JP7184651B2 - 生体試料のための多層式ディスポーザブルカートリッジ - Google Patents
生体試料のための多層式ディスポーザブルカートリッジ Download PDFInfo
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Description
Claims (16)
- 生体試料を分析するためのディスポーザブル品であって、
前記生体試料は、支持体(60)に担持され、免疫蛍光染色によって標識付けされる組織または細胞を含み、
第1のリジッド層(20)であって、分析エリア(24)と、複数の流体貯蔵器(22)と、該第1のリジッド層(20)に形成された複数の流体通路とを有しており、該流体通路が前記流体貯蔵器との流体連通を提供する、第1のリジッド層(20)と、
前記流体貯蔵器(22)のうち少なくとも1つの流体貯蔵器と流体連通した複数の流体制御ポイント(33)を有するフレキシブル層(30)と、
第2のリジッド層(40)であって、該第2のリジッド層(40)に形成された複数の空気圧通路を有し、該空気圧通路が少なくとも1つの前記流体制御ポイント(33)との空気圧連通を提供する、第2のリジッド層(40)と、を備え、
複数の前記流体貯蔵器(22)のうち1つの流体貯蔵器だけから、前記流体通路への、または前記流体通路からの流れを生じさせるように、各流体制御ポイント(33)を空気圧で制御可能であり、
前記第2のリジッド層(40)は、前記支持体(60)を保持するための取り付け機構(45)をさらに有しており、前記支持体(60)と前記リジッド層(40,20)と前記フレキシブル層(30)とによって、標本分析容積体(500)が規定され、
前記第1のリジッド層は、前記標本分析容積体(500)の少なくとも一方の側部に隣接したトレンチ(220)をさらに有しており、該トレンチによって、少なくとも1つの貯蔵器から流れる流体が、前記標本分析容積体(500)の側部全体を介して受け入れられて分散される、
生体試料を分析するためのディスポーザブル品。 - 前記流体制御ポイント(33)は、前記第2のリジッド層の空気圧通路から前記フレキシブル層の裏面に向かって印加される吸引力によって、空気圧で制御され、前記フレキシブル層が第1の停止位置から第2の停止位置に向かって引っ張られて、前記標本分析容積体(500)へ、および前記標本分析容積体(500)から、流体を流すことができる、請求項1記載のディスポーザブル品。
- 前記流体制御ポイント(33)は、前記第2のリジッド層の空気圧通路から前記フレキシブル層の裏面に向かって印加される吸引力によって、空気圧で制御され、前記フレキシブル層が第1の停止位置に当接して静止した位置におかれて、前記標本分析容積体(500)への、および前記標本分析容積体(500)からの、流体の流れが阻止される、請求項1記載のディスポーザブル品。
- 前記流体制御ポイント(33)は、前記フレキシブル層(30)の薄膜化部分(133)を有する、請求項1記載のディスポーザブル品。
- 前記流体制御ポイント(33)は、前記フレキシブル層(30)の薄膜化部分(133)を有しており、該薄膜化部分(133)は、第1の停止位置(120)と第2の停止位置(43)とに向かって撓まされる、請求項1記載のディスポーザブル品。
- 前記流体制御ポイント(33)は、前記流体通路内に突入し前記フレキシブル層(30)の前記薄膜化部分(133)のための第1の停止位置(120)を規定する、前記第1のリジッド層(20)における突出構造要素(120)と、前記フレキシブル層(30)の前記薄膜化部分(133)のための第2の停止位置(43)である、前記第2のリジッド層(40)の空気圧通路における開口部とを有しており、
前記薄膜化部分(133)によって、前記第1のリジッド層(20)内の流体通路が開放および閉鎖される、請求項5記載のディスポーザブル品。 - 前記第2のリジッド層(40)は圧力ポイント(43)を有しており、該圧力ポイント(43)は、前記フレキシブル層(30)の前記薄膜化部分(133)のための第2の停止位置として、前記フレキシブル層(30)のキャビティに突入している、請求項5記載のディスポーザブル品。
- 前記圧力ポイント(43)が前記キャビティに突入することによって、前記フレキシブル層(30)が前記リジッド層(40)に対し、前記フレキシブル層(30)の前記薄膜化部分(133)に形成されたボタンと隣接する場所で位置合わせされる、請求項7記載のディスポーザブル品。
- 前記フレキシブル層(30)は、空気圧力によって作動するポンピング機構(200)をさらに有する、請求項1記載のディスポーザブル品。
- 前記ポンピング機構(200)は、流体通路の容積を変化させるように構成された可動部分(210)を前記フレキシブル層(30)内に有しており、
前記可動部分(210)は、第1の流体制御ポイント(100)と第2の流体制御ポイント(300)との間を流体連通させる、請求項9記載のディスポーザブル品。 - 前記第2のリジッド層は、複数の流体制御ポイントから成る1つの行に対し吸引力を与える第1の空気圧通路と、複数の流体制御ポイントから成る1つの列に対し吸引力を与える第2の空気圧通路とを有しており、2つの前記空気圧通路が共働して、一度に複数の前記流体貯蔵器のうち1つの流体貯蔵器のみから流体が計量分配されるようになる、請求項1記載のディスポーザブル品。
- 前記トレンチ(220)は非対称の断面を有する、請求項1記載のディスポーザブル品。
- 前記第1のリジッド層(20)は、前記標本分析容積体(500)の少なくとも一方の側部に隣接するバリア(240)をさらに有しており、該バリア(240)は、流体が前記バリア(240)と前記支持体(60)との間を流れてから前記標本分析容積体(500)に入るように、前記標本分析容積体(500)に突入している、請求項1記載のディスポーザブル品。
- 前記標本分析容積体(500)は高さh1を、前記トレンチ(220)は深さh2を、前記バリア(240)は深さh3を、前記生体試料は高さh4を有しており、
ただしh1,h2,h3およびh4は、
(0.05~0.5)×h3=h4、および/または
(0.1~0.5)×h2=h1、および/または
(0.1~0.5)×h1=h4
という比を有する、請求項13記載のディスポーザブル品。 - 前記フレキシブル層(30)は、前記第1のリジッド層(20)を前記第2のリジッド層(40)に対し封止し、かつ/または前記第2のリジッド層(40)を前記支持体(60)に対し封止する、請求項1記載のディスポーザブル品。
- 前記複数の流体貯蔵器(22)は複数の試薬を含み、該複数の試薬のうちの少なくとも1つは、蛍光分子と共役された抗体である、請求項1記載のディスポーザブル品。
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US201662356310P | 2016-06-29 | 2016-06-29 | |
US62/356,310 | 2016-06-29 | ||
PCT/EP2017/064886 WO2018001767A1 (en) | 2016-06-29 | 2017-06-19 | Multilevel disposable cartridge for biological specimens |
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JP2019525159A JP2019525159A (ja) | 2019-09-05 |
JP7184651B2 true JP7184651B2 (ja) | 2022-12-06 |
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US (1) | US11161111B2 (ja) |
EP (1) | EP3478409A1 (ja) |
JP (1) | JP7184651B2 (ja) |
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EP3823754A2 (en) * | 2018-07-16 | 2021-05-26 | Ventana Medical Systems, Inc. | Automated slide processing systems, consumable stainer units, and related technologies |
US11633741B2 (en) | 2019-03-19 | 2023-04-25 | Miltenyi Biotec B.V. & Co. KG | Slide chamber |
WO2021183687A2 (en) | 2020-03-10 | 2021-09-16 | Cellares Corporation | Systems, devices, and methods for cell processing |
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JP2009524054A (ja) | 2006-01-19 | 2009-06-25 | キオニックス インコーポレイテッド | 微小流体チップ及び分析システム |
US20110305607A1 (en) | 2010-06-15 | 2011-12-15 | Samsung Electronics Co., Ltd | Microfluidic device having microvalve |
JP2015517804A (ja) | 2012-04-01 | 2015-06-25 | イー・エム・デイー・ミリポア・コーポレイシヨン | 細胞培養及び傾斜移動アッセイ方法及び装置 |
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