JP2009503045A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009503045A5 JP2009503045A5 JP2008524588A JP2008524588A JP2009503045A5 JP 2009503045 A5 JP2009503045 A5 JP 2009503045A5 JP 2008524588 A JP2008524588 A JP 2008524588A JP 2008524588 A JP2008524588 A JP 2008524588A JP 2009503045 A5 JP2009503045 A5 JP 2009503045A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- inflammatory
- disease
- arthritis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 208000027866 inflammatory disease Diseases 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 3
- 208000030090 Acute Disease Diseases 0.000 claims 2
- 201000005569 Gout Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 208000037976 chronic inflammation Diseases 0.000 claims 2
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010018634 Gouty Arthritis Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 208000033464 Reiter syndrome Diseases 0.000 claims 1
- 201000002661 Spondylitis Diseases 0.000 claims 1
- 206010048873 Traumatic arthritis Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000002917 arthritic effect Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- GKIRPKYJQBWNGO-OCEACIFDSA-N clomifene Chemical group C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(\Cl)C1=CC=CC=C1 GKIRPKYJQBWNGO-OCEACIFDSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000002158 endotoxin Substances 0.000 claims 1
- 230000028709 inflammatory response Effects 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate group Chemical group CS(=O)(=O)[O-] AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 208000002574 reactive arthritis Diseases 0.000 claims 1
- 201000005404 rubella Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0516168.2A GB0516168D0 (en) | 2005-08-05 | 2005-08-05 | Pharmaceutical compounds |
| PCT/GB2006/002909 WO2007017643A1 (en) | 2005-08-05 | 2006-08-04 | 3 , llB-CIS-DIHYDROTETRABENAZINE FOR THE TREATMENT OF A PROLIFERATIVE DISEASE OR AN INFLAMMATION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009503045A JP2009503045A (ja) | 2009-01-29 |
| JP2009503045A5 true JP2009503045A5 (enExample) | 2009-09-17 |
Family
ID=34984180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008524588A Pending JP2009503045A (ja) | 2005-08-05 | 2006-08-04 | 増殖性疾患または炎症に用いられる３，１１ｂ−シス−ジヒドロテトラベナジン |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20090275605A1 (enExample) |
| EP (2) | EP1964565A1 (enExample) |
| JP (1) | JP2009503045A (enExample) |
| KR (1) | KR20080033501A (enExample) |
| CN (1) | CN101321528B (enExample) |
| AT (1) | ATE412414T1 (enExample) |
| AU (1) | AU2006277836B8 (enExample) |
| CA (1) | CA2620952A1 (enExample) |
| CY (1) | CY1108729T1 (enExample) |
| DE (1) | DE602006003415D1 (enExample) |
| DK (1) | DK1861100T3 (enExample) |
| ES (1) | ES2317564T3 (enExample) |
| GB (1) | GB0516168D0 (enExample) |
| HR (1) | HRP20090017T3 (enExample) |
| MX (1) | MX2008001546A (enExample) |
| NZ (1) | NZ566010A (enExample) |
| PL (1) | PL1861100T3 (enExample) |
| PT (1) | PT1861100E (enExample) |
| RS (1) | RS50720B (enExample) |
| RU (1) | RU2409364C2 (enExample) |
| SI (1) | SI1861100T1 (enExample) |
| WO (1) | WO2007017643A1 (enExample) |
| ZA (2) | ZA200801171B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2410947B (en) * | 2004-02-11 | 2008-09-17 | Cambridge Lab Ltd | Pharmaceutical compounds |
| GB0514501D0 (en) * | 2005-07-14 | 2005-08-24 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| DK2081929T3 (da) | 2006-11-08 | 2013-04-15 | Neurocrine Biosciences Inc | Substituerede 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11B-hexahydro-2H-pyrido[2,1-A]isoquinolin-2-ol-forbindelser og fremgangsmåder angående disse |
| GB0721669D0 (en) * | 2007-11-02 | 2007-12-12 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| GB0810857D0 (en) * | 2008-06-13 | 2008-07-23 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| GB2462611A (en) * | 2008-08-12 | 2010-02-17 | Cambridge Lab | Pharmaceutical composition comprising tetrabenazine |
| US20110053866A1 (en) * | 2008-08-12 | 2011-03-03 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compositions |
| GB2463451A (en) | 2008-09-08 | 2010-03-17 | Cambridge Lab | 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia |
| GB2463283A (en) * | 2008-09-08 | 2010-03-10 | Cambridge Lab | 3,11b-cis-dihydrotetrabenazine for use in treating asthma |
| GB2463452A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof |
| CA2801061A1 (en) | 2010-06-01 | 2011-12-08 | Auspex Pharmaceuticals, Inc. | Benzoquinolone inhibitors of vmat2 |
| CN102285984B (zh) * | 2010-11-25 | 2012-10-10 | 江苏威凯尔医药科技有限公司 | (2R,3R,11bR)-二氢丁苯那嗪及相关化合物的制备方法 |
| CA2936823A1 (en) | 2014-01-27 | 2015-07-30 | Auspex Pharmaceuticals, Inc. | Benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| MA41177A (fr) * | 2014-12-15 | 2017-10-24 | Esteve Labor Dr | Utilisation de ligands des récepteurs sigma dans l'arthrose |
| WO2017164407A1 (ja) * | 2016-03-25 | 2017-09-28 | 国立大学法人東北大学 | 免疫チェックポイント阻害作用を有するインドールアルカロイド型化合物 |
| CN109283279B (zh) * | 2017-07-21 | 2019-11-01 | 南京正大天晴制药有限公司 | 通过高效液相色谱法分离测定雷替曲塞及其对映异构体的方法 |
| CN109283263B (zh) * | 2017-07-21 | 2019-06-25 | 南京正大天晴制药有限公司 | 用于雷替曲塞合成质量控制的检测分析方法 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3053845A (en) * | 1962-09-11 | Benzofykedocolines | ||
| US2954382A (en) * | 1960-09-27 | Xpreparation of hexahydrobenzoquinol- | ||
| US2830993A (en) | 1958-04-15 | Quinolizine derivatives | ||
| US2843591A (en) | 1958-07-15 | Method for preparing same | ||
| US3132147A (en) * | 1964-05-05 | |||
| US3079395A (en) * | 1963-02-26 | Novel z-oxq-benzoquinoliaine | ||
| US3123609A (en) * | 1964-03-03 | Benzo | ||
| US3314966A (en) * | 1967-04-18 | Substituted benzo[a]quinolizines | ||
| US3009918A (en) * | 1961-11-21 | Chz ch | ||
| US3159638A (en) * | 1964-12-01 | Xcha-chj | ||
| US3209005A (en) * | 1965-09-28 | Hexahydro-llbh-benzo[a] quinolizines and processes therefor | ||
| US3095419A (en) * | 1963-06-25 | Process for preparing z-oxo-j- | ||
| US3045021A (en) * | 1959-09-24 | 1962-07-17 | Hoffmann La Roche | Preparation of substituted 2-oxobenzoquinolizines |
| GB999092A (en) * | 1959-11-24 | 1965-07-21 | Wellcome Found | Method for making benzo(a)-quinolizine derivatives |
| US3375254A (en) * | 1961-09-29 | 1968-03-26 | Burroughs Wellcome Co | Manufacture of 1, 2, 3, 4, 6, 7-hexahydro-2-oxo-11bh-benzo(a)quinolizines |
| US3105079A (en) * | 1961-12-29 | 1963-09-24 | Pfizer & Co C | 10-aminobenzopyridocolines |
| US3390152A (en) * | 1965-10-21 | 1968-06-25 | Abbott Lab | 9, 10-alkoxy-3-alkyl-2, 2-(dithiosubstituted)-benzoquinolizines |
| US3635986A (en) * | 1969-12-22 | 1972-01-18 | Miles Lab | 2-substituted amino-hexahydrobenzo(a)quinolizines |
| US3634431A (en) * | 1969-12-22 | 1972-01-11 | Miles Lab | Acylated and alkylated derivatives of 2-aminohexahydrobenzo(a)quinolizines |
| YU264675A (en) * | 1974-10-23 | 1982-05-31 | Chinoin Gyogyszer Es Vegyeszet | Process for obtaining benzo (a)-quinolizidine derivatives |
| GB1513824A (en) * | 1975-05-22 | 1978-06-14 | Wyeth John & Brother Ltd | 1,3,4,6,7,11b-hexahydro-2h-benzo(a)quinolizine derivative |
| US4133812A (en) * | 1975-11-21 | 1979-01-09 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | Process for producing benzo (a) quinolizine derivatives |
| US4304913A (en) * | 1978-11-20 | 1981-12-08 | Miles Laboratories, Inc. | Trans-2-substituted-amido-hexahydrobenzo [A]quinolizines |
| US4353656A (en) * | 1980-10-14 | 1982-10-12 | Xerox Corporation | Moving coil, multiple energy print hammer system including a closed loop servo |
| US4778054A (en) * | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| EP0211595B1 (en) * | 1985-07-30 | 1991-11-13 | Glaxo Group Limited | Devices for administering medicaments to patients |
| GB9004781D0 (en) * | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| US6087376A (en) * | 1997-02-05 | 2000-07-11 | University Of Kentucky Research Foundation | Use of lobeline compounds in the treatment of central nervous system diseases and pathologies |
| FR2794742B1 (fr) * | 1999-06-11 | 2005-06-03 | Sanofi Synthelabo | Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant |
| US6632666B2 (en) * | 2000-01-14 | 2003-10-14 | Biolife Solutions, Inc. | Normothermic, hypothermic and cryopreservation maintenance and storage of cells, tissues and organs in gel-based media |
| BR0110302A (pt) * | 2000-04-18 | 2003-01-14 | Agouron Pharma | Compostos de pirazol para inibição de proteìnas cinase, sal e pró-droga farmaceuticamente aceitável, metabólito farmaceuticamente ativo ou sal farmaceuticamente aceitável de metabólito, composição farmacêutica, método de tratamento de condição doentia em mamìferos mediada pela atividade de proteìna cinase, método de modulação ou inibição da atividade de um receptor de proteìna cinase |
| CA2673334C (en) * | 2003-06-16 | 2013-11-12 | Andrx Pharmaceuticals, Llc | Oral extended-release composition |
| GB2410947B (en) * | 2004-02-11 | 2008-09-17 | Cambridge Lab Ltd | Pharmaceutical compounds |
| KR100682506B1 (ko) * | 2005-01-18 | 2007-02-15 | (주)젠크로스 | 프라지콴텔, 또는 이의 염을 포함하는 약학 조성물 |
| GB0514501D0 (en) * | 2005-07-14 | 2005-08-24 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| GB0810857D0 (en) * | 2008-06-13 | 2008-07-23 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| US20110053866A1 (en) * | 2008-08-12 | 2011-03-03 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compositions |
| GB2462611A (en) * | 2008-08-12 | 2010-02-17 | Cambridge Lab | Pharmaceutical composition comprising tetrabenazine |
| GB2463451A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia |
| GB2463283A (en) * | 2008-09-08 | 2010-03-10 | Cambridge Lab | 3,11b-cis-dihydrotetrabenazine for use in treating asthma |
| GB2463452A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof |
-
2005
- 2005-08-05 GB GBGB0516168.2A patent/GB0516168D0/en not_active Ceased
-
2006
- 2006-08-04 CN CN2006800366007A patent/CN101321528B/zh not_active Expired - Fee Related
- 2006-08-04 EP EP08104275A patent/EP1964565A1/en not_active Withdrawn
- 2006-08-04 NZ NZ566010A patent/NZ566010A/en not_active IP Right Cessation
- 2006-08-04 AT AT06765213T patent/ATE412414T1/de active
- 2006-08-04 US US11/997,675 patent/US20090275605A1/en not_active Abandoned
- 2006-08-04 KR KR1020087005309A patent/KR20080033501A/ko not_active Withdrawn
- 2006-08-04 EP EP06765213A patent/EP1861100B1/en active Active
- 2006-08-04 RU RU2008108516/15A patent/RU2409364C2/ru not_active IP Right Cessation
- 2006-08-04 HR HR20090017T patent/HRP20090017T3/xx unknown
- 2006-08-04 MX MX2008001546A patent/MX2008001546A/es active IP Right Grant
- 2006-08-04 JP JP2008524588A patent/JP2009503045A/ja active Pending
- 2006-08-04 ES ES06765213T patent/ES2317564T3/es active Active
- 2006-08-04 PT PT06765213T patent/PT1861100E/pt unknown
- 2006-08-04 DE DE602006003415T patent/DE602006003415D1/de active Active
- 2006-08-04 DK DK06765213T patent/DK1861100T3/da active
- 2006-08-04 RS RSP-2009/0015A patent/RS50720B/sr unknown
- 2006-08-04 SI SI200630187T patent/SI1861100T1/sl unknown
- 2006-08-04 WO PCT/GB2006/002909 patent/WO2007017643A1/en not_active Ceased
- 2006-08-04 AU AU2006277836A patent/AU2006277836B8/en not_active Expired - Fee Related
- 2006-08-04 ZA ZA200801171A patent/ZA200801171B/xx unknown
- 2006-08-04 CA CA002620952A patent/CA2620952A1/en not_active Abandoned
- 2006-08-04 PL PL06765213T patent/PL1861100T3/pl unknown
- 2006-08-04 ZA ZA200801170A patent/ZA200801170B/xx unknown
-
2009
- 2009-01-27 CY CY20091100100T patent/CY1108729T1/el unknown