) * 2004-09-09 2006-03-09 Jorn Gorlach Method of producing a plurality of isolated antibodies to a plurality of cognate antigens
US7968308B2 (en) * 2004-10-22 2011-06-28 Danisco Us Inc. Isolating human antibodies
US7462697B2 (en) * 2004-11-08 2008-12-09 Epitomics, Inc. Methods for antibody engineering
GB0425972D0 (en) 2004-11-25 2004-12-29 Celltech R&D Ltd Biological products
PA8672101A1 (es) * 2005-04-29 2006-12-07 Centocor Inc Anticuerpos anti-il-6, composiciones, métodos y usos
US20070092943A1 (en) * 2005-09-28 2007-04-26 The University Of Chicago Versatile vectors for expression of foreign proteins in photosynthetic bacteria

Also Published As

Publication number Publication date
AU2007307324A1 (en) 2008-04-17
EP2021463B1 (en) 2016-11-23
US20130316353A1 (en) 2013-11-28
IL195285A (en) 2012-07-31
CN101600793A (zh) 2009-12-09
CA2652392A1 (en) 2008-04-17
JP2009537176A (ja) 2009-10-29
CA2652392C (en) 2017-10-10
MX2008014692A (es) 2009-08-18
CN101600793B (zh) 2013-06-26
JP5607357B2 (ja) 2014-10-15
EP2021463A1 (en) 2009-02-11
NZ572807A (en) 2011-10-28
IL195285A0 (en) 2011-08-01
AU2007307324B2 (en) 2013-08-15
EP2021463A4 (en) 2009-09-02
US20070269868A1 (en) 2007-11-22
DK2021463T3 (en) 2017-01-16
WO2008045140A1 (en) 2008-04-17
US20120141982A1 (en) 2012-06-07

Similar Documents

Publication Publication Date Title
NO20084835L (no) Dyrkingsmetode for a oppna en klonpopulasjon av antigen-spesifikke B celler
WO2007106545A3 (en) Propagation of primary cells
WO2008002914A3 (en) Method of culturing mesenchymal stem cells
EP1773383A4 (en) MIMETIC T CELL RECEPTOR ANTIBODIES AND METHODS OF MAKING AND USING SAME
GB2432609A (en) Method of expansion
GB2446525A (en) Stem cell culture medium and method
DK2030476T3 (da) Fremgangsmåde og system til forbedring af forståeligheden af lyde
DK1623017T3 (da) Frembringelse og isolering af antigenspecifikke T-celler
WO2008024769A3 (en) Intensified perfusion production method
WO2011002926A3 (en) Isolated adult cells, artificial organs,rehabilitated organs, research rools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same
NO20090775L (no) System og fremgangsmate for synkronisering av TDMA-maskenettverk
EP2343361A4 (en) CELL CULTURE KIT, TEST PROCEDURE AND MANUFACTURING PROCESS FOR THE CELL CULTURE KIT
NO20072719L (no) Serumfritt cellekulturmedium for pattedyrceller
WO2010020876A3 (en) Cell culture method to form aggregates
EP2246414A4 (en) CELL CULTURE PROCESS AND SCREENING METHOD
ATE468390T1 (de) System und verfahren zur produktion von antikörpern in der pflanzenzellkultur
WO2012019002A3 (en) Somatic stem cells
WO2006136953A3 (en) Method of producing organotypic cell cultures
DK2092044T3 (da) Fremgangsmåde og udstyr til produktion af syntesegas fra biomasse
EP2516624A4 (en) CELL LINE 3M
WO2007017915A3 (en) Use of common ϝ chain cytokines for the visualization, isolation and genetic modification of memory t lymphocytes.
EA200800996A1 (ru) Способ получения т-клеточной популяции
MX2010003027A (es) Linea de celulas madre vegetales derivadas del centro en reposo y metodo para el aislamiento de las mismas.
EP1765983A4 (en) METHOD AND COMPOSITIONS FOR THE PRODUCTION OF STEM CELLS FROM BUTCHMARK DERIVED GLAND STEM CELLS
EP1941275A4 (en) METHOD OF IDENTIFYING MEMBRANE-LG-SPECIFIC ANTIBODY AND USE THEREOF FOR CONTROLLING IMMUNOGLOBULIN-PRODUCING PRECURSOR CELLS