JP2009529523A5 - - Google Patents

Info

Publication number

JP2009529523A5

JP2009529523A5 JP2008557846A JP2008557846A JP2009529523A5 JP 2009529523 A5 JP2009529523 A5 JP 2009529523A5 JP 2008557846 A JP2008557846 A JP 2008557846A JP 2008557846 A JP2008557846 A JP 2008557846A JP 2009529523 A5 JP2009529523 A5 JP 2009529523A5

Authority

JP

Japan

Prior art keywords

integer

cooh

amino

alkanoyloxy

configuration

Prior art date

2007-03-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 33
• 125000004423 acyloxy group Chemical group 0.000 claims 21
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 17
• 239000008194 pharmaceutical composition Substances 0.000 claims 14
• -1 dihydroxyphosphoryloxy Chemical group 0.000 claims 10
• 125000000217 alkyl group Chemical group 0.000 claims 7
• 229910052799 carbon Inorganic materials 0.000 claims 6
• 229920001577 copolymer Chemical group 0.000 claims 6
• 125000004432 carbon atom Chemical group C* 0.000 claims 4
• 150000001875 compounds Chemical class 0.000 claims 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
• 230000002757 inflammatory effect Effects 0.000 claims 4
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
• 108090000695 Cytokines Proteins 0.000 claims 3
• 102000004127 Cytokines Human genes 0.000 claims 3
• DUVFGVANBUHUNU-GBYUNDSOSA-N [(3r)-1-[[(2s)-4-hydroxy-1-[[(4r)-5-hydroxy-4-[[(3r)-3-hydroxytetradecanoyl]amino]pentyl]amino]-1-oxobutan-2-yl]amino]-1-oxotetradecan-3-yl] dodecanoate Chemical compound CCCCCCCCCCC[C@@H](O)CC(=O)N[C@@H](CO)CCCNC(=O)[C@H](CCO)NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC DUVFGVANBUHUNU-GBYUNDSOSA-N 0.000 claims 3
• 125000002252 acyl group Chemical group 0.000 claims 3
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
• 125000001589 carboacyl group Chemical group 0.000 claims 3
• 201000010099 disease Diseases 0.000 claims 3
• FJKVIRFMBJTEIJ-UHFFFAOYSA-N 6,7-dihydroxyheptanoic acid Chemical compound OCC(O)CCCCC(O)=O FJKVIRFMBJTEIJ-UHFFFAOYSA-N 0.000 claims 2
• 238000012261 overproduction Methods 0.000 claims 2
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
• 206010012438 Dermatitis atopic Diseases 0.000 claims 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
• 102100037850 Interferon gamma Human genes 0.000 claims 1
• 108010074328 Interferon-gamma Proteins 0.000 claims 1
• 108090000176 Interleukin-13 Proteins 0.000 claims 1
• 108090000978 Interleukin-4 Proteins 0.000 claims 1
• 108010002616 Interleukin-5 Proteins 0.000 claims 1
• 108090001005 Interleukin-6 Proteins 0.000 claims 1
• 108090001007 Interleukin-8 Proteins 0.000 claims 1
• 108010002335 Interleukin-9 Proteins 0.000 claims 1
• 206010039085 Rhinitis allergic Diseases 0.000 claims 1
• 210000001744 T-lymphocyte Anatomy 0.000 claims 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
• RWKSHMIMEZGXJM-ZGIXZKLDSA-N [(3R)-1-[[(2S)-6-amino-1-[[(4R)-5-hydroxy-4-[[(3R)-3-hydroxytetradecanoyl]amino]pentyl]amino]-1-oxohexan-2-yl]amino]-1-oxotetradecan-3-yl] dodecanoate Chemical compound CCCCCCCCCCC[C@@H](O)CC(=O)N[C@@H](CO)CCCNC(=O)[C@H](CCCCN)NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC RWKSHMIMEZGXJM-ZGIXZKLDSA-N 0.000 claims 1
• 210000000683 abdominal cavity Anatomy 0.000 claims 1
• 125000004442 acylamino group Chemical group 0.000 claims 1
• 239000000443 aerosol Substances 0.000 claims 1
• 125000003545 alkoxy group Chemical group 0.000 claims 1
• 201000010105 allergic rhinitis Diseases 0.000 claims 1
• 150000001408 amides Chemical class 0.000 claims 1
• 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims 1
• 210000000612 antigen-presenting cell Anatomy 0.000 claims 1
• 229960005261 aspartic acid Drugs 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 201000008937 atopic dermatitis Diseases 0.000 claims 1
• 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 230000002519 immonomodulatory effect Effects 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 210000001616 monocyte Anatomy 0.000 claims 1
• 230000007935 neutral effect Effects 0.000 claims 1
• 231100000252 nontoxic Toxicity 0.000 claims 1
• 230000003000 nontoxic effect Effects 0.000 claims 1
• 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
• 201000007094 prostatitis Diseases 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 229920006395 saturated elastomer Polymers 0.000 claims 1
• 239000012453 solvate Substances 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 125000001424 substituent group Chemical group 0.000 claims 1