JP2020534336A5 - - Google Patents

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JP2020534336A5
JP2020534336A5 JP2020516814A JP2020516814A JP2020534336A5 JP 2020534336 A5 JP2020534336 A5 JP 2020534336A5 JP 2020516814 A JP2020516814 A JP 2020516814A JP 2020516814 A JP2020516814 A JP 2020516814A JP 2020534336 A5 JP2020534336 A5 JP 2020534336A5
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JP2020534336A (ja
JP7548814B2 (ja
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Priority claimed from PCT/CN2018/106768 external-priority patent/WO2019057123A1/zh
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JP2020516814A 2017-09-20 2018-09-20 Ｉｄｏ阻害剤および／またはｉｄｏ－ｈｄａｃ二重阻害剤としての多環式化合物 Active JP7548814B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN201710854520.2 2017-09-20
CN201710854520 2017-09-20
CN201711397888 2017-12-21
CN201711397888.7 2017-12-21
CN201810119324 2018-02-06
CN201810119324.5 2018-02-06
PCT/CN2018/106768 WO2019057123A1 (zh) 2017-09-20 2018-09-20 作为ido抑制剂和/或ido-hdac双重抑制剂的多环化合物

Publications (3)

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JP2020534336A JP2020534336A (ja) 2020-11-26
JP2020534336A5 true JP2020534336A5 (https=) 2021-11-04
JP7548814B2 JP7548814B2 (ja) 2024-09-10

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JP2020516814A Active JP7548814B2 (ja) 2017-09-20 2018-09-20 Ｉｄｏ阻害剤および／またはｉｄｏ－ｈｄａｃ二重阻害剤としての多環式化合物

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US (1) US11266640B2 (https=)
EP (1) EP3686196B1 (https=)
JP (1) JP7548814B2 (https=)
CN (1) CN109843872B (https=)
WO (1) WO2019057123A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7312749B2 (ja) 2017-08-04 2023-07-21 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングをモジュレートする方法および組成物
US11180497B2 (en) * 2017-10-18 2021-11-23 Angex Pharmaceutical, Inc. Cyclic compounds as immunomodulating agents
CN110156674A (zh) * 2018-02-13 2019-08-23 中国科学院上海有机化学研究所 一种作为吲哚胺-2,3-双加氧酶抑制剂的螺环化合物
CN110357813A (zh) * 2018-04-09 2019-10-22 信达生物制药(苏州)有限公司 一种新型吲哚胺2,3-双加氧酶抑制剂及其制备方法和用途
MD3784664T2 (ro) 2018-04-26 2025-06-30 Pfizer Derivați de 2-amino-piridină sau de 2-amino-pirimidină utilizați ca inhibitori de kinaze dependente de cicline
KR102833434B1 (ko) * 2018-09-27 2025-07-15 쉔젠 칩스크린 바이오사이언스 씨오., 엘티디. 인돌아민-2,3-디옥시게나아제 억제 활성을 갖는 퀴놀린 유도체
JP7551629B2 (ja) 2019-02-05 2024-09-17 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
WO2020163405A1 (en) 2019-02-05 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
JP7603594B2 (ja) 2019-02-06 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
JP7603595B2 (ja) 2019-02-06 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
CN111909107B (zh) * 2019-05-10 2023-02-03 药康众拓(江苏)医药科技有限公司 Ido/hdac双重抑制剂及其药物组合物和应用
KR20220100904A (ko) * 2019-11-12 2022-07-18 남미 테라퓨틱스, 인크. 암의 치료에 유용한 ido 길항제 전구약물을 함유하는 제제화된 및/또는 공동-제제화된 리포솜 조성물 및 그의 방법

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL338947A1 (en) * 1997-08-15 2000-12-04 Pfizer Prod Inc Derivatives of 2-(4-aryl or heteroaryl piperazin-1-ylmethyl)-1h-indole
MY137020A (en) * 2000-04-27 2008-12-31 Abbott Lab Diazabicyclic central nervous system active agents
EP1177792A3 (en) * 2000-07-27 2002-10-23 Pfizer Products Inc. Dopamine D4 Ligands for the treatment of novelty-seeking disorders
WO2003070244A1 (en) * 2002-02-22 2003-08-28 Abbott Laboratories Antagonist of melanin concentrating hormone and their uses
US7435830B2 (en) * 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US8415354B2 (en) * 2004-04-29 2013-04-09 Abbott Laboratories Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US20060063930A1 (en) * 2004-08-20 2006-03-23 Agoston Gregory E Compositions and methods comprising proteinase activated receptor antagonists
GB0510204D0 (en) * 2005-05-19 2005-06-22 Chroma Therapeutics Ltd Enzyme inhibitors
AR069126A1 (es) * 2007-10-31 2009-12-30 Janssen Pharmaceutica Nv Diaminas en puente o fusionadas sustituidas con arilo como moduladores de leucotrieno a4 hidrolasa
FR2924343A1 (fr) * 2007-12-04 2009-06-05 Palumed Sa Nouvelles utilisations therapeutiques de molecules duales contenant un derive peroxydique.
FR2945533B1 (fr) * 2009-05-12 2011-05-27 Sanofi Aventis Derives de cyclopenta°c!pyrrolyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
US20140088124A1 (en) * 2011-06-02 2014-03-27 Robert J. DeVita Imidazole derivatives
KR102032934B1 (ko) * 2011-12-21 2019-10-16 지앙수 헨그루이 메디슨 컴퍼니 리미티드 피롤 6원 헤테로아릴 고리 유도체, 그의 제조 방법, 및 그의 의약 용도
US9637450B2 (en) * 2013-03-14 2017-05-02 The Trustees Of Columbia University In The City Of New York Octahydrocyclopentapyrroles, their preparation and use
US9073922B2 (en) * 2013-03-14 2015-07-07 Abbvie, Inc. Pyrrolo[2,3-B]pyridine CDK9 kinase inhibitors
MX2015012899A (es) * 2013-03-14 2016-06-02 Abbvie Inc Pirrolo [2,3-b] piridina como inhibidores de quinasa cdk9.
MX2016009403A (es) * 2014-02-03 2016-09-16 Cadila Healthcare Ltd Compuestos heterociclicos.
CN106535884A (zh) 2014-06-06 2017-03-22 弗雷克萨斯生物科学公司 免疫调节剂
MX2017005462A (es) 2014-11-05 2017-07-28 Flexus Biosciences Inc Agentes inmunorreguladores.
UY36390A (es) * 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
UY36391A (es) * 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen
US11225469B2 (en) * 2015-01-15 2022-01-18 Whitehead Institute For Biomedical Research Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof
US10001765B2 (en) 2015-07-02 2018-06-19 buildpulse, Inc. Advanced identification and classification of sensors and other points in a building automation system
LT3319959T (lt) * 2015-07-06 2021-12-27 Alkermes, Inc. Histono deacetilazės hetero-halogeno inhibitoriai
WO2017024996A1 (zh) 2015-08-07 2017-02-16 江苏恒瑞医药股份有限公司 羟基脒类衍生物、其制备方法及其在医药上的应用
CN106478607B (zh) * 2015-08-28 2019-05-24 广东东阳光药业有限公司 取代的杂芳基化合物及其组合物和用途
WO2017044434A1 (en) * 2015-09-11 2017-03-16 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use
TW201735769A (zh) * 2015-10-09 2017-10-16 盧森堡商艾伯維公司 經取代之吡唑并［３，４－ｂ］吡啶－６－羧酸及使用方法
US10414765B2 (en) * 2015-12-10 2019-09-17 Bayer Pharma Aktiengesellschaft Substituted perhydropyrrolo[3,4-c]pyrrole derivatives and the use of same
JP2019516682A (ja) 2016-05-04 2019-06-20 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ インドールアミン２，３−ジオキシゲナーゼ阻害剤およびその使用方法
WO2017192744A1 (en) 2016-05-04 2017-11-09 Motif BioSciences Inc. Systems and methods for treating bacterial infection
CN109414420A (zh) 2016-05-04 2019-03-01 百时美施贵宝公司 吲哚胺2,3-双加氧酶的抑制剂及其使用方法
CN106916164A (zh) * 2017-03-06 2017-07-04 中国药科大学 噻唑并嘧啶酮类ido1抑制剂及其医药用途
CN110540521A (zh) * 2018-05-28 2019-12-06 北京诺诚健华医药科技有限公司 八氢戊搭烯类化合物、其制备方法及其在医药学上的应用

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