CN101267834B - 白介素-1偶联物及其用途 - Google Patents

白介素-1偶联物及其用途 Download PDF

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CN101267834B
CN101267834B CN2006800343698A CN200680034369A CN101267834B CN 101267834 B CN101267834 B CN 101267834B CN 2006800343698 A CN2006800343698 A CN 2006800343698A CN 200680034369 A CN200680034369 A CN 200680034369A CN 101267834 B CN101267834 B CN 101267834B
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CN101267834A (zh
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M·巴克曼
G·斯庞
A·蒂索特
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Cytos Biotechnology AG
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CN2006800343698A 2005-09-28 2006-09-28 白介素-1偶联物及其用途 Expired - Fee Related CN101267834B (zh)

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US72110605P 2005-09-28 2005-09-28
US60/721,106 2005-09-28
PCT/EP2006/066866 WO2007039552A1 (en) 2005-09-28 2006-09-28 Interleukin-1 conjugates and uses thereof

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CN101267834B true CN101267834B (zh) 2013-06-05

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EP (2) EP2431468A1 (enExample)
JP (1) JP5312028B2 (enExample)
KR (1) KR20080047564A (enExample)
CN (2) CN101267834B (enExample)
AU (1) AU2006298767B2 (enExample)
BR (1) BRPI0616446A2 (enExample)
CA (1) CA2623287A1 (enExample)
IL (1) IL189245A0 (enExample)
NZ (1) NZ566971A (enExample)
RU (1) RU2441067C2 (enExample)
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Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE447967T1 (de) 2001-09-14 2009-11-15 Cytos Biotechnology Ag Verpackung von immunstimulierendem cpg in virusähnlichen partikeln: herstellungsverfahren und verwendung
CN109187944A (zh) 2005-08-02 2019-01-11 埃克斯生物科技公司 使用IL-1α自身抗体诊断、治疗和预防血管疾病
AU2007251239B2 (en) * 2006-05-15 2013-08-22 Xbiotech Inc. IL-1alpha immunization induces autoantibodies protective against atherosclerosis
US20110008282A1 (en) * 2006-05-15 2011-01-13 Xbiotech, Inc. IL-1alpha immunization induces autoantibodies protective against atherosclerosis
NZ573622A (en) 2006-06-12 2011-12-22 Cytos Biotechnology Ag Processes for packaging oligonucleotides into virus-like particles of rna bacteriophages
WO2008071774A1 (en) * 2006-12-14 2008-06-19 Cytos Biotechnology Ag Purification process for coat protein of rna bacteriophages
WO2009040361A1 (en) * 2007-09-25 2009-04-02 Intervet International B.V. Vaccine for the treatment of osteoarthritis
AU2009221114A1 (en) * 2008-03-05 2009-09-11 Cytos Biotechnology Ag Use of interleukin-1 conjugates in the treatment of diabetes
CN105467136B (zh) 2008-05-30 2018-02-16 埃克斯生物科技公司 白细胞介素‑1α抗体及使用方法
WO2010030979A2 (en) 2008-09-12 2010-03-18 Xbiotech, Inc. Targeting pathogenic monocytes
PL222496B1 (pl) * 2009-04-10 2016-08-31 Inst Biochemii I Biofizyki Pan Wektorowa cząsteczka wirusopodobna, sposób jej wytwarzania oraz kompozycja farmaceutyczna zawierająca wektorową cząsteczkę wirusopodobną
US8993715B2 (en) * 2009-07-06 2015-03-31 Canon Kabushiki Kaisha Labeled protein and method for obtaining the same
US20130115189A1 (en) * 2009-09-10 2013-05-09 Cytos Biotechnology Ag Use of Interleukin-1 Beta Mutein Conjugates in the Treatment of Diabetes
JP6324720B2 (ja) 2010-06-18 2018-05-16 エックスバイオテク, インコーポレイテッドXbiotech, Inc. 関節炎治療
KR102748255B1 (ko) 2010-08-23 2024-12-31 엑스바이오테크 인코포레이티드 종양성 질병들에 대한 치료
US9724409B2 (en) 2011-04-01 2017-08-08 Xbiotech, Inc. Treatment of inflammatory skin disease
JP6204915B2 (ja) 2011-09-23 2017-09-27 エックスバイオテク, インコーポレイテッドXbiotech, Inc. 悪液質治療
SG11201404991YA (en) 2012-02-23 2014-09-26 Stage Cell Therapeutics Gmbh Chromatographic isolation of cells and other complex biological materials
US9545441B2 (en) 2012-09-18 2017-01-17 Xbiotech, Inc. Treatment of diabetes
GB201300684D0 (en) 2013-01-15 2013-02-27 Apitope Int Nv Peptide
US11168306B2 (en) 2014-02-25 2021-11-09 The Regents Of The University Of California Phage wrapping
WO2016112921A1 (en) 2015-01-15 2016-07-21 University Of Copenhagen Virus-like particle with efficient epitope display
MA45489A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés de culture de cellules, kits et appareil associés
MA45488A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés, kits et appareil de culture de cellules
KR20180108567A (ko) * 2015-10-22 2018-10-04 주노 테라퓨틱스 게엠베하 형질도입을 위한 방법, 키트, 제제 및 장치
WO2017071713A1 (en) 2015-10-30 2017-05-04 University Of Copenhagen Virus like particle with efficient epitope display
KR20190117579A (ko) 2017-02-16 2019-10-16 엑스바이오테크, 인크. 화농성 한선염의 치료
IL270142B2 (en) 2017-04-27 2025-05-01 Juno Therapeutics Gmbh Oligomeric particle reagents and methods of use thereof
EP3752194A4 (en) 2018-02-13 2022-03-16 Checkmate Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR TUMOR IMMUNOTHERAPY
EP3775218A1 (en) 2018-04-09 2021-02-17 Checkmate Pharmaceuticals Packaging oligonucleotides into virus-like particles
EP3845556A1 (fr) * 2019-12-31 2021-07-07 Peptinov SAS Conjugue immunogene destine a induire une reponse immunitaire dirigee contre l interleukine-6
CN115768787A (zh) * 2020-05-22 2023-03-07 阿法姆海外股份有限公司 IL1-R1衍生的IL-1β抑制剂及其用途
WO2023283638A1 (en) * 2021-07-08 2023-01-12 Orionis Biosciences, Inc. Interleukin-1 alpha chimeric protein
US20250281585A1 (en) 2024-03-06 2025-09-11 Elanco Us Inc. Veterinary compositions of modified virus-like particles of cmv and il-1 beta mutein antigens

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1668637A (zh) * 2002-07-17 2005-09-14 希托斯生物技术股份公司 使用衍生自ap205外壳蛋白的病毒样颗粒的分子抗原阵列

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374426A (en) 1986-09-03 1994-12-20 University Of Saskatchewan Rotavirus nucleocapsid protein VP6 in vaccine compositions
DE69032251T2 (de) 1989-02-27 1998-08-13 Massachusetts Institute Of Technology, Cambridge, Mass. Il-1, dessen biologische aktivität inhibiert ist
JPH06503821A (ja) 1990-12-20 1994-04-28 スミスクライン・ビーチャム・バイオロジカルス（ソシエテ・アノニム） Ｂ型肝炎表面抗原に基づくワクチン
GB9101550D0 (en) 1991-01-24 1991-03-06 Mastico Robert A Antigen-presenting chimaeric protein
FR2677654B1 (fr) 1991-06-17 1995-11-17 Pasteur Merieux Serums Vacc Composes a effet immunogene anti-cytokine, a effet immunogene anticytostatique ou a effet vaccinal anti-infection a hiv.
GB9114003D0 (en) 1991-06-28 1991-08-14 Mastico Robert A Chimaeric protein
AU700819B2 (en) * 1994-10-07 1999-01-14 Chugai Seiyaku Kabushiki Kaisha Rheumatoid arthritis remedy containing IL-6 antagonist as effective component
EP0817854A2 (en) 1995-03-31 1998-01-14 Wolf, Hans, Prof. Dr. Antigen presentation system based on retrovirus-like particles
GB9621091D0 (en) 1996-10-09 1996-11-27 Fondation Pour Le Perfectionem Attenuated microorganisms strains and their uses
AU770802B2 (en) * 1998-10-21 2004-03-04 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Virus-like particles for the induction of autoantibodies
ES2317711T3 (es) 1998-11-30 2009-04-16 Cytos Biotechnology Ag Presentacion molecular de alergenos, metodos de preparacion y uso.
EP1196193B1 (en) 1999-12-03 2008-11-05 Celltech Chiroscience Limited Interleukin-1 mutein useful as vaccine adjuvant
DE10004232A1 (de) 2000-02-01 2001-08-02 Megamat Gmbh Buero Und Lagerte Antriebseinrichtung für eine Lagervorrichtung
US6843987B2 (en) * 2000-02-02 2005-01-18 Schering Corporation Mammalian cytokines; receptors; related reagents and methods
AU2001252458A1 (en) 2000-05-05 2001-11-20 Martin Bachmann Molecular antigen arrays and vaccines
US7320793B2 (en) 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
ATE447967T1 (de) 2001-09-14 2009-11-15 Cytos Biotechnology Ag Verpackung von immunstimulierendem cpg in virusähnlichen partikeln: herstellungsverfahren und verwendung
AU2002362696B2 (en) * 2001-10-05 2008-05-29 Cytos Biotechnology Ag Angiotensin peptide-carrier conjugates and uses thereof
JP4533626B2 (ja) * 2001-11-07 2010-09-01 サイトス バイオテクノロジー アーゲー アレルギー性好酸球性疾患を治療するための抗原アレイ
JP4658475B2 (ja) * 2001-11-07 2011-03-23 サイトス バイオテクノロジー アーゲー 骨疾患治療用の抗原アレイ
PL369863A1 (en) * 2001-11-07 2005-05-02 Cytos Biotechnology Ag Antigen arrays for treatment of allergic eosinophilic diseases
FR2838444B1 (fr) 2002-04-10 2016-01-01 Neovacs Nouveaux peptides et leur application en therapeutique
EP2392345A3 (en) * 2002-07-18 2012-03-07 Cytos Biotechnology AG Hapten-carrier conjugates comprising virus like particles and uses thereof
WO2004009124A2 (en) 2002-07-19 2004-01-29 Cytos Biotechnology Ag Ghrelin-carrier conjugates
WO2005068639A2 (en) * 2004-01-20 2005-07-28 Cytos Biotechnology Ag Particle-induced ghrelin immune response
BRPI0516953A (pt) 2004-09-21 2008-09-30 Cytos Biotechnology Ag partìculas do tipo vìrus compreendendo uma proteìna de fusão da proteìna de revestimento de ap205 e um polipeptìdeo antigênico
AU2005291231B2 (en) 2004-10-05 2010-12-23 Cytos Biotechnology Ag VLP-antigen conjugates and their uses as vaccines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1668637A (zh) * 2002-07-17 2005-09-14 希托斯生物技术股份公司 使用衍生自ap205外壳蛋白的病毒样颗粒的分子抗原阵列

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Dinarello CA,et al.《白介素1在疾病中的应用》.《国际骨科学杂志》.1993,第14卷(第3期),141-144. *

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CA2623287A1 (en) 2007-04-12
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