JP2020534336A5 - - Google Patents
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- JP2020534336A5 JP2020534336A5 JP2020516814A JP2020516814A JP2020534336A5 JP 2020534336 A5 JP2020534336 A5 JP 2020534336A5 JP 2020516814 A JP2020516814 A JP 2020516814A JP 2020516814 A JP2020516814 A JP 2020516814A JP 2020534336 A5 JP2020534336 A5 JP 2020534336A5
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- 0 CC*CC1[C@@](C(C)*)C(C)C(CC(C)C)C1 Chemical compound CC*CC1[C@@](C(C)*)C(C)C(CC(C)C)C1 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710854520 | 2017-09-20 | ||
| CN201710854520.2 | 2017-09-20 | ||
| CN201711397888 | 2017-12-21 | ||
| CN201711397888.7 | 2017-12-21 | ||
| CN201810119324 | 2018-02-06 | ||
| CN201810119324.5 | 2018-02-06 | ||
| PCT/CN2018/106768 WO2019057123A1 (zh) | 2017-09-20 | 2018-09-20 | 作为ido抑制剂和/或ido-hdac双重抑制剂的多环化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020534336A JP2020534336A (ja) | 2020-11-26 |
| JP2020534336A5 true JP2020534336A5 (https=) | 2021-11-04 |
| JP7548814B2 JP7548814B2 (ja) | 2024-09-10 |
Family
ID=65810056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020516814A Active JP7548814B2 (ja) | 2017-09-20 | 2018-09-20 | Ido阻害剤および/またはido-hdac二重阻害剤としての多環式化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11266640B2 (https=) |
| EP (1) | EP3686196B1 (https=) |
| JP (1) | JP7548814B2 (https=) |
| CN (1) | CN109843872B (https=) |
| WO (1) | WO2019057123A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019028440A1 (en) | 2017-08-04 | 2019-02-07 | Skyhawk Therapeutics, Inc. | METHODS AND COMPOSITIONS FOR MODULATING SPLICING |
| WO2019078968A2 (en) * | 2017-10-18 | 2019-04-25 | Angex Pharmaceutical, Inc. | CYCLIC COMPOUNDS AS IMMUNOMODULATORS |
| CN110156674A (zh) * | 2018-02-13 | 2019-08-23 | 中国科学院上海有机化学研究所 | 一种作为吲哚胺-2,3-双加氧酶抑制剂的螺环化合物 |
| CN110357813A (zh) * | 2018-04-09 | 2019-10-22 | 信达生物制药(苏州)有限公司 | 一种新型吲哚胺2,3-双加氧酶抑制剂及其制备方法和用途 |
| GEP20227433B (en) | 2018-04-26 | 2022-10-25 | Pfizer | 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors |
| CN116574105B (zh) | 2018-09-27 | 2025-10-10 | 深圳微芯生物科技股份有限公司 | 具有吲哚胺-2,3-双加氧酶抑制活性的喹啉衍生物 |
| WO2020163248A1 (en) | 2019-02-04 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| EP3920915A4 (en) | 2019-02-05 | 2022-10-05 | Skyhawk Therapeutics, Inc. | METHODS AND COMPOSITIONS FOR MODULATING SPLICE |
| CN114126613A (zh) | 2019-02-05 | 2022-03-01 | 斯基霍克疗法公司 | 用于调节剪接的方法和组合物 |
| WO2020163544A1 (en) | 2019-02-06 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| CN113661162A (zh) | 2019-02-06 | 2021-11-16 | 斯基霍克疗法公司 | 用于调节剪接的方法和组合物 |
| CN111909107B (zh) * | 2019-05-10 | 2023-02-03 | 药康众拓(江苏)医药科技有限公司 | Ido/hdac双重抑制剂及其药物组合物和应用 |
| AU2020384481B2 (en) * | 2019-11-12 | 2025-12-11 | Nammi Therapeutics, Inc. | Formulated and/or co-formulated liposome compositions containing IDO antagonist prodrugs useful in the treatment of cancer and methods thereof |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL133960A0 (en) | 1997-08-15 | 2001-04-30 | Pfizer Prod Inc | 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives |
| MY145722A (en) * | 2000-04-27 | 2012-03-30 | Abbott Lab | Diazabicyclic central nervous system active agents |
| EP1177792A3 (en) | 2000-07-27 | 2002-10-23 | Pfizer Products Inc. | Dopamine D4 Ligands for the treatment of novelty-seeking disorders |
| WO2003070244A1 (en) | 2002-02-22 | 2003-08-28 | Abbott Laboratories | Antagonist of melanin concentrating hormone and their uses |
| US7435830B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US8415354B2 (en) | 2004-04-29 | 2013-04-09 | Abbott Laboratories | Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| JP2008510726A (ja) * | 2004-08-20 | 2008-04-10 | エントレメッド インコーポレイテッド | プロテイナーゼ活性化受容体アンタゴニストを含む組成物および方法 |
| GB0510204D0 (en) * | 2005-05-19 | 2005-06-22 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| AR069126A1 (es) * | 2007-10-31 | 2009-12-30 | Janssen Pharmaceutica Nv | Diaminas en puente o fusionadas sustituidas con arilo como moduladores de leucotrieno a4 hidrolasa |
| FR2924343A1 (fr) * | 2007-12-04 | 2009-06-05 | Palumed Sa | Nouvelles utilisations therapeutiques de molecules duales contenant un derive peroxydique. |
| FR2945533B1 (fr) * | 2009-05-12 | 2011-05-27 | Sanofi Aventis | Derives de cyclopenta°c!pyrrolyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique |
| AU2012264651A1 (en) * | 2011-06-02 | 2013-12-12 | Intervet International B.V. | Imidazole derivatives |
| PT2796460T (pt) * | 2011-12-21 | 2018-11-05 | Shanghai hengrui pharmaceutical co ltd | Derivado pirrole de anel heteroarilo de seis membros, método de preparação do mesmo e suas utilizações médicas |
| WO2014152018A1 (en) | 2013-03-14 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | Octahydrocyclopentapyrroles, their preparation and use |
| WO2014151444A1 (en) * | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Pyrrolo[2,3-b]pyridine cdk9 kinase inhibitors |
| US9796708B2 (en) | 2013-03-14 | 2017-10-24 | Abbvie Inc. | Pyrrolo [2,3-B] pyridine CDK9 kinase inhibitors |
| WO2015132799A2 (en) * | 2014-02-03 | 2015-09-11 | Cadila Healthcare Limited | Novel heterocyclic compounds |
| RU2016149812A (ru) | 2014-06-06 | 2018-07-17 | Флексус Байосайенсиз, Инк. | Иммунорегулирующие средства |
| UY36390A (es) * | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
| UY36391A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen |
| BR112017008809A2 (pt) | 2014-11-05 | 2017-12-19 | Flexus Biosciences Inc | agentes imunorreguladores |
| WO2016115463A1 (en) * | 2015-01-15 | 2016-07-21 | Whitehead Institute For Biomedical Research | Inhibitors of phosphoglycerate dehydrogenase (phgdh) and uses thereof |
| CA2991224A1 (en) | 2015-07-02 | 2017-01-05 | buildpulse, Inc. | Advanced identification and classification of sensors and other points in a building automation system |
| WO2017007756A1 (en) * | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc | Hetero-halo inhibitors of histone deacetylase |
| CN107001271B (zh) | 2015-08-07 | 2019-05-10 | 江苏恒瑞医药股份有限公司 | 羟基脒类衍生物、其制备方法及其在医药上的应用 |
| CN106478607B (zh) * | 2015-08-28 | 2019-05-24 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其组合物和用途 |
| JP2018527362A (ja) * | 2015-09-11 | 2018-09-20 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドSunshine Lake Pharma Co.,Ltd. | 置換されたヘテロアリール化合物および使用方法 |
| AU2016333855A1 (en) * | 2015-10-09 | 2018-04-26 | AbbVie S.à.r.l. | Substituted pyrazolo[3,4-b]pyridin-6-carboxylic acids and their use |
| WO2017097671A1 (de) | 2015-12-10 | 2017-06-15 | Bayer Pharma Aktiengesellschaft | Substituierte perhydropyrrolo[3,4-c]pyrrol-derivate und ihre verwendung |
| US10076522B2 (en) | 2016-05-04 | 2018-09-18 | Motif BioSciences Inc. | Systems and methods for treating bacterial infection |
| WO2017192844A1 (en) | 2016-05-04 | 2017-11-09 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| WO2017192840A1 (en) | 2016-05-04 | 2017-11-09 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| CN106916164A (zh) | 2017-03-06 | 2017-07-04 | 中国药科大学 | 噻唑并嘧啶酮类ido1抑制剂及其医药用途 |
| CN110540521A (zh) * | 2018-05-28 | 2019-12-06 | 北京诺诚健华医药科技有限公司 | 八氢戊搭烯类化合物、其制备方法及其在医药学上的应用 |
-
2018
- 2018-09-20 US US16/649,455 patent/US11266640B2/en active Active
- 2018-09-20 JP JP2020516814A patent/JP7548814B2/ja active Active
- 2018-09-20 WO PCT/CN2018/106768 patent/WO2019057123A1/zh not_active Ceased
- 2018-09-20 CN CN201880002070.7A patent/CN109843872B/zh active Active
- 2018-09-20 EP EP18857966.8A patent/EP3686196B1/en active Active
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