JP2009502830A5 - - Google Patents
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- Publication number
- JP2009502830A5 JP2009502830A5 JP2008523189A JP2008523189A JP2009502830A5 JP 2009502830 A5 JP2009502830 A5 JP 2009502830A5 JP 2008523189 A JP2008523189 A JP 2008523189A JP 2008523189 A JP2008523189 A JP 2008523189A JP 2009502830 A5 JP2009502830 A5 JP 2009502830A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkylene
- halogen
- aryl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 133
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 56
- 125000000623 heterocyclic group Chemical group 0.000 claims description 55
- 229910052736 halogen Inorganic materials 0.000 claims description 40
- 150000002367 halogens Chemical class 0.000 claims description 40
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims description 27
- 125000002947 alkylene group Chemical group 0.000 claims description 19
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 16
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 12
- 125000003118 aryl group Chemical group 0.000 claims description 7
- -1 R ′ Chemical group 0.000 claims description 3
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 2
- 125000001072 heteroaryl group Chemical group 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 54
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 10
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
- 239000005977 Ethylene Substances 0.000 claims 2
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 102000000568 rho-Associated Kinases Human genes 0.000 claims 2
- 108010041788 rho-Associated Kinases Proteins 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- 208000020084 Bone disease Diseases 0.000 claims 1
- 201000006474 Brain Ischemia Diseases 0.000 claims 1
- 125000004399 C1-C4 alkenyl group Chemical group 0.000 claims 1
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims 1
- 208000006029 Cardiomegaly Diseases 0.000 claims 1
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
- 206010017964 Gastrointestinal infection Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010019663 Hepatic failure Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010020880 Hypertrophy Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 102000011131 Myosin-Light-Chain Phosphatase Human genes 0.000 claims 1
- 108010037801 Myosin-Light-Chain Phosphatase Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010030043 Ocular hypertension Diseases 0.000 claims 1
- 206010053159 Organ failure Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000005107 Premature Birth Diseases 0.000 claims 1
- 206010036590 Premature baby Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 230000002124 endocrine Effects 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 206010061989 glomerulosclerosis Diseases 0.000 claims 1
- 201000001881 impotence Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000001286 intracranial vasospasm Diseases 0.000 claims 1
- 208000023589 ischemic disease Diseases 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 208000007903 liver failure Diseases 0.000 claims 1
- 231100000835 liver failure Toxicity 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000008816 organ damage Effects 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 201000004240 prostatic hypertrophy Diseases 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 208000002815 pulmonary hypertension Diseases 0.000 claims 1
- 201000002793 renal fibrosis Diseases 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 0 CC(C)IC(CCC(C1)N(*)*)CC1(C)*(C)(C)C Chemical compound CC(C)IC(CCC(C1)N(*)*)CC1(C)*(C)(C)C 0.000 description 6
- 229910052799 carbon Inorganic materials 0.000 description 2
- VZBNAIGAEFJEEX-WGSAOQKQSA-N CC(C)CN(CC(C)C)[C@H](CC1)CC[C@@H]1Oc(c(Cl)c1)cc(C=CN2)c1C2=O Chemical compound CC(C)CN(CC(C)C)[C@H](CC1)CC[C@@H]1Oc(c(Cl)c1)cc(C=CN2)c1C2=O VZBNAIGAEFJEEX-WGSAOQKQSA-N 0.000 description 1
- QYVOLGBZIPOVSS-HDICACEKSA-N CCCCN(CCCC)[C@H](CC1)CC[C@H]1Oc(ccc1c2C=CNC1=O)c2Cl Chemical compound CCCCN(CCCC)[C@H](CC1)CC[C@H]1Oc(ccc1c2C=CNC1=O)c2Cl QYVOLGBZIPOVSS-HDICACEKSA-N 0.000 description 1
- OGNHHNRUWSNYEA-UHFFFAOYSA-N CCCCNC(CC1)CCC1Oc(ccc1c2C=CNC1=O)c2Cl Chemical compound CCCCNC(CC1)CCC1Oc(ccc1c2C=CNC1=O)c2Cl OGNHHNRUWSNYEA-UHFFFAOYSA-N 0.000 description 1
- CYICIBLRDQJLCB-SHTZXODSSA-N CCCCN[C@H](CC1)CC[C@@H]1Oc(c(Cl)c1)cc(C=CN2)c1C2=O Chemical compound CCCCN[C@H](CC1)CC[C@@H]1Oc(c(Cl)c1)cc(C=CN2)c1C2=O CYICIBLRDQJLCB-SHTZXODSSA-N 0.000 description 1
- FOLOFNFIUXAKTG-BETUJISGSA-N CCCN[C@H](CC1)CC[C@H]1Oc(ccc1c2C=CNC1=O)c2Cl Chemical compound CCCN[C@H](CC1)CC[C@H]1Oc(ccc1c2C=CNC1=O)c2Cl FOLOFNFIUXAKTG-BETUJISGSA-N 0.000 description 1
- JOXARZLBTLZPFJ-UHFFFAOYSA-N CCN(CC)C(CC1)CCC1Oc(cc(C=CNC1=O)c1c1)c1Cl Chemical compound CCN(CC)C(CC1)CCC1Oc(cc(C=CNC1=O)c1c1)c1Cl JOXARZLBTLZPFJ-UHFFFAOYSA-N 0.000 description 1
- LIMSIGMDFMYUKA-UHFFFAOYSA-N CCNC(CC1)CCC1Oc(c(Cl)c1)cc(C=CN2)c1C2=O Chemical compound CCNC(CC1)CCC1Oc(c(Cl)c1)cc(C=CN2)c1C2=O LIMSIGMDFMYUKA-UHFFFAOYSA-N 0.000 description 1
- RTHDGXFTVSXYHO-JOCQHMNTSA-N Cc(cc(c(C=CN1)c2)C1=O)c2O[C@H](CC1)CC[C@@H]1N Chemical compound Cc(cc(c(C=CN1)c2)C1=O)c2O[C@H](CC1)CC[C@@H]1N RTHDGXFTVSXYHO-JOCQHMNTSA-N 0.000 description 1
- WLCYOZRJHQABCX-UHFFFAOYSA-N NC(CC1)CCC1Oc(c(Cl)c1C=CN2)ccc1C2=O Chemical compound NC(CC1)CCC1Oc(c(Cl)c1C=CN2)ccc1C2=O WLCYOZRJHQABCX-UHFFFAOYSA-N 0.000 description 1
- KBSJOEJDHQZYQG-UHFFFAOYSA-N N[C@@H](CC1)CC/C1=[O]/c(c(Br)c1)cc(C=CN2)c1C2=O Chemical compound N[C@@H](CC1)CC/C1=[O]/c(c(Br)c1)cc(C=CN2)c1C2=O KBSJOEJDHQZYQG-UHFFFAOYSA-N 0.000 description 1
- SOTIKWJYKQEPQG-HAQNSBGRSA-N N[C@H](CC1)CC[C@@H]1Oc(cc1C=CN2)ccc1C2=O Chemical compound N[C@H](CC1)CC[C@@H]1Oc(cc1C=CN2)ccc1C2=O SOTIKWJYKQEPQG-HAQNSBGRSA-N 0.000 description 1
- XRTZZJKVSCLQQA-PHIMTYICSA-N N[C@H](CC1)CC[C@H]1Oc(cc(C=CNC1=O)c1c1)c1Cl Chemical compound N[C@H](CC1)CC[C@H]1Oc(cc(C=CNC1=O)c1c1)c1Cl XRTZZJKVSCLQQA-PHIMTYICSA-N 0.000 description 1
- CROIMRXJKJJJOR-UHFFFAOYSA-N O=C(c1c2)NC=Cc1cc(OC(CC1)CCC1NCc1cc(cccc3)c3cc1)c2Cl Chemical compound O=C(c1c2)NC=Cc1cc(OC(CC1)CCC1NCc1cc(cccc3)c3cc1)c2Cl CROIMRXJKJJJOR-UHFFFAOYSA-N 0.000 description 1
- RFKHGHPILFCCFX-CALCHBBNSA-N O=C(c1c2)NC=Cc1cc(O[C@H](CC1)CC[C@H]1N(C1CC1)C1CC1)c2Cl Chemical compound O=C(c1c2)NC=Cc1cc(O[C@H](CC1)CC[C@H]1N(C1CC1)C1CC1)c2Cl RFKHGHPILFCCFX-CALCHBBNSA-N 0.000 description 1
- MQHXOTMFMZOJKP-CALCHBBNSA-N O=C(c1c2)NC=Cc1cc(O[C@H](CC1)CC[C@H]1NCc(cc(cc1)Cl)c1Cl)c2Cl Chemical compound O=C(c1c2)NC=Cc1cc(O[C@H](CC1)CC[C@H]1NCc(cc(cc1)Cl)c1Cl)c2Cl MQHXOTMFMZOJKP-CALCHBBNSA-N 0.000 description 1
- GZQYPOITTJUQHS-UHFFFAOYSA-N O=C1NC=Cc(cc2OC(CC3)CCC3N(CC3CC3)CC3CC3)c1cc2Cl Chemical compound O=C1NC=Cc(cc2OC(CC3)CCC3N(CC3CC3)CC3CC3)c1cc2Cl GZQYPOITTJUQHS-UHFFFAOYSA-N 0.000 description 1
- BYLDLMKWKCVHHO-UHFFFAOYSA-N O=C1NC=Cc(cc2OC(CC3)CCC3NCc(ccc(Cl)c3)c3Cl)c1cc2Cl Chemical compound O=C1NC=Cc(cc2OC(CC3)CCC3NCc(ccc(Cl)c3)c3Cl)c1cc2Cl BYLDLMKWKCVHHO-UHFFFAOYSA-N 0.000 description 1
- BWURLRXDQRQBHC-UHFFFAOYSA-N O=C1NC=Cc(cc2OC(CC3)CCC3NCc3cc(Cl)cc(Cl)c3)c1cc2Cl Chemical compound O=C1NC=Cc(cc2OC(CC3)CCC3NCc3cc(Cl)cc(Cl)c3)c1cc2Cl BWURLRXDQRQBHC-UHFFFAOYSA-N 0.000 description 1
- AMGDQHUPGDPSNZ-UHFFFAOYSA-N O=C1NC=Cc(cc2OC(CC3)CCC3NCc3cccc(Cl)c3)c1cc2Cl Chemical compound O=C1NC=Cc(cc2OC(CC3)CCC3NCc3cccc(Cl)c3)c1cc2Cl AMGDQHUPGDPSNZ-UHFFFAOYSA-N 0.000 description 1
- GZQYPOITTJUQHS-WGSAOQKQSA-N O=C1NC=Cc(cc2O[C@H](CC3)CC[C@@H]3N(CC3CC3)CC3CC3)c1cc2Cl Chemical compound O=C1NC=Cc(cc2O[C@H](CC3)CC[C@@H]3N(CC3CC3)CC3CC3)c1cc2Cl GZQYPOITTJUQHS-WGSAOQKQSA-N 0.000 description 1
- QJVVGSVZENUWLR-OKILXGFUSA-N O=C1NC=Cc(cc2O[C@H](CC3)CC[C@H]3NC3CC3)c1cc2Cl Chemical compound O=C1NC=Cc(cc2O[C@H](CC3)CC[C@H]3NC3CC3)c1cc2Cl QJVVGSVZENUWLR-OKILXGFUSA-N 0.000 description 1
- ULRFTORYRITKEX-IYBDPMFKSA-N O=C1NC=Cc2c1ccc(O[C@H](CC1)CC[C@H]1NCC1CC1)c2 Chemical compound O=C1NC=Cc2c1ccc(O[C@H](CC1)CC[C@H]1NCC1CC1)c2 ULRFTORYRITKEX-IYBDPMFKSA-N 0.000 description 1
- RDAQBRIXBUKLRS-OKILXGFUSA-N O=C1NC=Cc2c1ccc(O[C@H](CC1)CC[C@H]1NCC1CC1)c2Cl Chemical compound O=C1NC=Cc2c1ccc(O[C@H](CC1)CC[C@H]1NCC1CC1)c2Cl RDAQBRIXBUKLRS-OKILXGFUSA-N 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05016153 | 2005-07-26 | ||
| EP05016153.8 | 2005-07-26 | ||
| PCT/EP2006/007140 WO2007012422A1 (en) | 2005-07-26 | 2006-07-20 | Cyclohexylamin isoquinolone derivatives as rho-kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009502830A JP2009502830A (ja) | 2009-01-29 |
| JP2009502830A5 true JP2009502830A5 (https=) | 2009-09-03 |
| JP5049970B2 JP5049970B2 (ja) | 2012-10-17 |
Family
ID=35115842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008523189A Expired - Fee Related JP5049970B2 (ja) | 2005-07-26 | 2006-07-20 | Ｒｈｏ−キナーゼ阻害剤としてのシクロヘキシルアミンイソキノロン誘導体 |
Country Status (36)
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ565040A (en) | 2005-06-28 | 2010-05-28 | Sanofi Aventis | Isoquinoline derivatives as inhibitors of RHO-kinase |
| KR101373535B1 (ko) | 2005-07-26 | 2014-03-12 | 사노피 | Ｒｈｏ-키나제 억제제로서의 피페리디닐-치환된 이소퀴놀론유도체 |
| JP5049970B2 (ja) | 2005-07-26 | 2012-10-17 | サノフイ | Ｒｈｏ−キナーゼ阻害剤としてのシクロヘキシルアミンイソキノロン誘導体 |
| US7893088B2 (en) * | 2006-08-18 | 2011-02-22 | N.V. Organon | 6-substituted isoquinoline derivatives |
| WO2008033757A2 (en) * | 2006-09-11 | 2008-03-20 | N.V. Organon | 2-(1-oxo-1h-isoquinolin-2-yl) acetamide derivatives |
| EP2114920A1 (en) | 2006-12-27 | 2009-11-11 | Sanofi-Aventis | Substituted isoquinoline and isoquinolinone derivatives |
| WO2008077555A2 (en) | 2006-12-27 | 2008-07-03 | Sanofi-Aventis | Substituted isoquinolines and their use as rho-kinase inhibitors |
| KR20090092303A (ko) * | 2006-12-27 | 2009-08-31 | 사노피-아벤티스 | 사이클로알킬아민 치환된 이소퀴놀린 유도체 |
| RU2468011C2 (ru) | 2006-12-27 | 2012-11-27 | Санофи-Авентис | Замещенные циклоалкиламином производные изохинолина и изохинолинона |
| NZ577980A (en) | 2006-12-27 | 2012-01-12 | Sanofi Aventis | Cycloalkylamine substituted isoquinolone derivatives |
| RU2455302C2 (ru) | 2006-12-27 | 2012-07-10 | Санофи-Авентис | ЗАМЕЩЕННЫЕ ИЗОХИНОЛИНОВЫЕ И ИЗОХИНОЛИНОНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ |
| TW200845988A (en) | 2007-04-05 | 2008-12-01 | Astrazeneca Ab | New compounds and their uses 707 |
| CN101910133A (zh) * | 2007-10-24 | 2010-12-08 | 默沙东公司 | 杂环苯基酰胺t-型钙通道拮抗剂 |
| HRP20131040T1 (hr) * | 2008-06-24 | 2013-12-06 | Sanofi | Bi- i policikliäśki supstituirani izokinolin i derivati izokinolina kao inhibitori rho-kinaze |
| CN102131784B (zh) | 2008-06-24 | 2014-08-27 | 赛诺菲-安万特 | 作为rho激酶抑制剂的取代的异喹啉和异喹啉酮 |
| PT2313374E (pt) * | 2008-06-24 | 2013-11-29 | Sanofi Sa | Isoquinolinas e isoquinolinonas 6-substituídas |
| BRPI0917936A2 (pt) * | 2008-08-25 | 2017-07-11 | Irm Llc | Moduladores de via hedgehog |
| AR073711A1 (es) | 2008-10-01 | 2010-11-24 | Astrazeneca Ab | Derivados de isoquinolina |
| JP6488239B2 (ja) * | 2013-01-18 | 2019-03-20 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｒｏｃｋ阻害剤としてのフタラジノンおよびイソキノリノン |
| EP3290407B1 (en) | 2013-10-18 | 2020-01-01 | Celgene Quanticel Research, Inc | Bromodomain inhibitors |
| JP6307088B2 (ja) * | 2013-10-23 | 2018-04-04 | 中外製薬株式会社 | キナゾリノンおよびイソキノリノン誘導体 |
| FR3017868A1 (fr) | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN105085478B (zh) * | 2014-04-28 | 2019-04-12 | 南京明德新药研发股份有限公司 | 异喹啉磺胺衍生物及其药物组合物和制药用途 |
| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| WO2016180918A1 (en) | 2015-05-12 | 2016-11-17 | Platod | Combination of pharmacological and microfluidic features for improved platelets production |
| WO2017003723A1 (en) | 2015-07-01 | 2017-01-05 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| AU2017252276A1 (en) | 2016-04-18 | 2018-11-15 | Celgene Quanticel Research, Inc. | Therapeutic compounds |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| US11028068B2 (en) | 2017-07-25 | 2021-06-08 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| ES3028093T3 (en) | 2018-06-07 | 2025-06-18 | Disarm Therapeutics Inc | Inhibitors of sarm1 |
| CN114874236B (zh) * | 2022-06-24 | 2023-05-05 | 中国工程物理研究院化工材料研究所 | 一种五元氮杂稠环骨架及其制备方法 |
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| JPH06501921A (ja) | 1990-07-31 | 1994-03-03 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 選択されたハロカーボンの触媒平衡化 |
| US5480883A (en) | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| GB9516709D0 (en) | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
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| NZ513800A (en) * | 1996-08-12 | 2001-09-28 | Welfide Corp | Treatment of diseases using Rho kinase inhibitors |
| JPH1087629A (ja) | 1996-09-18 | 1998-04-07 | Fujisawa Pharmaceut Co Ltd | 新規イソキノリン誘導体、およびその医薬用途 |
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| TW575567B (en) | 1998-10-23 | 2004-02-11 | Akzo Nobel Nv | Serine protease inhibitor |
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