JP2009510126A5 - - Google Patents
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- JP2009510126A5 JP2009510126A5 JP2008533776A JP2008533776A JP2009510126A5 JP 2009510126 A5 JP2009510126 A5 JP 2009510126A5 JP 2008533776 A JP2008533776 A JP 2008533776A JP 2008533776 A JP2008533776 A JP 2008533776A JP 2009510126 A5 JP2009510126 A5 JP 2009510126A5
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- Prior art keywords
- pharmaceutical composition
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- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 claims 29
- 230000027455 binding Effects 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 229920000642 polymer Polymers 0.000 claims 7
- 229910001414 potassium ion Inorganic materials 0.000 claims 6
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 150000001768 cations Chemical class 0.000 claims 5
- 239000000306 component Substances 0.000 claims 5
- 239000011591 potassium Substances 0.000 claims 5
- 229910052700 potassium Inorganic materials 0.000 claims 5
- 239000011258 core-shell material Substances 0.000 claims 4
- 229910001425 magnesium ion Inorganic materials 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 3
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 150000001412 amines Chemical class 0.000 claims 3
- 239000008358 core component Substances 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 239000011777 magnesium Substances 0.000 claims 3
- 229910052749 magnesium Inorganic materials 0.000 claims 3
- 238000003756 stirring Methods 0.000 claims 3
- MIIIXQJBDGSIKL-UHFFFAOYSA-N 2-morpholin-4-ylethanesulfonic acid;hydrate Chemical compound O.OS(=O)(=O)CCN1CCOCC1 MIIIXQJBDGSIKL-UHFFFAOYSA-N 0.000 claims 2
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 239000003431 cross linking reagent Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000002688 persistence Effects 0.000 claims 2
- 230000009870 specific binding Effects 0.000 claims 2
- 239000006228 supernatant Substances 0.000 claims 2
- BCAGFJXMCZSAHD-UHFFFAOYSA-N 1,2-bis(2-iodoethoxy)ethane Chemical compound ICCOCCOCCI BCAGFJXMCZSAHD-UHFFFAOYSA-N 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 238000005341 cation exchange Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000002550 fecal effect Effects 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 229920001519 homopolymer Polymers 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- -1 magnesium ions ions Chemical class 0.000 claims 1
- JAYXSROKFZAHRQ-UHFFFAOYSA-N n,n-bis(oxiran-2-ylmethyl)aniline Chemical compound C1OC1CN(C=1C=CC=CC=1)CC1CO1 JAYXSROKFZAHRQ-UHFFFAOYSA-N 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 229940049964 oleate Drugs 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 1
- JAJWGJBVLPIOOH-IZYKLYLVSA-M sodium taurocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 JAJWGJBVLPIOOH-IZYKLYLVSA-M 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72307305P | 2005-09-30 | 2005-09-30 | |
| PCT/US2006/038602 WO2007041569A1 (en) | 2005-09-30 | 2006-10-02 | Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009510126A JP2009510126A (ja) | 2009-03-12 |
| JP2009510126A5 true JP2009510126A5 (cg-RX-API-DMAC7.html) | 2009-11-26 |
Family
ID=37607162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008533776A Pending JP2009510126A (ja) | 2005-09-30 | 2006-10-02 | 哺乳類の胃腸管からカリウムイオンを選択的に除去するための方法および組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US8617609B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1928476A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2009510126A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20080059265A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101316601A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2006299449B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0616604A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2624170C (cg-RX-API-DMAC7.html) |
| DE (1) | DE112006002618T5 (cg-RX-API-DMAC7.html) |
| GB (1) | GB2446077B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2007041569A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (28)
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| KR101228233B1 (ko) * | 2004-03-30 | 2013-01-31 | 리립사, 인크. | 이온 결합 중합체 및 이의 용도 |
| GB2446077B (en) | 2005-09-30 | 2010-10-13 | Ilypsa Inc | Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal |
| WO2010022381A1 (en) * | 2008-08-22 | 2010-02-25 | Relypsa, Inc. | Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties |
| ES2939021T3 (es) * | 2008-08-22 | 2023-04-18 | Vifor Int Ltd | Composiciones que comprenden polímeros reticulados de intercambio catiónico y uso en el tratamiento de la hipercalemia |
| US20100111892A1 (en) * | 2008-08-22 | 2010-05-06 | Relypsa, Inc. | Crosslinked polyfluoroacrylic acid and processes for the preparation thereof |
| AU2013204879B2 (en) * | 2008-08-22 | 2015-10-29 | Vifor (International) Ltd. | Crosslinked cation exchange polymers, compositions and use in treating hyperkalemia |
| WO2010022380A2 (en) * | 2008-08-22 | 2010-02-25 | Relypsa, Inc. | Linear polyol stabilized polyfluoroacrylate compositions |
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| EA023933B1 (ru) | 2010-10-15 | 2016-07-29 | ЭВОКУА УОТЕР ТЕКНОЛОДЖИЗ ЭлЭлСи | Способ получения катионообменной мембраны |
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| CN104797263B (zh) | 2012-10-22 | 2018-02-09 | Zs制药公司 | 用于治疗高钾血症的微孔硅酸锆 |
| US10695365B2 (en) | 2012-10-22 | 2020-06-30 | ZS Pharma, Inc. | Microporous zirconium silicate for the treatment of hyperkalemia |
| KR20210131457A (ko) | 2013-06-05 | 2021-11-02 | 트리시다, 인크. | 경구 투여를 위한 양성자-결합 중합체 |
| ES2787218T3 (es) | 2014-12-10 | 2020-10-15 | Tricida Inc | Polímeros de unión de protones para la administración oral |
| US9592253B1 (en) | 2015-10-14 | 2017-03-14 | ZS Pharma, Inc. | Extended use zirconium silicate compositions and methods of use thereof |
| CN105597699B (zh) * | 2016-01-29 | 2018-07-13 | 四川农业大学 | 一种高效吸附Cu2+的改性蚯蚓粪微球、制备方法及应用 |
| EP3452028A4 (en) | 2016-05-06 | 2020-04-15 | Tricida Inc. | COMPOSITIONS AND METHOD FOR TREATING ACID-BASED DISORDERS |
| SG11202003451UA (en) | 2017-11-03 | 2020-05-28 | Tricida Inc | Compositions for and method of treating acid-base disorders |
| KR102771421B1 (ko) | 2018-09-25 | 2025-02-20 | 에보쿠아 워터 테크놀로지스 엘엘씨 | Uv 개시 중합을 통한 이온 교환막 |
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| US7182798B2 (en) * | 2004-07-29 | 2007-02-27 | Rohm And Haas Electronic Materials Cmp Holdings, Inc. | Polymer-coated particles for chemical mechanical polishing |
| CA2593525C (en) * | 2004-12-28 | 2011-05-10 | Renal Solutions, Inc. | Method of synthesizing zirconium phosphate particles |
| GB2446077B (en) | 2005-09-30 | 2010-10-13 | Ilypsa Inc | Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal |
| KR101367279B1 (ko) | 2007-07-11 | 2014-02-28 | 삼성전자주식회사 | 클록을 내장한 데이터 신호를 전송하는 디스플레이 장치 |
| NL2009207C2 (nl) | 2012-07-19 | 2013-05-01 | Driessen Blueberries B V | Inrichting geschikt voor het oogsten van aan een plant hangend fruit alsmede een werkwijze voor het oogsten van het oogsten van aan een plant hangend fruit. |
-
2006
- 2006-10-02 GB GB0806896A patent/GB2446077B/en not_active Expired - Fee Related
- 2006-10-02 BR BRPI0616604-0A patent/BRPI0616604A2/pt not_active IP Right Cessation
- 2006-10-02 KR KR1020087010227A patent/KR20080059265A/ko not_active Ceased
- 2006-10-02 AU AU2006299449A patent/AU2006299449B2/en not_active Ceased
- 2006-10-02 DE DE112006002618T patent/DE112006002618T5/de not_active Withdrawn
- 2006-10-02 WO PCT/US2006/038602 patent/WO2007041569A1/en not_active Ceased
- 2006-10-02 JP JP2008533776A patent/JP2009510126A/ja active Pending
- 2006-10-02 EP EP06816101A patent/EP1928476A1/en not_active Withdrawn
- 2006-10-02 CA CA2624170A patent/CA2624170C/en not_active Expired - Fee Related
- 2006-10-02 US US12/088,625 patent/US8617609B2/en not_active Expired - Fee Related
- 2006-10-02 CN CNA2006800442481A patent/CN101316601A/zh active Pending
-
2013
- 2013-05-24 US US13/901,918 patent/US20130259949A1/en not_active Abandoned
- 2013-10-15 US US14/053,725 patent/US9301974B2/en active Active
-
2016
- 2016-03-14 US US15/069,607 patent/US10058567B2/en active Active
-
2018
- 2018-01-12 US US15/869,930 patent/US10905711B2/en active Active
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