JP2009529915A5 - - Google Patents

Info

Publication number

JP2009529915A5

JP2009529915A5 JP2009501410A JP2009501410A JP2009529915A5 JP 2009529915 A5 JP2009529915 A5 JP 2009529915A5 JP 2009501410 A JP2009501410 A JP 2009501410A JP 2009501410 A JP2009501410 A JP 2009501410A JP 2009529915 A5 JP2009529915 A5 JP 2009529915A5

Authority

JP

Japan

Prior art keywords

amino acid

antibody

acid sequence

light chain

heavy chain

Prior art date

2006-12-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 150000001413 amino acids Chemical group 0.000 claims 72
• 102400000921 Gastrin Human genes 0.000 claims 9
• 108091035707 Consensus sequence Proteins 0.000 claims 7
• 108010052343 Gastrins Proteins 0.000 claims 6
• AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 claims 6
• 238000000034 method Methods 0.000 claims 4
• 108010066264 gastrin 17 Proteins 0.000 claims 3
• GKDWRERMBNGKCZ-RNXBIMIWSA-N gastrin-17 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 GKDWRERMBNGKCZ-RNXBIMIWSA-N 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 238000003556 assay Methods 0.000 claims 1
• 230000003185 calcium uptake Effects 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• 238000006386 neutralization reaction Methods 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 239000013598 vector Substances 0.000 claims 1