JP2009532018A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009532018A5 JP2009532018A5 JP2008554816A JP2008554816A JP2009532018A5 JP 2009532018 A5 JP2009532018 A5 JP 2009532018A5 JP 2008554816 A JP2008554816 A JP 2008554816A JP 2008554816 A JP2008554816 A JP 2008554816A JP 2009532018 A5 JP2009532018 A5 JP 2009532018A5
- Authority
- JP
- Japan
- Prior art keywords
- strain
- lactose
- milk
- fermentation
- vpp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008101 lactose Substances 0.000 description 47
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 44
- 238000000855 fermentation Methods 0.000 description 38
- 230000004151 fermentation Effects 0.000 description 38
- DOFAQXCYFQKSHT-SRVKXCTJSA-N Val-Pro-Pro Chemical compound CC(C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(O)=O)CCC1 DOFAQXCYFQKSHT-SRVKXCTJSA-N 0.000 description 35
- 108010015385 valyl-prolyl-proline Proteins 0.000 description 35
- 241000186660 Lactobacillus Species 0.000 description 29
- 235000013336 milk Nutrition 0.000 description 29
- 239000008267 milk Substances 0.000 description 29
- 210000004080 milk Anatomy 0.000 description 29
- 108010031424 isoleucyl-prolyl-proline Proteins 0.000 description 28
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 28
- FQYQMFCIJNWDQZ-CYDGBPFRSA-N Ile-Pro-Pro Chemical compound CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(O)=O)CCC1 FQYQMFCIJNWDQZ-CYDGBPFRSA-N 0.000 description 26
- 239000002609 medium Substances 0.000 description 26
- 235000013305 food Nutrition 0.000 description 24
- 238000000034 method Methods 0.000 description 21
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 description 19
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 description 19
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 description 19
- 239000000047 product Substances 0.000 description 19
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 18
- 239000008103 glucose Substances 0.000 description 18
- 108090000765 processed proteins & peptides Proteins 0.000 description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- 239000004310 lactic acid Substances 0.000 description 14
- 235000014655 lactic acid Nutrition 0.000 description 14
- 238000004519 manufacturing process Methods 0.000 description 14
- 239000000523 sample Substances 0.000 description 14
- 235000015140 cultured milk Nutrition 0.000 description 13
- 238000002360 preparation method Methods 0.000 description 13
- 230000007935 neutral effect Effects 0.000 description 12
- 229930091371 Fructose Natural products 0.000 description 10
- 239000005715 Fructose Substances 0.000 description 10
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 10
- 229940039696 lactobacillus Drugs 0.000 description 10
- 230000035772 mutation Effects 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 239000006228 supernatant Substances 0.000 description 10
- 235000013365 dairy product Nutrition 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 238000011534 incubation Methods 0.000 description 8
- 229960001052 streptozocin Drugs 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 230000020477 pH reduction Effects 0.000 description 7
- 102000004196 processed proteins & peptides Human genes 0.000 description 7
- 235000018102 proteins Nutrition 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 108020004705 Codon Proteins 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 240000002605 Lactobacillus helveticus Species 0.000 description 6
- QIAFMBKCNZACKA-UHFFFAOYSA-N N-benzoylglycine Chemical compound OC(=O)CNC(=O)C1=CC=CC=C1 QIAFMBKCNZACKA-UHFFFAOYSA-N 0.000 description 6
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 6
- 230000036772 blood pressure Effects 0.000 description 6
- 235000013399 edible fruits Nutrition 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 6
- 206010020772 Hypertension Diseases 0.000 description 5
- 239000002028 Biomass Substances 0.000 description 4
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 241000282414 Homo sapiens Species 0.000 description 4
- 235000013967 Lactobacillus helveticus Nutrition 0.000 description 4
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 4
- 229910021538 borax Inorganic materials 0.000 description 4
- 235000014048 cultured milk product Nutrition 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 4
- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 4
- 101150056134 lacL gene Proteins 0.000 description 4
- 229940054346 lactobacillus helveticus Drugs 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 4
- 238000009629 microbiological culture Methods 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 239000006041 probiotic Substances 0.000 description 4
- 235000018291 probiotics Nutrition 0.000 description 4
- 239000012429 reaction media Substances 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 230000001953 sensory effect Effects 0.000 description 4
- 238000012163 sequencing technique Methods 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 235000010339 sodium tetraborate Nutrition 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 4
- 239000012137 tryptone Substances 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 108010064733 Angiotensins Proteins 0.000 description 3
- 102000015427 Angiotensins Human genes 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 102000005936 beta-Galactosidase Human genes 0.000 description 3
- 108010005774 beta-Galactosidase Proteins 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 235000013351 cheese Nutrition 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 235000021001 fermented dairy product Nutrition 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000009928 pasteurization Methods 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- 230000000529 probiotic effect Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 2
- 102000011632 Caseins Human genes 0.000 description 2
- 108010076119 Caseins Proteins 0.000 description 2
- 241000589989 Helicobacter Species 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 102000014171 Milk Proteins Human genes 0.000 description 2
- 108010011756 Milk Proteins Proteins 0.000 description 2
- 108020004485 Nonsense Codon Proteins 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
- 229960005305 adenosine Drugs 0.000 description 2
- 230000003276 anti-hypertensive effect Effects 0.000 description 2
- 239000012496 blank sample Substances 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- 239000005018 casein Substances 0.000 description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical class NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 2
- 235000021240 caseins Nutrition 0.000 description 2
- 238000004737 colorimetric analysis Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 235000019253 formic acid Nutrition 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 230000001631 hypertensive effect Effects 0.000 description 2
- 239000000411 inducer Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 235000021239 milk protein Nutrition 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 239000006872 mrs medium Substances 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 238000003359 percent control normalization Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 235000020183 skimmed milk Nutrition 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
- 239000003643 water by type Substances 0.000 description 2
- 235000013618 yogurt Nutrition 0.000 description 2
- AAXWBCKQYLBQKY-IRXDYDNUSA-N (2s)-2-[[(2s)-2-[(2-benzamidoacetyl)amino]-3-(1h-imidazol-5-yl)propanoyl]amino]-4-methylpentanoic acid Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)CNC(=O)C=1C=CC=CC=1)C1=CN=CN1 AAXWBCKQYLBQKY-IRXDYDNUSA-N 0.000 description 1
- 101000741065 Bos taurus Beta-casein Proteins 0.000 description 1
- 241000282832 Camelidae Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 208000021479 Cardiovascular injury Diseases 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 101001010029 Lactobacillus helveticus Putative phosphotransferase enzyme IIA component Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 108091081024 Start codon Proteins 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- PQLVXDKIJBQVDF-UHFFFAOYSA-N acetic acid;hydrate Chemical compound O.CC(O)=O PQLVXDKIJBQVDF-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 235000019728 animal nutrition Nutrition 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000019219 chocolate Nutrition 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229940104302 cytosine Drugs 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000000132 electrospray ionisation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229940068517 fruit extracts Drugs 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 108010016268 hippuryl-histidyl-leucine Proteins 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 235000015141 kefir Nutrition 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000008176 lyophilized powder Substances 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 230000037434 nonsense mutation Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000019614 sour taste Nutrition 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000013595 supernatant sample Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06290286.1 | 2006-02-20 | ||
| EP06290286A EP1820851B9 (fr) | 2006-02-20 | 2006-02-20 | Souches de Lactobacillus helveticus ne fermentant pas le lactose |
| US77465406P | 2006-02-21 | 2006-02-21 | |
| US60/774,654 | 2006-02-21 | ||
| PCT/FR2007/000294 WO2007096510A2 (fr) | 2006-02-20 | 2007-02-19 | Souches de lactobacillus helveticus ne fermentant pas le lactose |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009532018A JP2009532018A (ja) | 2009-09-10 |
| JP2009532018A5 true JP2009532018A5 (enExample) | 2009-10-22 |
| JP5184378B2 JP5184378B2 (ja) | 2013-04-17 |
Family
ID=36619331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008554816A Expired - Fee Related JP5184378B2 (ja) | 2006-02-20 | 2007-02-19 | ヘルベティカス乳酸桿菌の新規株 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8323951B2 (enExample) |
| EP (2) | EP1820851B9 (enExample) |
| JP (1) | JP5184378B2 (enExample) |
| KR (1) | KR20080108247A (enExample) |
| CN (1) | CN101421390B (enExample) |
| AR (1) | AR059863A1 (enExample) |
| AT (2) | ATE548445T1 (enExample) |
| AU (1) | AU2007217318A1 (enExample) |
| BR (1) | BRPI0707985B1 (enExample) |
| CA (1) | CA2642891C (enExample) |
| ES (2) | ES2384096T3 (enExample) |
| MX (1) | MX2008010642A (enExample) |
| MY (1) | MY149886A (enExample) |
| PL (2) | PL1820851T3 (enExample) |
| RU (1) | RU2422509C2 (enExample) |
| WO (1) | WO2007096510A2 (enExample) |
| ZA (1) | ZA200807147B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010022790A1 (en) * | 2008-08-29 | 2010-03-04 | Chr. Hansen A/S | Method for making cheese |
| WO2012063826A1 (ja) * | 2010-11-09 | 2012-05-18 | カルピス株式会社 | 高タンパク質分解活性を有するラクトバチルス・ヘルベティカス菌 |
| AU2015276091B2 (en) * | 2014-06-19 | 2018-12-13 | Chr. Hansen A/S | Method of producing a fermented milk product with improved control of post acidification |
| CN105309972A (zh) * | 2014-08-01 | 2016-02-10 | 内蒙古蒙牛乳业（集团）股份有限公司 | 一种充气的褐色活性乳酸菌饮料及其制备方法 |
| RU2577112C1 (ru) * | 2014-12-25 | 2016-03-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Горский государственный аграрный университет" | Штамм lactobacillus helveticus вкпм в-11175, полученный на доступных питательных средах |
| EA201991400A1 (ru) * | 2017-01-13 | 2020-01-16 | Кхр. Хансен А/С | Способ получения ферментированного молочного продукта |
| CN109517763B (zh) * | 2018-12-27 | 2022-03-22 | 内蒙古农业大学 | 瑞士乳杆菌h11及其应用 |
| CN111206003B (zh) * | 2020-02-20 | 2021-09-10 | 扬州大学 | 弱后酸化瑞士乳杆菌sh2-5-66及其应用 |
| CN116762858B (zh) * | 2022-03-07 | 2025-09-19 | 内蒙古伊利实业集团股份有限公司 | 一种常温活菌发酵乳的制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52151761A (en) * | 1976-06-09 | 1977-12-16 | Snow Brand Milk Products Co Ltd | Method of producing fermented milk |
| JPS5747429A (en) | 1980-09-02 | 1982-03-18 | Sanyo Kokusaku Pulp Co | Sheet for baking and cooking tray |
| US4452895A (en) * | 1982-03-17 | 1984-06-05 | Microlife Genetics | Non-lactose fermenting Pediococcus pentosaceus |
| US4599313A (en) * | 1982-04-15 | 1986-07-08 | Microlife Technics, Inc. | Preservation of foods with non-lactose fermenting Streptococcus lactis subspecies diacetilactis |
| JP2589553B2 (ja) * | 1988-08-18 | 1997-03-12 | 雪印乳業株式会社 | 発酵乳の製造方法 |
| JPH02268644A (ja) * | 1989-04-12 | 1990-11-02 | Sankyo Nyugyo Kk | 発酵乳の製造方法 |
| JP2782142B2 (ja) | 1992-07-23 | 1998-07-30 | カルピス株式会社 | アンジオテンシン変換酵素阻害剤及びその製造法 |
| JP2824821B2 (ja) * | 1993-11-04 | 1998-11-18 | カルピス株式会社 | 乳酸菌及び発酵乳製品 |
| JP3028411B2 (ja) | 1997-09-26 | 2000-04-04 | カルピス株式会社 | トリペプチド高生産性ラクトバチルス・ヘルベチカス乳酸菌 |
| FR2778921B1 (fr) * | 1998-05-22 | 2001-05-11 | Gervais Danone Sa | Souches mutantes de lactobacillus bulgaricus depourvues d'activite beta-galactosidase |
| ATE253640T1 (de) * | 1998-06-17 | 2003-11-15 | Nestle Sa | Mobile genetische elemente als werkzeuge zur genetischen modifikation von l. delbrueckii oder l. helveticus |
| NL1010096C2 (nl) * | 1998-09-15 | 2000-03-17 | Agronomique Inst Nat Rech | Zuivelproduct alsmede werkwijze ter bereiding daarvan. |
| FI113741B (fi) * | 1999-11-01 | 2004-06-15 | Valio Oy | Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi |
| AU2001262250A1 (en) * | 2000-05-15 | 2001-11-26 | Societe Des Produits Nestle S.A. | Probiotic lactic acid bacteria, unable to utilize lactose |
| FI112031B (fi) * | 2002-02-25 | 2003-10-31 | Valio Oy | Biologisesti aktiivisen tuotteen uusi käyttö |
| EA200501093A1 (ru) | 2003-01-06 | 2005-12-29 | Юнилевер Н.В. | ФЕРМЕНТИРОВАННЫЙ МОЛОЧНЫЙ ПРОДУКТ, СОДЕРЖАЩИЙ ТРИПЕПТИДЫ VPP (Val-Pro-Pro) И/ИЛИ IPP (Ile-Pro-Pro) |
| WO2006004105A1 (ja) * | 2004-07-05 | 2006-01-12 | Calpis Co., Ltd. | ペプチド混合物の製造法、抗高血圧ペプチド含有発酵乳の製造法及び抗高血圧ペプチド製剤の製造法 |
-
2006
- 2006-02-20 AT AT06290286T patent/ATE548445T1/de active
- 2006-02-20 PL PL06290286T patent/PL1820851T3/pl unknown
- 2006-02-20 ES ES06290286T patent/ES2384096T3/es active Active
- 2006-02-20 EP EP06290286A patent/EP1820851B9/fr active Active
-
2007
- 2007-02-19 CA CA2642891A patent/CA2642891C/fr not_active Expired - Fee Related
- 2007-02-19 ES ES07731005T patent/ES2380595T3/es active Active
- 2007-02-19 EP EP07731005A patent/EP1991661B1/fr active Active
- 2007-02-19 WO PCT/FR2007/000294 patent/WO2007096510A2/fr not_active Ceased
- 2007-02-19 JP JP2008554816A patent/JP5184378B2/ja not_active Expired - Fee Related
- 2007-02-19 PL PL07731005T patent/PL1991661T3/pl unknown
- 2007-02-19 RU RU2008137627/10A patent/RU2422509C2/ru active
- 2007-02-19 AT AT07731005T patent/ATE541918T1/de active
- 2007-02-19 KR KR1020087023009A patent/KR20080108247A/ko not_active Withdrawn
- 2007-02-19 BR BRPI0707985A patent/BRPI0707985B1/pt not_active IP Right Cessation
- 2007-02-19 AU AU2007217318A patent/AU2007217318A1/en not_active Abandoned
- 2007-02-19 MY MYPI20083184A patent/MY149886A/en unknown
- 2007-02-19 MX MX2008010642A patent/MX2008010642A/es active IP Right Grant
- 2007-02-19 CN CN200780013463XA patent/CN101421390B/zh not_active Expired - Fee Related
- 2007-02-19 US US12/279,951 patent/US8323951B2/en active Active
- 2007-02-20 AR ARP070100718A patent/AR059863A1/es active IP Right Grant
-
2008
- 2008-08-19 ZA ZA200807147A patent/ZA200807147B/xx unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5184378B2 (ja) | ヘルベティカス乳酸桿菌の新規株 | |
| JP2009532018A5 (enExample) | ||
| US20030064501A1 (en) | Lactobacillus helveticus bacterium having high capability of producing tripeptide, fermented milk product, and process for preparing the same | |
| WO2007096498A1 (fr) | Nouvelles souches de lactobacillus helveticus | |
| US11272716B2 (en) | Bacteria | |
| US11345883B2 (en) | Bacteria | |
| US11910803B2 (en) | Lactobacillus plantarum strain imparting high thickness and/or high ropiness and/or high mouth thickness to a dairy product produced therewith and uses thereof | |
| JP2008516620A (ja) | 代謝能力が低減した微生物を用いた生物活性食品成分の保護 | |
| ES2323087T3 (es) | Nuevas cepas de lactobacillus helveticus. | |
| EP3394294B1 (en) | Compositions for increasing or maintaining faecalibacterium prausnitzii populations | |
| EP1820405B1 (fr) | Nouvelles souches de Lactobacillus Helveticus |