JP2009504664A5 - - Google Patents
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- Publication number
- JP2009504664A5 JP2009504664A5 JP2008526175A JP2008526175A JP2009504664A5 JP 2009504664 A5 JP2009504664 A5 JP 2009504664A5 JP 2008526175 A JP2008526175 A JP 2008526175A JP 2008526175 A JP2008526175 A JP 2008526175A JP 2009504664 A5 JP2009504664 A5 JP 2009504664A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- benzyl
- imidazol
- amino
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(*)(c1nc(*)c(*)[n]1*)N(*)C(N(*)*)=O Chemical compound *C(*)(c1nc(*)c(*)[n]1*)N(*)C(N(*)*)=O 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70690105P | 2005-08-09 | 2005-08-09 | |
| US60/706,901 | 2005-08-09 | ||
| PCT/US2006/031129 WO2007021794A1 (en) | 2005-08-09 | 2006-08-09 | Substituted imidazole compounds as ksp inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009504664A JP2009504664A (ja) | 2009-02-05 |
| JP2009504664A5 true JP2009504664A5 (enExample) | 2012-02-23 |
| JP4975745B2 JP4975745B2 (ja) | 2012-07-11 |
Family
ID=37421032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008526175A Expired - Fee Related JP4975745B2 (ja) | 2005-08-09 | 2006-08-09 | Ｋｓｐインヒビターとしての置換イミダゾール化合物 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7626040B2 (enExample) |
| EP (1) | EP1912972B1 (enExample) |
| JP (1) | JP4975745B2 (enExample) |
| KR (1) | KR20080036611A (enExample) |
| CN (1) | CN101253167A (enExample) |
| AR (1) | AR056025A1 (enExample) |
| AT (1) | ATE526324T1 (enExample) |
| AU (1) | AU2006279991B2 (enExample) |
| BR (1) | BRPI0614547A2 (enExample) |
| CA (1) | CA2618747A1 (enExample) |
| ES (1) | ES2374449T3 (enExample) |
| GT (1) | GT200600366A (enExample) |
| MY (1) | MY147188A (enExample) |
| PE (1) | PE20070352A1 (enExample) |
| PL (1) | PL1912972T3 (enExample) |
| PT (1) | PT1912972E (enExample) |
| RU (1) | RU2413721C9 (enExample) |
| TW (1) | TW200800951A (enExample) |
| WO (1) | WO2007021794A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7902240B2 (en) * | 2006-11-13 | 2011-03-08 | Novartis Ag | Substituted pyrazole and triazole compounds as KSP inhibitors |
| EP2106399A2 (en) * | 2007-01-05 | 2009-10-07 | Novartis AG | Imidazole derivatives as kinesin spindle protein inhibitors (eg-5) |
| CN101903365B (zh) | 2007-10-19 | 2014-02-05 | 默沙东公司 | 用于抑制ksp驱动蛋白活性的螺缩合的1,3,4-噻二唑衍生物 |
| US8252832B2 (en) * | 2007-12-14 | 2012-08-28 | Novartis Ag | Kinesin inhibitors as cancer therapeutics |
| KR20130100056A (ko) | 2010-04-15 | 2013-09-09 | 노파르티스 아게 | Ｋｓｐ 억제제로서의 트리아졸 화합물 |
| WO2014151030A1 (en) * | 2013-03-15 | 2014-09-25 | Novartis Ag | Cell proliferation inhibitors and conjugates thereof |
| US9498540B2 (en) | 2013-03-15 | 2016-11-22 | Novartis Ag | Cell proliferation inhibitors and conjugates thereof |
| JP6721507B2 (ja) * | 2013-12-23 | 2020-07-15 | バイエル・ファルマ・アクティエンゲゼルシャフト | Ｋｓｐ阻害剤との抗体薬物複合体（ａｄｃ） |
| WO2016020791A1 (en) | 2014-08-05 | 2016-02-11 | Novartis Ag | Ckit antibody drug conjugates |
| SG10201908685QA (en) | 2015-06-22 | 2019-10-30 | Bayer Pharma AG | Antibody drug conjugates (adcs) and antibody prodrug conjugates (apdcs) with enzymatically cleavable groups |
| CN107921146A (zh) * | 2015-06-23 | 2018-04-17 | 拜耳医药股份有限公司 | 纺锤体驱动蛋白(ksp)抑制剂与抗‑cd123的抗体的抗体药物缀合物(adc) |
| CA3027445A1 (en) | 2016-06-15 | 2017-12-21 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies |
| MX2019007641A (es) | 2016-12-21 | 2019-09-09 | Bayer Pharma AG | Conjugados de ligando-farmaco (adcs) con grupos escindibles enzimaticamente. |
| WO2018114804A1 (de) | 2016-12-21 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | Spezifische antikörper-wirkstoff-konjugate (adcs) mit ksp-inhibitoren |
| CN112601553A (zh) | 2018-06-18 | 2021-04-02 | 拜耳股份有限公司 | 具有可酶切的接头和改善的活性谱的针对cxcr5的结合剂-药物缀合物 |
| CN109481436A (zh) * | 2018-08-21 | 2019-03-19 | 广东医科大学 | 血栓素a2合成酶抑制剂奥扎格雷在制备治疗吸烟所致肺癌药物中的应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| WO1998027108A2 (en) | 1996-12-16 | 1998-06-25 | Fujisawa Pharmaceutical Co., Ltd. | New amide compounds and their use as nitric oxide synthase inhibitors |
| US6117940A (en) | 1997-10-17 | 2000-09-12 | Mjalli; Adnan M. M. | Amino-ketone solid support templates |
| AU746963B2 (en) * | 1998-06-12 | 2002-05-09 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Imidazolyl derivatives |
| EP1686120A3 (en) * | 1999-10-27 | 2007-05-30 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| US6545004B1 (en) * | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| US6620882B1 (en) | 2000-05-02 | 2003-09-16 | Advanced Syntech, Llc | Solid support template for preparation of highly functionalized heterocycle compounds |
| KR20030020960A (ko) * | 2000-08-01 | 2003-03-10 | 소시에떼 더 콘세이유 더 레세르세 에 다플리까띠옹 시엔띠피끄, 에스.아.에스. | 이미다졸일 유도체 |
| US7026312B2 (en) | 2002-03-14 | 2006-04-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof |
| DE10211770A1 (de) | 2002-03-14 | 2003-10-02 | Boehringer Ingelheim Pharma | Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| RU2005100783A (ru) * | 2002-06-14 | 2005-07-20 | Мерк энд Ко., Инк. (US) | Ингибиторы митотического кинезина |
| US20040186151A1 (en) | 2003-02-12 | 2004-09-23 | Mjalli Adnan M.M. | Substituted azole derivatives as therapeutic agents |
| WO2004100873A2 (en) * | 2003-05-07 | 2004-11-25 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| JP2007500746A (ja) * | 2003-05-15 | 2007-01-18 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
| US20080132549A1 (en) | 2004-04-14 | 2008-06-05 | Pfizer Inc. | Sulphur-Linked Imidazone Compounds for the Treatment of Hiv/Aids |
| US7618981B2 (en) | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
| US7576221B2 (en) * | 2004-06-18 | 2009-08-18 | Novartis Vaccines And Diagnostics, Inc. | Substituted imidazole derivatives |
-
2006
- 2006-08-08 TW TW095129062A patent/TW200800951A/zh unknown
- 2006-08-08 MY MYPI20063824A patent/MY147188A/en unknown
- 2006-08-09 PE PE2006000968A patent/PE20070352A1/es not_active Application Discontinuation
- 2006-08-09 WO PCT/US2006/031129 patent/WO2007021794A1/en not_active Ceased
- 2006-08-09 KR KR1020087003946A patent/KR20080036611A/ko not_active Ceased
- 2006-08-09 CA CA002618747A patent/CA2618747A1/en not_active Abandoned
- 2006-08-09 PT PT06789653T patent/PT1912972E/pt unknown
- 2006-08-09 US US11/502,303 patent/US7626040B2/en not_active Expired - Fee Related
- 2006-08-09 EP EP06789653A patent/EP1912972B1/en active Active
- 2006-08-09 BR BRPI0614547-7A patent/BRPI0614547A2/pt not_active IP Right Cessation
- 2006-08-09 PL PL06789653T patent/PL1912972T3/pl unknown
- 2006-08-09 GT GT200600366A patent/GT200600366A/es unknown
- 2006-08-09 CN CNA2006800293472A patent/CN101253167A/zh active Pending
- 2006-08-09 AT AT06789653T patent/ATE526324T1/de active
- 2006-08-09 RU RU2008108939/04A patent/RU2413721C9/ru not_active IP Right Cessation
- 2006-08-09 AR ARP060103489A patent/AR056025A1/es not_active Application Discontinuation
- 2006-08-09 AU AU2006279991A patent/AU2006279991B2/en not_active Ceased
- 2006-08-09 ES ES06789653T patent/ES2374449T3/es active Active
- 2006-08-09 JP JP2008526175A patent/JP4975745B2/ja not_active Expired - Fee Related
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