CA2624170C - Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal - Google Patents
Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal Download PDFInfo
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- CA2624170C CA2624170C CA2624170A CA2624170A CA2624170C CA 2624170 C CA2624170 C CA 2624170C CA 2624170 A CA2624170 A CA 2624170A CA 2624170 A CA2624170 A CA 2624170A CA 2624170 C CA2624170 C CA 2624170C
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- 229910001414 potassium ion Inorganic materials 0.000 title claims description 104
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 title claims description 96
- 210000001035 gastrointestinal tract Anatomy 0.000 title claims description 76
- 241000124008 Mammalia Species 0.000 title claims description 33
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- 230000027455 binding Effects 0.000 claims abstract description 294
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims abstract description 134
- 239000011591 potassium Substances 0.000 claims abstract description 132
- 229910052700 potassium Inorganic materials 0.000 claims abstract description 131
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- 208000002682 Hyperkalemia Diseases 0.000 claims abstract description 37
- 238000011282 treatment Methods 0.000 claims abstract description 29
- 150000001768 cations Chemical class 0.000 claims description 148
- 238000003556 assay Methods 0.000 claims description 141
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims description 75
- 229910001425 magnesium ion Inorganic materials 0.000 claims description 69
- 229910001868 water Inorganic materials 0.000 claims description 62
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- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 42
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- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 4
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Landscapes
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| PCT/US2006/038602 WO2007041569A1 (en) | 2005-09-30 | 2006-10-02 | Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal |
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| KR101228233B1 (ko) * | 2004-03-30 | 2013-01-31 | 리립사, 인크. | 이온 결합 중합체 및 이의 용도 |
| GB2446077B (en) | 2005-09-30 | 2010-10-13 | Ilypsa Inc | Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal |
| WO2010022381A1 (en) * | 2008-08-22 | 2010-02-25 | Relypsa, Inc. | Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties |
| ES2939021T3 (es) * | 2008-08-22 | 2023-04-18 | Vifor Int Ltd | Composiciones que comprenden polímeros reticulados de intercambio catiónico y uso en el tratamiento de la hipercalemia |
| US20100111892A1 (en) * | 2008-08-22 | 2010-05-06 | Relypsa, Inc. | Crosslinked polyfluoroacrylic acid and processes for the preparation thereof |
| AU2013204879B2 (en) * | 2008-08-22 | 2015-10-29 | Vifor (International) Ltd. | Crosslinked cation exchange polymers, compositions and use in treating hyperkalemia |
| WO2010022380A2 (en) * | 2008-08-22 | 2010-02-25 | Relypsa, Inc. | Linear polyol stabilized polyfluoroacrylate compositions |
| JP5948243B2 (ja) | 2009-08-26 | 2016-07-06 | エヴォクア ウォーター テクノロジーズ ピーティーイー リミテッド | イオン交換膜 |
| US9314523B2 (en) | 2010-09-21 | 2016-04-19 | Elwha Llc | Ingestible salt grabber |
| SG189895A1 (en) * | 2010-10-15 | 2013-06-28 | Siemens Industry Inc | Anion exchange membranes and process for making |
| EA023933B1 (ru) | 2010-10-15 | 2016-07-29 | ЭВОКУА УОТЕР ТЕКНОЛОДЖИЗ ЭлЭлСи | Способ получения катионообменной мембраны |
| CN109106725A (zh) | 2011-02-11 | 2019-01-01 | Zs制药公司 | 用于治疗高钾血症的微孔性的硅酸锆 |
| RU2618220C2 (ru) | 2011-06-27 | 2017-05-03 | Релипса, Инк. | Способ преобразования полимера сложного эфира в полимерную кислоту |
| EP2570183A1 (en) * | 2011-09-15 | 2013-03-20 | InstrAction GmbH | Sorbent comprising on its surface an aliphatic unit for the purification of organic molecules |
| US9943637B2 (en) | 2012-06-11 | 2018-04-17 | ZS Pharma, Inc. | Microporous zirconium silicate and its method of production |
| AU2013290141A1 (en) | 2012-07-11 | 2015-02-05 | Alvaro F. Guillem | Microporous zirconium silicate for the treatment of hyperkalemia in hypercalcemic patients and improved calcium-containing compositions for the treatment of hyperkalemia |
| WO2014055123A1 (en) | 2012-10-04 | 2014-04-10 | Evoqua Water Technologies Llc | High-performance anion exchange membranes and methods of making same |
| WO2014058905A2 (en) * | 2012-10-08 | 2014-04-17 | Relypsa, Inc. | Potassium-binding agents for treating hypertension and hyperkalemia |
| US9540261B2 (en) | 2012-10-11 | 2017-01-10 | Evoqua Water Technologies Llc | Coated ion exchange membranes |
| CN104797263B (zh) | 2012-10-22 | 2018-02-09 | Zs制药公司 | 用于治疗高钾血症的微孔硅酸锆 |
| US10695365B2 (en) | 2012-10-22 | 2020-06-30 | ZS Pharma, Inc. | Microporous zirconium silicate for the treatment of hyperkalemia |
| KR20210131457A (ko) | 2013-06-05 | 2021-11-02 | 트리시다, 인크. | 경구 투여를 위한 양성자-결합 중합체 |
| ES2787218T3 (es) | 2014-12-10 | 2020-10-15 | Tricida Inc | Polímeros de unión de protones para la administración oral |
| US9592253B1 (en) | 2015-10-14 | 2017-03-14 | ZS Pharma, Inc. | Extended use zirconium silicate compositions and methods of use thereof |
| CN105597699B (zh) * | 2016-01-29 | 2018-07-13 | 四川农业大学 | 一种高效吸附Cu2+的改性蚯蚓粪微球、制备方法及应用 |
| EP3452028A4 (en) | 2016-05-06 | 2020-04-15 | Tricida Inc. | COMPOSITIONS AND METHOD FOR TREATING ACID-BASED DISORDERS |
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-
2006
- 2006-10-02 GB GB0806896A patent/GB2446077B/en not_active Expired - Fee Related
- 2006-10-02 BR BRPI0616604-0A patent/BRPI0616604A2/pt not_active IP Right Cessation
- 2006-10-02 KR KR1020087010227A patent/KR20080059265A/ko not_active Ceased
- 2006-10-02 AU AU2006299449A patent/AU2006299449B2/en not_active Ceased
- 2006-10-02 DE DE112006002618T patent/DE112006002618T5/de not_active Withdrawn
- 2006-10-02 WO PCT/US2006/038602 patent/WO2007041569A1/en not_active Ceased
- 2006-10-02 JP JP2008533776A patent/JP2009510126A/ja active Pending
- 2006-10-02 EP EP06816101A patent/EP1928476A1/en not_active Withdrawn
- 2006-10-02 CA CA2624170A patent/CA2624170C/en not_active Expired - Fee Related
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2016
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2018
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| Publication number | Publication date |
|---|---|
| AU2006299449B2 (en) | 2013-07-04 |
| US10058567B2 (en) | 2018-08-28 |
| US20160193247A1 (en) | 2016-07-07 |
| WO2007041569A1 (en) | 2007-04-12 |
| KR20080059265A (ko) | 2008-06-26 |
| US20180133244A1 (en) | 2018-05-17 |
| US8617609B2 (en) | 2013-12-31 |
| GB0806896D0 (en) | 2008-05-21 |
| US20090155370A1 (en) | 2009-06-18 |
| GB2446077A (en) | 2008-07-30 |
| US20140044804A1 (en) | 2014-02-13 |
| BRPI0616604A2 (pt) | 2012-12-25 |
| CN101316601A (zh) | 2008-12-03 |
| EP1928476A1 (en) | 2008-06-11 |
| AU2006299449A1 (en) | 2007-04-12 |
| JP2009510126A (ja) | 2009-03-12 |
| US10905711B2 (en) | 2021-02-02 |
| CA2624170A1 (en) | 2007-04-12 |
| US20130259949A1 (en) | 2013-10-03 |
| US9301974B2 (en) | 2016-04-05 |
| GB2446077B (en) | 2010-10-13 |
| DE112006002618T5 (de) | 2008-08-28 |
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