JP2009536218A5 - - Google Patents
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- JP2009536218A5 JP2009536218A5 JP2009510100A JP2009510100A JP2009536218A5 JP 2009536218 A5 JP2009536218 A5 JP 2009536218A5 JP 2009510100 A JP2009510100 A JP 2009510100A JP 2009510100 A JP2009510100 A JP 2009510100A JP 2009536218 A5 JP2009536218 A5 JP 2009536218A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- hydrogen
- halogen
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(NCc(nc1*)c(*)[n]1-c(cc1*)c(*)cc1S)=O Chemical compound *C(NCc(nc1*)c(*)[n]1-c(cc1*)c(*)cc1S)=O 0.000 description 12
- MEJIGHZPRMKCHW-UHFFFAOYSA-N CC(C)N(C=CN=C1)C1=O Chemical compound CC(C)N(C=CN=C1)C1=O MEJIGHZPRMKCHW-UHFFFAOYSA-N 0.000 description 1
- VZWZDYSMVHQTHD-UHFFFAOYSA-N CC(C)N1N=CC=CC1=O Chemical compound CC(C)N1N=CC=CC1=O VZWZDYSMVHQTHD-UHFFFAOYSA-N 0.000 description 1
- LQKMCBPMBNUKSU-UHFFFAOYSA-N CN(C=CC=N1)C1=O Chemical compound CN(C=CC=N1)C1=O LQKMCBPMBNUKSU-UHFFFAOYSA-N 0.000 description 1
- GGYVTHJIUNGKFZ-UHFFFAOYSA-N CN(CCCC1)C1=O Chemical compound CN(CCCC1)C1=O GGYVTHJIUNGKFZ-UHFFFAOYSA-N 0.000 description 1
- COYPZADTXISTSJ-UHFFFAOYSA-N CN(CCCN1)C1=O Chemical compound CN(CCCN1)C1=O COYPZADTXISTSJ-UHFFFAOYSA-N 0.000 description 1
- JTPZTKBRUCILQD-UHFFFAOYSA-N CN(CCN1)C1=O Chemical compound CN(CCN1)C1=O JTPZTKBRUCILQD-UHFFFAOYSA-N 0.000 description 1
- HOURFTFBPLQQTA-UHFFFAOYSA-N COC(c(cc(cc1)N(C=CC=C2)C2=O)c1-[n]1cnc(CNC(c([s]2)ccc2Cl)=O)c1)=O Chemical compound COC(c(cc(cc1)N(C=CC=C2)C2=O)c1-[n]1cnc(CNC(c([s]2)ccc2Cl)=O)c1)=O HOURFTFBPLQQTA-UHFFFAOYSA-N 0.000 description 1
- VUZDBGMBMPEGLU-UHFFFAOYSA-N CS(c(cc(cc1)N(C=CC=C2)C2=O)c1-[n]1cnc(CNC(c([s]2)ccc2Cl)=O)c1)(=O)=O Chemical compound CS(c(cc(cc1)N(C=CC=C2)C2=O)c1-[n]1cnc(CNC(c([s]2)ccc2Cl)=O)c1)(=O)=O VUZDBGMBMPEGLU-UHFFFAOYSA-N 0.000 description 1
- AWRRWVACWCKVAB-UHFFFAOYSA-N CSc1nc(CNC(c([s]2)ccc2Cl)=O)c[n]1-c(cc1)ccc1N(C=CC=C1)C1=O Chemical compound CSc1nc(CNC(c([s]2)ccc2Cl)=O)c[n]1-c(cc1)ccc1N(C=CC=C1)C1=O AWRRWVACWCKVAB-UHFFFAOYSA-N 0.000 description 1
- AWRRWVACWCKVAB-UHFFFAOYSA-O C[SH+]c1nc(CNC(c([s]2)ccc2Cl)=O)c[n]1-c(cc1)ccc1N(C=CC=C1)C1=O Chemical compound C[SH+]c1nc(CNC(c([s]2)ccc2Cl)=O)c[n]1-c(cc1)ccc1N(C=CC=C1)C1=O AWRRWVACWCKVAB-UHFFFAOYSA-O 0.000 description 1
- QZWFIJCOFXOLBT-UHFFFAOYSA-N O=C(c([s]1)ccc1Cl)NCc(nc1)c[n]1-c(cc1)ccc1N(C=CC=C1)C1=O Chemical compound O=C(c([s]1)ccc1Cl)NCc(nc1)c[n]1-c(cc1)ccc1N(C=CC=C1)C1=O QZWFIJCOFXOLBT-UHFFFAOYSA-N 0.000 description 1
- FMRVZCFQPFDOBB-UHFFFAOYSA-N O=C(c([s]1)ccc1Cl)NCc(nc1)c[n]1-c(cc1)ccc1N(CCS(C1)(=O)=O)C1=O Chemical compound O=C(c([s]1)ccc1Cl)NCc(nc1)c[n]1-c(cc1)ccc1N(CCS(C1)(=O)=O)C1=O FMRVZCFQPFDOBB-UHFFFAOYSA-N 0.000 description 1
- KIVALIXZTZZARM-UHFFFAOYSA-N O=C(c([s]1)ccc1Cl)NCc(nc1)c[n]1-c(cc1)ccc1N(CCS(C1)=O)C1=O Chemical compound O=C(c([s]1)ccc1Cl)NCc(nc1)c[n]1-c(cc1)ccc1N(CCS(C1)=O)C1=O KIVALIXZTZZARM-UHFFFAOYSA-N 0.000 description 1
- CJGVACPFTXQBCJ-UHFFFAOYSA-N O=C(c([s]1)ccc1Cl)NCc(nc1)c[n]1-c(cc1)ccc1N(CCSC1)C1=O Chemical compound O=C(c([s]1)ccc1Cl)NCc(nc1)c[n]1-c(cc1)ccc1N(CCSC1)C1=O CJGVACPFTXQBCJ-UHFFFAOYSA-N 0.000 description 1
- CRUMWEIFBNZNPN-UHFFFAOYSA-N O=C(c([s]1)ccc1Cl)NCc(nc1)c[n]1-c(cc1F)ccc1N(C=CC=C1)C1=O Chemical compound O=C(c([s]1)ccc1Cl)NCc(nc1)c[n]1-c(cc1F)ccc1N(C=CC=C1)C1=O CRUMWEIFBNZNPN-UHFFFAOYSA-N 0.000 description 1
- RQSYBZQWMSQDFK-UHFFFAOYSA-N O=C(c([s]1)ccc1Cl)NCc(nc1)c[n]1-c(ccc(N(C=CC=C1)C1=O)c1)c1F Chemical compound O=C(c([s]1)ccc1Cl)NCc(nc1)c[n]1-c(ccc(N(C=CC=C1)C1=O)c1)c1F RQSYBZQWMSQDFK-UHFFFAOYSA-N 0.000 description 1
- WIMLENNNCRQYLE-UHFFFAOYSA-N O=C(c([s]1)ccc1Cl)NCc(nc1)c[n]1-c(ccc(N(C=CC=C1)C1=O)c1)c1N(CC1)CCS1(=O)=O Chemical compound O=C(c([s]1)ccc1Cl)NCc(nc1)c[n]1-c(ccc(N(C=CC=C1)C1=O)c1)c1N(CC1)CCS1(=O)=O WIMLENNNCRQYLE-UHFFFAOYSA-N 0.000 description 1
- LUGWMEWUBXERDW-UHFFFAOYSA-N O=C(c([s]1)ccc1Cl)NCc(nc1)c[n]1-c(ccc(N(C=CC=C1)C1=O)c1)c1N(CCN1)CC1=O Chemical compound O=C(c([s]1)ccc1Cl)NCc(nc1)c[n]1-c(ccc(N(C=CC=C1)C1=O)c1)c1N(CCN1)CC1=O LUGWMEWUBXERDW-UHFFFAOYSA-N 0.000 description 1
- XBFQEWMEELMQKX-UHFFFAOYSA-N O=C(c([s]1)ccc1Cl)NCc(nc1)c[n]1-c(ccc(N(C=CC=C1)C1=O)c1)c1N1CCSCC1 Chemical compound O=C(c([s]1)ccc1Cl)NCc(nc1)c[n]1-c(ccc(N(C=CC=C1)C1=O)c1)c1N1CCSCC1 XBFQEWMEELMQKX-UHFFFAOYSA-N 0.000 description 1
- ZTMZOKIEPBNNST-UHFFFAOYSA-N O=C(c([s]1)ccc1Cl)NCc(nc1S=O)c[n]1-c(cc1)ccc1N(C=CC=C1)C1=O Chemical compound O=C(c([s]1)ccc1Cl)NCc(nc1S=O)c[n]1-c(cc1)ccc1N(C=CC=C1)C1=O ZTMZOKIEPBNNST-UHFFFAOYSA-N 0.000 description 1
- KMANCAXITPTEII-UHFFFAOYSA-N OCCNc(cc(cc1)N(C=CC=C2)C2=O)c1-[n]1cnc(CNC(c([s]2)ccc2Cl)=O)c1 Chemical compound OCCNc(cc(cc1)N(C=CC=C2)C2=O)c1-[n]1cnc(CNC(c([s]2)ccc2Cl)=O)c1 KMANCAXITPTEII-UHFFFAOYSA-N 0.000 description 1
- GEIVFFPHNYQVML-UHFFFAOYSA-N OS(CCCCNc(cc1)ccc1-[n]1cnc(CNC(c([s]2)ccc2Cl)=O)c1)O Chemical compound OS(CCCCNc(cc1)ccc1-[n]1cnc(CNC(c([s]2)ccc2Cl)=O)c1)O GEIVFFPHNYQVML-UHFFFAOYSA-N 0.000 description 1
- MHVQVYXOJMLSMZ-UHFFFAOYSA-N Oc(cc(cc1)N(C=CC=C2)C2=O)c1-[n]1cnc(CNC(c([s]2)ccc2Cl)=O)c1 Chemical compound Oc(cc(cc1)N(C=CC=C2)C2=O)c1-[n]1cnc(CNC(c([s]2)ccc2Cl)=O)c1 MHVQVYXOJMLSMZ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79795406P | 2006-05-05 | 2006-05-05 | |
| US60/797,954 | 2006-05-05 | ||
| US88366707P | 2007-01-05 | 2007-01-05 | |
| US60/883,667 | 2007-01-05 | ||
| PCT/US2007/068262 WO2007131179A1 (en) | 2006-05-05 | 2007-05-04 | Factor xa inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009536218A JP2009536218A (ja) | 2009-10-08 |
| JP2009536218A5 true JP2009536218A5 (enExample) | 2011-05-26 |
| JP5227311B2 JP5227311B2 (ja) | 2013-07-03 |
Family
ID=38480433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009510100A Expired - Fee Related JP5227311B2 (ja) | 2006-05-05 | 2007-05-04 | 第Ｘａ因子阻害剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US7763608B2 (enExample) |
| EP (1) | EP2016072B1 (enExample) |
| JP (1) | JP5227311B2 (enExample) |
| KR (1) | KR20090010098A (enExample) |
| CN (1) | CN101490036B (enExample) |
| AR (1) | AR060768A1 (enExample) |
| AU (1) | AU2007247928B2 (enExample) |
| BR (1) | BRPI0711296A2 (enExample) |
| CA (1) | CA2651303A1 (enExample) |
| EA (1) | EA015942B1 (enExample) |
| IL (1) | IL194891A (enExample) |
| MX (1) | MX2008014193A (enExample) |
| NZ (1) | NZ572418A (enExample) |
| TW (1) | TW200813017A (enExample) |
| WO (1) | WO2007131179A1 (enExample) |
| ZA (2) | ZA200809362B (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001250783A1 (en) * | 2000-02-29 | 2001-09-12 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| NZ552187A (en) | 2004-06-18 | 2010-08-27 | Millennium Pharm Inc | Thiophene-2-carboxamide derivatives |
| US7696352B2 (en) * | 2004-06-18 | 2010-04-13 | Millennium Pharmaceuticals, Inc. | Factor Xa inhibitors |
| RS53599B1 (sr) | 2005-05-10 | 2015-02-27 | Intermune, Inc. | Piridon derivati za modulaciju stresom aktiviranog sistema proteinskih kinaza |
| US20080200431A1 (en) * | 2005-07-08 | 2008-08-21 | Astrazeneca Ab | Heterocyclic Sulfonamide Derivatives as Inhibitors of Factor Xa |
| US20080214495A1 (en) * | 2005-07-08 | 2008-09-04 | Astrazeneca Ab | Heterocyclic Sulfonamide Derivatives as Inhibitors of Factor Xa |
| WO2007112367A2 (en) * | 2006-03-27 | 2007-10-04 | Portola Pharmaceuticals, Inc. | Potassium channel modulators and platelet procoagulant activity |
| EP2016072B1 (en) | 2006-05-05 | 2014-07-16 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
| EP2077995B1 (en) | 2006-11-02 | 2012-02-08 | Millennium Pharmaceuticals, Inc. | Methods of synthesizing pharmaceutical salts of a factor xa inhibitor |
| JP2010515691A (ja) * | 2007-01-05 | 2010-05-13 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 第Ｘａ因子阻害剤 |
| JP5469595B2 (ja) * | 2007-04-13 | 2014-04-16 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | 第Ｘａ因子阻害薬として作用する化合物との併用抗凝固療法 |
| EP2586439A1 (en) * | 2007-05-02 | 2013-05-01 | Portola Pharmaceuticals, Inc. | Combination therapy with a compound acting as a platelet ADP receptor inhibitor |
| WO2009063029A2 (en) * | 2007-11-16 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Substituted amides, manufacturing and use thereof as medicaments |
| JP5627574B2 (ja) | 2008-06-03 | 2014-11-19 | インターミューン， インコーポレイテッド | 炎症性および線維性疾患を治療するための化合物および方法 |
| JP5766204B2 (ja) | 2009-12-17 | 2015-08-19 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 第Ｘａ因子阻害剤の合成方法 |
| US8530501B2 (en) | 2009-12-17 | 2013-09-10 | Millennium Pharmaceuticals, Inc. | Salts and crystalline forms of a factor Xa inhibitor |
| US20110160250A1 (en) | 2009-12-17 | 2011-06-30 | Millennium Pharmaceuticals, Inc. | Crystalline forms of a factor xa inhibitor |
| US8742120B2 (en) * | 2009-12-17 | 2014-06-03 | Millennium Pharmaceuticals, Inc. | Methods of preparing factor xa inhibitors and salts thereof |
| TW201221128A (en) | 2010-09-01 | 2012-06-01 | Portola Pharm Inc | Crystalline forms of a factor Xa inhibitor |
| AR082803A1 (es) | 2010-09-01 | 2013-01-09 | Portola Pharm Inc | Metodos y formulaciones para el tratamiento de la trombosis con betrixaban y un inhibidor de la glicoproteina p |
| US20150224091A1 (en) | 2011-08-31 | 2015-08-13 | Portola Pharmaceuticals, Inc. | Prevention and treatment of thrombosis in medically ill patients |
| CN103242310A (zh) * | 2012-02-10 | 2013-08-14 | 苏州迈泰生物技术有限公司 | 吡唑并吡啶酮类化合物及其在制备抗凝血药物中的用途 |
| JP6186434B2 (ja) * | 2012-07-18 | 2017-08-23 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． | 窒素複素環誘導体及びその医薬品への応用 |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| MX380585B (es) * | 2012-12-24 | 2025-03-12 | Coagulant Therapeutics Corp | Polipeptidos del factor vii de acción corta. |
| TWI633089B (zh) | 2013-03-28 | 2018-08-21 | 拜耳製藥股份有限公司 | 經取代的酮基吡啶衍生物 |
| CA2929394C (en) | 2013-12-19 | 2021-11-16 | Sunshine Lake Pharma Co., Ltd. | Nitrogenous heterocyclic derivatives and their application in drugs |
| CN106459042B (zh) | 2014-04-02 | 2019-06-28 | 英特穆恩公司 | 抗纤维化吡啶酮类 |
| CN106687458B (zh) * | 2014-09-24 | 2020-10-27 | 拜耳制药股份公司 | 取代的氧代吡啶衍生物 |
| CA2979937A1 (en) * | 2015-03-19 | 2016-09-22 | Bayer Pharma Aktiengesellschaft | Oxo-pyridine-derivatives as factor xia inhibitors for the treatment of thrombosis |
| EP3078378B1 (en) | 2015-04-08 | 2020-06-24 | Vaiomer | Use of factor xa inhibitors for regulating glycemia |
| PE20181173A1 (es) | 2015-07-06 | 2018-07-20 | Bayer Cropscience Ag | Heterociclos nitrogenados como pesticidas |
| JO3703B1 (ar) | 2015-07-09 | 2021-01-31 | Bayer Pharma AG | مشتقات أوكسوبيريدين مستبدلة |
| US10148678B2 (en) | 2015-10-01 | 2018-12-04 | The Boeing Company | Cybersecurity system with differentiated capacity to deal with complex cyber attacks |
| TWI752421B (zh) | 2015-12-16 | 2022-01-11 | 日商日本曹達股份有限公司 | 芳基唑化合物及有害生物防除劑 |
| CN105753804A (zh) * | 2016-04-15 | 2016-07-13 | 大连信科化工有限公司 | 一种制备3-吗啉酮的方法 |
| WO2019105871A1 (de) | 2017-11-29 | 2019-06-06 | Bayer Aktiengesellschaft | Stickstoffhaltige heterocyclen als schädlingsbekämpfungsmittel |
| WO2019215076A1 (de) * | 2018-05-08 | 2019-11-14 | Bayer Aktiengesellschaft | Verfahren zur herstellung stickstoffhaltiger heterocyclen |
| CN108715584B (zh) * | 2018-06-22 | 2021-06-25 | 四川大学华西医院 | 以n-吡啶-2-(1h)-腈亚氨为母核的荧光分子及其制备与应用 |
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