JP2011502137A5 - - Google Patents
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- Publication number
- JP2011502137A5 JP2011502137A5 JP2010531449A JP2010531449A JP2011502137A5 JP 2011502137 A5 JP2011502137 A5 JP 2011502137A5 JP 2010531449 A JP2010531449 A JP 2010531449A JP 2010531449 A JP2010531449 A JP 2010531449A JP 2011502137 A5 JP2011502137 A5 JP 2011502137A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- domain
- seq
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000003814 Interleukin-10 Human genes 0.000 claims 12
- 108090000174 Interleukin-10 Proteins 0.000 claims 12
- 229940076144 interleukin-10 Drugs 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 102000016359 Fibronectins Human genes 0.000 claims 6
- 108010067306 Fibronectins Proteins 0.000 claims 6
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 102000001708 Protein Isoforms Human genes 0.000 claims 2
- 108010029485 Protein Isoforms Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98360607P | 2007-10-30 | 2007-10-30 | |
| US60/983,606 | 2007-10-30 | ||
| PCT/EP2008/009070 WO2009056268A1 (en) | 2007-10-30 | 2008-10-27 | An antigen associated with rheumatoid arthritis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012219986A Division JP6154594B2 (ja) | 2007-10-30 | 2012-10-02 | 関節リウマチと関連する抗原 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011502137A JP2011502137A (ja) | 2011-01-20 |
| JP2011502137A5 true JP2011502137A5 (enExample) | 2012-08-30 |
| JP5106635B2 JP5106635B2 (ja) | 2012-12-26 |
Family
ID=40282320
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010531449A Active JP5106635B2 (ja) | 2007-10-30 | 2008-10-27 | 関節リウマチと関連する抗原 |
| JP2012219986A Active JP6154594B2 (ja) | 2007-10-30 | 2012-10-02 | 関節リウマチと関連する抗原 |
| JP2014210887A Active JP6198703B2 (ja) | 2007-10-30 | 2014-10-15 | 関節リウマチと関連する抗原 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012219986A Active JP6154594B2 (ja) | 2007-10-30 | 2012-10-02 | 関節リウマチと関連する抗原 |
| JP2014210887A Active JP6198703B2 (ja) | 2007-10-30 | 2014-10-15 | 関節リウマチと関連する抗原 |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US8222377B2 (enExample) |
| EP (3) | EP2209805B1 (enExample) |
| JP (3) | JP5106635B2 (enExample) |
| KR (3) | KR101836968B1 (enExample) |
| CN (2) | CN101918443B (enExample) |
| AU (1) | AU2008317941B2 (enExample) |
| BR (1) | BRPI0818272B8 (enExample) |
| CA (1) | CA2704296C (enExample) |
| DK (2) | DK3281952T3 (enExample) |
| ES (2) | ES2807753T3 (enExample) |
| HU (2) | HUE050038T2 (enExample) |
| MX (1) | MX2010004726A (enExample) |
| NO (1) | NO2209805T3 (enExample) |
| PL (2) | PL3281952T3 (enExample) |
| PT (2) | PT3281952T (enExample) |
| RU (2) | RU2486198C2 (enExample) |
| SI (2) | SI3281952T1 (enExample) |
| WO (1) | WO2009056268A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070084556A1 (en) | 2005-10-14 | 2007-04-19 | Langseder Neal E | Method of applying a label to a squeeze tube |
| MX2009010639A (es) | 2007-04-02 | 2009-10-23 | Philogen Spa | Nuevo antigeno asociado con la neovasculatura de metastasis tumoral. |
| US10202442B2 (en) | 2007-07-25 | 2019-02-12 | Philogen S.P.A. | Antigen associated with lung cancers and lymphomas |
| HUE050038T2 (hu) | 2007-10-30 | 2020-11-30 | Philogen Spa | Rheumatoid arthritisszel kapcsolatos antigén |
| EP2379116B1 (en) | 2009-01-07 | 2015-08-26 | Philogen S.p.A. | Antigens associated with endometriosis |
| US8679488B2 (en) | 2009-08-05 | 2014-03-25 | Philogen S.P.A. | Targeting of bone marrow neovasculature |
| ES2706428T3 (es) * | 2011-07-27 | 2019-03-28 | Philogen Spa | Inmunoconjugado de IL-12 |
| CA2876285A1 (en) * | 2012-08-08 | 2014-02-13 | Roche Glycart Ag | Interleukin-10 fusion proteins and uses thereof |
| TWI499426B (zh) * | 2012-09-27 | 2015-09-11 | Philogen Spa | 與發炎性腸病有關之抗原 |
| US9695232B2 (en) | 2012-10-03 | 2017-07-04 | Philogen S.P.A. | Anti-ED-A immunoconjugates for inflammatory bowel disease |
| KR20160117463A (ko) * | 2014-02-06 | 2016-10-10 | 에프. 호프만-라 로슈 아게 | 인터루킨-10 면역접합체 |
| GB201507908D0 (en) | 2015-05-08 | 2015-06-24 | Philogen Spa | IL2 and TNF immunoconjugates |
| BR112018000909A2 (pt) | 2015-07-16 | 2018-09-11 | Philogen Spa | imunoconjugados de il22 |
| US20190309060A1 (en) | 2016-01-15 | 2019-10-10 | Philogen S.P.A. | Intestinal antigens for pharmacodelivery applications |
| WO2018224550A1 (en) | 2017-06-07 | 2018-12-13 | Philogen S.P.A | Vascular endothelial growth factor/anti-fibronectin antibody fusion proteins |
| JP2017197558A (ja) * | 2017-06-07 | 2017-11-02 | フィロゲン エスピーエー | 炎症性腸疾患に関連する抗原 |
| CN113811549A (zh) | 2019-02-21 | 2021-12-17 | Xencor股份有限公司 | 非靶向和靶向性il-10 fc融合蛋白 |
| CA3132385A1 (en) * | 2019-03-06 | 2020-09-10 | Deka Biosciences, Inc. | Il-10 variant molecules and methods of treating inflammatory disease and oncology |
| WO2020249757A1 (en) | 2019-06-14 | 2020-12-17 | Philogen S.P.A | Immunoconjugates comprising a single chain diabody and interleukin-15 or interleukin-15 and a sushi domain of interleukin-15 receptor alpha |
| JP2023534847A (ja) | 2020-07-20 | 2023-08-14 | デカ バイオサイエンシーズ， インコーポレイテッド | Ｉｌ－１０を含む二重サイトカイン融合タンパク質 |
| EP4185615A1 (en) | 2020-07-22 | 2023-05-31 | Philogen S.p.A. | Treatment of pulmonary hypertension |
| CN113480636B (zh) * | 2021-06-23 | 2023-11-03 | 烟台科瑞斯生物技术有限责任公司 | 重组人纤连蛋白及其制备、活性测定和稳定性实验方法 |
| EP4493210A1 (en) | 2022-03-17 | 2025-01-22 | Universitätsklinikum Jena | Anti-ed-a antibodies for the treatment of pulmonary hypertension |
| WO2026003203A1 (en) | 2024-06-27 | 2026-01-02 | Philogen S.P.A. | Combination of an immunocytokine comprising targeted il2 and a jak inhibitor |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| IT1217724B (it) | 1988-05-26 | 1990-03-30 | Ist Naz Ric Sul Cancro | Anticorpo monoclonale specifico per una sequenza di fibronettina espressa in cellule trasformate ibridoma secernente tale anticorpo e impiego dell'anticorpo monoclonale per la diagnosi di tumori |
| US5420012A (en) * | 1989-05-08 | 1995-05-30 | Locus Genex Oy | Method for the detection of reactive conditions |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| GB9206318D0 (en) | 1992-03-24 | 1992-05-06 | Cambridge Antibody Tech | Binding substances |
| EP0580859A4 (en) * | 1991-03-26 | 1994-09-14 | Otsuka Pharma Co Ltd | Anti-eda monoclonal antibody |
| DE69230142T2 (de) | 1991-05-15 | 2000-03-09 | Cambridge Antibody Technology Ltd. | Verfahren zur herstellung von spezifischen bindungspaargliedern |
| US5962255A (en) | 1992-03-24 | 1999-10-05 | Cambridge Antibody Technology Limited | Methods for producing recombinant vectors |
| US5858657A (en) | 1992-05-15 | 1999-01-12 | Medical Research Council | Methods for producing members of specific binding pairs |
| US6492160B1 (en) | 1991-05-15 | 2002-12-10 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| US6225447B1 (en) | 1991-05-15 | 2001-05-01 | Cambridge Antibody Technology Ltd. | Methods for producing members of specific binding pairs |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| US5872215A (en) | 1991-12-02 | 1999-02-16 | Medical Research Council | Specific binding members, materials and methods |
| ES2341666T3 (es) | 1991-12-02 | 2010-06-24 | Medimmune Limited | Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos. |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| DK0672142T3 (da) | 1992-12-04 | 2001-06-18 | Medical Res Council | Multivalente og multispecifikke bindingsproteiner samt fremstilling og anvendelse af disse |
| US5644033A (en) | 1992-12-22 | 1997-07-01 | Health Research, Inc. | Monoclonal antibodies that define a unique antigen of human B cell antigen receptor complex and methods of using same for diagnosis and treatment |
| WO1994017411A1 (en) | 1993-01-27 | 1994-08-04 | Duke University | Methods and agents for the diagnosis and treatment of rheumatoid arthritis |
| US6054312A (en) | 1997-08-29 | 2000-04-25 | Selective Genetics, Inc. | Receptor-mediated gene delivery using bacteriophage vectors |
| DE69941267D1 (de) | 1998-12-10 | 2009-09-24 | Bristol Myers Squibb Co | Proteingerüste für antikörper-nachahmer und andere bindende proteine |
| AU2001239470A1 (en) | 2000-02-24 | 2001-09-03 | Philogen S.R.L. | Compositions and methods for treatment of angiogenesis in pathological lesions |
| US20030152572A1 (en) * | 2000-04-06 | 2003-08-14 | Yoshimi Homma | Diagnostic and therapeutic agents for rheumatoid arthritis |
| WO2001083816A2 (en) | 2000-05-04 | 2001-11-08 | Philogen S.R.L. | Method for detecting tumors |
| YU17503A (sh) * | 2000-09-07 | 2006-05-25 | Schering Aktiengesellschaft | Receptor oblasti (ii) edb-fibronektina |
| US6780594B2 (en) * | 2000-09-25 | 2004-08-24 | Schering Aktiengesellschaft | Method for in vitro diagnosis of endometriosis |
| IT1317108B1 (it) | 2000-12-06 | 2003-05-26 | Philogen Srl | Processo per la selezione di frammenti anticorporali anti-angiogenesi,frammenti anticorpali anti-angiogenesi cosi' ottenuti e loro uso. |
| US20020187100A1 (en) | 2000-12-21 | 2002-12-12 | David Rizzieri | Anti-tenascin monoclonal antibody therapy for lymphoma |
| EP1224943A1 (en) | 2001-01-19 | 2002-07-24 | Crucell Holland B.V. | Fibronectin as a tumor marker detected by phage antibodies |
| GB0209896D0 (en) * | 2002-04-30 | 2002-06-05 | Molmed Spa | Conjugate |
| AU2003238284A1 (en) | 2002-06-21 | 2004-01-06 | Duke University | Anti-tenascin antibody fragments and minibodies for treatment of lymphoma |
| AU2003282752A1 (en) * | 2002-10-08 | 2004-05-04 | Immunomedics, Inc. | Antibody therapy |
| EP1572242B1 (en) | 2002-12-13 | 2014-04-16 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
| US20040202666A1 (en) | 2003-01-24 | 2004-10-14 | Immunomedics, Inc. | Anti-cancer anthracycline drug-antibody conjugates |
| CA2523452A1 (en) | 2003-04-22 | 2004-11-04 | A & G Pharmaceutical, Inc. | Cancer specific monoclonal antibodies |
| WO2005009366A2 (en) | 2003-07-24 | 2005-02-03 | Cornell Research Foundation, Inc. | Restoring vascular function |
| CA2533878A1 (en) | 2003-07-29 | 2005-09-22 | Immunomedics, Inc. | Fluorinated carbohydrate conjugates |
| JP2007517506A (ja) | 2004-01-05 | 2007-07-05 | イーエムディー・レキシゲン・リサーチ・センター・コーポレーション | 標的化用化合物 |
| US20060024722A1 (en) | 2004-07-30 | 2006-02-02 | Mark Fischer-Colbrie | Samples for detection of oncofetal fibronectin and uses thereof |
| US7785591B2 (en) * | 2004-10-14 | 2010-08-31 | Morphosys Ag | Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies |
| JP2008518609A (ja) | 2004-11-09 | 2008-06-05 | フィロゲン エスピーエー | テネイシンｃに対する抗体 |
| CA2593964A1 (en) * | 2004-12-23 | 2006-06-29 | Molmed Spa | Conjugation product |
| KR101281208B1 (ko) * | 2005-05-11 | 2013-07-26 | 필로겐 에스.피.에이. | 피브로넥틴 ｅｄ-ｂ에 대한 항체 ｌ１９ 및 인터루킨１２의 융합 단백질 |
| EP1893244A4 (en) | 2005-06-23 | 2009-06-24 | Univ Emory | AGENTS FOR IMAGING |
| CA2650953A1 (en) | 2006-05-03 | 2007-11-15 | Bayer Schering Pharma Aktiengesellschaft | Combination of an anti edb fibronectin domain antibody l19-sip and an anti-egfr antibody |
| WO2007128563A1 (en) * | 2006-05-08 | 2007-11-15 | Philogen Spa | Antibody-targeted cytokines for therapy |
| MX2009010639A (es) | 2007-04-02 | 2009-10-23 | Philogen Spa | Nuevo antigeno asociado con la neovasculatura de metastasis tumoral. |
| US10202442B2 (en) | 2007-07-25 | 2019-02-12 | Philogen S.P.A. | Antigen associated with lung cancers and lymphomas |
| CA2691218C (en) * | 2007-07-25 | 2018-04-24 | Philogen S.P.A. | An antigen associated with lung cancers and lymphomas |
| HUE050038T2 (hu) | 2007-10-30 | 2020-11-30 | Philogen Spa | Rheumatoid arthritisszel kapcsolatos antigén |
| AU2009336800A1 (en) | 2009-01-07 | 2011-07-21 | Philogen S.P.A. | Cancer treatment |
| EP2379116B1 (en) | 2009-01-07 | 2015-08-26 | Philogen S.p.A. | Antigens associated with endometriosis |
| WO2012041451A1 (en) | 2010-09-29 | 2012-04-05 | Philogen S.P.A. | Thiazolidine linker for the conjugation of drugs to antibodies |
| ES2706428T3 (es) | 2011-07-27 | 2019-03-28 | Philogen Spa | Inmunoconjugado de IL-12 |
| US9695232B2 (en) | 2012-10-03 | 2017-07-04 | Philogen S.P.A. | Anti-ED-A immunoconjugates for inflammatory bowel disease |
| WO2014174105A1 (en) | 2013-04-25 | 2014-10-30 | Philochem Ag | Antibody-drug conjugates |
| JP2016519111A (ja) | 2013-04-26 | 2016-06-30 | フィロゲン エスピーエー | 細胞外マトリックス成分に対する抗体にコンジュゲートしたｉｌ４ |
| US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
-
2008
- 2008-10-27 HU HUE17189028A patent/HUE050038T2/hu unknown
- 2008-10-27 PT PT171890288T patent/PT3281952T/pt unknown
- 2008-10-27 DK DK17189028.8T patent/DK3281952T3/da active
- 2008-10-27 NO NO08844563A patent/NO2209805T3/no unknown
- 2008-10-27 DK DK08844563.0T patent/DK2209805T3/en active
- 2008-10-27 MX MX2010004726A patent/MX2010004726A/es active IP Right Grant
- 2008-10-27 SI SI200832134T patent/SI3281952T1/sl unknown
- 2008-10-27 KR KR1020167007916A patent/KR101836968B1/ko active Active
- 2008-10-27 RU RU2010121874/10A patent/RU2486198C2/ru active
- 2008-10-27 EP EP08844563.0A patent/EP2209805B1/en active Active
- 2008-10-27 KR KR1020187006283A patent/KR102002739B1/ko active Active
- 2008-10-27 HU HUE08844563A patent/HUE037036T2/hu unknown
- 2008-10-27 EP EP17189028.8A patent/EP3281952B1/en active Active
- 2008-10-27 ES ES17189028T patent/ES2807753T3/es active Active
- 2008-10-27 AU AU2008317941A patent/AU2008317941B2/en active Active
- 2008-10-27 CA CA2704296A patent/CA2704296C/en active Active
- 2008-10-27 CN CN2008801231862A patent/CN101918443B/zh active Active
- 2008-10-27 US US12/740,641 patent/US8222377B2/en active Active
- 2008-10-27 EP EP20181520.6A patent/EP3783019A1/en not_active Withdrawn
- 2008-10-27 KR KR1020107011773A patent/KR101608544B1/ko active Active
- 2008-10-27 WO PCT/EP2008/009070 patent/WO2009056268A1/en not_active Ceased
- 2008-10-27 SI SI200831867T patent/SI2209805T1/sl unknown
- 2008-10-27 CN CN201310233951.9A patent/CN103396483B/zh active Active
- 2008-10-27 BR BRPI0818272A patent/BRPI0818272B8/pt active IP Right Grant
- 2008-10-27 PL PL17189028T patent/PL3281952T3/pl unknown
- 2008-10-27 ES ES08844563.0T patent/ES2646228T3/es active Active
- 2008-10-27 JP JP2010531449A patent/JP5106635B2/ja active Active
- 2008-10-27 PT PT88445630T patent/PT2209805T/pt unknown
- 2008-10-27 PL PL08844563T patent/PL2209805T3/pl unknown
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2012
- 2012-06-05 US US13/489,123 patent/US9556257B2/en active Active
- 2012-10-02 JP JP2012219986A patent/JP6154594B2/ja active Active
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2013
- 2013-04-09 RU RU2013115891A patent/RU2649368C2/ru active
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2014
- 2014-10-15 JP JP2014210887A patent/JP6198703B2/ja active Active
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2016
- 2016-12-15 US US15/380,167 patent/US10385121B2/en active Active
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2019
- 2019-07-17 US US16/514,080 patent/US20190352384A1/en not_active Abandoned