JP2009524054A - 微小流体チップ及び分析システム - Google Patents
微小流体チップ及び分析システム Download PDFInfo
- Publication number
- JP2009524054A JP2009524054A JP2008551300A JP2008551300A JP2009524054A JP 2009524054 A JP2009524054 A JP 2009524054A JP 2008551300 A JP2008551300 A JP 2008551300A JP 2008551300 A JP2008551300 A JP 2008551300A JP 2009524054 A JP2009524054 A JP 2009524054A
- Authority
- JP
- Japan
- Prior art keywords
- container
- flow path
- reagent
- insert
- substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
- F04B43/14—Machines, pumps, or pumping installations having flexible working members having peristaltic action having plate-like flexible members
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B1/00—Devices without movable or flexible elements, e.g. microcapillary devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B7/00—Microstructural systems; Auxiliary parts of microstructural devices or systems
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
- F04B43/04—Pumps having electric drive
- F04B43/043—Micropumps
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
- F16K99/0015—Diaphragm or membrane valves
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
- F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
- F16K99/0059—Operating means specially adapted for microvalves actuated by fluids actuated by a pilot fluid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/028—Modular arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0621—Control of the sequence of chambers filled or emptied
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0654—Lenses; Optical fibres
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0874—Three dimensional network
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0666—Solenoid valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0082—Microvalves adapted for a particular use
- F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0082—Microvalves adapted for a particular use
- F16K2099/0094—Micropumps
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/0318—Processes
- Y10T137/0324—With control of flow by a condition or characteristic of a fluid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Mechanical Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Hematology (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Computer Hardware Design (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
Description
図1は、本発明の微小流体チップの1つの実施形態を示す。
図2は、図1の微小流体チップの別の図を示す。
図3a、bは、図1に示された実施形態で使用される微小流体弁を示す。
図4a〜fは、図1に示された実施形態で使用される微小流体ポンプを示す。
図5a〜cは、図1に示された実施形態で使用される入口弁を示す。
図6a、bは、図1に示された実施形態で使用されるカートリッジと容器を示す。
図7は、分離した試薬チップに結合した導管を有する分析チップを示す。
図8〜10は、図7の素子の製造のための段階を示す。
図11a〜cは、図1に示された実施形態に取り付ける大きさと形状の例示的な挿入物を示す。
図12は、単一の駆動力で試薬を複数の出口容器に分配するチップの実施形態を示す。
図13は、複数の駆動力で試薬を複数の出口容器に分配するチップの実施形態を示す。
図14は、複数の試薬を複数の出口容器に分配する複数の駆動力を有するチップの実施形態を示す。
図15a〜cは、図1に示された実施形態の流路内に図11a〜cの例示的挿入物を取り付ける方法を示す。
図16a、bは、微小流体に基づくオンチップ免疫分析過程の結果を示す。
図17は、標的分析物を含む標本を同定する段階を示す。
図18は、計算機、コントローラ及びチップを含む、完全かつ内蔵型の微小流体システムを示す。
図19は、コントローラに接続したチップの他の実施形態を示す。
Claims (35)
- 複数の流路がその中に形成された基板、
物質を保持できる種類の少なくとも1つの試薬容器、及び
前記少なくとも1つの試薬容器から複数の出口容器へ、分配弁に結合された少なくとも1つの前記流路を介して前記物質の流れを制御可能に導くよう適合された分配弁
から成る微小流体装置。 - 前記基板が、これにエッチングされた複数の流路と前記物質を前記複数の流路の少なくとも1つに導入するためにプラスチック基板の頂面に取り外し可能に結合された少なくとも1つの試薬容器とを有するプラスチック基板である、請求項1の装置。
- 前記分配弁が、前記物質を少なくとも1つの試薬容器から複数の出口容器の少なくとも1つへポンプ動作により輸送する少なくとも1つの双方向性ポンプに結合されている、請求項1の装置。
- 更に、少なくとも1つの流路内に取り付けるように構成され、かつ前記物質と相互作用する反応面を有する少なくとも1つの挿入物から成る、請求項1の装置。
- 更に、開と閉の状態を有し、少なくとも1つの試薬容器を複数の出口容器へ分配弁を介して流体的に結合する少なくとも1つの試薬弁から成る、請求項1の装置。
- 更に、少なくとも1つの流路に関連する少なくとも1つの双方向性ポンプから成る、請求項1の装置。
- 前記双方向性ポンプが、それぞれ1つの流路により直列に結合され、独立に動作し得る少なくとも3個の弁構造体を含む、請求項6の装置。
- 前記少なくとも1つの流路が第1容器と第2容器を結合し、前記少なくとも1つの双方向性ポンプが第1容器へ向かう第1方向と第2容器へ向かう第2方向で前記物質を往復させるように適合している、請求項6の装置。
- 更に、それぞれ1つの前記流路に関連する複数の双方向性ポンプから成り、
前記分配弁は、それぞれ1つの前記流路に対応する1つの前記双方向性ポンプを介して流体的に結合し、
閉状態では、前記分配弁は、流路間及び少なくとも1つの試薬容器と流路の間の流体連通を実質的に阻止する、
請求項1の装置。 - 更に、前記基板に取り外し可能に結合し、かつ前記物質を基板に配置された複数の流路に運ぶためにその上に配置された少なくとも1つの試薬容器を有するように適合されたカートリッジから成る、請求項1の装置。
- 前記挿入物は、少なくとも1つの流路の空洞空間内に取り外し可能に取り付けられ、
前記挿入物の反応面と前記空洞空間の表面との間には、前記物質を通過させるのに適した空隙が形成されている、
請求項4の装置。 - 前記空洞空間は、前記挿入物を前記空洞空間に流体的に結合された少なくとも1つの容器の開口から受け入れるように適合しており、前記空洞空間の幅は少なくとも前記挿入物の幅にほぼ等しい、請求項11の装置。
- 前記空洞空間は、前記挿入物を前記空洞空間の開口から受け入れるように適合しており、ふた部材が前記開口を取り外し可能に覆うように提供されている、請求項11の装置。
- 前記挿入物が薄膜から成る、請求項4の装置。
- 前記挿入物が、更に、前記薄膜の粘着層開口部上方に配置された少なくとも1つの薄膜円板から成る、請求項14の装置。
- 前記開口部が、円形状、及び円形領域とこの円形領域に開いた2つの対向する矩形領域とから成る形状の一方である、請求項15の装置。
- 前記薄膜円板は化学的物質と生物学的物質の少なくとも一方が塗布されている、請求項15の装置。
- 前記薄膜円板はニトロセルロース、PVDF、ポリスチレン及びナイロンの1つから構成されている、請求項15の装置。
- 前記基板が複数の重ねられた層を含み、少なくとも1つの層に配置された複数の流路を有する、請求項1の装置。
- 前記物質が、流体物質、気体物質、流体物質中に実質的に溶解している固体物質、泥状流動体物質、乳濁液物質及びその中に粒子が懸濁している流体物質の1つである、請求項1の装置。
- 更に、前記物質の温度を調節する少なくとも1つの加熱要素から成る、請求項1の装置。
- 更に、
独立して作動できる複数の弁構造体を有する少なくとも1つのポンプ、及び
少なくとも1つの試薬容器から複数の出口容器へ分配弁に結合された少なくとも1つの流路を介して物質の流れを導くための弁構造体を空気圧で作動することができるプログラマブルコントローラ
から成る、請求項1の装置。 - その中に複数の流路が配置された基板、
前記基板の複数の流路のそれぞれ1つと流体的に連通し、複数の容器がその上に配置された試薬チップ、及び
前記容器から前記基板の流路へその中の複数の導管流路を介して流体物質を運ぶ導管チップ
から成る、微小流体装置。 - 前記試薬チップが、更に、
内部に分配弁が配置された積み込みチップ、及び
前記積み込みチップに取り外し可能に結合され、その上に前記容器が配置されたカードリッジを含み、
前記分配弁が前記容器から前記基板の複数の流路へ前記導管流路を介して前記流体物質を導く、
請求項23の装置。 - 更に、前記試薬チップに結合された複数の基板から成り、前記流体物質が前記容器から前記複数の基板の少なくとも1つに配置された複数の流路へ運ばれる、請求項23の装置。
- 基板及び内部に配置された少なくとも1つの流路から成る微小流体装置を備えること、
前記流路内に少なくとも1つの挿入物を取り付けること、
内部の前記挿入物に接触するように前記流路を通じて少なくとも1つの流体物質を流すこと、
前記流体物質を前記挿入物から抜き去ること、そして
前記挿入物の相互作用を検知すること
から成る、生物学的分析を遂行するための方法。 - 前記少なくとも1つの流体物質を流すことが、試薬を試薬容器から複数の出口容器へ流すために分配弁を作動させることから成る、請求項26の方法。
- 前記少なくとも1つの流体物質を流すことが、前記流路に結合された第1の容器に向かう第1の方向と前記流路に結合された第2の容器に向かう第2の方向で前記流体物質を繰り返し往復させることから成り、
前記流路に結合された分配弁は、分配弁が閉の状態のとき、前記流路の流体物質を実質的に閉じこめるものである
請求項26の方法。 - 前記流体物質を前記挿入物から抜き去ることは、流路に結合された第1の容器に向かう第1の方向と前記流路に結合された第2の容器に向かう第2の方向の少なくとも1つで前記流体物質を流すことから成る、請求項26の方法。
- 更に、廃棄物を前記流路から前記基板上の容器へ輸送することから成る、請求項26の方法。
- 相互作用を検知することが、前記挿入物の少なくとも1つの標本に対応する色強度値を発生することから成る、請求項26の方法。
- 色強度値を発生することが、
複数の画素を発生するために標本に対応する色をデジタル化すること、
前記複数の画素のそれぞれ1つに対して複数の数値を与えること、及び
前記色強度値を与えるために前記複数の数値の平均をとること
から成る、請求項31の方法。 - 更に、閾値を計算すること及び前記相互作用を検知するために前記色強度値を前記閾値と比較することから成る、請求項31の方法。
- 更に、少なくとも1つの前記色強度値と前記閾値をデータベースに記憶することから成る、請求項33の方法。
- 前記閾値が少なくとも1つの陰性対照標本を用いて計算される、請求項33の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76055206P | 2006-01-19 | 2006-01-19 | |
US60/760,552 | 2006-01-19 | ||
PCT/US2007/000960 WO2007084425A2 (en) | 2006-01-19 | 2007-01-12 | Flexible and modular microfluidic device |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2009524054A true JP2009524054A (ja) | 2009-06-25 |
JP5250425B2 JP5250425B2 (ja) | 2013-07-31 |
Family
ID=38137391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008551300A Active JP5250425B2 (ja) | 2006-01-19 | 2007-01-12 | 微小流体チップ及び分析システム |
Country Status (6)
Country | Link |
---|---|
US (8) | US7976795B2 (ja) |
EP (1) | EP1979097B1 (ja) |
JP (1) | JP5250425B2 (ja) |
KR (1) | KR20080085898A (ja) |
CN (1) | CN101495236B (ja) |
WO (1) | WO2007084425A2 (ja) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013508715A (ja) * | 2009-10-21 | 2013-03-07 | バイオカルティス、ソシエテ、アノニム | 平行空気圧インターフェース・プレートを備えたミクロ流体カートリッジ |
JP2014507155A (ja) * | 2011-02-21 | 2014-03-27 | リーアニクス・インコーポレイテッド | マイクロ流体素子を基礎とした核酸精製方法 |
JP2015529110A (ja) * | 2012-08-29 | 2015-10-05 | エスエフシー フルーイディクス、インコーポレイテッド | 電気化学的に作動するマイクロ流体デバイス |
JPWO2013153912A1 (ja) * | 2012-04-12 | 2015-12-17 | 国立大学法人 東京大学 | バルブ、マイクロ流体デバイス、マイクロ構造体、及びバルブシート、並びに、バルブシートの製造方法、及びマイクロ流体デバイスの製造方法 |
JP2017502687A (ja) * | 2013-11-29 | 2017-01-26 | ジェネウェーブ | 分子診断用のマイクロ流体カートリッジ、このようなマイクロ流体カートリッジを用いるドッキングステーション、及び生物学的サンプルを分析するためのプロセス |
JP2018528407A (ja) * | 2015-07-17 | 2018-09-27 | キュー インコーポレイテッド | 検体の向上された検出および量子化のためのシステムおよび方法 |
JP2019080911A (ja) * | 2017-10-27 | 2019-05-30 | 研能科技股▲ふん▼有限公司 | マイクロポンプ |
JP2019148590A (ja) * | 2011-06-06 | 2019-09-05 | アボット・ラボラトリーズAbbott Laboratories | 空間分解リガンド−受容体結合アッセイ |
JP2019525159A (ja) * | 2016-06-29 | 2019-09-05 | ミルテニー バイオテック ゲゼルシャフト ミット ベシュレンクテル ハフツングMiltenyi Biotec GmbH | 生体試料のための多層式ディスポーザブルカートリッジ |
JP2019530884A (ja) * | 2016-09-30 | 2019-10-24 | テル−アレイ ダイアグノスティックス インコーポレイテッド | マイクロ流体デバイス |
JP2021081449A (ja) * | 2013-03-16 | 2021-05-27 | ドン ロバーツ レスリー | 自己完結型モジュラー分析カートリッジ及びプログラム可能試薬送達システム |
Families Citing this family (248)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6432290B1 (en) | 1999-11-26 | 2002-08-13 | The Governors Of The University Of Alberta | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
US7419638B2 (en) | 2003-01-14 | 2008-09-02 | Micronics, Inc. | Microfluidic devices for fluid manipulation and analysis |
AU2005233571B2 (en) | 2004-04-07 | 2008-10-09 | Levine, Robert A. | Disposable chamber for analyzing biologic fluids |
US20070248958A1 (en) | 2004-09-15 | 2007-10-25 | Microchip Biotechnologies, Inc. | Microfluidic devices |
US8986614B2 (en) * | 2010-02-23 | 2015-03-24 | Rheonix, Inc. | Self-contained biological assay apparatus, methods, and applications |
WO2010144814A2 (en) | 2009-06-13 | 2010-12-16 | Arryx, Inc. | Particle sorting using fluid streams |
US7731901B2 (en) | 2005-10-19 | 2010-06-08 | Abbott Laboratories | Apparatus and method for performing counts within a biologic fluid sample |
US7976795B2 (en) * | 2006-01-19 | 2011-07-12 | Rheonix, Inc. | Microfluidic systems |
US20070172941A1 (en) * | 2006-01-25 | 2007-07-26 | Amir Porat | Disposable vessels or tips having ultra-thin areas therein, and methods for manufacture of same |
KR20080096567A (ko) | 2006-02-03 | 2008-10-30 | 마이크로칩 바이오테크놀로지스, 인크. | 마이크로유체 장치 |
US8974748B2 (en) * | 2007-04-05 | 2015-03-10 | Corning Incorporated | Dual inlet microchannel device and method for using same |
GB0618966D0 (en) * | 2006-09-26 | 2006-11-08 | Iti Scotland Ltd | Cartridge system |
US20080187445A1 (en) * | 2007-02-02 | 2008-08-07 | Gale Bruce K | Diffusion membrane micropump, device, and associated method |
US20110039303A1 (en) | 2007-02-05 | 2011-02-17 | Stevan Bogdan Jovanovich | Microfluidic and nanofluidic devices, systems, and applications |
US7906074B2 (en) * | 2007-04-09 | 2011-03-15 | Auburn University | Microfluidic array system for biological, chemical, and biochemical assessments |
KR20080107212A (ko) * | 2007-06-05 | 2008-12-10 | 삼성전자주식회사 | 유체 컨테이너를 구비한 미세유동 장치 |
WO2009034187A1 (de) * | 2007-09-12 | 2009-03-19 | Gernot Heuser | Mikrodosiersystem |
EP2265375A1 (en) * | 2007-10-12 | 2010-12-29 | Rheonix, Inc. | Integrated microfluidic device and methods |
EP2065703A1 (en) * | 2007-11-30 | 2009-06-03 | Services Pétroliers Schlumberger | Natural gas analyzer on a micro-chip |
WO2009108260A2 (en) | 2008-01-22 | 2009-09-03 | Microchip Biotechnologies, Inc. | Universal sample preparation system and use in an integrated analysis system |
US8961902B2 (en) * | 2008-04-23 | 2015-02-24 | Bioscale, Inc. | Method and apparatus for analyte processing |
WO2009155935A1 (en) * | 2008-06-27 | 2009-12-30 | Toxispot A/S | Cartridge and system for liquid handling automation |
US20090325159A1 (en) * | 2008-06-30 | 2009-12-31 | Canon U.S. Life Sciences, Inc. | System and method to prevent cross-contamination in assays performed in a microfluidic channel |
US8122901B2 (en) | 2008-06-30 | 2012-02-28 | Canon U.S. Life Sciences, Inc. | System and method for microfluidic flow control |
KR102140055B1 (ko) | 2008-07-16 | 2020-07-31 | 칠드런'즈 메디컬 센터 코포레이션 | 마이크로채널을 갖는 기관 모방 장치 및 그 사용 및 제조 방법 |
JP5492207B2 (ja) * | 2008-08-27 | 2014-05-14 | ライフ テクノロジーズ コーポレーション | 生物学的サンプルの処理装置および処理方法 |
US10512910B2 (en) | 2008-09-23 | 2019-12-24 | Bio-Rad Laboratories, Inc. | Droplet-based analysis method |
US9598725B2 (en) | 2010-03-02 | 2017-03-21 | Bio-Rad Laboratories, Inc. | Emulsion chemistry for encapsulated droplets |
US8709762B2 (en) | 2010-03-02 | 2014-04-29 | Bio-Rad Laboratories, Inc. | System for hot-start amplification via a multiple emulsion |
US9399215B2 (en) | 2012-04-13 | 2016-07-26 | Bio-Rad Laboratories, Inc. | Sample holder with a well having a wicking promoter |
US9132394B2 (en) | 2008-09-23 | 2015-09-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
US9764322B2 (en) | 2008-09-23 | 2017-09-19 | Bio-Rad Laboratories, Inc. | System for generating droplets with pressure monitoring |
US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
US9417190B2 (en) | 2008-09-23 | 2016-08-16 | Bio-Rad Laboratories, Inc. | Calibrations and controls for droplet-based assays |
US9492797B2 (en) | 2008-09-23 | 2016-11-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
US8951939B2 (en) | 2011-07-12 | 2015-02-10 | Bio-Rad Laboratories, Inc. | Digital assays with multiplexed detection of two or more targets in the same optical channel |
US11130128B2 (en) | 2008-09-23 | 2021-09-28 | Bio-Rad Laboratories, Inc. | Detection method for a target nucleic acid |
US8633015B2 (en) | 2008-09-23 | 2014-01-21 | Bio-Rad Laboratories, Inc. | Flow-based thermocycling system with thermoelectric cooler |
US8318439B2 (en) | 2008-10-03 | 2012-11-27 | Micronics, Inc. | Microfluidic apparatus and methods for performing blood typing and crossmatching |
US20110014297A1 (en) * | 2008-10-08 | 2011-01-20 | The Regents Of The University Of California | Multimodal therapeutic hybrid particle complex and system |
US20110301535A1 (en) * | 2008-10-10 | 2011-12-08 | The Regents Of The University Of Michigan | Microfluidic control systems |
CN102281950B (zh) * | 2008-12-08 | 2015-05-06 | 富鲁达公司 | 可编程微流体数字阵列 |
US8448499B2 (en) | 2008-12-23 | 2013-05-28 | C A Casyso Ag | Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method |
WO2010073020A1 (en) * | 2008-12-24 | 2010-07-01 | Heriot-Watt University | A microfluidic system and method |
CN102341691A (zh) | 2008-12-31 | 2012-02-01 | 尹特根埃克斯有限公司 | 具有微流体芯片的仪器 |
US8100293B2 (en) * | 2009-01-23 | 2012-01-24 | Formulatrix, Inc. | Microfluidic dispensing assembly |
WO2010128483A2 (en) * | 2009-05-07 | 2010-11-11 | International Business Machines Corporation | Multilayer microfluidic probe head and method of fabrication thereof |
CN102459565A (zh) | 2009-06-02 | 2012-05-16 | 尹特根埃克斯有限公司 | 具有隔膜阀的流控设备 |
KR20120031218A (ko) | 2009-06-05 | 2012-03-30 | 인터젠엑스 인크. | 만능 샘플 제조 시스템 및 집적 분석 시스템에서의 사용 |
EP2940153B1 (en) | 2009-09-02 | 2020-05-13 | Bio-Rad Laboratories, Inc. | System for mixing fluids by coalescence of multiple emulsions |
DE102009045685A1 (de) * | 2009-10-14 | 2011-04-21 | Robert Bosch Gmbh | Mikrofluidischer Chip |
US8584703B2 (en) | 2009-12-01 | 2013-11-19 | Integenx Inc. | Device with diaphragm valve |
WO2011075667A2 (en) | 2009-12-18 | 2011-06-23 | Abbott Point Of Care, Inc. | Biologic fluid analysis cartridge |
US9321051B2 (en) * | 2009-12-22 | 2016-04-26 | Samsung Electronics Co., Ltd. | Microfluidic device and method of manufacturing the same |
AU2011221244B2 (en) * | 2010-02-23 | 2014-02-13 | Rheonix, Inc. | Self-contained biological assay apparatus, methods, and applications |
US9102979B2 (en) | 2010-02-23 | 2015-08-11 | Rheonix, Inc. | Self-contained biological assay apparatus, methods, and applications |
CN102161967A (zh) * | 2010-02-24 | 2011-08-24 | 中国科学院大连化学物理研究所 | 一种基于微流控的核酸杂交反应平台及杂交分析方法 |
KR101951906B1 (ko) * | 2010-03-09 | 2019-05-31 | 에이엔디이 코포레이션 | 샘플 투입 및 결과 발생 처리를 제공하기 위한 단일한 바이오칩 및 이의 제조 방법 |
US8720036B2 (en) | 2010-03-09 | 2014-05-13 | Netbio, Inc. | Unitary biochip providing sample-in to results-out processing and methods of manufacture |
CA2767113A1 (en) | 2010-03-25 | 2011-09-29 | Bio-Rad Laboratories, Inc. | Detection system for droplet-based assays |
JP6155419B2 (ja) | 2010-03-25 | 2017-07-05 | バイオ−ラッド・ラボラトリーズ・インコーポレーテッド | 検出用の液滴輸送システム |
EP2550528B1 (en) | 2010-03-25 | 2019-09-11 | Bio-Rad Laboratories, Inc. | Droplet generation for droplet-based assays |
GB201007261D0 (en) * | 2010-04-30 | 2010-06-16 | Isis Innovation | Reactor |
US8512538B2 (en) | 2010-05-28 | 2013-08-20 | Integenx Inc. | Capillary electrophoresis device |
GB2481425A (en) | 2010-06-23 | 2011-12-28 | Iti Scotland Ltd | Method and device for assembling polynucleic acid sequences |
DE102010031103A1 (de) * | 2010-07-08 | 2012-01-12 | Robert Bosch Gmbh | Verfahren zur Herstellung eines integrierten mikrofluidischen Systems und integriertes mikrofluidisches System |
DE102010038445B4 (de) * | 2010-07-27 | 2020-08-27 | Robert Bosch Gmbh | Verfahren zur Herstellung eines mikrofluidischen Systems |
TWI427280B (zh) * | 2010-08-13 | 2014-02-21 | Univ Nat Taiwan | 碟片型流體收集裝置 |
US8763642B2 (en) | 2010-08-20 | 2014-07-01 | Integenx Inc. | Microfluidic devices with mechanically-sealed diaphragm valves |
EP2606154B1 (en) | 2010-08-20 | 2019-09-25 | Integenx Inc. | Integrated analysis system |
WO2012039994A1 (en) * | 2010-09-22 | 2012-03-29 | Corning Incorporated | Microporous microfluidic device |
US10023832B2 (en) * | 2013-07-16 | 2018-07-17 | Vanderbilt University | Interconnections of multiple perfused engineered tissue constructs and microbioreactors, multi-microformulators and applications of the same |
CN106268390B (zh) * | 2010-11-01 | 2020-01-10 | 伯乐生命医学产品有限公司 | 用于形成乳液的系统 |
JP5761987B2 (ja) * | 2010-12-20 | 2015-08-12 | キヤノン株式会社 | マイクロ流路内における流体の温度測定方法 |
CN103282123B (zh) | 2010-12-30 | 2015-05-06 | 艾博特健康公司 | 带有样品处理区和分析室区的生物液体分析卡式盒 |
CA2826095C (en) | 2011-01-27 | 2020-06-23 | Invisible Sentinel, Inc. | Analyte detection devices, multiplex and tabletop devices for detection of analytes, and uses thereof |
EP2490020A1 (en) | 2011-02-18 | 2012-08-22 | Koninklijke Philips Electronics N.V. | Measurement chip, microfluidic device and method of measurement chip manufacture |
EP3498818A1 (en) | 2011-02-28 | 2019-06-19 | President and Fellows of Harvard College | Cell culture system |
US20120245042A1 (en) * | 2011-03-14 | 2012-09-27 | The Trustees Of The University Of Pennsylvania | Debubbler for microfluidic systems |
EP2686449B1 (en) | 2011-03-18 | 2020-11-18 | Bio-Rad Laboratories, Inc. | Multiplexed digital assays with combinatorial use of signals |
AU2012249759A1 (en) | 2011-04-25 | 2013-11-07 | Bio-Rad Laboratories, Inc. | Methods and compositions for nucleic acid analysis |
US20140137973A1 (en) * | 2011-06-14 | 2014-05-22 | Idex Health & Science Llc | Clog resistant fluid pathway |
DE102011078976A1 (de) | 2011-07-11 | 2013-01-17 | Robert Bosch Gmbh | Mikrofluidische Vorrichtung sowie Verfahren zur Herstellung einer mikrofluidischen Vorrichtung |
WO2013019751A1 (en) | 2011-07-29 | 2013-02-07 | Bio-Rad Laboratories, Inc., | Library characterization by digital assay |
EP2556887A1 (en) | 2011-08-08 | 2013-02-13 | SAW instruments GmbH | Improved microfluidic devices useful for selective exposure of one or more sample liquids to one or more sample regions |
CN102319593B (zh) * | 2011-08-16 | 2013-11-20 | 北京博晖创新光电技术股份有限公司 | 膜动聚合物微流控芯片及其制备方法 |
EP2748618A1 (en) | 2011-08-24 | 2014-07-02 | Abbott Point of Care Inc. | Biologic fluid sample analysis cartridge |
US9365418B2 (en) | 2011-09-02 | 2016-06-14 | The Regents Of The University Of California | Universal hardware platform and toolset for operating and fabricating microfluidic devices |
TWI448413B (zh) * | 2011-09-07 | 2014-08-11 | Ind Tech Res Inst | 氣動式微幫浦 |
SG11201401911XA (en) * | 2011-09-30 | 2014-08-28 | Life Technologies Corp | Systems and methods for biological analysis |
CA2882675C (en) * | 2011-10-09 | 2020-02-25 | Bonnie L. GRAY | Microfluidic reconfigurable device for multi-plexed sample analysis |
US20150136604A1 (en) | 2011-10-21 | 2015-05-21 | Integenx Inc. | Sample preparation, processing and analysis systems |
US10865440B2 (en) | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
US9725687B2 (en) | 2011-12-09 | 2017-08-08 | President And Fellows Of Harvard College | Integrated human organ-on-chip microphysiological systems |
US20130161193A1 (en) * | 2011-12-21 | 2013-06-27 | Sharp Kabushiki Kaisha | Microfluidic system with metered fluid loading system for microfluidic device |
CN103184143A (zh) * | 2011-12-29 | 2013-07-03 | 三星电子株式会社 | 固体试剂溶解器件以及使用其溶解固体试剂的方法 |
EP2834425A4 (en) | 2012-02-21 | 2016-05-11 | Fluidigm Corp | METHOD AND SYSTEMS FOR MICROFLUIDIC LOGIC DEVICES |
US9347938B2 (en) | 2012-03-09 | 2016-05-24 | Invisible Sentinel, Inc. | Methods for detecting multiple analytes with a single signal |
CN102671726B (zh) * | 2012-04-23 | 2014-04-02 | 北京博晖创新光电技术股份有限公司 | 一种有导流体的微流体芯片及其应用 |
PL398979A1 (pl) * | 2012-04-25 | 2013-10-28 | Scope Fluidics Spólka Z Ograniczona Odpowiedzialnoscia | Urzadzenie mikroprzeplywowe i uklad mikroprzeplywowy obejmujacy jedno lub wiecej urzadzen mikroprzeplywowych |
US20130341188A1 (en) * | 2012-06-20 | 2013-12-26 | María de les Neus SABATÉ VIZCARRA | Fuel cell and analysis device that comprise it |
JP6276264B2 (ja) | 2012-07-16 | 2018-02-07 | フォーミュラトリックス,インク.Formulatrix, Inc. | 流体送達システム、並びに関連する装置及び方法 |
US9192934B2 (en) * | 2012-10-25 | 2015-11-24 | General Electric Company | Insert assembly for a microfluidic device |
CN102998472B (zh) * | 2012-11-19 | 2014-04-02 | 浙江大学 | 一种用于非均相免疫快速分析的自动化装置及其使用方法 |
JP6093783B2 (ja) * | 2013-01-31 | 2017-03-08 | 株式会社日立ハイテクノロジーズ | 生化学用カートリッジ、生化学用カートリッジ及びカートリッジホルダのセット |
JP6202713B2 (ja) * | 2013-02-22 | 2017-09-27 | 株式会社日立ハイテクノロジーズ | 生化学用カートリッジおよび生化学用送液システム |
US20190025297A1 (en) * | 2013-03-15 | 2019-01-24 | Nri R&D Patent Licensing, Llc | Stepwise and Blockwise Biochemical Network Laboratory Breadboard Systems and Techniques for Signaling, Disease Research, Drug Discovery, Cell Biology, and Other Applications |
US20140273045A1 (en) * | 2013-03-15 | 2014-09-18 | Lester F. Ludwig | Modular Biochemical Signaling Laboratory Breadboard for Disease Research, Drug Discovery, Cell Biology, and Other Applications |
USD733313S1 (en) * | 2013-03-19 | 2015-06-30 | Panasonic Healthcare Holdings Co., Ltd. | Chip for biochemical examination |
ES2745752T3 (es) * | 2013-05-02 | 2020-03-03 | Quanta Matrix Co Ltd | Equipo de prueba para cultivos celulares basado en pocillos múltiples para microfluidos |
WO2014182844A1 (en) | 2013-05-07 | 2014-11-13 | Micronics, Inc. | Microfluidic devices and methods for performing serum separation and blood cross-matching |
DE102013209866B4 (de) * | 2013-05-28 | 2021-11-04 | Robert Bosch Gmbh | Vorrichtung mit vorgegebener Fluidverdrängung |
CN104235497B (zh) * | 2013-06-24 | 2018-11-30 | 浙江盾安禾田金属有限公司 | 具有改进的空气清除能力的微阀 |
DE202013103016U1 (de) * | 2013-07-08 | 2013-07-15 | Bürkert Werke GmbH | Mikrofluiddosiereinheit und Testvorrichtung für Biomaterial |
US9855554B2 (en) | 2013-07-22 | 2018-01-02 | President And Fellows Of Harvard College | Microfluidic cartridge assembly |
EP2851121B1 (en) * | 2013-09-20 | 2022-11-02 | thinXXS Microtechnology GmbH | Devices for and methods of forming microchannels or microfluid reservoirs |
WO2015048798A1 (en) * | 2013-09-30 | 2015-04-02 | Gnubio, Inc. | Microfluidic cartridge device and methods of use and assembly |
KR101396110B1 (ko) | 2013-10-30 | 2014-05-16 | 아주대학교산학협력단 | 장쇄 분지를 갖는 지방족 폴리카보네이트 및 이의 방향족 폴리에스터 공중합체 |
CN114471756B (zh) * | 2013-11-18 | 2024-04-16 | 尹特根埃克斯有限公司 | 用于样本分析的卡盒和仪器 |
US9283560B2 (en) * | 2013-11-22 | 2016-03-15 | Sharp Kabushiki Kaisha | Passive microfluidic metering device |
US11119093B2 (en) | 2013-12-20 | 2021-09-14 | President And Fellows Of Harvard College | Low shear microfluidic devices and methods of use and manufacturing thereof |
US10406521B2 (en) * | 2014-02-21 | 2019-09-10 | Shilps Sciences Private Limited | Micro-droplet array for multiple screening of a sample |
JP2015201646A (ja) | 2014-04-07 | 2015-11-12 | ラム リサーチ コーポレーションLam Research Corporation | 構成独立型のガス供給システム |
EP2988872B1 (en) * | 2014-04-18 | 2018-06-13 | Bio-rad Laboratories, Inc. | Microfluidic devices for automated assays |
JP6637962B2 (ja) | 2014-04-24 | 2020-01-29 | ルシラ ヘルス インコーポレイテッド | 核酸増幅の比色検出方法 |
GB2544198B (en) | 2014-05-21 | 2021-01-13 | Integenx Inc | Fluidic cartridge with valve mechanism |
EP3151965B1 (en) | 2014-06-04 | 2021-02-24 | Edan Instruments, Inc. | Sample collection and analysis devices |
KR102195769B1 (ko) * | 2014-07-10 | 2020-12-30 | 주식회사 미코바이오메드 | 미세유체 칩, 이의 제조 방법 및 이를 이용한 분석 장치 |
EP3169626A4 (en) | 2014-07-14 | 2018-04-04 | President and Fellows of Harvard College | Systems and methods for improved performance of fluidic and microfluidic systems |
US20160111257A1 (en) * | 2014-10-17 | 2016-04-21 | Lam Research Corporation | Substrate for mounting gas supply components and methods thereof |
US10557197B2 (en) | 2014-10-17 | 2020-02-11 | Lam Research Corporation | Monolithic gas distribution manifold and various construction techniques and use cases therefor |
WO2016065073A1 (en) | 2014-10-22 | 2016-04-28 | Integenx Inc. | Systems and methods for sample preparation, processing and analysis |
GB201418899D0 (en) | 2014-10-23 | 2014-12-10 | Univ Hull | System for radiopharmaceutical production |
GB201418893D0 (en) | 2014-10-23 | 2014-12-10 | Univ Hull | Monolithic body |
GB201418897D0 (en) | 2014-10-23 | 2014-12-10 | Univ Hull | Methods and apparatus for the analysis of compounds |
US9970437B2 (en) | 2014-11-25 | 2018-05-15 | Genia Technologies, Inc. | Two-way pump selectable valve and bypass waste channel |
EP3230748B1 (en) * | 2015-01-30 | 2020-03-18 | Hewlett-Packard Development Company, L.P. | Diagnostic chip |
US9861982B2 (en) | 2015-03-09 | 2018-01-09 | Emd Millipore Corporation | Connectors for pneumatic devices in microfluidic systems |
FR3035009B1 (fr) * | 2015-04-20 | 2020-02-07 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Dispositif microfluidique de controle d'ecoulement d'un fluide |
US10288633B2 (en) | 2015-06-26 | 2019-05-14 | Abbott Laboratories | Reaction vessel moving member for moving reaction vessels from a processing track to a rotating device in a diagnostic analyzer |
EP3314269A4 (en) | 2015-06-26 | 2019-01-23 | Abbott Laboratories | REACTION TANK EXCHANGER DEVICE FOR DIAGNOSTIC ANALYZER |
US9956558B2 (en) | 2015-07-24 | 2018-05-01 | HJ Science & Technology, Inc. | Reconfigurable microfluidic systems: homogeneous assays |
WO2017019221A1 (en) * | 2015-07-24 | 2017-02-02 | HJ Science & Technology, Inc. | Reconfigurable microfluidic systems: homogeneous assays |
US10022689B2 (en) | 2015-07-24 | 2018-07-17 | Lam Research Corporation | Fluid mixing hub for semiconductor processing tool |
US9956557B2 (en) | 2015-07-24 | 2018-05-01 | HJ Science & Technology, Inc. | Reconfigurable microfluidic systems: microwell plate interface |
US9733239B2 (en) | 2015-07-24 | 2017-08-15 | HJ Science & Technology, Inc. | Reconfigurable microfluidic systems: scalable, multiplexed immunoassays |
US10202569B2 (en) | 2015-07-24 | 2019-02-12 | President And Fellows Of Harvard College | Radial microfluidic devices and methods of use |
SG10201811548PA (en) | 2015-08-26 | 2019-02-27 | Emulate Inc | Perfusion Manifold Assembly |
US10118263B2 (en) | 2015-09-02 | 2018-11-06 | Lam Researech Corporation | Monolithic manifold mask and substrate concepts |
WO2017066631A1 (en) * | 2015-10-15 | 2017-04-20 | Iowa State University Research Foundation, Inc. | Miniaturized continuous-flow fermenting apparatus, systems, and methods |
US10934512B2 (en) * | 2015-11-26 | 2021-03-02 | Pusan National University Industry-University Cooperation Foundation | Microfluidic perfusion cell culture system |
CN205246655U (zh) * | 2015-12-07 | 2016-05-18 | 光宝电子(广州)有限公司 | 检测试片装置 |
US10378526B2 (en) * | 2015-12-21 | 2019-08-13 | Funai Electric Co., Ltd | Method and apparatus for metering and vaporizing fluids |
WO2017120464A1 (en) * | 2016-01-08 | 2017-07-13 | Siemens Healthcare Diagnostics Inc. | Heating element for sensor array |
US10215317B2 (en) | 2016-01-15 | 2019-02-26 | Lam Research Corporation | Additively manufactured gas distribution manifold |
TWI789343B (zh) | 2016-02-01 | 2023-01-11 | 丹麥商碩騰丹麥有限公司 | 微流體分析系統、執行分析的微流體匣及方法 |
US11504681B2 (en) | 2016-02-19 | 2022-11-22 | Perkinelmer Health Sciences, Inc. | Microfluidic mixing device and method |
WO2017160840A1 (en) | 2016-03-14 | 2017-09-21 | Diassess Inc. | Selectively vented biological assay devices and associated methods |
CA3015368A1 (en) | 2016-03-14 | 2017-09-21 | Diassess Inc. | Systems and methods for performing biological assays |
JP6949864B2 (ja) | 2016-03-14 | 2021-10-13 | ルシラ ヘルス インコーポレイテッド | 生物学的アッセイ試料調製および送り出しのための装置および方法 |
EP3222351A1 (en) * | 2016-03-23 | 2017-09-27 | Ecole Polytechnique Federale de Lausanne (EPFL) | Microfluidic network device |
CN107238573A (zh) * | 2016-03-29 | 2017-10-10 | 光宝电子(广州)有限公司 | 流体检测装置 |
CN106513062B (zh) * | 2016-05-30 | 2019-02-22 | 苏州汶颢芯片科技有限公司 | 酶联免疫快速检测的微流控芯片及其预处理和检测方法 |
US10240688B2 (en) * | 2016-06-29 | 2019-03-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Device having a plurality of latching micro-actuators and method of operating the same |
USD812766S1 (en) * | 2016-07-12 | 2018-03-13 | EMULATE, Inc. | Microfluidic chip for use with a fluid perfusion module |
USD800335S1 (en) * | 2016-07-13 | 2017-10-17 | Precision Nanosystems Inc. | Microfluidic chip |
US10500587B2 (en) | 2016-07-20 | 2019-12-10 | Boise State University | Ferro-magnetic shape memory alloy microcavity fluid sensor |
US20180029033A1 (en) * | 2016-07-31 | 2018-02-01 | Ancera Corp. | Multilayer disposable cartridge for ferrofluid-based assays and method of use |
US11541584B1 (en) * | 2016-09-02 | 2023-01-03 | Kemeera Inc. | 3D printed injection side of a multi-piece mold with internal thermal manifold |
USD816861S1 (en) * | 2016-09-07 | 2018-05-01 | EMULATE, Inc. | Transparent microfluidic chip without pressure features for use with a fluid perfusion module |
USD842493S1 (en) * | 2016-09-07 | 2019-03-05 | EMULATE, Inc. | Microfluidic chip without pressure features for use with a fluid perfusion module |
EP3512935B1 (en) | 2016-09-13 | 2022-02-23 | President and Fellows of Harvard College | Methods relating to intestinal organ-on-a-chip |
FR3058995B1 (fr) | 2016-11-18 | 2021-02-19 | Commissariat Energie Atomique | Procede et systeme de commande d'un dispositif microfluidique |
DE102016015207A1 (de) * | 2016-12-21 | 2018-06-21 | Fresenius Medical Care Deutschland Gmbh | Betätigungseinrichtung und Verfahren zum Betreiben einer Betätigungseinrichtung sowie Membranpumpe mit einer Betätigungseinrichtung und einer Membranpumpeneinrichtung und eine Blutbehandlungsvorrichtung mit einer Membranpumpe |
EP3559464B1 (de) * | 2016-12-21 | 2020-11-25 | Fresenius Medical Care Deutschland GmbH | Membranpumpeneinrichtung und membranpumpe mit einer membranpumpeneinrichtung und einer betätigungseinrichtung |
US11080848B2 (en) | 2017-04-06 | 2021-08-03 | Lucira Health, Inc. | Image-based disease diagnostics using a mobile device |
USD849265S1 (en) * | 2017-04-21 | 2019-05-21 | Precision Nanosystems Inc | Microfluidic chip |
CN107051599A (zh) * | 2017-05-15 | 2017-08-18 | 深圳先进技术研究院 | 微流控芯片及微流控芯片控制方法 |
US10544413B2 (en) | 2017-05-18 | 2020-01-28 | 10X Genomics, Inc. | Methods and systems for sorting droplets and beads |
EP4215616A1 (en) | 2017-05-18 | 2023-07-26 | 10X Genomics, Inc. | Methods and systems for sorting droplets and beads |
KR102205804B1 (ko) * | 2017-05-24 | 2021-01-22 | 바이오파이어 디펜스, 엘엘씨 | 사용 시점에서 어레이의 배기를 위한 시스템 및 방법 |
EP3635412A4 (en) | 2017-06-06 | 2021-03-10 | The Regents of The University of California | SYSTEMS AND METHODS FOR FAST GENERATION OF DROP BANKS |
US10821442B2 (en) | 2017-08-22 | 2020-11-03 | 10X Genomics, Inc. | Devices, systems, and kits for forming droplets |
US10549275B2 (en) | 2017-09-14 | 2020-02-04 | Lucira Health, Inc. | Multiplexed biological assay device with electronic readout |
CN113777011A (zh) * | 2017-09-14 | 2021-12-10 | 卢西拉健康公司 | 具有电子读出的复用生物测定装置 |
TWI653393B (zh) | 2017-09-29 | 2019-03-11 | 研能科技股份有限公司 | 流體系統 |
TWI654374B (zh) * | 2017-09-29 | 2019-03-21 | 研能科技股份有限公司 | 流體系統 |
WO2019083852A1 (en) | 2017-10-26 | 2019-05-02 | 10X Genomics, Inc. | MICROFLUIDIC CHANNEL NETWORKS FOR PARTITIONING |
US11124821B2 (en) | 2017-11-10 | 2021-09-21 | Reliant Immune Diagnostics, Inc. | Microfluidic testing system with cell capture/analysis regions for processing in a parallel and serial manner |
US11200986B2 (en) | 2017-11-10 | 2021-12-14 | Reliant Immune Diagnostics, Inc. | Database and machine learning in response to parallel serial dual microfluidic chip |
US10930381B2 (en) | 2017-11-10 | 2021-02-23 | Reliant Immune Diagnostics, Inc. | Microfluidic testing system for mobile veterinary applications |
US11527324B2 (en) | 2017-11-10 | 2022-12-13 | Reliant Immune Diagnostics, Inc. | Artificial intelligence response system based on testing with parallel/serial dual microfluidic chip |
US11041185B2 (en) * | 2017-11-10 | 2021-06-22 | Reliant Immune Diagnostics, Inc. | Modular parallel/serial dual microfluidic chip |
US10930380B2 (en) | 2017-11-10 | 2021-02-23 | Reliant Immune Diagnostics, Inc. | Communication loop and record loop system for parallel/serial dual microfluidic chip |
TWI721241B (zh) * | 2018-01-22 | 2021-03-11 | 研能科技股份有限公司 | 流體系統 |
CN110067791B (zh) * | 2018-01-22 | 2021-11-16 | 研能科技股份有限公司 | 流体系统 |
JP6976361B2 (ja) * | 2018-01-30 | 2021-12-08 | 京セラ株式会社 | 検査用流路デバイスおよび検査装置 |
JP7452927B2 (ja) * | 2018-03-02 | 2024-03-19 | ナショナル リサーチ カウンシル オブ カナダ | 高分子マイクロ流体バルブ |
DE102018204633A1 (de) * | 2018-03-27 | 2019-10-02 | Robert Bosch Gmbh | Mikrofluidische Vorrichtung und Verfahren zum Prozessieren einer Flüssigkeit |
USD878622S1 (en) * | 2018-04-07 | 2020-03-17 | Precision Nanosystems Inc. | Microfluidic chip |
WO2019203727A1 (en) * | 2018-04-19 | 2019-10-24 | Nanyang Technological University | Microfluidic board and method of forming the same |
WO2019213060A1 (en) | 2018-04-30 | 2019-11-07 | Protein Fluidics, Inc. | Valveless fluidic switching flowchip and uses thereof |
CN108789966A (zh) * | 2018-05-04 | 2018-11-13 | 南通优耐特实验器材有限公司 | 一种微流道成形工艺 |
CA3182405A1 (en) * | 2018-07-10 | 2020-01-16 | Precision Planting Llc | Agricultural sampling system and related methods |
US10307755B1 (en) | 2018-07-19 | 2019-06-04 | Bioceryx Inc. | Apparatuses and methods for sample-specific self-configuration |
CN109187448B (zh) * | 2018-07-25 | 2021-08-13 | 西安交通大学 | 一种多目标物碟式侧流试纸芯片及其激光切割制备方法、使用方法、应用和检测装置 |
CN108760686B (zh) * | 2018-08-07 | 2024-05-14 | 天津诺迈科技有限公司 | 散射比浊法检测微流控芯片及使用该芯片的生化免疫机 |
GB201815798D0 (en) * | 2018-09-27 | 2018-11-14 | Ge Healthcare Bio Sciences Ab | System and method for a pharmaceutical product |
US20210370300A1 (en) * | 2018-10-25 | 2021-12-02 | Savran Technologies, Inc. | Particle capture systems and methods |
GB201819415D0 (en) * | 2018-11-29 | 2019-01-16 | Quantumdx Group Ltd | Microfluidic apparatus and method |
FR3090792B1 (fr) | 2018-12-21 | 2021-01-22 | Commissariat Energie Atomique | Dispositif de vanne fluidique anti-retour |
USD910200S1 (en) | 2018-12-21 | 2021-02-09 | Lucira Health, Inc. | Test tube |
CN109682574B (zh) * | 2019-01-14 | 2020-10-27 | 北京工业大学 | 一种实时测量微液滴/气泡在通道中运动时流阻的装置和方法 |
CA3047880A1 (en) | 2019-06-25 | 2020-12-25 | Run Ze R. Z. G. Gao | Air microfluidics and air minifluidics enabled active compression apparel |
KR20220039780A (ko) * | 2019-07-26 | 2022-03-29 | 램 리써치 코포레이션 | 반도체 프로세싱 장비를 위한 비엘라스토머 (non-elastomeric), 비폴리머 (non-polymeric), 비금속 멤브레인 밸브들 |
USD979092S1 (en) | 2019-10-02 | 2023-02-21 | Becton, Dickinson And Company | Microfluidic cartridge |
WO2021067353A1 (en) * | 2019-10-02 | 2021-04-08 | Becton, Dickinson And Company | Microfluidic cartridges for enhanced amplification of polynucleotide-containing samples |
CN110893354B (zh) * | 2019-10-22 | 2022-04-29 | 长春技特生物技术有限公司 | 一种多模块的乳液微滴生成控制装置 |
US11927740B2 (en) | 2019-11-20 | 2024-03-12 | Nuclera Ltd | Spatially variable hydrophobic layers for digital microfluidics |
DK3839037T3 (da) * | 2019-12-20 | 2022-11-21 | Astraveus | Biobehandlingsanordning |
TW202128281A (zh) * | 2019-12-30 | 2021-08-01 | 美商伊路米納有限公司 | 與流動池一同使用之致動系統及方法 |
CN114945426A (zh) | 2020-01-17 | 2022-08-26 | 核酸有限公司 | 用于数字微流体的空间可变介电层 |
WO2021154627A1 (en) | 2020-01-27 | 2021-08-05 | E Ink Corporation | Method for degassing liquid droplets by electrowetting actuation at higher temperatures |
USD989342S1 (en) * | 2020-02-04 | 2023-06-13 | Ut-Battelle, Llc | Microfluidic polymer chip interface bracket |
USD993443S1 (en) * | 2020-02-04 | 2023-07-25 | Ut-Battelle, Llc | Microfluidic glass chip interface bracket |
CA3167346A1 (en) | 2020-02-13 | 2021-08-19 | Ramaswamy Kalyanasundaram | Vaccine and methods for detecting and preventing filariasis |
EP4106921A4 (en) | 2020-02-18 | 2024-01-10 | Nuclera Nucleics Ltd | ADAPTIVE GATE CONTROL FOR HIGH FREQUENCY AC CONTROL OF EWOD NETWORKS |
JP2023514278A (ja) | 2020-02-19 | 2023-04-05 | ヌークレラ ヌクリークス, リミテッド | EWoDアレイの高周波数AC駆動のためのラッチ付きトランジスタ駆動 |
CN111551752B (zh) * | 2020-04-03 | 2021-10-08 | 深圳市科瑞达生物技术有限公司 | 一种化学发光免疫检测芯片及应用 |
US11372481B2 (en) | 2020-04-14 | 2022-06-28 | Ecole Polytechnique Federale De Lausanne (Epfl) | Hydraulically amplified dielectric actuator taxels |
EP4142942A4 (en) | 2020-04-27 | 2024-05-22 | Nuclera Ltd | SEGMENTED COVER PLATE FOR VARIABLE DRIVE AND SHORT CIRCUIT PROTECTION FOR DIGITAL MICROFLUIDICS |
USD953561S1 (en) | 2020-05-05 | 2022-05-31 | Lucira Health, Inc. | Diagnostic device with LED display |
USD962470S1 (en) | 2020-06-03 | 2022-08-30 | Lucira Health, Inc. | Assay device with LCD display |
US20230241606A1 (en) | 2020-06-15 | 2023-08-03 | Nuclera Nucleics Ltd | Liquid sample recovery in high density digital microfluidic arrays |
WO2022109721A1 (en) * | 2020-11-30 | 2022-06-02 | Precision Nanosystems Inc. | Non aggregating microfluidic mixer and methods therefor |
EP4267304A1 (en) * | 2020-12-24 | 2023-11-01 | Invivoscribe, Inc. | Chemical processing system, instrument and sample cartridge |
WO2022169835A1 (en) | 2021-02-03 | 2022-08-11 | The Board Of Trustees Of The University Of Illinois | Vaccine and methods for preventing filariasis and dirofilariasis |
WO2023049352A1 (en) * | 2021-09-24 | 2023-03-30 | University Of Hawaii | Epidermal microfluidic devices for the capture, storage, and analysis of sweat |
WO2023049456A1 (en) * | 2021-09-24 | 2023-03-30 | Arete Biosciences, Llc | Timed system for rapid assay |
CN113915532B (zh) * | 2021-10-26 | 2023-11-03 | 浙江华章科技有限公司 | 一种集装模块化流量检测设备 |
FR3130780A1 (fr) | 2021-12-17 | 2023-06-23 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Composant fluidique et dispositif de type vanne fluidique pour scellement |
FR3130921A1 (fr) | 2021-12-17 | 2023-06-23 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Composant fluidique et dispositif de type vanne fluidique pour isolation |
FR3130781A1 (fr) | 2021-12-17 | 2023-06-23 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Composant fluidique et dispositif de contrôle d'accès fluidique |
WO2023147674A1 (en) * | 2022-02-07 | 2023-08-10 | Nicoya Lifesciences, Inc. | Digital microfluidics system, instrument, and cartridge assembly including reagent plate |
KR20230132183A (ko) * | 2022-03-08 | 2023-09-15 | 주식회사 유진셀 | 검사 카트리지 및 이의 제조 방법 |
DE102022111381A1 (de) | 2022-03-09 | 2023-09-14 | Hnp Mikrosysteme Gmbh | Fluidisches Element, fluidisches System und Verfahren zum Betreiben eines fluidischen Systems |
EP4286452A1 (en) | 2022-05-30 | 2023-12-06 | Covestro LLC | Polycarbonate diagnostic components with reduced fluorescence |
FR3143088A1 (fr) | 2022-12-08 | 2024-06-14 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Dispositif de type vanne fluidique normalement fermée |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5731212A (en) * | 1994-12-20 | 1998-03-24 | International Technidyne Corporation | Test apparatus and method for testing cuvette accommodated samples |
DE19947495A1 (de) * | 1999-10-01 | 2001-05-17 | Hewlett Packard Co | Mikrostrukturankopplung für einen Labor-Mikrochip |
US20020166585A1 (en) * | 2000-11-06 | 2002-11-14 | Nanostream, Inc. | Microfluidic regulating device |
WO2005114169A1 (en) * | 2004-05-22 | 2005-12-01 | Agilent Technologies, Inc. | Parallel processing microfluid chip |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5062942A (en) * | 1989-04-12 | 1991-11-05 | Hitachi, Ltd. | Fluorescence detection type electrophoresis apparatus |
US5932799A (en) | 1997-07-21 | 1999-08-03 | Ysi Incorporated | Microfluidic analyzer module |
US6485690B1 (en) * | 1999-05-27 | 2002-11-26 | Orchid Biosciences, Inc. | Multiple fluid sample processor and system |
CN1117284C (zh) * | 1999-10-27 | 2003-08-06 | 陆祖宏 | 微流体生物芯片检测分析板及其应用方法 |
US7867763B2 (en) * | 2004-01-25 | 2011-01-11 | Fluidigm Corporation | Integrated chip carriers with thermocycler interfaces and methods of using the same |
EP1334279A1 (en) | 2000-11-06 | 2003-08-13 | Nanostream, Inc. | Uni-directional flow microfluidic components |
US20020098122A1 (en) * | 2001-01-22 | 2002-07-25 | Angad Singh | Active disposable microfluidic system with externally actuated micropump |
US20020155010A1 (en) | 2001-04-24 | 2002-10-24 | Karp Christoph D. | Microfluidic valve with partially restrained element |
US20030198576A1 (en) * | 2002-02-22 | 2003-10-23 | Nanostream, Inc. | Ratiometric dilution devices and methods |
US7238164B2 (en) * | 2002-07-19 | 2007-07-03 | Baxter International Inc. | Systems, methods and apparatuses for pumping cassette-based therapies |
DE10238600A1 (de) | 2002-08-22 | 2004-03-04 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Peristaltische Mikropumpe |
US7455770B2 (en) * | 2002-09-09 | 2008-11-25 | Cytonome, Inc. | Implementation of microfluidic components in a microfluidic system |
US6936167B2 (en) * | 2002-10-31 | 2005-08-30 | Nanostream, Inc. | System and method for performing multiple parallel chromatographic separations |
US20060073484A1 (en) * | 2002-12-30 | 2006-04-06 | Mathies Richard A | Methods and apparatus for pathogen detection and analysis |
US7335335B2 (en) * | 2003-08-01 | 2008-02-26 | Enrique Saldivar | Apparatus and method to measure platelet contractility |
US20050254998A1 (en) * | 2004-03-01 | 2005-11-17 | Ebara Corporation | Reactive detection chip and spotter suitable for manufacturing the chip |
US7611840B2 (en) * | 2004-08-03 | 2009-11-03 | Agency For Science, Technology And Research | Method and device for the treatment of biological samples |
US7832429B2 (en) * | 2004-10-13 | 2010-11-16 | Rheonix, Inc. | Microfluidic pump and valve structures and fabrication methods |
US7976795B2 (en) * | 2006-01-19 | 2011-07-12 | Rheonix, Inc. | Microfluidic systems |
WO2009126826A1 (en) * | 2008-04-11 | 2009-10-15 | Fluidigm Corporation | Multilevel microfluidic systems and methods |
CN102459565A (zh) * | 2009-06-02 | 2012-05-16 | 尹特根埃克斯有限公司 | 具有隔膜阀的流控设备 |
-
2006
- 2006-11-08 US US11/594,444 patent/US7976795B2/en active Active
-
2007
- 2007-01-05 US US11/650,006 patent/US7959875B2/en active Active
- 2007-01-12 KR KR1020087018628A patent/KR20080085898A/ko not_active Application Discontinuation
- 2007-01-12 EP EP07716595.9A patent/EP1979097B1/en active Active
- 2007-01-12 WO PCT/US2007/000960 patent/WO2007084425A2/en active Application Filing
- 2007-01-12 CN CN2007800025115A patent/CN101495236B/zh active Active
- 2007-01-12 JP JP2008551300A patent/JP5250425B2/ja active Active
-
2011
- 2011-05-19 US US13/111,137 patent/US8372355B2/en active Active
- 2011-06-03 US US13/152,881 patent/US8101428B2/en active Active
- 2011-07-25 US US13/189,787 patent/US8323586B2/en active Active
-
2013
- 2013-02-05 US US13/759,131 patent/US8778280B2/en active Active
- 2013-12-11 US US14/103,008 patent/US9151701B2/en not_active Expired - Fee Related
-
2014
- 2014-05-02 US US14/268,399 patent/US9134207B2/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5731212A (en) * | 1994-12-20 | 1998-03-24 | International Technidyne Corporation | Test apparatus and method for testing cuvette accommodated samples |
DE19947495A1 (de) * | 1999-10-01 | 2001-05-17 | Hewlett Packard Co | Mikrostrukturankopplung für einen Labor-Mikrochip |
US20020166585A1 (en) * | 2000-11-06 | 2002-11-14 | Nanostream, Inc. | Microfluidic regulating device |
WO2005114169A1 (en) * | 2004-05-22 | 2005-12-01 | Agilent Technologies, Inc. | Parallel processing microfluid chip |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013508715A (ja) * | 2009-10-21 | 2013-03-07 | バイオカルティス、ソシエテ、アノニム | 平行空気圧インターフェース・プレートを備えたミクロ流体カートリッジ |
JP2014507155A (ja) * | 2011-02-21 | 2014-03-27 | リーアニクス・インコーポレイテッド | マイクロ流体素子を基礎とした核酸精製方法 |
JP2019148590A (ja) * | 2011-06-06 | 2019-09-05 | アボット・ラボラトリーズAbbott Laboratories | 空間分解リガンド−受容体結合アッセイ |
JPWO2013153912A1 (ja) * | 2012-04-12 | 2015-12-17 | 国立大学法人 東京大学 | バルブ、マイクロ流体デバイス、マイクロ構造体、及びバルブシート、並びに、バルブシートの製造方法、及びマイクロ流体デバイスの製造方法 |
JP2015529110A (ja) * | 2012-08-29 | 2015-10-05 | エスエフシー フルーイディクス、インコーポレイテッド | 電気化学的に作動するマイクロ流体デバイス |
JP2021081449A (ja) * | 2013-03-16 | 2021-05-27 | ドン ロバーツ レスリー | 自己完結型モジュラー分析カートリッジ及びプログラム可能試薬送達システム |
US10654039B2 (en) | 2013-11-29 | 2020-05-19 | Genewave | Microfluidic cartridge for molecular diagnosis, docking station using a microfluidic cartridge, and process for analyzing a biological sample |
JP2017502687A (ja) * | 2013-11-29 | 2017-01-26 | ジェネウェーブ | 分子診断用のマイクロ流体カートリッジ、このようなマイクロ流体カートリッジを用いるドッキングステーション、及び生物学的サンプルを分析するためのプロセス |
US11813609B2 (en) | 2013-11-29 | 2023-11-14 | Genewave Sas | Microfluidic cartridge for molecular diagnosis |
JP2018528407A (ja) * | 2015-07-17 | 2018-09-27 | キュー インコーポレイテッド | 検体の向上された検出および量子化のためのシステムおよび方法 |
JP2019525159A (ja) * | 2016-06-29 | 2019-09-05 | ミルテニー バイオテック ゲゼルシャフト ミット ベシュレンクテル ハフツングMiltenyi Biotec GmbH | 生体試料のための多層式ディスポーザブルカートリッジ |
JP7184651B2 (ja) | 2016-06-29 | 2022-12-06 | ミルテニー バイオテック ベー.フェー. ウント コー. カー・ゲー | 生体試料のための多層式ディスポーザブルカートリッジ |
JP2019530884A (ja) * | 2016-09-30 | 2019-10-24 | テル−アレイ ダイアグノスティックス インコーポレイテッド | マイクロ流体デバイス |
JP7114602B2 (ja) | 2016-09-30 | 2022-08-08 | テル-アレイ ダイアグノスティックス インコーポレイテッド | マイクロ流体デバイス |
JP7064409B2 (ja) | 2017-10-27 | 2022-05-10 | 研能科技股▲ふん▼有限公司 | マイクロポンプ |
JP2019080911A (ja) * | 2017-10-27 | 2019-05-30 | 研能科技股▲ふん▼有限公司 | マイクロポンプ |
Also Published As
Publication number | Publication date |
---|---|
US20110293489A1 (en) | 2011-12-01 |
KR20080085898A (ko) | 2008-09-24 |
US8323586B2 (en) | 2012-12-04 |
WO2007084425A9 (en) | 2007-11-29 |
US8101428B2 (en) | 2012-01-24 |
US9134207B2 (en) | 2015-09-15 |
US8778280B2 (en) | 2014-07-15 |
US20140322099A1 (en) | 2014-10-30 |
US20130209327A1 (en) | 2013-08-15 |
EP1979097A2 (en) | 2008-10-15 |
US20110275160A1 (en) | 2011-11-10 |
EP1979097B1 (en) | 2019-08-07 |
US8372355B2 (en) | 2013-02-12 |
US20070166200A1 (en) | 2007-07-19 |
US7976795B2 (en) | 2011-07-12 |
CN101495236B (zh) | 2013-06-05 |
US20110214745A1 (en) | 2011-09-08 |
US20070166199A1 (en) | 2007-07-19 |
US7959875B2 (en) | 2011-06-14 |
WO2007084425A3 (en) | 2009-04-02 |
CN101495236A (zh) | 2009-07-29 |
AU2007207681A1 (en) | 2007-07-26 |
US20140093431A1 (en) | 2014-04-03 |
WO2007084425A2 (en) | 2007-07-26 |
JP5250425B2 (ja) | 2013-07-31 |
US9151701B2 (en) | 2015-10-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5250425B2 (ja) | 微小流体チップ及び分析システム | |
US10209250B2 (en) | PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use | |
US8697007B2 (en) | Biodetection cassette with automated actuator | |
US7241421B2 (en) | Miniaturized fluid delivery and analysis system | |
US9546932B2 (en) | Microfluidic assay operating system and methods of use | |
WO2008103824A1 (en) | Sensitivity-enhanced dot-antibody linked immunogold assay for virus detection | |
CN106552682B (zh) | 微流体装置以及制造方法和用途 | |
US20190061329A1 (en) | Microfluidic Assay Assemblies and Methods of Manufacture | |
US9651568B2 (en) | Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays | |
US10220385B2 (en) | Micro-tube particles for microfluidic assays and methods of manufacture | |
US20170297022A1 (en) | Methods and Systems for Manufacture of Microarray Assay Systems, Conducting Microfluidic Assays, and Monitoring and Scanning to Obtain Microfluidic Assay Results | |
JP2007136322A (ja) | 反応物質同士の拡散および反応を効率化したマイクロリアクタ、およびそれを用いた反応方法 | |
JP2007136379A (ja) | マイクロリアクタおよびその製造方法 | |
US9855735B2 (en) | Portable microfluidic assay devices and methods of manufacture and use | |
WO2013142847A1 (en) | Pdms membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them | |
AU2007207681B2 (en) | Microfluidic chips and assay systems |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20090630 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20100112 |
|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20110223 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20111108 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120207 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120214 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120307 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20121127 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130225 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130402 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20130415 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 Ref document number: 5250425 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20160419 Year of fee payment: 3 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |