JP2009510025A5 - - Google Patents
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- Publication number
- JP2009510025A5 JP2009510025A5 JP2008532788A JP2008532788A JP2009510025A5 JP 2009510025 A5 JP2009510025 A5 JP 2009510025A5 JP 2008532788 A JP2008532788 A JP 2008532788A JP 2008532788 A JP2008532788 A JP 2008532788A JP 2009510025 A5 JP2009510025 A5 JP 2009510025A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- attachment site
- amino acid
- composition
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 23
- 108010002352 Interleukin-1 Proteins 0.000 claims 17
- 102000000589 Interleukin-1 Human genes 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 7
- 229960005486 vaccine Drugs 0.000 claims 7
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 235000018102 proteins Nutrition 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 241001515965 unidentified phage Species 0.000 claims 4
- 101001033249 Homo sapiens Interleukin-1 beta Proteins 0.000 claims 3
- 102000008300 Mutant Proteins Human genes 0.000 claims 3
- 108010021466 Mutant Proteins Proteins 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 3
- 101710132601 Capsid protein Proteins 0.000 claims 2
- 101710094648 Coat protein Proteins 0.000 claims 2
- 206010016207 Familial Mediterranean fever Diseases 0.000 claims 2
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 claims 2
- 101001002634 Homo sapiens Interleukin-1 alpha Proteins 0.000 claims 2
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 2
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 2
- 101710125418 Major capsid protein Proteins 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 101710141454 Nucleoprotein Proteins 0.000 claims 2
- 101710083689 Probable capsid protein Proteins 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 241001672158 Acinetobacter phage AP205 Species 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 101001033286 Mus musculus Interleukin-1 beta Proteins 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 208000019069 chronic childhood arthritis Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72110605P | 2005-09-28 | 2005-09-28 | |
| US60/721,106 | 2005-09-28 | ||
| PCT/EP2006/066866 WO2007039552A1 (en) | 2005-09-28 | 2006-09-28 | Interleukin-1 conjugates and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009510025A JP2009510025A (ja) | 2009-03-12 |
| JP2009510025A5 true JP2009510025A5 (enExample) | 2009-11-05 |
| JP5312028B2 JP5312028B2 (ja) | 2013-10-09 |
Family
ID=37497973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008532788A Expired - Fee Related JP5312028B2 (ja) | 2005-09-28 | 2006-09-28 | インターロイキン−１コンジュゲート及びその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20110027220A1 (enExample) |
| EP (2) | EP2431468A1 (enExample) |
| JP (1) | JP5312028B2 (enExample) |
| KR (1) | KR20080047564A (enExample) |
| CN (2) | CN101267834B (enExample) |
| AU (1) | AU2006298767B2 (enExample) |
| BR (1) | BRPI0616446A2 (enExample) |
| CA (1) | CA2623287A1 (enExample) |
| IL (1) | IL189245A0 (enExample) |
| NZ (1) | NZ566971A (enExample) |
| RU (1) | RU2441067C2 (enExample) |
| WO (1) | WO2007039552A1 (enExample) |
| ZA (1) | ZA200802225B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE447967T1 (de) | 2001-09-14 | 2009-11-15 | Cytos Biotechnology Ag | Verpackung von immunstimulierendem cpg in virusähnlichen partikeln: herstellungsverfahren und verwendung |
| CN109187944A (zh) | 2005-08-02 | 2019-01-11 | 埃克斯生物科技公司 | 使用IL-1α自身抗体诊断、治疗和预防血管疾病 |
| AU2007251239B2 (en) * | 2006-05-15 | 2013-08-22 | Xbiotech Inc. | IL-1alpha immunization induces autoantibodies protective against atherosclerosis |
| US20110008282A1 (en) * | 2006-05-15 | 2011-01-13 | Xbiotech, Inc. | IL-1alpha immunization induces autoantibodies protective against atherosclerosis |
| NZ573622A (en) | 2006-06-12 | 2011-12-22 | Cytos Biotechnology Ag | Processes for packaging oligonucleotides into virus-like particles of rna bacteriophages |
| WO2008071774A1 (en) * | 2006-12-14 | 2008-06-19 | Cytos Biotechnology Ag | Purification process for coat protein of rna bacteriophages |
| WO2009040361A1 (en) * | 2007-09-25 | 2009-04-02 | Intervet International B.V. | Vaccine for the treatment of osteoarthritis |
| AU2009221114A1 (en) * | 2008-03-05 | 2009-09-11 | Cytos Biotechnology Ag | Use of interleukin-1 conjugates in the treatment of diabetes |
| CN105467136B (zh) | 2008-05-30 | 2018-02-16 | 埃克斯生物科技公司 | 白细胞介素‑1α抗体及使用方法 |
| WO2010030979A2 (en) | 2008-09-12 | 2010-03-18 | Xbiotech, Inc. | Targeting pathogenic monocytes |
| PL222496B1 (pl) * | 2009-04-10 | 2016-08-31 | Inst Biochemii I Biofizyki Pan | Wektorowa cząsteczka wirusopodobna, sposób jej wytwarzania oraz kompozycja farmaceutyczna zawierająca wektorową cząsteczkę wirusopodobną |
| US8993715B2 (en) * | 2009-07-06 | 2015-03-31 | Canon Kabushiki Kaisha | Labeled protein and method for obtaining the same |
| US20130115189A1 (en) * | 2009-09-10 | 2013-05-09 | Cytos Biotechnology Ag | Use of Interleukin-1 Beta Mutein Conjugates in the Treatment of Diabetes |
| JP6324720B2 (ja) | 2010-06-18 | 2018-05-16 | エックスバイオテク, インコーポレイテッドXbiotech, Inc. | 関節炎治療 |
| KR102748255B1 (ko) | 2010-08-23 | 2024-12-31 | 엑스바이오테크 인코포레이티드 | 종양성 질병들에 대한 치료 |
| US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
| JP6204915B2 (ja) | 2011-09-23 | 2017-09-27 | エックスバイオテク, インコーポレイテッドXbiotech, Inc. | 悪液質治療 |
| SG11201404991YA (en) | 2012-02-23 | 2014-09-26 | Stage Cell Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| US9545441B2 (en) | 2012-09-18 | 2017-01-17 | Xbiotech, Inc. | Treatment of diabetes |
| GB201300684D0 (en) | 2013-01-15 | 2013-02-27 | Apitope Int Nv | Peptide |
| US11168306B2 (en) | 2014-02-25 | 2021-11-09 | The Regents Of The University Of California | Phage wrapping |
| WO2016112921A1 (en) | 2015-01-15 | 2016-07-21 | University Of Copenhagen | Virus-like particle with efficient epitope display |
| MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
| MA45488A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
| KR20180108567A (ko) * | 2015-10-22 | 2018-10-04 | 주노 테라퓨틱스 게엠베하 | 형질도입을 위한 방법, 키트, 제제 및 장치 |
| WO2017071713A1 (en) | 2015-10-30 | 2017-05-04 | University Of Copenhagen | Virus like particle with efficient epitope display |
| KR20190117579A (ko) | 2017-02-16 | 2019-10-16 | 엑스바이오테크, 인크. | 화농성 한선염의 치료 |
| IL270142B2 (en) | 2017-04-27 | 2025-05-01 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
| EP3752194A4 (en) | 2018-02-13 | 2022-03-16 | Checkmate Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS FOR TUMOR IMMUNOTHERAPY |
| EP3775218A1 (en) | 2018-04-09 | 2021-02-17 | Checkmate Pharmaceuticals | Packaging oligonucleotides into virus-like particles |
| EP3845556A1 (fr) * | 2019-12-31 | 2021-07-07 | Peptinov SAS | Conjugue immunogene destine a induire une reponse immunitaire dirigee contre l interleukine-6 |
| CN115768787A (zh) * | 2020-05-22 | 2023-03-07 | 阿法姆海外股份有限公司 | IL1-R1衍生的IL-1β抑制剂及其用途 |
| WO2023283638A1 (en) * | 2021-07-08 | 2023-01-12 | Orionis Biosciences, Inc. | Interleukin-1 alpha chimeric protein |
| US20250281585A1 (en) | 2024-03-06 | 2025-09-11 | Elanco Us Inc. | Veterinary compositions of modified virus-like particles of cmv and il-1 beta mutein antigens |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5374426A (en) | 1986-09-03 | 1994-12-20 | University Of Saskatchewan | Rotavirus nucleocapsid protein VP6 in vaccine compositions |
| DE69032251T2 (de) | 1989-02-27 | 1998-08-13 | Massachusetts Institute Of Technology, Cambridge, Mass. | Il-1, dessen biologische aktivität inhibiert ist |
| JPH06503821A (ja) | 1990-12-20 | 1994-04-28 | スミスクライン・ビーチャム・バイオロジカルス（ソシエテ・アノニム） | Ｂ型肝炎表面抗原に基づくワクチン |
| GB9101550D0 (en) | 1991-01-24 | 1991-03-06 | Mastico Robert A | Antigen-presenting chimaeric protein |
| FR2677654B1 (fr) | 1991-06-17 | 1995-11-17 | Pasteur Merieux Serums Vacc | Composes a effet immunogene anti-cytokine, a effet immunogene anticytostatique ou a effet vaccinal anti-infection a hiv. |
| GB9114003D0 (en) | 1991-06-28 | 1991-08-14 | Mastico Robert A | Chimaeric protein |
| AU700819B2 (en) * | 1994-10-07 | 1999-01-14 | Chugai Seiyaku Kabushiki Kaisha | Rheumatoid arthritis remedy containing IL-6 antagonist as effective component |
| EP0817854A2 (en) | 1995-03-31 | 1998-01-14 | Wolf, Hans, Prof. Dr. | Antigen presentation system based on retrovirus-like particles |
| GB9621091D0 (en) | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
| AU770802B2 (en) * | 1998-10-21 | 2004-03-04 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Virus-like particles for the induction of autoantibodies |
| ES2317711T3 (es) | 1998-11-30 | 2009-04-16 | Cytos Biotechnology Ag | Presentacion molecular de alergenos, metodos de preparacion y uso. |
| EP1196193B1 (en) | 1999-12-03 | 2008-11-05 | Celltech Chiroscience Limited | Interleukin-1 mutein useful as vaccine adjuvant |
| DE10004232A1 (de) | 2000-02-01 | 2001-08-02 | Megamat Gmbh Buero Und Lagerte | Antriebseinrichtung für eine Lagervorrichtung |
| US6843987B2 (en) * | 2000-02-02 | 2005-01-18 | Schering Corporation | Mammalian cytokines; receptors; related reagents and methods |
| AU2001252458A1 (en) | 2000-05-05 | 2001-11-20 | Martin Bachmann | Molecular antigen arrays and vaccines |
| US7320793B2 (en) | 2001-01-19 | 2008-01-22 | Cytos Biotechnology Ag | Molecular antigen array |
| ATE447967T1 (de) | 2001-09-14 | 2009-11-15 | Cytos Biotechnology Ag | Verpackung von immunstimulierendem cpg in virusähnlichen partikeln: herstellungsverfahren und verwendung |
| AU2002362696B2 (en) * | 2001-10-05 | 2008-05-29 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| JP4533626B2 (ja) * | 2001-11-07 | 2010-09-01 | サイトス バイオテクノロジー アーゲー | アレルギー性好酸球性疾患を治療するための抗原アレイ |
| JP4658475B2 (ja) * | 2001-11-07 | 2011-03-23 | サイトス バイオテクノロジー アーゲー | 骨疾患治療用の抗原アレイ |
| PL369863A1 (en) * | 2001-11-07 | 2005-05-02 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| FR2838444B1 (fr) | 2002-04-10 | 2016-01-01 | Neovacs | Nouveaux peptides et leur application en therapeutique |
| RU2324704C2 (ru) * | 2002-07-17 | 2008-05-20 | Цитос Байотекнолоджи Аг | Молекулярные массивы антигенов |
| EP2392345A3 (en) * | 2002-07-18 | 2012-03-07 | Cytos Biotechnology AG | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| WO2004009124A2 (en) | 2002-07-19 | 2004-01-29 | Cytos Biotechnology Ag | Ghrelin-carrier conjugates |
| WO2005068639A2 (en) * | 2004-01-20 | 2005-07-28 | Cytos Biotechnology Ag | Particle-induced ghrelin immune response |
| BRPI0516953A (pt) | 2004-09-21 | 2008-09-30 | Cytos Biotechnology Ag | partìculas do tipo vìrus compreendendo uma proteìna de fusão da proteìna de revestimento de ap205 e um polipeptìdeo antigênico |
| AU2005291231B2 (en) | 2004-10-05 | 2010-12-23 | Cytos Biotechnology Ag | VLP-antigen conjugates and their uses as vaccines |
-
2006
- 2006-09-28 KR KR1020087006840A patent/KR20080047564A/ko not_active Withdrawn
- 2006-09-28 EP EP11175319A patent/EP2431468A1/en not_active Withdrawn
- 2006-09-28 EP EP06793894A patent/EP1931383A1/en not_active Withdrawn
- 2006-09-28 RU RU2008116323/10A patent/RU2441067C2/ru not_active IP Right Cessation
- 2006-09-28 JP JP2008532788A patent/JP5312028B2/ja not_active Expired - Fee Related
- 2006-09-28 AU AU2006298767A patent/AU2006298767B2/en not_active Ceased
- 2006-09-28 BR BRPI0616446-3A patent/BRPI0616446A2/pt not_active IP Right Cessation
- 2006-09-28 ZA ZA200802225A patent/ZA200802225B/xx unknown
- 2006-09-28 WO PCT/EP2006/066866 patent/WO2007039552A1/en not_active Ceased
- 2006-09-28 CA CA002623287A patent/CA2623287A1/en not_active Abandoned
- 2006-09-28 NZ NZ566971A patent/NZ566971A/en not_active IP Right Cessation
- 2006-09-28 CN CN2006800343698A patent/CN101267834B/zh not_active Expired - Fee Related
- 2006-09-28 CN CN2013101441929A patent/CN103230590A/zh active Pending
- 2006-09-28 US US11/992,731 patent/US20110027220A1/en not_active Abandoned
-
2007
- 2007-03-29 US US12/443,344 patent/US8449874B2/en not_active Expired - Fee Related
-
2008
- 2008-02-04 IL IL189245A patent/IL189245A0/en unknown
-
2012
- 2012-08-01 US US13/564,576 patent/US20130230484A1/en not_active Abandoned
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