JP2011502137A5 - - Google Patents

Download PDF

Info

Publication number
JP2011502137A5
JP2011502137A5 JP2010531449A JP2010531449A JP2011502137A5 JP 2011502137 A5 JP2011502137 A5 JP 2011502137A5 JP 2010531449 A JP2010531449 A JP 2010531449A JP 2010531449 A JP2010531449 A JP 2010531449A JP 2011502137 A5 JP2011502137 A5 JP 2011502137A5
Authority
JP
Japan
Prior art keywords
antibody
domain
seq
amino acid
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010531449A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011502137A (ja
JP5106635B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2008/009070 external-priority patent/WO2009056268A1/en
Publication of JP2011502137A publication Critical patent/JP2011502137A/ja
Publication of JP2011502137A5 publication Critical patent/JP2011502137A5/ja
Application granted granted Critical
Publication of JP5106635B2 publication Critical patent/JP5106635B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010531449A 2007-10-30 2008-10-27 関節リウマチと関連する抗原 Active JP5106635B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98360607P 2007-10-30 2007-10-30
US60/983,606 2007-10-30
PCT/EP2008/009070 WO2009056268A1 (en) 2007-10-30 2008-10-27 An antigen associated with rheumatoid arthritis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012219986A Division JP6154594B2 (ja) 2007-10-30 2012-10-02 関節リウマチと関連する抗原

Publications (3)

Publication Number Publication Date
JP2011502137A JP2011502137A (ja) 2011-01-20
JP2011502137A5 true JP2011502137A5 (enExample) 2012-08-30
JP5106635B2 JP5106635B2 (ja) 2012-12-26

Family

ID=40282320

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2010531449A Active JP5106635B2 (ja) 2007-10-30 2008-10-27 関節リウマチと関連する抗原
JP2012219986A Active JP6154594B2 (ja) 2007-10-30 2012-10-02 関節リウマチと関連する抗原
JP2014210887A Active JP6198703B2 (ja) 2007-10-30 2014-10-15 関節リウマチと関連する抗原

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2012219986A Active JP6154594B2 (ja) 2007-10-30 2012-10-02 関節リウマチと関連する抗原
JP2014210887A Active JP6198703B2 (ja) 2007-10-30 2014-10-15 関節リウマチと関連する抗原

Country Status (18)

Country Link
US (4) US8222377B2 (enExample)
EP (3) EP3281952B1 (enExample)
JP (3) JP5106635B2 (enExample)
KR (3) KR102002739B1 (enExample)
CN (2) CN101918443B (enExample)
AU (1) AU2008317941B2 (enExample)
BR (1) BRPI0818272B8 (enExample)
CA (1) CA2704296C (enExample)
DK (2) DK2209805T3 (enExample)
ES (2) ES2646228T3 (enExample)
HU (2) HUE050038T2 (enExample)
MX (1) MX2010004726A (enExample)
NO (1) NO2209805T3 (enExample)
PL (2) PL3281952T3 (enExample)
PT (2) PT2209805T (enExample)
RU (2) RU2486198C2 (enExample)
SI (2) SI2209805T1 (enExample)
WO (1) WO2009056268A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070084556A1 (en) 2005-10-14 2007-04-19 Langseder Neal E Method of applying a label to a squeeze tube
WO2008120101A2 (en) * 2007-04-02 2008-10-09 Philogen S.P.A. The ed-a antigen of fibrinogen is associated with the neovasculature of tumour metastases
US10202442B2 (en) 2007-07-25 2019-02-12 Philogen S.P.A. Antigen associated with lung cancers and lymphomas
MX2010004726A (es) * 2007-10-30 2010-05-20 Philogen Spa Antigeno asociado con artritis reumatoide.
ES2549362T3 (es) 2009-01-07 2015-10-27 Philogen S.P.A. Antígenos asociados a endometriosis
EP2947096B1 (en) 2009-08-05 2018-11-28 Philogen S.p.A. Targeting of bone marrow neovasculature
CA2842053C (en) * 2011-07-27 2018-01-16 Philogen S.P.A. Il-12 immunoconjugate
EP2882774B1 (en) * 2012-08-08 2018-10-03 Roche Glycart AG Interleukin-10 fusion proteins and uses thereof
TWI499426B (zh) * 2012-09-27 2015-09-11 Philogen Spa 與發炎性腸病有關之抗原
CN104768563B (zh) * 2012-10-03 2020-02-28 菲罗根股份公司 与炎性肠病有关的抗原
CA2935665A1 (en) * 2014-02-06 2015-08-13 F. Hoffmann-La Roche Ag Interleukine 10 immunoconjugates
GB201507908D0 (en) 2015-05-08 2015-06-24 Philogen Spa IL2 and TNF immunoconjugates
CA2992366A1 (en) 2015-07-16 2017-01-19 Philogen S.P.A. Il22 immunoconjugates
US20190309060A1 (en) 2016-01-15 2019-10-10 Philogen S.P.A. Intestinal antigens for pharmacodelivery applications
EP3634999A1 (en) 2017-06-07 2020-04-15 Philogen S.p.A. Vascular endothelial growth factor/anti-fibronectin antibody fusion proteins
JP2017197558A (ja) * 2017-06-07 2017-11-02 フィロゲン エスピーエー 炎症性腸疾患に関連する抗原
US12006345B2 (en) 2019-02-21 2024-06-11 Xencor, Inc. Untargeted and targeted IL-10 Fc-fusion proteins
US10858412B2 (en) * 2019-03-06 2020-12-08 Deka Biosciences, Inc. Antibody variable domain regions fused to IL-10 variant molecules
WO2020249757A1 (en) 2019-06-14 2020-12-17 Philogen S.P.A Immunoconjugates comprising a single chain diabody and interleukin-15 or interleukin-15 and a sushi domain of interleukin-15 receptor alpha
MX2023000948A (es) 2020-07-20 2023-04-14 Deka Biosciences Inc Proteínas de fusión de citocina doble que comprenden interleucina-10 (il-10).
US20230285585A1 (en) 2020-07-22 2023-09-14 Philogen S.P.A. Treatment of pulmonary hypertension
CN113480636B (zh) * 2021-06-23 2023-11-03 烟台科瑞斯生物技术有限责任公司 重组人纤连蛋白及其制备、活性测定和稳定性实验方法
WO2023175077A1 (en) 2022-03-17 2023-09-21 Philogen S.P.A Anti-ed-a antibodies for the treatment of pulmonary hypertension
WO2026003203A1 (en) 2024-06-27 2026-01-02 Philogen S.P.A. Combination of an immunocytokine comprising targeted il2 and a jak inhibitor

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
IT1217724B (it) 1988-05-26 1990-03-30 Ist Naz Ric Sul Cancro Anticorpo monoclonale specifico per una sequenza di fibronettina espressa in cellule trasformate ibridoma secernente tale anticorpo e impiego dell'anticorpo monoclonale per la diagnosi di tumori
US5420012A (en) 1989-05-08 1995-05-30 Locus Genex Oy Method for the detection of reactive conditions
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
GB9206318D0 (en) 1992-03-24 1992-05-06 Cambridge Antibody Tech Binding substances
EP0580859A4 (en) * 1991-03-26 1994-09-14 Otsuka Pharma Co Ltd Anti-eda monoclonal antibody
US5871907A (en) 1991-05-15 1999-02-16 Medical Research Council Methods for producing members of specific binding pairs
US6225447B1 (en) 1991-05-15 2001-05-01 Cambridge Antibody Technology Ltd. Methods for producing members of specific binding pairs
US5858657A (en) 1992-05-15 1999-01-12 Medical Research Council Methods for producing members of specific binding pairs
US5962255A (en) 1992-03-24 1999-10-05 Cambridge Antibody Technology Limited Methods for producing recombinant vectors
US6492160B1 (en) 1991-05-15 2002-12-10 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5872215A (en) 1991-12-02 1999-02-16 Medical Research Council Specific binding members, materials and methods
ATE408012T1 (de) 1991-12-02 2008-09-15 Medical Res Council Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
DE69329974T2 (de) 1992-12-04 2001-07-19 Medical Research Council, London Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
US5644033A (en) 1992-12-22 1997-07-01 Health Research, Inc. Monoclonal antibodies that define a unique antigen of human B cell antigen receptor complex and methods of using same for diagnosis and treatment
AU6098994A (en) 1993-01-27 1994-08-15 Duke University Methods and agents for the diagnosis and treatment of rheumatoid arthritis
US6054312A (en) 1997-08-29 2000-04-25 Selective Genetics, Inc. Receptor-mediated gene delivery using bacteriophage vectors
DE69941267D1 (de) 1998-12-10 2009-09-24 Bristol Myers Squibb Co Proteingerüste für antikörper-nachahmer und andere bindende proteine
ATE333900T1 (de) 2000-02-24 2006-08-15 Philogen Spa Zusamensetzungen und verfahren zur behandlung von angiogenese in pathologischen schädigungen
CA2404919A1 (en) * 2000-04-06 2002-10-01 Kyowa Hakko Kogyo Co. Ltd. Diagnostic and therapeutic agents for rheumatoid arthritis
WO2001083816A2 (en) 2000-05-04 2001-11-08 Philogen S.R.L. Method for detecting tumors
AU1218202A (en) * 2000-09-07 2002-03-22 Schering Ag Receptor in the ED<sub>b</sub> fibronectin domain
US6780594B2 (en) 2000-09-25 2004-08-24 Schering Aktiengesellschaft Method for in vitro diagnosis of endometriosis
IT1317108B1 (it) 2000-12-06 2003-05-26 Philogen Srl Processo per la selezione di frammenti anticorporali anti-angiogenesi,frammenti anticorpali anti-angiogenesi cosi' ottenuti e loro uso.
US20020187100A1 (en) 2000-12-21 2002-12-12 David Rizzieri Anti-tenascin monoclonal antibody therapy for lymphoma
EP1224943A1 (en) 2001-01-19 2002-07-24 Crucell Holland B.V. Fibronectin as a tumor marker detected by phage antibodies
GB0209896D0 (en) 2002-04-30 2002-06-05 Molmed Spa Conjugate
WO2004000216A2 (en) 2002-06-21 2003-12-31 Duke University Anti-tenascin antibody fragments and minibodies for treatment of lymphoma
KR20050065587A (ko) * 2002-10-08 2005-06-29 이뮤노메딕스, 인코오포레이티드 항체 치료법
CA2508831C (en) 2002-12-13 2012-05-01 Immunomedics, Inc. Immunoconjugates with an intracellularly-cleavable linkage
US20040202666A1 (en) 2003-01-24 2004-10-14 Immunomedics, Inc. Anti-cancer anthracycline drug-antibody conjugates
US7560095B2 (en) 2003-04-22 2009-07-14 A & G Pharmaceutical, Inc. Cancer specific monoclonal antibodies
WO2005009366A2 (en) 2003-07-24 2005-02-03 Cornell Research Foundation, Inc. Restoring vascular function
EP1660519B1 (en) 2003-07-29 2014-05-14 Immunomedics, Inc. Conjugates comprising 2-[18F]fluoro-2-deoxy-D-glucose and a peptide molecule
CA2552590A1 (en) 2004-01-05 2005-07-21 Emd Lexigen Research Center Corp. Interleukin-12 targeted to oncofoetal fibronectin
NZ582466A (en) * 2004-07-30 2011-09-30 Adeza Biomedical Corp Oncofetal fibronectin as a marker for disease and other conditions and methods for detection of oncofetal fibronectin
US7785591B2 (en) * 2004-10-14 2010-08-31 Morphosys Ag Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies
SI1817345T1 (sl) 2004-11-09 2009-10-31 Philogen Spa Protitelesa proti tenascinu-C
JP2008525424A (ja) * 2004-12-23 2008-07-17 モルメド エスピーエー 複合生成物
KR101281208B1 (ko) * 2005-05-11 2013-07-26 필로겐 에스.피.에이. 피브로넥틴 ｅｄ-ｂ에 대한 항체 ｌ１９ 및 인터루킨１２의 융합 단백질
AU2006262502A1 (en) 2005-06-23 2007-01-04 Emory Univerisity Imaging agents
EP2015775B1 (en) 2006-05-03 2011-06-01 Bayer Schering Pharma Aktiengesellschaft Combination of an anti edb fibronectin domain antibody l19-sip and an anti-egfr antibody
AU2007247380B2 (en) * 2006-05-08 2011-03-10 Philogen Spa Antibody-targeted cytokines for therapy
WO2008120101A2 (en) * 2007-04-02 2008-10-09 Philogen S.P.A. The ed-a antigen of fibrinogen is associated with the neovasculature of tumour metastases
CA2691218C (en) * 2007-07-25 2018-04-24 Philogen S.P.A. An antigen associated with lung cancers and lymphomas
US10202442B2 (en) 2007-07-25 2019-02-12 Philogen S.P.A. Antigen associated with lung cancers and lymphomas
MX2010004726A (es) 2007-10-30 2010-05-20 Philogen Spa Antigeno asociado con artritis reumatoide.
ES2549362T3 (es) 2009-01-07 2015-10-27 Philogen S.P.A. Antígenos asociados a endometriosis
WO2010078945A2 (en) 2009-01-07 2010-07-15 Philogen S.P.A. Cancer treatment
EP2621535A1 (en) 2010-09-29 2013-08-07 Philogen S.p.A. Thiazolidine linker for the conjugation of drugs to antibodies
CA2842053C (en) 2011-07-27 2018-01-16 Philogen S.P.A. Il-12 immunoconjugate
CN104768563B (zh) 2012-10-03 2020-02-28 菲罗根股份公司 与炎性肠病有关的抗原
WO2014174105A1 (en) 2013-04-25 2014-10-30 Philochem Ag Antibody-drug conjugates
JP2016519111A (ja) 2013-04-26 2016-06-30 フィロゲン エスピーエー 細胞外マトリックス成分に対する抗体にコンジュゲートしたｉｌ４
US9209965B2 (en) 2014-01-14 2015-12-08 Microsemi Semiconductor Ulc Network interface with clock recovery module on line card

Similar Documents

Publication Publication Date Title
JP2011502137A5 (enExample)
RU2486198C2 (ru) Антиген, ассоциированный с ревматоидным артритом
JP2022191301A5 (enExample)
JP2013121353A5 (enExample)
JP2010534237A5 (enExample)
JP2016135783A5 (enExample)
JP2010523541A5 (enExample)
JP2021501744A5 (enExample)
NZ600768A (en) Human antibodies to human angiopoietin-like protein 4
JP2020537520A5 (enExample)
JP2011509245A5 (enExample)
JP2015503909A5 (enExample)
HRP20140108T1 (hr) Protutijela protiv sklerostina
PE20090161A1 (es) Anticuerpos monoclonales anti cxcl13
NZ608660A (en) Anti-cd48 antibodies and uses thereof
NZ714313A (en) Monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
IL259036A (en) asct2-specific binding molecules and their uses
IL273841B1 (en) Antibodies targeting cd137 and methods of use thereof
EA201190132A1 (ru) Гуманизированные антитела, связывающиеся с cd19, и их применение
JP2015514110A5 (enExample)
JP2014534239A5 (enExample)
JP2017526339A5 (enExample)
RU2571204C3 (ru) Специфические связывающие агенты против в7-н1
JP2012521217A5 (enExample)
JP2017519501A5 (enExample)