JP2009507846A5 - - Google Patents
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- JP2009507846A5 JP2009507846A5 JP2008530176A JP2008530176A JP2009507846A5 JP 2009507846 A5 JP2009507846 A5 JP 2009507846A5 JP 2008530176 A JP2008530176 A JP 2008530176A JP 2008530176 A JP2008530176 A JP 2008530176A JP 2009507846 A5 JP2009507846 A5 JP 2009507846A5
- Authority
- JP
- Japan
- Prior art keywords
- fluoro
- substituted
- group
- optionally
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000217 alkyl group Chemical group 0.000 claims 267
- 125000001424 substituent group Chemical group 0.000 claims 204
- 125000003545 alkoxy group Chemical group 0.000 claims 193
- 125000004414 alkyl thio group Chemical group 0.000 claims 185
- 125000003342 alkenyl group Chemical group 0.000 claims 156
- 125000001153 fluoro group Chemical group F* 0.000 claims 155
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 122
- 125000000304 alkynyl group Chemical group 0.000 claims 121
- 125000000753 cycloalkyl group Chemical group 0.000 claims 120
- 125000003118 aryl group Chemical group 0.000 claims 119
- 125000001072 heteroaryl group Chemical group 0.000 claims 101
- 229910052799 carbon Inorganic materials 0.000 claims 100
- 229910052736 halogen Inorganic materials 0.000 claims 72
- 150000002367 halogens Chemical class 0.000 claims 72
- 150000001875 compounds Chemical class 0.000 claims 71
- 229910052739 hydrogen Inorganic materials 0.000 claims 70
- 239000001257 hydrogen Substances 0.000 claims 70
- 125000006578 monocyclic heterocycloalkyl group Chemical group 0.000 claims 59
- 150000002431 hydrogen Chemical class 0.000 claims 51
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 47
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 47
- -1 alkynyl carbon Chemical compound 0.000 claims 30
- 229910052717 sulfur Inorganic materials 0.000 claims 29
- 150000001336 alkenes Chemical class 0.000 claims 22
- 150000001345 alkine derivatives Chemical class 0.000 claims 22
- 229910052757 nitrogen Inorganic materials 0.000 claims 21
- 229910052760 oxygen Inorganic materials 0.000 claims 19
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 18
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 17
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 13
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 125000000732 arylene group Chemical group 0.000 claims 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 3
- 125000005549 heteroarylene group Chemical group 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 claims 2
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- IHJHHCVJCWPZSS-UHFFFAOYSA-N 2-[3-(2-methoxyethoxy)-5-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonylphenyl]acetic acid Chemical compound COCCOC1=CC(CC(O)=O)=CC(S(=O)(=O)C=2C=CC(OC=3C=CC(OC(F)(F)F)=CC=3)=CC=2)=C1 IHJHHCVJCWPZSS-UHFFFAOYSA-N 0.000 claims 1
- CEKHZFHIHJERHQ-UHFFFAOYSA-N 2-[3-(2-methoxyethoxy)-5-[4-[4-(trifluoromethyl)phenoxy]phenyl]sulfonylphenyl]acetic acid Chemical compound COCCOC1=CC(CC(O)=O)=CC(S(=O)(=O)C=2C=CC(OC=3C=CC(=CC=3)C(F)(F)F)=CC=2)=C1 CEKHZFHIHJERHQ-UHFFFAOYSA-N 0.000 claims 1
- GQDMBZOZBCUGQK-UHFFFAOYSA-N 2-[3-butoxy-5-(3-methoxyphenyl)sulfonylphenyl]acetic acid Chemical compound CCCCOC1=CC(CC(O)=O)=CC(S(=O)(=O)C=2C=C(OC)C=CC=2)=C1 GQDMBZOZBCUGQK-UHFFFAOYSA-N 0.000 claims 1
- WTELPLYTCOFJFY-UHFFFAOYSA-N 2-[3-butoxy-5-(4-methoxyphenyl)sulfonylphenyl]acetic acid Chemical compound CCCCOC1=CC(CC(O)=O)=CC(S(=O)(=O)C=2C=CC(OC)=CC=2)=C1 WTELPLYTCOFJFY-UHFFFAOYSA-N 0.000 claims 1
- MRSHRGKNKISYBA-UHFFFAOYSA-N 2-[3-butoxy-5-[4-(trifluoromethoxy)phenyl]sulfonylphenyl]acetic acid Chemical compound CCCCOC1=CC(CC(O)=O)=CC(S(=O)(=O)C=2C=CC(OC(F)(F)F)=CC=2)=C1 MRSHRGKNKISYBA-UHFFFAOYSA-N 0.000 claims 1
- IJOLUFWMGKWNPI-UHFFFAOYSA-N 2-[3-butoxy-5-[4-(trifluoromethyl)phenyl]sulfonylphenyl]acetic acid Chemical compound CCCCOC1=CC(CC(O)=O)=CC(S(=O)(=O)C=2C=CC(=CC=2)C(F)(F)F)=C1 IJOLUFWMGKWNPI-UHFFFAOYSA-N 0.000 claims 1
- BQAWBJUQGUXEQK-UHFFFAOYSA-N 2-[3-butoxy-5-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonylphenyl]acetic acid Chemical compound CCCCOC1=CC(CC(O)=O)=CC(S(=O)(=O)C=2C=CC(OC=3C=CC(OC(F)(F)F)=CC=3)=CC=2)=C1 BQAWBJUQGUXEQK-UHFFFAOYSA-N 0.000 claims 1
- HWWVMIYSYZMXEK-UHFFFAOYSA-N 2-[3-butoxy-5-[4-[4-(trifluoromethyl)phenoxy]phenyl]sulfonylphenyl]acetic acid Chemical compound CCCCOC1=CC(CC(O)=O)=CC(S(=O)(=O)C=2C=CC(OC=3C=CC(=CC=3)C(F)(F)F)=CC=2)=C1 HWWVMIYSYZMXEK-UHFFFAOYSA-N 0.000 claims 1
- GFTGSSOVYIDTQX-UHFFFAOYSA-N 2-[3-ethoxy-5-[3-[4-(trifluoromethoxy)phenyl]phenyl]sulfonylphenyl]acetic acid Chemical compound CCOC1=CC(CC(O)=O)=CC(S(=O)(=O)C=2C=C(C=CC=2)C=2C=CC(OC(F)(F)F)=CC=2)=C1 GFTGSSOVYIDTQX-UHFFFAOYSA-N 0.000 claims 1
- JKCQLPOSPFIXDP-UHFFFAOYSA-N 2-[3-ethoxy-5-[3-[4-(trifluoromethyl)phenyl]phenyl]sulfonylphenyl]acetic acid Chemical compound CCOC1=CC(CC(O)=O)=CC(S(=O)(=O)C=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)=C1 JKCQLPOSPFIXDP-UHFFFAOYSA-N 0.000 claims 1
- ZRFIFPKHFSIRSB-UHFFFAOYSA-N 2-[3-ethoxy-5-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonylphenyl]acetic acid Chemical compound CCOC1=CC(CC(O)=O)=CC(S(=O)(=O)C=2C=CC(OC=3C=CC(OC(F)(F)F)=CC=3)=CC=2)=C1 ZRFIFPKHFSIRSB-UHFFFAOYSA-N 0.000 claims 1
- XOJKBKULRZPPPY-UHFFFAOYSA-N 2-[3-ethoxy-5-[4-[4-(trifluoromethyl)phenoxy]phenyl]sulfonylphenyl]acetic acid Chemical compound CCOC1=CC(CC(O)=O)=CC(S(=O)(=O)C=2C=CC(OC=3C=CC(=CC=3)C(F)(F)F)=CC=2)=C1 XOJKBKULRZPPPY-UHFFFAOYSA-N 0.000 claims 1
- BAARUDNIARHAJS-UHFFFAOYSA-N 2-[3-methoxy-5-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonylphenyl]acetic acid Chemical compound COC1=CC(CC(O)=O)=CC(S(=O)(=O)C=2C=CC(OC=3C=CC(OC(F)(F)F)=CC=3)=CC=2)=C1 BAARUDNIARHAJS-UHFFFAOYSA-N 0.000 claims 1
- HMQOFLFXBQSSIO-UHFFFAOYSA-N 2-[3-methoxy-5-[4-[4-(trifluoromethyl)phenoxy]phenyl]sulfonylphenyl]acetic acid Chemical compound COC1=CC(CC(O)=O)=CC(S(=O)(=O)C=2C=CC(OC=3C=CC(=CC=3)C(F)(F)F)=CC=2)=C1 HMQOFLFXBQSSIO-UHFFFAOYSA-N 0.000 claims 1
- FUSQDOIFQZHNPK-UHFFFAOYSA-N 2-[3-phenylmethoxy-5-[4-[4-(trifluoromethyl)phenoxy]phenyl]sulfonylphenyl]acetic acid Chemical compound C=1C(S(=O)(=O)C=2C=CC(OC=3C=CC(=CC=3)C(F)(F)F)=CC=2)=CC(CC(=O)O)=CC=1OCC1=CC=CC=C1 FUSQDOIFQZHNPK-UHFFFAOYSA-N 0.000 claims 1
- YDUHFCTYFILBMK-UHFFFAOYSA-N 2-[3-propoxy-5-[3-[4-(trifluoromethyl)phenoxy]phenyl]sulfonylphenyl]acetic acid Chemical compound CCCOC1=CC(CC(O)=O)=CC(S(=O)(=O)C=2C=C(OC=3C=CC(=CC=3)C(F)(F)F)C=CC=2)=C1 YDUHFCTYFILBMK-UHFFFAOYSA-N 0.000 claims 1
- ASJOVILUAIGECY-UHFFFAOYSA-N 2-[3-propoxy-5-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonylphenyl]acetic acid Chemical compound CCCOC1=CC(CC(O)=O)=CC(S(=O)(=O)C=2C=CC(OC=3C=CC(OC(F)(F)F)=CC=3)=CC=2)=C1 ASJOVILUAIGECY-UHFFFAOYSA-N 0.000 claims 1
- WHGZCAWAMSJCBT-UHFFFAOYSA-N 3-[3-ethoxy-5-[4-[4-(trifluoromethyl)phenoxy]phenyl]sulfonylphenyl]propanoic acid Chemical compound CCOC1=CC(CCC(O)=O)=CC(S(=O)(=O)C=2C=CC(OC=3C=CC(=CC=3)C(F)(F)F)=CC=2)=C1 WHGZCAWAMSJCBT-UHFFFAOYSA-N 0.000 claims 1
- AFSOYHDWYCTBQG-UHFFFAOYSA-N 3-[3-propoxy-5-[4-[4-(trifluoromethyl)phenoxy]phenyl]sulfonylphenyl]propanoic acid Chemical compound CCCOC1=CC(CCC(O)=O)=CC(S(=O)(=O)C=2C=CC(OC=3C=CC(=CC=3)C(F)(F)F)=CC=2)=C1 AFSOYHDWYCTBQG-UHFFFAOYSA-N 0.000 claims 1
- TVEXGJYMHHTVKP-UHFFFAOYSA-N 6-oxabicyclo[3.2.1]oct-3-en-7-one Chemical compound C1C2C(=O)OC1C=CC2 TVEXGJYMHHTVKP-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000000103 Anorexia Nervosa Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 208000032841 Bulimia Diseases 0.000 claims 1
- 206010006550 Bulimia nervosa Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 206010007749 Cataract diabetic Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000026372 Congenital cystic kidney disease Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000026292 Cystic Kidney disease Diseases 0.000 claims 1
- 208000002249 Diabetes Complications Diseases 0.000 claims 1
- 206010012655 Diabetic complications Diseases 0.000 claims 1
- 208000008960 Diabetic foot Diseases 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
- 208000002705 Glucose Intolerance Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 208000001204 Hashimoto Disease Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 206010019375 Helicobacter infections Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 206010060378 Hyperinsulinaemia Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000000693 Neurogenic Urinary Bladder Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010061876 Obstruction Diseases 0.000 claims 1
- 206010033307 Overweight Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000034038 Pathologic Neovascularization Diseases 0.000 claims 1
- 241000721454 Pemphigus Species 0.000 claims 1
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 206010047642 Vitiligo Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 208000002552 acute disseminated encephalomyelitis Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 201000001981 dermatomyositis Diseases 0.000 claims 1
- 201000007025 diabetic cataract Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000003451 hyperinsulinaemic effect Effects 0.000 claims 1
- 201000008980 hyperinsulinism Diseases 0.000 claims 1
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 201000001881 impotence Diseases 0.000 claims 1
- 201000008319 inclusion body myositis Diseases 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000000509 infertility Diseases 0.000 claims 1
- 230000036512 infertility Effects 0.000 claims 1
- 231100000535 infertility Toxicity 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 210000002429 large intestine Anatomy 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- VEKBGZJJJKZNBI-UHFFFAOYSA-N methyl 2-[3-ethoxy-5-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonylphenyl]acetate Chemical compound CCOC1=CC(CC(=O)OC)=CC(S(=O)(=O)C=2C=CC(OC=3C=CC(OC(F)(F)F)=CC=3)=CC=2)=C1 VEKBGZJJJKZNBI-UHFFFAOYSA-N 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 201000008383 nephritis Diseases 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 230000002981 neuropathic effect Effects 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 claims 1
- 208000005987 polymyositis Diseases 0.000 claims 1
- 201000009104 prediabetes syndrome Diseases 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71521405P | 2005-09-07 | 2005-09-07 | |
| US78938706P | 2006-04-05 | 2006-04-05 | |
| PCT/US2006/034764 WO2007030567A2 (en) | 2005-09-07 | 2006-09-06 | Pparactive compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009507846A JP2009507846A (ja) | 2009-02-26 |
| JP2009507846A5 true JP2009507846A5 (https=) | 2009-11-05 |
Family
ID=37831846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008530176A Pending JP2009507846A (ja) | 2005-09-07 | 2006-09-06 | Ｐｐａｒ活性化合物 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20080249137A1 (https=) |
| EP (1) | EP1940767A2 (https=) |
| JP (1) | JP2009507846A (https=) |
| KR (1) | KR20080042170A (https=) |
| AR (1) | AR057800A1 (https=) |
| AU (1) | AU2006287521A1 (https=) |
| BR (1) | BRPI0615948A2 (https=) |
| CA (1) | CA2621406A1 (https=) |
| CR (1) | CR9869A (https=) |
| EC (1) | ECSP088254A (https=) |
| GT (1) | GT200600407A (https=) |
| IL (1) | IL189775A0 (https=) |
| NO (1) | NO20081042L (https=) |
| PE (1) | PE20071185A1 (https=) |
| RU (1) | RU2008108221A (https=) |
| TW (1) | TW200800872A (https=) |
| WO (1) | WO2007030567A2 (https=) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ589276A (en) | 2005-02-03 | 2012-06-29 | Topotarget Uk Ltd | Combination therapies using hdac inhibitors and erlotinib (tarceva) |
| CN101189003B (zh) | 2005-05-13 | 2012-02-08 | 托波塔吉特英国有限公司 | Hdac抑制剂的药物制剂 |
| CA2614746C (en) | 2005-07-09 | 2011-05-10 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes |
| JP4324221B2 (ja) | 2005-08-26 | 2009-09-02 | 株式会社医薬分子設計研究所 | Ｐｐａｒアゴニスト活性を有する誘導体 |
| JP5377968B2 (ja) * | 2005-11-10 | 2013-12-25 | トポターゲット ユーケー リミテッド | 癌治療のために単独で用いるまたは化学療法薬と併用するヒストンデアセチラーゼ（ｈｄａｃ）阻害剤 |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| EP2098517B1 (en) * | 2006-12-01 | 2013-12-18 | Msd K.K. | Novel phenyl-isoxazol-3-ol derivative |
| FR2917084B1 (fr) * | 2007-06-05 | 2009-07-17 | Galderma Res & Dev | Nouveaux derives d'acide 3-phenyl propanoique activateurs des recpteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques. |
| FR2917086B1 (fr) * | 2007-06-05 | 2009-07-17 | Galderma Res & Dev | Nouveaux derives d'acide 3-phenyl acrylique activateurs des recepteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques. |
| JP2010533729A (ja) | 2007-07-17 | 2010-10-28 | プレキシコン，インコーポレーテッド | キナーゼ調節のための化合物と方法、及びそのための適応 |
| JP2010540426A (ja) * | 2007-09-25 | 2010-12-24 | トポターゲット ユーケー リミテッド | 特定のヒドロキサム酸化合物の合成方法 |
| AU2009220942B2 (en) * | 2008-03-07 | 2015-05-28 | Onxeo Dk, Branch Of Onxeo S.A., France | Methods of treatment employing prolonged continuous infusion of Belinostat |
| WO2009143018A2 (en) | 2008-05-19 | 2009-11-26 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| NZ592603A (en) * | 2008-10-21 | 2013-02-22 | Metabolex Inc | Aryl gpr120 receptor agonists and uses thereof |
| GB0900555D0 (en) * | 2009-01-14 | 2009-02-11 | Topotarget As | New methods |
| MX2012003778A (es) * | 2009-09-29 | 2012-06-01 | Glaxo Group Ltd | Compuestos novedosos. |
| CN102596921B (zh) * | 2009-09-29 | 2015-04-29 | 葛兰素集团有限公司 | 新化合物 |
| US8673928B2 (en) | 2009-11-18 | 2014-03-18 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| CN102753549A (zh) | 2009-12-23 | 2012-10-24 | 普莱希科公司 | 用于激酶调节的化合物和方法及其适应症 |
| TWI619713B (zh) | 2010-04-21 | 2018-04-01 | 普雷辛肯公司 | 用於激酶調節的化合物和方法及其適應症 |
| CN102285933B (zh) | 2010-06-18 | 2016-03-09 | 浙江海正药业股份有限公司 | 一种对亚型过氧化物酶增殖物激活受体具有激动作用的化合物、其制备方法和应用 |
| WO2012008549A1 (ja) * | 2010-07-15 | 2012-01-19 | 武田薬品工業株式会社 | 複素環化合物 |
| KR101911972B1 (ko) | 2011-02-07 | 2018-10-25 | 플렉시콘 인코퍼레이티드 | 키나제 조절을 위한 화합물 및 방법, 및 그에 대한 적응증 |
| AU2012255275B2 (en) | 2011-05-17 | 2016-01-28 | Plexxikon Inc. | Kinase modulation and indications therefor |
| BR112014005935A2 (pt) | 2011-09-16 | 2017-03-28 | Fovea Pharmaceuticals | derivados de anilina, sua preparação e sua aplicação terapêutica |
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- 2006-09-06 RU RU2008108221/04A patent/RU2008108221A/ru not_active Application Discontinuation
- 2006-09-06 AU AU2006287521A patent/AU2006287521A1/en not_active Abandoned
- 2006-09-06 BR BRPI0615948-6A patent/BRPI0615948A2/pt not_active IP Right Cessation
- 2006-09-06 EP EP06803072A patent/EP1940767A2/en not_active Withdrawn
- 2006-09-06 CA CA002621406A patent/CA2621406A1/en not_active Abandoned
- 2006-09-06 GT GT200600407A patent/GT200600407A/es unknown
- 2006-09-06 TW TW095132980A patent/TW200800872A/zh unknown
- 2006-09-06 WO PCT/US2006/034764 patent/WO2007030567A2/en not_active Ceased
- 2006-09-06 US US11/517,572 patent/US20080249137A1/en not_active Abandoned
- 2006-09-06 JP JP2008530176A patent/JP2009507846A/ja active Pending
- 2006-09-07 PE PE2006001078A patent/PE20071185A1/es not_active Application Discontinuation
- 2006-09-07 AR ARP060103888A patent/AR057800A1/es unknown
-
2008
- 2008-02-26 IL IL189775A patent/IL189775A0/en unknown
- 2008-02-28 NO NO20081042A patent/NO20081042L/no not_active Application Discontinuation
- 2008-03-07 EC EC2008008254A patent/ECSP088254A/es unknown
- 2008-04-04 CR CR9869A patent/CR9869A/es not_active Application Discontinuation
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