AU2002311919B8 - Specific binding proteins and uses thereof - Google Patents

Specific binding proteins and uses thereof Download PDF

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Publication number
AU2002311919B8
AU2002311919B8 AU2002311919A AU2002311919A AU2002311919B8 AU 2002311919 B8 AU2002311919 B8 AU 2002311919B8 AU 2002311919 A AU2002311919 A AU 2002311919A AU 2002311919 A AU2002311919 A AU 2002311919A AU 2002311919 B8 AU2002311919 B8 AU 2002311919B8
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AU
Australia
Prior art keywords
antibody
egfr
mab
active fragment
cells
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Expired
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AU2002311919A
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English (en)
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AU2002311919A1 (en
AU2002311919B2 (en
Inventor
Anthony Wilks Burgess
Webster K. Cavenee
Peter Collins
Huei-Jen Huang
Terrance Grant Johns
Achim Jungbluth
Edouard Collins Nice
Lloyd J. Old
Con Panousis
Christoph Renner
Gerd Ritter
Andrew Mark Scott
Elisabeth Stockert
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Ludwig Cancer Research
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Ludwig Cancer Research
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Application filed by Ludwig Cancer Research filed Critical Ludwig Cancer Research
Publication of AU2002311919A1 publication Critical patent/AU2002311919A1/en
Application granted granted Critical
Publication of AU2002311919B2 publication Critical patent/AU2002311919B2/en
Publication of AU2002311919B8 publication Critical patent/AU2002311919B8/en
Assigned to LUDWIG INSTITUTE FOR CANCER RESEARCH LTD reassignment LUDWIG INSTITUTE FOR CANCER RESEARCH LTD Request to Amend Deed and Register Assignors: LUDWIG INSTITUTE FOR CANCER RESEARCH
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2002311919A 2001-05-11 2002-05-13 Specific binding proteins and uses thereof Expired AU2002311919B8 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US29041001P 2001-05-11 2001-05-11
US60/290,410 2001-05-11
US32601901P 2001-09-28 2001-09-28
US60/326,019 2001-09-28
US34225801P 2001-12-21 2001-12-21
US60/342,258 2001-12-21
PCT/US2002/015185 WO2002092771A2 (en) 2001-05-11 2002-05-13 Specific binding proteins and uses thereof

Publications (3)

Publication Number Publication Date
AU2002311919A1 AU2002311919A1 (en) 2003-05-01
AU2002311919B2 AU2002311919B2 (en) 2007-02-08
AU2002311919B8 true AU2002311919B8 (en) 2007-03-22

Family

ID=27403978

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002311919A Expired AU2002311919B8 (en) 2001-05-11 2002-05-13 Specific binding proteins and uses thereof

Country Status (12)

Country Link
US (3) US7589180B2 (enExample)
EP (3) EP2163256B1 (enExample)
JP (4) JP4414142B2 (enExample)
AT (1) ATE446317T1 (enExample)
AU (1) AU2002311919B8 (enExample)
CA (1) CA2447139C (enExample)
CY (1) CY1109725T1 (enExample)
DE (1) DE60234094D1 (enExample)
DK (2) DK1392359T4 (enExample)
ES (2) ES2552281T3 (enExample)
PT (2) PT1392359E (enExample)
WO (1) WO2002092771A2 (enExample)

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