JP2009100745A5 - - Google Patents

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Publication number

JP2009100745A5

JP2009100745A5 JP2008292842A JP2008292842A JP2009100745A5 JP 2009100745 A5 JP2009100745 A5 JP 2009100745A5 JP 2008292842 A JP2008292842 A JP 2008292842A JP 2008292842 A JP2008292842 A JP 2008292842A JP 2009100745 A5 JP2009100745 A5 JP 2009100745A5

Authority

JP

Japan

Prior art keywords

active fragment

isolated antibody

amino acid

acid sequence

antibody

Prior art date

2008-11-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000012634 fragment Substances 0.000 claims 81
• 125000003275 alpha amino acid group Chemical group 0.000 claims 53
• 108090000765 processed proteins & peptides Proteins 0.000 claims 53
• 229920001184 polypeptide Polymers 0.000 claims 47
• 102000004196 processed proteins & peptides Human genes 0.000 claims 47
• 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 30
• 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 30
• 206010028980 Neoplasm Diseases 0.000 claims 28
• YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 24
• 210000004027 cell Anatomy 0.000 claims 23
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 13
• 101150039808 Egfr gene Proteins 0.000 claims 12
• 108700021358 erbB-1 Genes Proteins 0.000 claims 12
• 150000001413 amino acids Chemical class 0.000 claims 11
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 7
• 230000003321 amplification Effects 0.000 claims 6
• 201000011510 cancer Diseases 0.000 claims 6
• 238000000034 method Methods 0.000 claims 6
• 238000003199 nucleic acid amplification method Methods 0.000 claims 6
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• 239000002246 antineoplastic agent Substances 0.000 claims 5
• 229940127089 cytotoxic agent Drugs 0.000 claims 4
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• 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 2
• 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 2
• NHFDRBXTEDBWCZ-ZROIWOOFSA-N 3-[2,4-dimethyl-5-[(z)-(2-oxo-1h-indol-3-ylidene)methyl]-1h-pyrrol-3-yl]propanoic acid Chemical compound OC(=O)CCC1=C(C)NC(\C=C/2C3=CC=CC=C3NC\2=O)=C1C NHFDRBXTEDBWCZ-ZROIWOOFSA-N 0.000 claims 1
• 206010003571 Astrocytoma Diseases 0.000 claims 1
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• 208000003174 Brain Neoplasms Diseases 0.000 claims 1
• 101100348617 Candida albicans (strain SC5314 / ATCC MYA-2876) NIK1 gene Proteins 0.000 claims 1
• 208000032170 Congenital Abnormalities Diseases 0.000 claims 1
• 102000053602 DNA Human genes 0.000 claims 1
• 241000588724 Escherichia coli Species 0.000 claims 1
• 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 claims 1
• 241000238631 Hexapoda Species 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
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• 241001465754 Metazoa Species 0.000 claims 1
• 229910019142 PO4 Inorganic materials 0.000 claims 1
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• 108020004511 Recombinant DNA Proteins 0.000 claims 1
• 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
• 101100007329 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) COS1 gene Proteins 0.000 claims 1
• 101100221606 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) COS7 gene Proteins 0.000 claims 1
• 241000187747 Streptomyces Species 0.000 claims 1
• 239000003080 antimitotic agent Substances 0.000 claims 1
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• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
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• 239000003085 diluting agent Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
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• AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 1
• 229960001433 erlotinib Drugs 0.000 claims 1
• XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 1
• 229960002584 gefitinib Drugs 0.000 claims 1
• 208000005017 glioblastoma Diseases 0.000 claims 1
• 239000003966 growth inhibitor Substances 0.000 claims 1
• 210000005260 human cell Anatomy 0.000 claims 1
• 238000009396 hybridization Methods 0.000 claims 1
• KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims 1
• 229960002411 imatinib Drugs 0.000 claims 1
• 229940127121 immunoconjugate Drugs 0.000 claims 1
• 238000003364 immunohistochemistry Methods 0.000 claims 1
• 239000003446 ligand Substances 0.000 claims 1
• 210000005228 liver tissue Anatomy 0.000 claims 1
• 206010027191 meningioma Diseases 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 239000003607 modifier Substances 0.000 claims 1
• 208000014500 neuronal tumor Diseases 0.000 claims 1
• 229960001972 panitumumab Drugs 0.000 claims 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
• 239000010452 phosphate Substances 0.000 claims 1
• 230000001323 posttranslational effect Effects 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 239000000523 sample Substances 0.000 claims 1
• 230000011664 signaling Effects 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 210000001519 tissue Anatomy 0.000 claims 1
• 239000003053 toxin Substances 0.000 claims 1
• 231100000765 toxin Toxicity 0.000 claims 1
• 108700012359 toxins Proteins 0.000 claims 1
• 210000004881 tumor cell Anatomy 0.000 claims 1
• 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 claims 1
• GFNNBHLJANVSQV-UHFFFAOYSA-N tyrphostin AG 1478 Chemical group C=12C=C(OC)C(OC)=CC2=NC=NC=1NC1=CC=CC(Cl)=C1 GFNNBHLJANVSQV-UHFFFAOYSA-N 0.000 claims 1