JP5250425B2 - 微小流体チップ及び分析システム - Google Patents
微小流体チップ及び分析システム Download PDFInfo
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- JP5250425B2 JP5250425B2 JP2008551300A JP2008551300A JP5250425B2 JP 5250425 B2 JP5250425 B2 JP 5250425B2 JP 2008551300 A JP2008551300 A JP 2008551300A JP 2008551300 A JP2008551300 A JP 2008551300A JP 5250425 B2 JP5250425 B2 JP 5250425B2
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Description
図1は、本発明の微小流体チップの1つの実施形態を示す。
図2は、図1の微小流体チップの別の図を示す。
図3a、bは、図1に示された実施形態で使用される微小流体弁を示す。
図4a〜fは、図1に示された実施形態で使用される微小流体ポンプを示す。
図5a〜cは、図1に示された実施形態で使用される入口弁を示す。
図6a、bは、図1に示された実施形態で使用されるカートリッジと容器を示す。
図7は、分離した試薬チップに結合した導管を有する分析チップを示す。
図8〜10は、図7の素子の製造のための段階を示す。
図11a〜cは、図1に示された実施形態に取り付ける大きさと形状の例示的な挿入物を示す。
図12は、単一の駆動力で試薬を複数の出口容器に分配するチップの実施形態を示す。
図13は、複数の駆動力で試薬を複数の出口容器に分配するチップの実施形態を示す。
図14は、複数の試薬を複数の出口容器に分配する複数の駆動力を有するチップの実施形態を示す。
図15a〜cは、図1に示された実施形態の流路内に図11a〜cの例示的挿入物を取り付ける方法を示す。
図16a、bは、微小流体に基づくオンチップ免疫分析過程の結果を示す。
図17は、標的分析物を含む標本を同定する段階を示す。
図18は、計算機、コントローラ及びチップを含む、完全かつ内蔵型の微小流体システムを示す。
図19は、コントローラに接続したチップの他の実施形態を示す。
Claims (10)
- 入口端と出口端とをそれぞれが有する複数の流路(20,38,40)がその中に形成された基板(6,7)、
物質を保持できる種類の少なくとも1つの試薬容器(12)、
前記複数の流路の各出口端に結合した複数の出口容器(48)、
それぞれ1つの前記流路により直列に結合され、独立に動作し得る少なくとも3個の弁構造体(402,404,406)からなる少なくとも1つの双方向性ダイアフラムポンプ(400)、及び
前記少なくとも1つの試薬容器から複数の出口容器へ、分配弁に結合された少なくとも1つの前記流路を介して前記物質の流れを制御可能に導くよう適合され、前記少なくとも1つの試薬容器と前記少なくとも1つの出口端に流体結合されて配置された分配弁(25)
から成る微小流体装置(1)。 - 前記基板がプラスチック基板であり、前記物質を前記複数の流路(20,38,40)の少なくとも1つに導入するために前記少なくとも1つの試薬容器(12)が該プラスチック基板の頂面に取り外し可能に結合(610)されている、請求項1の装置。
- 開と閉の状態を有し、少なくとも1つの試薬容器(12)を複数の出口容器(48)へ分配弁(25)を介して流体的に結合する少なくとも1つの試薬弁(14)をさらに備える、請求項1の装置。
- 少なくとも1つの流路(730,1130,1520)内に取り付けるように構成され、かつ前記物質と相互作用する反応面を有する少なくとも1つの挿入物(1107,1507,2017)をさらに備える、請求項1の装置。
- 前記基板が複数の重ねられた層(6,7,8)を含み、少なくとも1つの層(6,7,8)に配置された複数の流路(20,38,40)を有する、請求項1の装置。
- 前記物質の温度を調節する少なくとも1つの加熱要素をさらに含む、請求項1の装置。
- 独立して作動できる複数の弁構造体を有する少なくとも1つのポンプ、及び
少なくとも1つの試薬容器から複数の出口容器へ分配弁に結合された少なくとも1つの流路を介して物質の流れを導くための弁構造体を空気圧で作動することができるプログラマブルコントローラ(1915)をさらに備える、請求項1の装置。 - 前記複数の流路の各々が複数の試薬容器(12)の1つと結合した端部と、前記分配弁(25)に結合した他端とを有し、好ましくは少なくとも2つの流路の長さが異なり、または前記複数の流路の各々が好ましくは共通の弁に接続された端部を有している、請求項1の装置。
- 請求項1に記載の微小流体装置を備えること、
前記流路内に少なくとも1つの挿入物を取り付けること、
内部の前記挿入物に接触するように前記流路を通じて少なくとも1つの流体物質を流すこと、
前記流体物質を前記挿入物から抜き去ること、そして
前記挿入物の相互作用を検知すること
から成る、生物学的分析を遂行するための方法。 - 前記少なくとも1つの流体物質を流すことが、前記流路に結合された第1の容器に向かう第1の方向と前記流路に結合された第2の容器に向かう第2の方向で前記流体物質を繰り返し往復させることから成り、
前記流路に結合された分配弁は、分配弁が閉の状態のとき、前記流路の流体物質を実質的に閉じこめるものであり、
好ましくは、相互作用を検知することが前記挿入物の少なくとも1つの標本に対応する色強度値を発生することから成り、
さらに好ましくは、閾値が少なくとも1つの陰性対照標本を用いて計算される、請求項9の方法。
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- 2007-01-12 KR KR1020087018628A patent/KR20080085898A/ko not_active Application Discontinuation
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JP2009524054A (ja) | 2009-06-25 |
WO2007084425A2 (en) | 2007-07-26 |
US9134207B2 (en) | 2015-09-15 |
US8778280B2 (en) | 2014-07-15 |
CN101495236A (zh) | 2009-07-29 |
US20070166199A1 (en) | 2007-07-19 |
WO2007084425A3 (en) | 2009-04-02 |
US8372355B2 (en) | 2013-02-12 |
US20140093431A1 (en) | 2014-04-03 |
US9151701B2 (en) | 2015-10-06 |
WO2007084425A9 (en) | 2007-11-29 |
US20070166200A1 (en) | 2007-07-19 |
US20130209327A1 (en) | 2013-08-15 |
CN101495236B (zh) | 2013-06-05 |
US20110293489A1 (en) | 2011-12-01 |
EP1979097A2 (en) | 2008-10-15 |
US20140322099A1 (en) | 2014-10-30 |
KR20080085898A (ko) | 2008-09-24 |
US20110214745A1 (en) | 2011-09-08 |
AU2007207681A1 (en) | 2007-07-26 |
EP1979097B1 (en) | 2019-08-07 |
US7959875B2 (en) | 2011-06-14 |
US7976795B2 (en) | 2011-07-12 |
US20110275160A1 (en) | 2011-11-10 |
US8323586B2 (en) | 2012-12-04 |
US8101428B2 (en) | 2012-01-24 |
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