JP2009511084A5 - - Google Patents
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- Publication number
- JP2009511084A5 JP2009511084A5 JP2008536796A JP2008536796A JP2009511084A5 JP 2009511084 A5 JP2009511084 A5 JP 2009511084A5 JP 2008536796 A JP2008536796 A JP 2008536796A JP 2008536796 A JP2008536796 A JP 2008536796A JP 2009511084 A5 JP2009511084 A5 JP 2009511084A5
- Authority
- JP
- Japan
- Prior art keywords
- influenza
- vaccine
- proteins
- influenza virus
- vlp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960005486 vaccine Drugs 0.000 claims 35
- 241000712461 unidentified influenza virus Species 0.000 claims 27
- 108090000623 proteins and genes Proteins 0.000 claims 22
- 102000004169 proteins and genes Human genes 0.000 claims 22
- 206010022000 influenza Diseases 0.000 claims 17
- 230000001932 seasonal effect Effects 0.000 claims 8
- 230000036039 immunity Effects 0.000 claims 6
- 230000009385 viral infection Effects 0.000 claims 5
- 230000001939 inductive effect Effects 0.000 claims 3
- 241000282412 Homo Species 0.000 claims 2
- 241000712431 Influenza A virus Species 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 101710154606 Hemagglutinin Proteins 0.000 claims 1
- 102000005348 Neuraminidase Human genes 0.000 claims 1
- 108010006232 Neuraminidase Proteins 0.000 claims 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 1
- 101710176177 Protein A56 Proteins 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000185 hemagglutinin Substances 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72751305P | 2005-10-18 | 2005-10-18 | |
| US60/727,513 | 2005-10-18 | ||
| US78084706P | 2006-03-10 | 2006-03-10 | |
| US60/780,847 | 2006-03-10 | ||
| US80000606P | 2006-05-15 | 2006-05-15 | |
| US60/800,006 | 2006-05-15 | ||
| US83119606P | 2006-07-17 | 2006-07-17 | |
| US60/831,196 | 2006-07-17 | ||
| US83211606P | 2006-07-21 | 2006-07-21 | |
| US60/832,116 | 2006-07-21 | ||
| US84549506P | 2006-09-19 | 2006-09-19 | |
| US60/845,495 | 2006-09-19 | ||
| PCT/US2006/040862 WO2007047831A2 (en) | 2005-10-18 | 2006-10-18 | Functional influenza virus like particles (vlps) |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012115616A Division JP5771558B2 (ja) | 2005-10-18 | 2012-05-21 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2015016492A Division JP2015083018A (ja) | 2005-10-18 | 2015-01-30 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009511084A JP2009511084A (ja) | 2009-03-19 |
| JP2009511084A5 true JP2009511084A5 (OSRAM) | 2009-12-03 |
| JP5714799B2 JP5714799B2 (ja) | 2015-05-07 |
Family
ID=37963272
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008536796A Active JP5714799B2 (ja) | 2005-10-18 | 2006-10-18 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2012115616A Active JP5771558B2 (ja) | 2005-10-18 | 2012-05-21 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2015016492A Withdrawn JP2015083018A (ja) | 2005-10-18 | 2015-01-30 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2016088847A Withdrawn JP2016135142A (ja) | 2005-10-18 | 2016-04-27 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2017144662A Pending JP2017189178A (ja) | 2005-10-18 | 2017-07-26 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012115616A Active JP5771558B2 (ja) | 2005-10-18 | 2012-05-21 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2015016492A Withdrawn JP2015083018A (ja) | 2005-10-18 | 2015-01-30 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2016088847A Withdrawn JP2016135142A (ja) | 2005-10-18 | 2016-04-27 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2017144662A Pending JP2017189178A (ja) | 2005-10-18 | 2017-07-26 | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1937301B1 (OSRAM) |
| JP (5) | JP5714799B2 (OSRAM) |
| KR (1) | KR101359723B1 (OSRAM) |
| CN (2) | CN103865892B (OSRAM) |
| AU (1) | AU2006304640B2 (OSRAM) |
| BR (1) | BRPI0617486A2 (OSRAM) |
| CA (1) | CA2625406C (OSRAM) |
| DK (1) | DK1937301T3 (OSRAM) |
| ES (1) | ES2543056T3 (OSRAM) |
| HU (1) | HUE026136T2 (OSRAM) |
| IL (1) | IL190775A (OSRAM) |
| NZ (1) | NZ567164A (OSRAM) |
| PL (1) | PL1937301T3 (OSRAM) |
| PT (1) | PT1937301E (OSRAM) |
| RU (1) | RU2483751C2 (OSRAM) |
| SG (1) | SG2014012868A (OSRAM) |
| SI (1) | SI1937301T1 (OSRAM) |
| TW (1) | TWI488968B (OSRAM) |
| WO (1) | WO2007047831A2 (OSRAM) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0250488A (ja) * | 1988-08-11 | 1990-02-20 | Nec Corp | 超伝導配線 |
| US8551756B2 (en) | 2003-07-11 | 2013-10-08 | Novavax, Inc. | Avian influenza chimeric VLPS |
| US9101578B2 (en) | 2006-05-01 | 2015-08-11 | Technovax, Inc. | Polyvalent influenza virus-like particle (VLP) compositions |
| US8778353B2 (en) | 2006-05-01 | 2014-07-15 | Technovax, Inc. | Influenza virus-like particle (VLP) compositions |
| CA2659275C (en) * | 2006-07-27 | 2017-01-10 | Ligocyte Pharmaceuticals, Inc. | Chimeric influenza virus-like particles |
| US8202967B2 (en) | 2006-10-27 | 2012-06-19 | Boehringer Ingelheim Vetmedica, Inc. | H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use |
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| CN101801411A (zh) * | 2007-07-19 | 2010-08-11 | 诺瓦瓦克斯股份有限公司 | 嵌合水痘带状疱疹病毒病毒样颗粒 |
| WO2009073330A2 (en) | 2007-11-12 | 2009-06-11 | The Trustees Of The University Of Pennsylvania | Novel vaccines against multiple subtypes of influenza virus |
| ES2554703T3 (es) | 2007-11-27 | 2015-12-22 | Medicago Inc. | Partículas recombinantes semejantes al virus de la influenza (VLP) producidas en plantas transgénicas que expresan hemaglutinina |
| CN105753948A (zh) | 2008-07-08 | 2016-07-13 | 麦迪卡格公司 | 可溶性重组流感抗原 |
| CA2730668C (en) * | 2008-07-18 | 2020-04-28 | Medicago Inc. | New influenza virus immunizing epitope |
| EP3542815A1 (en) * | 2008-11-28 | 2019-09-25 | Boehringer Ingelheim Animal Health USA Inc. | Recombinant avian influenza vaccine and uses thereof |
| JP2012525134A (ja) * | 2009-04-30 | 2012-10-22 | サイトス バイオテクノロジー アーゲー | インフルエンザ赤血球凝集素の組成物とその使用 |
| SG175781A1 (en) * | 2009-05-01 | 2011-12-29 | Redbiotec Ag | Recombinant virus-like particles encoded by multi-gene vector |
| TW201738562A (zh) * | 2009-05-28 | 2017-11-01 | 亞培生物股份有限公司 | 體外病原體檢驗技術 |
| EP2445928B1 (en) | 2009-06-24 | 2018-03-28 | Medicago Inc. | Chimeric influenza virus-like particles comprising hemagglutinin |
| MX2012003372A (es) | 2009-09-22 | 2012-05-29 | Medicago Inc | Metodo para preparar proteina derivada de vegetales. |
| WO2011102900A1 (en) * | 2010-02-18 | 2011-08-25 | Technovax, Inc. | Universal virus-like particle (vlp) influenza vaccines |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| JP2012036154A (ja) * | 2010-08-11 | 2012-02-23 | Goshu Yakuhin Kk | 食品 |
| CN101947317B (zh) * | 2010-09-27 | 2012-05-30 | 武汉大学 | 一种h5n1禽流感病毒样颗粒疫苗的规模化制备方法 |
| WO2012122858A1 (zh) * | 2011-03-17 | 2012-09-20 | 中国科学院上海巴斯德研究所 | 一种利用果蝇细胞生产病毒样颗粒的方法及应用 |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| EA016866B1 (ru) * | 2011-06-06 | 2012-08-30 | Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт") | Вакцина для специфической профилактики гриппа |
| KR101302245B1 (ko) * | 2011-06-27 | 2013-09-02 | 조지아 스테이트 유니버시티 리서치 파운데이션, 인코포레이티드 | 넓은 범위의 교차 방어능력을 갖는 신규한 보강 인플루엔자 백신 |
| AR088028A1 (es) * | 2011-08-15 | 2014-05-07 | Boehringer Ingelheim Vetmed | Proteinas h5, de h5n1 para un uso medicinal |
| WO2013032942A1 (en) | 2011-08-26 | 2013-03-07 | Yoshihiro Kawaoka | Influenza viruses with mutant pb2 gene segment as live attenuated vaccines |
| JP5884100B2 (ja) * | 2011-08-31 | 2016-03-15 | 公益財団法人東京都医学総合研究所 | 新型インフルエンザウイルス由来ヘマグルチニンタンパク質遺伝子を有するＤＩｓ株由来組換えワクシニアウイルス |
| CN103930435A (zh) * | 2011-09-30 | 2014-07-16 | 麦迪卡格公司 | 增加植物中病毒样颗粒的产率 |
| US11390878B2 (en) | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| EP2809345A4 (en) * | 2012-02-03 | 2015-11-25 | Univ Emory | IMMUNOSTIMULATING COMPOSITIONS, PARTICLES THEREFOR, AND USES THEREFOR |
| RU2485973C1 (ru) * | 2012-02-28 | 2013-06-27 | Общество с ограниченной ответственностью "НТфарма" | Рекомбинантная трехвалентная вакцина от гриппа человека |
| MX360137B (es) * | 2013-02-21 | 2018-10-24 | Boehringer Ingelheim Vetmedica Gmbh | Proteínas h5 del virus de la influenza h5n1 para usarse como un medicamento. |
| US9649375B2 (en) * | 2013-03-14 | 2017-05-16 | The Administrators Of The Tulane Educational Fund | Immunogenic peptide conjugate and method for inducing an anti-influenza therapeutic antibody response therewith |
| WO2014153674A1 (en) * | 2013-03-28 | 2014-10-02 | Medicago Inc. | Influenza virus-like particle production in plants |
| US12467058B2 (en) | 2013-03-28 | 2025-11-11 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
| DK3092309T3 (da) | 2014-01-10 | 2021-04-12 | Medicago Inc | Cpmv-forstærkerelementer |
| CN103740655A (zh) * | 2014-01-20 | 2014-04-23 | 瑞鑫百奥生物科技（深圳）有限公司 | H5n1禽流感病毒样颗粒及其应用和制备方法、疫苗 |
| US10563213B2 (en) | 2014-03-27 | 2020-02-18 | Medicago Inc. | Modified CPMV enhancer elements |
| WO2015195218A1 (en) * | 2014-06-20 | 2015-12-23 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Polyvalent influenza virus-like particles (vlps) and use as vaccines |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| JP2018530314A (ja) * | 2015-08-28 | 2018-10-18 | ウィスコンシン アルムニ リサーチ ファンデイション | ウイルス様粒子からの感染性インフルエンザウイルスの生成 |
| RU2639491C2 (ru) * | 2015-08-31 | 2017-12-21 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Вирионы и вирусоподобные частицы вируса мозаики альтернантеры как усилители иммунного ответа |
| CN114617959A (zh) | 2015-09-03 | 2022-06-14 | 诺瓦瓦克斯股份有限公司 | 具有改进的稳定性和免疫原性的疫苗组合物 |
| EP3417056A1 (en) | 2016-02-19 | 2018-12-26 | Wisconsin Alumni Research Foundation (WARF) | Improved influenza b virus replication for vaccine development |
| US11123421B2 (en) * | 2016-04-18 | 2021-09-21 | Versitech Limited | Cold adapted and virulence factor deleted live attenuated vaccine suitable for mucosal delivery |
| WO2019023811A1 (en) | 2017-08-04 | 2019-02-07 | The Hospital For Sick Children | NANOPARTICLE PLATFORM FOR ANTIBODY AND VACCINE DELIVERY |
| CN107353328A (zh) * | 2017-08-23 | 2017-11-17 | 上海市动物疫病预防控制中心 | 一种重组的h9n2亚型禽流感病毒样颗粒及其制备方法和用途 |
| CN110240634B (zh) * | 2018-03-08 | 2022-09-06 | 普莱柯生物工程股份有限公司 | 一种禽流感病毒样颗粒疫苗、及其制备方法和应用 |
| CN108409842A (zh) * | 2018-03-15 | 2018-08-17 | 山东省农业科学院畜牧兽医研究所 | 一种单克隆抗体及其制备方法 |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| EP3921413A1 (en) | 2019-02-08 | 2021-12-15 | Wisconsin Alumni Research Foundation (WARF) | Humanized cell line |
| US11390649B2 (en) | 2019-05-01 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| WO2021041624A2 (en) | 2019-08-27 | 2021-03-04 | Yoshihiro Kawaoka | Recombinant influenza viruses with stabilized ha for replication in eggs |
| JP2023511444A (ja) | 2020-01-24 | 2023-03-17 | ウィスコンシン アルムニ リサーチ ファンデイション | 安定化されたｎａを有する組換えインフルエンザウイルス |
| KR102151962B1 (ko) * | 2020-03-24 | 2020-09-04 | 안병철 | 어린 포유동물의 전염성 질병을 예방 또는 치료하기 위한 혈청 조성물의 제조방법, 상기 방법에 의해 제조된 혈청 조성물 및 이의 용도 |
| JP7672162B2 (ja) * | 2020-03-24 | 2025-05-07 | チョル アン，ビョン | 幼い哺乳動物の粘膜関連伝染性疾病を予防または治療するための血清組成物の製造方法、前記方法によって製造された血清組成物及びその用途 |
| US12290562B2 (en) | 2020-03-25 | 2025-05-06 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| CN113461786B (zh) * | 2020-03-30 | 2022-09-13 | 普莱柯生物工程股份有限公司 | 一种禽流感病毒样颗粒疫苗、及其制备方法和应用 |
| EP4144365A4 (en) | 2020-05-01 | 2024-06-05 | Sinocelltech Ltd. | METHODS FOR IMPROVING THE IMMUNOGENERICITY OF PROTEIN/PEPTIDE ANTIGEN |
| CN112342149A (zh) * | 2020-11-12 | 2021-02-09 | 新疆畜牧科学院兽医研究所（新疆畜牧科学院动物临床医学研究中心） | 一种禽流感病毒样颗粒组装表达系统及其应用 |
| CN112979796A (zh) * | 2021-04-27 | 2021-06-18 | 军事科学院军事医学研究院军事兽医研究所 | 马抗甲型h5n1虎源流感病毒免疫球蛋白和特异性免疫球蛋白及其精制方法 |
| CN113862284B (zh) * | 2021-09-13 | 2023-05-26 | 华南农业大学 | 一种编码重组禽流感病毒ha蛋白的基因、病毒样颗粒、疫苗及制备与应用 |
| CN114262720B (zh) * | 2021-12-27 | 2023-07-25 | 河南兴华生物技术有限公司 | 杆状病毒表达系统的信号肽及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4866034A (en) | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
| US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
| US4911928A (en) | 1987-03-13 | 1990-03-27 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
| US6387373B1 (en) | 1993-01-15 | 2002-05-14 | Novavax, Inc. | Vaccines containing paucilsmellar lipid vesicles as immunological adjuvants |
| US5629021A (en) | 1995-01-31 | 1997-05-13 | Novavax, Inc. | Micellar nanoparticles |
| CN1196788C (zh) | 2000-06-23 | 2005-04-13 | 惠氏控股有限公司 | 野生型和嵌合流感病毒样颗粒(vlp)的装配 |
| AU2003219760A1 (en) | 2002-02-14 | 2003-09-04 | Novavax, Inc. | Optimization of gene sequences of virus-like particles for expression in insect cells |
| US8592197B2 (en) * | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
-
2006
- 2006-10-18 CN CN201410085506.7A patent/CN103865892B/zh active Active
- 2006-10-18 TW TW095138390A patent/TWI488968B/zh active
- 2006-10-18 CN CN200680045850.7A patent/CN101325966B/zh active Active
- 2006-10-18 ES ES06826264.1T patent/ES2543056T3/es active Active
- 2006-10-18 AU AU2006304640A patent/AU2006304640B2/en active Active
- 2006-10-18 WO PCT/US2006/040862 patent/WO2007047831A2/en not_active Ceased
- 2006-10-18 BR BRPI0617486-8A patent/BRPI0617486A2/pt not_active Application Discontinuation
- 2006-10-18 PT PT68262641T patent/PT1937301E/pt unknown
- 2006-10-18 PL PL06826264T patent/PL1937301T3/pl unknown
- 2006-10-18 DK DK06826264.1T patent/DK1937301T3/en active
- 2006-10-18 KR KR1020087011963A patent/KR101359723B1/ko active Active
- 2006-10-18 RU RU2008119501/15A patent/RU2483751C2/ru active
- 2006-10-18 HU HUE06826264A patent/HUE026136T2/en unknown
- 2006-10-18 CA CA2625406A patent/CA2625406C/en active Active
- 2006-10-18 EP EP20060826264 patent/EP1937301B1/en active Active
- 2006-10-18 SI SI200631949T patent/SI1937301T1/sl unknown
- 2006-10-18 SG SG2014012868A patent/SG2014012868A/en unknown
- 2006-10-18 NZ NZ567164A patent/NZ567164A/en unknown
- 2006-10-18 JP JP2008536796A patent/JP5714799B2/ja active Active
-
2008
- 2008-04-10 IL IL190775A patent/IL190775A/en active IP Right Grant
-
2012
- 2012-05-21 JP JP2012115616A patent/JP5771558B2/ja active Active
-
2015
- 2015-01-30 JP JP2015016492A patent/JP2015083018A/ja not_active Withdrawn
-
2016
- 2016-04-27 JP JP2016088847A patent/JP2016135142A/ja not_active Withdrawn
-
2017
- 2017-07-26 JP JP2017144662A patent/JP2017189178A/ja active Pending
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