PE20070352A1 - Compuestos de imidazol sustituidos como inhibidores de ksp - Google Patents
Compuestos de imidazol sustituidos como inhibidores de kspInfo
- Publication number
- PE20070352A1 PE20070352A1 PE2006000968A PE2006000968A PE20070352A1 PE 20070352 A1 PE20070352 A1 PE 20070352A1 PE 2006000968 A PE2006000968 A PE 2006000968A PE 2006000968 A PE2006000968 A PE 2006000968A PE 20070352 A1 PE20070352 A1 PE 20070352A1
- Authority
- PE
- Peru
- Prior art keywords
- substituted
- alkyl
- imidazol
- aminopropyl
- carboxamide
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical group C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- -1 AMINO Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical class CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 abstract 3
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 102000010638 Kinesin Human genes 0.000 abstract 1
- 108010063296 Kinesin Proteins 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 208000025113 myeloid leukemia Diseases 0.000 abstract 1
- 210000000496 pancreas Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- JSPCTNUQYWIIOT-UHFFFAOYSA-N piperidine-1-carboxamide Chemical compound NC(=O)N1CCCCC1 JSPCTNUQYWIIOT-UHFFFAOYSA-N 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70690105P | 2005-08-09 | 2005-08-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070352A1 true PE20070352A1 (es) | 2007-05-30 |
Family
ID=37421032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000968A PE20070352A1 (es) | 2005-08-09 | 2006-08-09 | Compuestos de imidazol sustituidos como inhibidores de ksp |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7626040B2 (enExample) |
| EP (1) | EP1912972B1 (enExample) |
| JP (1) | JP4975745B2 (enExample) |
| KR (1) | KR20080036611A (enExample) |
| CN (1) | CN101253167A (enExample) |
| AR (1) | AR056025A1 (enExample) |
| AT (1) | ATE526324T1 (enExample) |
| AU (1) | AU2006279991B2 (enExample) |
| BR (1) | BRPI0614547A2 (enExample) |
| CA (1) | CA2618747A1 (enExample) |
| ES (1) | ES2374449T3 (enExample) |
| GT (1) | GT200600366A (enExample) |
| MY (1) | MY147188A (enExample) |
| PE (1) | PE20070352A1 (enExample) |
| PL (1) | PL1912972T3 (enExample) |
| PT (1) | PT1912972E (enExample) |
| RU (1) | RU2413721C9 (enExample) |
| TW (1) | TW200800951A (enExample) |
| WO (1) | WO2007021794A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7902240B2 (en) * | 2006-11-13 | 2011-03-08 | Novartis Ag | Substituted pyrazole and triazole compounds as KSP inhibitors |
| EP2106399A2 (en) * | 2007-01-05 | 2009-10-07 | Novartis AG | Imidazole derivatives as kinesin spindle protein inhibitors (eg-5) |
| CN101903365B (zh) | 2007-10-19 | 2014-02-05 | 默沙东公司 | 用于抑制ksp驱动蛋白活性的螺缩合的1,3,4-噻二唑衍生物 |
| US8252832B2 (en) * | 2007-12-14 | 2012-08-28 | Novartis Ag | Kinesin inhibitors as cancer therapeutics |
| KR20130100056A (ko) | 2010-04-15 | 2013-09-09 | 노파르티스 아게 | Ｋｓｐ 억제제로서의 트리아졸 화합물 |
| WO2014151030A1 (en) * | 2013-03-15 | 2014-09-25 | Novartis Ag | Cell proliferation inhibitors and conjugates thereof |
| US9498540B2 (en) | 2013-03-15 | 2016-11-22 | Novartis Ag | Cell proliferation inhibitors and conjugates thereof |
| JP6721507B2 (ja) * | 2013-12-23 | 2020-07-15 | バイエル・ファルマ・アクティエンゲゼルシャフト | Ｋｓｐ阻害剤との抗体薬物複合体（ａｄｃ） |
| WO2016020791A1 (en) | 2014-08-05 | 2016-02-11 | Novartis Ag | Ckit antibody drug conjugates |
| SG10201908685QA (en) | 2015-06-22 | 2019-10-30 | Bayer Pharma AG | Antibody drug conjugates (adcs) and antibody prodrug conjugates (apdcs) with enzymatically cleavable groups |
| CN107921146A (zh) * | 2015-06-23 | 2018-04-17 | 拜耳医药股份有限公司 | 纺锤体驱动蛋白(ksp)抑制剂与抗‑cd123的抗体的抗体药物缀合物(adc) |
| CA3027445A1 (en) | 2016-06-15 | 2017-12-21 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies |
| MX2019007641A (es) | 2016-12-21 | 2019-09-09 | Bayer Pharma AG | Conjugados de ligando-farmaco (adcs) con grupos escindibles enzimaticamente. |
| WO2018114804A1 (de) | 2016-12-21 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | Spezifische antikörper-wirkstoff-konjugate (adcs) mit ksp-inhibitoren |
| CN112601553A (zh) | 2018-06-18 | 2021-04-02 | 拜耳股份有限公司 | 具有可酶切的接头和改善的活性谱的针对cxcr5的结合剂-药物缀合物 |
| CN109481436A (zh) * | 2018-08-21 | 2019-03-19 | 广东医科大学 | 血栓素a2合成酶抑制剂奥扎格雷在制备治疗吸烟所致肺癌药物中的应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| WO1998027108A2 (en) | 1996-12-16 | 1998-06-25 | Fujisawa Pharmaceutical Co., Ltd. | New amide compounds and their use as nitric oxide synthase inhibitors |
| US6117940A (en) | 1997-10-17 | 2000-09-12 | Mjalli; Adnan M. M. | Amino-ketone solid support templates |
| AU746963B2 (en) * | 1998-06-12 | 2002-05-09 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Imidazolyl derivatives |
| EP1686120A3 (en) * | 1999-10-27 | 2007-05-30 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| US6545004B1 (en) * | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| US6620882B1 (en) | 2000-05-02 | 2003-09-16 | Advanced Syntech, Llc | Solid support template for preparation of highly functionalized heterocycle compounds |
| KR20030020960A (ko) * | 2000-08-01 | 2003-03-10 | 소시에떼 더 콘세이유 더 레세르세 에 다플리까띠옹 시엔띠피끄, 에스.아.에스. | 이미다졸일 유도체 |
| US7026312B2 (en) | 2002-03-14 | 2006-04-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof |
| DE10211770A1 (de) | 2002-03-14 | 2003-10-02 | Boehringer Ingelheim Pharma | Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| RU2005100783A (ru) * | 2002-06-14 | 2005-07-20 | Мерк энд Ко., Инк. (US) | Ингибиторы митотического кинезина |
| US20040186151A1 (en) | 2003-02-12 | 2004-09-23 | Mjalli Adnan M.M. | Substituted azole derivatives as therapeutic agents |
| WO2004100873A2 (en) * | 2003-05-07 | 2004-11-25 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| JP2007500746A (ja) * | 2003-05-15 | 2007-01-18 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
| US20080132549A1 (en) | 2004-04-14 | 2008-06-05 | Pfizer Inc. | Sulphur-Linked Imidazone Compounds for the Treatment of Hiv/Aids |
| US7618981B2 (en) | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
| US7576221B2 (en) * | 2004-06-18 | 2009-08-18 | Novartis Vaccines And Diagnostics, Inc. | Substituted imidazole derivatives |
-
2006
- 2006-08-08 TW TW095129062A patent/TW200800951A/zh unknown
- 2006-08-08 MY MYPI20063824A patent/MY147188A/en unknown
- 2006-08-09 PE PE2006000968A patent/PE20070352A1/es not_active Application Discontinuation
- 2006-08-09 WO PCT/US2006/031129 patent/WO2007021794A1/en not_active Ceased
- 2006-08-09 KR KR1020087003946A patent/KR20080036611A/ko not_active Ceased
- 2006-08-09 CA CA002618747A patent/CA2618747A1/en not_active Abandoned
- 2006-08-09 PT PT06789653T patent/PT1912972E/pt unknown
- 2006-08-09 US US11/502,303 patent/US7626040B2/en not_active Expired - Fee Related
- 2006-08-09 EP EP06789653A patent/EP1912972B1/en active Active
- 2006-08-09 BR BRPI0614547-7A patent/BRPI0614547A2/pt not_active IP Right Cessation
- 2006-08-09 PL PL06789653T patent/PL1912972T3/pl unknown
- 2006-08-09 GT GT200600366A patent/GT200600366A/es unknown
- 2006-08-09 CN CNA2006800293472A patent/CN101253167A/zh active Pending
- 2006-08-09 AT AT06789653T patent/ATE526324T1/de active
- 2006-08-09 RU RU2008108939/04A patent/RU2413721C9/ru not_active IP Right Cessation
- 2006-08-09 AR ARP060103489A patent/AR056025A1/es not_active Application Discontinuation
- 2006-08-09 AU AU2006279991A patent/AU2006279991B2/en not_active Ceased
- 2006-08-09 ES ES06789653T patent/ES2374449T3/es active Active
- 2006-08-09 JP JP2008526175A patent/JP4975745B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AR056025A1 (es) | 2007-09-12 |
| PL1912972T3 (pl) | 2012-02-29 |
| EP1912972B1 (en) | 2011-09-28 |
| MY147188A (en) | 2012-11-14 |
| RU2413721C9 (ru) | 2011-05-20 |
| CN101253167A (zh) | 2008-08-27 |
| HK1111995A1 (en) | 2008-08-22 |
| PT1912972E (pt) | 2012-01-06 |
| RU2008108939A (ru) | 2009-09-20 |
| JP4975745B2 (ja) | 2012-07-11 |
| BRPI0614547A2 (pt) | 2011-03-29 |
| US20070037853A1 (en) | 2007-02-15 |
| ES2374449T3 (es) | 2012-02-16 |
| EP1912972A1 (en) | 2008-04-23 |
| US7626040B2 (en) | 2009-12-01 |
| KR20080036611A (ko) | 2008-04-28 |
| GT200600366A (es) | 2007-05-10 |
| TW200800951A (en) | 2008-01-01 |
| JP2009504664A (ja) | 2009-02-05 |
| ATE526324T1 (de) | 2011-10-15 |
| AU2006279991A1 (en) | 2007-02-22 |
| CA2618747A1 (en) | 2007-02-22 |
| AU2006279991B2 (en) | 2011-09-29 |
| WO2007021794A1 (en) | 2007-02-22 |
| RU2413721C2 (ru) | 2011-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |