RU2498813C2 - Иммуномодуляторные соединения и лечение заболеваний, связанных со сверхпродукцией воспалительных цитокинов - Google Patents

Иммуномодуляторные соединения и лечение заболеваний, связанных со сверхпродукцией воспалительных цитокинов Download PDF

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RU2498813C2
RU2498813C2 RU2008139985/15A RU2008139985A RU2498813C2 RU 2498813 C2 RU2498813 C2 RU 2498813C2 RU 2008139985/15 A RU2008139985/15 A RU 2008139985/15A RU 2008139985 A RU2008139985 A RU 2008139985A RU 2498813 C2 RU2498813 C2 RU 2498813C2
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integer
cooh
configuration
amino
alkanoyloxy
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RU2008139985/15A
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RU2008139985A (ru
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Жак БОЕР
Карло КЬЯВАРОЛИ
Стефан МУТЕЛЬ
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Ом Фарма
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/661Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/661Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
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    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P11/02Nasal agents, e.g. decongestants
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P37/02Immunomodulators
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
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    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
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    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/091Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

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  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Diabetes (AREA)
  • Biochemistry (AREA)
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  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2008139985/15A 2006-03-09 2007-03-09 Иммуномодуляторные соединения и лечение заболеваний, связанных со сверхпродукцией воспалительных цитокинов RU2498813C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IBPCT/IB2006/050748 2006-03-09
IBPCT/IB2006/050748 2006-03-09
PCT/IB2007/000567 WO2007102081A2 (en) 2006-03-09 2007-03-09 Immunomodulatory compounds and treatment of diseases related to an overproduction of inflammatory cytokines

Publications (2)

Publication Number Publication Date
RU2008139985A RU2008139985A (ru) 2010-04-20
RU2498813C2 true RU2498813C2 (ru) 2013-11-20

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RU2008139985/15A RU2498813C2 (ru) 2006-03-09 2007-03-09 Иммуномодуляторные соединения и лечение заболеваний, связанных со сверхпродукцией воспалительных цитокинов

Country Status (14)

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US (3) US7915240B2 (https=)
EP (1) EP2051728A4 (https=)
JP (1) JP5341526B2 (https=)
KR (1) KR20080105048A (https=)
CN (1) CN101511379A (https=)
AU (1) AU2007222135B2 (https=)
BR (1) BRPI0708363A2 (https=)
CA (1) CA2645053A1 (https=)
IL (1) IL192837A (https=)
MX (1) MX2008011360A (https=)
NO (1) NO20084195L (https=)
RU (1) RU2498813C2 (https=)
WO (1) WO2007102081A2 (https=)
ZA (1) ZA200806266B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007102081A2 (en) 2006-03-09 2007-09-13 Om Pharma Immunomodulatory compounds and treatment of diseases related to an overproduction of inflammatory cytokines
KR101108161B1 (ko) 2009-12-24 2012-01-31 삼성모바일디스플레이주식회사 유기 발광 표시 장치 및 그 제조방법
US10065978B2 (en) * 2015-11-24 2018-09-04 University Of South Carolina Cysteine-modifying substrate analogue inhibitors of ribose 5-phosphate isomerase for parasitic diseases, along with methods of their formation and use
US10682359B2 (en) 2017-03-31 2020-06-16 University Of South Carolina Inhibitors of glucose kinases, along with methods of their formation and use
US11059842B2 (en) 2019-04-29 2021-07-13 University Of South Carolina Monosaccharide amine and 3-nitro-2-phenyl-2H-chromene based inhibitors of glucose kinases
US11555047B2 (en) 2019-10-31 2023-01-17 University Of South Carolina One-step synthesis of phosphate-based inhibitors and applications thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2186569C2 (ru) * 1996-01-23 2002-08-10 Ай-Си-Эн ФАРМАСЬЮТИКАЛЗ Модуляция экспрессии тн1/тн2 цитокинов рибавирином и аналогами рибавирина в активированных т-лимфоцитах
RU2188828C2 (ru) * 1996-10-16 2002-09-10 Ай-Си-Эн Фармасьютикалз, Инк. Моноциклические l-нуклеозиды, их аналоги и применения
RU2190422C1 (ru) * 2001-04-25 2002-10-10 Кожемякин Леонид Андреевич Аэрозоль для ингаляций фармацевтической композиции глутовент и способ лечения с его использованием

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JP4305662B2 (ja) * 1996-09-30 2009-07-29 大塚製薬株式会社 サイトカイン産生抑制剤及び接着抑制剤
KR20010021789A (ko) 1997-08-04 2001-03-15 야스이 쇼사꾸 촉매 및 방향족 카보네이트의 제조방법
IT1296985B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
WO1999061412A1 (en) * 1998-05-22 1999-12-02 Welfide Corporation Hydroxamic acid derivatives and medicinal utilization thereof
CN1168702C (zh) * 1998-06-30 2004-09-29 Om药业 酰基-二肽类化合物,其制备方法以及含有前述化合物的药物组合物
US6831069B2 (en) 1999-08-27 2004-12-14 Ribapharm Inc. Pyrrolo[2,3-d]pyrimidine nucleoside analogs
WO2001046127A1 (fr) * 1999-12-22 2001-06-28 Om Pharma Pseudodipeptides acyles porteurs d'un bras auxiliaire fonctionnalise
EP1261736A4 (en) * 2000-01-25 2004-12-29 Nuvelo Inc PROCESS, POLYPEPTIDES AND POLYNUCLEOTIDES, ASSOCIATED WITH "PREADIPOCYTE FACTOR-1" (PREF-1)
JP2001316260A (ja) * 2000-02-29 2001-11-13 Meiji Milk Prod Co Ltd カバラクトン類を有効成分とするTNF−α産生抑制剤
DE20220947U1 (de) * 2001-02-28 2004-09-30 Ribapharm, Inc., Costa Mesa Pyrrolo2,3-dpyrimidin-Nucleosidanaloga
JP4902913B2 (ja) * 2001-07-11 2012-03-21 森下仁丹株式会社 TNF−α産生抑制剤
JP2004107220A (ja) * 2002-09-13 2004-04-08 Mitsubishi Pharma Corp TNF−α産生抑制剤
JP2004256403A (ja) * 2003-02-25 2004-09-16 Kyowa Hakko Kogyo Co Ltd TNF−α産生抑制剤
BRPI0407519A (pt) * 2003-03-07 2006-02-14 Kowa Co derivados de benzofurano
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Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2186569C2 (ru) * 1996-01-23 2002-08-10 Ай-Си-Эн ФАРМАСЬЮТИКАЛЗ Модуляция экспрессии тн1/тн2 цитокинов рибавирином и аналогами рибавирина в активированных т-лимфоцитах
RU2188828C2 (ru) * 1996-10-16 2002-09-10 Ай-Си-Эн Фармасьютикалз, Инк. Моноциклические l-нуклеозиды, их аналоги и применения
RU2190422C1 (ru) * 2001-04-25 2002-10-10 Кожемякин Леонид Андреевич Аэрозоль для ингаляций фармацевтической композиции глутовент и способ лечения с его использованием

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BYL В. et al. OM197-MP-AC induces the maturation of human dendritic cells and promotes a primary T cell response // Int. Immunopharmacology. - 2003, vol 3, pp.417-425. *

Also Published As

Publication number Publication date
NO20084195L (no) 2008-10-07
WO2007102081A3 (en) 2009-04-23
US20090054378A1 (en) 2009-02-26
WO2007102081A2 (en) 2007-09-13
JP2009529523A (ja) 2009-08-20
ZA200806266B (en) 2010-05-26
KR20080105048A (ko) 2008-12-03
RU2008139985A (ru) 2010-04-20
AU2007222135A1 (en) 2007-09-13
US8618080B2 (en) 2013-12-31
EP2051728A4 (en) 2010-03-31
MX2008011360A (es) 2009-03-03
US20120178721A1 (en) 2012-07-12
CA2645053A1 (en) 2007-09-13
EP2051728A2 (en) 2009-04-29
JP5341526B2 (ja) 2013-11-13
CN101511379A (zh) 2009-08-19
AU2007222135B2 (en) 2012-02-02
IL192837A (en) 2013-12-31
US20140086960A1 (en) 2014-03-27
US7915240B2 (en) 2011-03-29
BRPI0708363A2 (pt) 2011-05-24

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