PL1912972T3 - Podstawione związki imidazolowe jako inhibitory KSP - Google Patents
Podstawione związki imidazolowe jako inhibitory KSPInfo
- Publication number
- PL1912972T3 PL1912972T3 PL06789653T PL06789653T PL1912972T3 PL 1912972 T3 PL1912972 T3 PL 1912972T3 PL 06789653 T PL06789653 T PL 06789653T PL 06789653 T PL06789653 T PL 06789653T PL 1912972 T3 PL1912972 T3 PL 1912972T3
- Authority
- PL
- Poland
- Prior art keywords
- imidazole compounds
- substituted imidazole
- ksp inhibitors
- ksp
- inhibitors
- Prior art date
Links
- 150000002460 imidazoles Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70690105P | 2005-08-09 | 2005-08-09 | |
| EP06789653A EP1912972B1 (en) | 2005-08-09 | 2006-08-09 | Substituted imidazole compounds as ksp inhibitors |
| PCT/US2006/031129 WO2007021794A1 (en) | 2005-08-09 | 2006-08-09 | Substituted imidazole compounds as ksp inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1912972T3 true PL1912972T3 (pl) | 2012-02-29 |
Family
ID=37421032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06789653T PL1912972T3 (pl) | 2005-08-09 | 2006-08-09 | Podstawione związki imidazolowe jako inhibitory KSP |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7626040B2 (pl) |
| EP (1) | EP1912972B1 (pl) |
| JP (1) | JP4975745B2 (pl) |
| KR (1) | KR20080036611A (pl) |
| CN (1) | CN101253167A (pl) |
| AR (1) | AR056025A1 (pl) |
| AT (1) | ATE526324T1 (pl) |
| AU (1) | AU2006279991B2 (pl) |
| BR (1) | BRPI0614547A2 (pl) |
| CA (1) | CA2618747A1 (pl) |
| ES (1) | ES2374449T3 (pl) |
| GT (1) | GT200600366A (pl) |
| HK (1) | HK1111995A1 (pl) |
| MY (1) | MY147188A (pl) |
| PE (1) | PE20070352A1 (pl) |
| PL (1) | PL1912972T3 (pl) |
| PT (1) | PT1912972E (pl) |
| RU (1) | RU2413721C9 (pl) |
| TW (1) | TW200800951A (pl) |
| WO (1) | WO2007021794A1 (pl) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009005071A (es) * | 2006-11-13 | 2009-05-25 | Novartis Ag | Compuestos de pirazol y triazol sustituidos como inhibidores de ksp. |
| US7820646B2 (en) * | 2007-01-05 | 2010-10-26 | Novartis Vaccines And Diagnostics, Inc. | Cyclized derivatives as Eg-5 inhibitors |
| BRPI0818605A2 (pt) | 2007-10-19 | 2015-04-22 | Schering Corp | Derivados de 1,3,4-tiadiazl espiro-condensados para inibir a atividade de ksp cinesima |
| US8252832B2 (en) * | 2007-12-14 | 2012-08-28 | Novartis Ag | Kinesin inhibitors as cancer therapeutics |
| US8546434B2 (en) | 2010-04-15 | 2013-10-01 | Novartis Ag | Triazole compounds as KSP inhibitors |
| US9498540B2 (en) | 2013-03-15 | 2016-11-22 | Novartis Ag | Cell proliferation inhibitors and conjugates thereof |
| WO2014151030A1 (en) * | 2013-03-15 | 2014-09-25 | Novartis Ag | Cell proliferation inhibitors and conjugates thereof |
| NZ720736A (en) * | 2013-12-23 | 2020-08-28 | Bayer Pharma AG | Antibody drug conjugates (adcs) with kinesin spindel protein (ksp) |
| WO2016020791A1 (en) | 2014-08-05 | 2016-02-11 | Novartis Ag | Ckit antibody drug conjugates |
| CN108025084A (zh) * | 2015-06-22 | 2018-05-11 | 拜耳医药股份有限公司 | 具有酶可裂解基团的抗体药物缀合物（adc）和抗体前药缀合物（apdc） |
| JP7022707B2 (ja) | 2016-06-15 | 2022-02-18 | バイエル・ファルマ・アクティエンゲゼルシャフト | Ｋｓｐ阻害剤および抗ｃｄ１２３抗体を含む特異的抗体－薬物－コンジュゲート（ａｄｃ） |
| KR102583006B1 (ko) | 2016-12-21 | 2023-09-27 | 바이엘 파마 악티엔게젤샤프트 | 효소적으로 절단가능한 기를 갖는 항체 약물 접합체 (adc) |
| CN110072556B (zh) | 2016-12-21 | 2023-05-02 | 拜耳制药股份公司 | 具有ksp抑制剂的特异性抗体药物缀合物(adc) |
| SG11202012608VA (en) | 2018-06-18 | 2021-02-25 | Bayer Ag | Binder/active agent conjugates directed against cxcr5, having enzymatically cleavable linkers and improved activity profile |
| CN109481436A (zh) * | 2018-08-21 | 2019-03-19 | 广东医科大学 | 血栓素a2合成酶抑制剂奥扎格雷在制备治疗吸烟所致肺癌药物中的应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| JP2001505585A (ja) | 1996-12-16 | 2001-04-24 | 藤沢薬品工業株式会社 | 新規アミド化合物およびそれらの一酸化窒素シンターゼ阻害剤としての用途 |
| US6117940A (en) | 1997-10-17 | 2000-09-12 | Mjalli; Adnan M. M. | Amino-ketone solid support templates |
| PT1086086E (pt) * | 1998-06-12 | 2005-02-28 | Sod Conseils Rech Applic | Derivados imidazolilo e sua utilizacao como ligandos de receptores da somatostatina |
| US6545004B1 (en) * | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| ES2263501T3 (es) * | 1999-10-27 | 2006-12-16 | Cytokinetics, Inc. | Procedimiento y composiciones que utilizan quinazolinonas. |
| AU2001227812A1 (en) | 2000-05-02 | 2001-11-12 | Advanced Syntech, Llc A Kentucky Limited Liability Corporation | A novel solid support template for preparation of highly functionalized heterocycle compounds |
| JP2004518613A (ja) * | 2000-08-01 | 2004-06-24 | ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス | イミダゾリル誘導体 |
| US7026312B2 (en) * | 2002-03-14 | 2006-04-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof |
| DE10211770A1 (de) | 2002-03-14 | 2003-10-02 | Boehringer Ingelheim Pharma | Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| WO2004071448A2 (en) | 2003-02-12 | 2004-08-26 | Transtech Pharma Inc. | Substituted azole derivatives as inhibitors of protein tyrosine phosphatases |
| WO2004100873A2 (en) * | 2003-05-07 | 2004-11-25 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| WO2004103282A2 (en) * | 2003-05-15 | 2004-12-02 | Cytokinetics, Inc. | Compounds, compositions and methods |
| WO2005100322A1 (en) | 2004-04-14 | 2005-10-27 | Pfizer Limited | Sulphur-linked imidazole compounds for the treament of hiv |
| US7618981B2 (en) | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
| EP1765789B1 (en) * | 2004-06-18 | 2013-02-27 | Novartis AG | N-(1-(1-benzyl-4-phenyl-1h-imidazol-2-yl)-2,2-dimethylpropyl)benzamide derivatives and related compounds as kinesin spindle protein (ksp) inhibitors for the treatment of cancer |
-
2006
- 2006-08-08 MY MYPI20063824A patent/MY147188A/en unknown
- 2006-08-08 TW TW095129062A patent/TW200800951A/zh unknown
- 2006-08-09 AU AU2006279991A patent/AU2006279991B2/en not_active Ceased
- 2006-08-09 WO PCT/US2006/031129 patent/WO2007021794A1/en active Application Filing
- 2006-08-09 KR KR1020087003946A patent/KR20080036611A/ko not_active Application Discontinuation
- 2006-08-09 EP EP06789653A patent/EP1912972B1/en active Active
- 2006-08-09 CA CA002618747A patent/CA2618747A1/en not_active Abandoned
- 2006-08-09 BR BRPI0614547-7A patent/BRPI0614547A2/pt not_active IP Right Cessation
- 2006-08-09 US US11/502,303 patent/US7626040B2/en not_active Expired - Fee Related
- 2006-08-09 ES ES06789653T patent/ES2374449T3/es active Active
- 2006-08-09 PT PT06789653T patent/PT1912972E/pt unknown
- 2006-08-09 PE PE2006000968A patent/PE20070352A1/es not_active Application Discontinuation
- 2006-08-09 AR ARP060103489A patent/AR056025A1/es not_active Application Discontinuation
- 2006-08-09 GT GT200600366A patent/GT200600366A/es unknown
- 2006-08-09 JP JP2008526175A patent/JP4975745B2/ja not_active Expired - Fee Related
- 2006-08-09 RU RU2008108939/04A patent/RU2413721C9/ru not_active IP Right Cessation
- 2006-08-09 AT AT06789653T patent/ATE526324T1/de active
- 2006-08-09 CN CNA2006800293472A patent/CN101253167A/zh active Pending
- 2006-08-09 PL PL06789653T patent/PL1912972T3/pl unknown
-
2008
- 2008-06-26 HK HK08107126.4A patent/HK1111995A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006279991B2 (en) | 2011-09-29 |
| AR056025A1 (es) | 2007-09-12 |
| AU2006279991A1 (en) | 2007-02-22 |
| CA2618747A1 (en) | 2007-02-22 |
| ATE526324T1 (de) | 2011-10-15 |
| PT1912972E (pt) | 2012-01-06 |
| BRPI0614547A2 (pt) | 2011-03-29 |
| KR20080036611A (ko) | 2008-04-28 |
| US20070037853A1 (en) | 2007-02-15 |
| MY147188A (en) | 2012-11-14 |
| CN101253167A (zh) | 2008-08-27 |
| RU2413721C9 (ru) | 2011-05-20 |
| HK1111995A1 (en) | 2008-08-22 |
| RU2413721C2 (ru) | 2011-03-10 |
| PE20070352A1 (es) | 2007-05-30 |
| EP1912972B1 (en) | 2011-09-28 |
| JP4975745B2 (ja) | 2012-07-11 |
| US7626040B2 (en) | 2009-12-01 |
| TW200800951A (en) | 2008-01-01 |
| WO2007021794A1 (en) | 2007-02-22 |
| JP2009504664A (ja) | 2009-02-05 |
| RU2008108939A (ru) | 2009-09-20 |
| EP1912972A1 (en) | 2008-04-23 |
| ES2374449T3 (es) | 2012-02-16 |
| GT200600366A (es) | 2007-05-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUS1900033I1 (hu) | Szubsztituált enaminokarbonil vegyületek | |
| HK1111995A1 (en) | Substituted imidazole compounds as ksp inhibitors | |
| IL185185A0 (en) | Azolylacylguanidines as ??-secretase inhibitors | |
| IL205159A0 (en) | Imidazole compounds | |
| IL189194A0 (en) | Substituted benzimidazoles as kinase inhibitors | |
| IL190450A0 (en) | Substituted pyrazole compounds | |
| EP1790650B1 (en) | NEW SUBSTITUTED IMIDAZOLE DERIVATIVES | |
| EP1847531A4 (en) | PYRAZOLE DERIVATIVE | |
| EP1778693A4 (en) | AS KINASEINHIBITORS USEFUL COMPOUNDS OF TRICYCLIC HETEROARYL | |
| IL187279A0 (en) | Hydantoin compounds | |
| HK1117826A1 (en) | Benzimidazole compound | |
| ZA200902940B (en) | Substituted pyrazole and triazole compounds as KSP inhibitors | |
| ZA200900625B (en) | Substituted 1-(azolin-2-yl)-amino-2-aryl-1-hetaryl-ethane compounds | |
| IL184559A0 (en) | Imidazole derivatives | |
| ZA200802786B (en) | Substituted pyrazole compounds | |
| ZA200800506B (en) | Substituted benzimidazoles as kinase inhibitors | |
| ZA200708803B (en) | Benzimidazole compound | |
| ZA200901570B (en) | Substituted azolin-2-YL-amino compounds | |
| EP1998776A4 (en) | MACRO-HETEROCYL COMPOUNDS CONTAINING PYRIDINE AS KINASE INHIBITORS | |
| ZA200703075B (en) | Imidazole compound | |
| AU2006900914A0 (en) | Imidazole compounds | |
| EP1940411A4 (en) | MACROHETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | |
| PL1956027T3 (pl) | Związek karbapenemowy |