AU2002311919B8 - Specific binding proteins and uses thereof - Google Patents
Specific binding proteins and uses thereof Download PDFInfo
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- AU2002311919B8 AU2002311919B8 AU2002311919A AU2002311919A AU2002311919B8 AU 2002311919 B8 AU2002311919 B8 AU 2002311919B8 AU 2002311919 A AU2002311919 A AU 2002311919A AU 2002311919 A AU2002311919 A AU 2002311919A AU 2002311919 B8 AU2002311919 B8 AU 2002311919B8
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (7)
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| US29041001P | 2001-05-11 | 2001-05-11 | |
| US60/290,410 | 2001-05-11 | ||
| US32601901P | 2001-09-28 | 2001-09-28 | |
| US60/326,019 | 2001-09-28 | ||
| US34225801P | 2001-12-21 | 2001-12-21 | |
| US60/342,258 | 2001-12-21 | ||
| PCT/US2002/015185 WO2002092771A2 (en) | 2001-05-11 | 2002-05-13 | Specific binding proteins and uses thereof |
Publications (3)
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| AU2002311919A1 AU2002311919A1 (en) | 2003-05-01 |
| AU2002311919B2 AU2002311919B2 (en) | 2007-02-08 |
| AU2002311919B8 true AU2002311919B8 (en) | 2007-03-22 |
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| EP (3) | EP2163256B1 (enExample) |
| JP (4) | JP4414142B2 (enExample) |
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| AU (1) | AU2002311919B8 (enExample) |
| CA (1) | CA2447139C (enExample) |
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| ES (2) | ES2334494T5 (enExample) |
| PT (2) | PT2163256E (enExample) |
| WO (1) | WO2002092771A2 (enExample) |
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| US20100056762A1 (en) * | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| US20110313230A1 (en) | 2001-05-11 | 2011-12-22 | Terrance Grant Johns | Specific binding proteins and uses thereof |
| EP2163256B1 (en) * | 2001-05-11 | 2015-09-02 | Ludwig Institute for Cancer Research Ltd. | Specific binding proteins and uses thereof |
| AT413486B (de) | 2002-07-03 | 2006-03-15 | Igeneon Krebs Immuntherapie | Verwendung eines antikörpers gerichtet gegen lewis-antigene |
| US20100003253A1 (en) * | 2002-11-08 | 2010-01-07 | Ablynx N.V. | Single domain antibodies directed against epidermal growth factor receptor and uses therefor |
| BRPI0316092B8 (pt) * | 2002-11-08 | 2021-05-25 | Ablynx Nv | anticorpos de domínio único direcionados contra o fator de necrose tumoral alfa e usos para os mesmos |
| EP2284192A3 (en) * | 2002-11-08 | 2011-07-20 | Ablynx N.V. | Camelidae antibodies for sublingual administration |
| ATE517922T1 (de) * | 2002-11-08 | 2011-08-15 | Ablynx Nv | Stabilisierte einzel-domänen-antikörper in einer pharmazeutischen zusammensetzung ausgestaltet für inhalation |
| US9320792B2 (en) | 2002-11-08 | 2016-04-26 | Ablynx N.V. | Pulmonary administration of immunoglobulin single variable domains and constructs thereof |
| US20060034845A1 (en) * | 2002-11-08 | 2006-02-16 | Karen Silence | Single domain antibodies directed against tumor necrosis factor alpha and uses therefor |
| EP1576966A4 (en) * | 2002-12-27 | 2006-07-26 | Shenzhen Tsinghua Yuanxing Bio | PROCESS FOR PREPARING A VACCINE AND ANTITUMOR VACCINES |
| BRPI0408683A (pt) * | 2003-03-24 | 2006-03-28 | Zymogenetics Inc | métodos de produzir um anticorpo para um polipeptìdeo, anticorpo ou fragmento de anticorpo, método para reduzir ou inibir a proliferação ou diferenciação induzida por il-22 ou induzida por il-20 de células hematopoiéticas e progenitores de células hematopoiéticas, uso de um anticorpo, de uma composição de um anticorpo ou fragmento de anticorpo, uso de um antagonista de il-22 ou il-20, uso de um antagonista de il-22ra |
| US7767792B2 (en) * | 2004-02-20 | 2010-08-03 | Ludwig Institute For Cancer Research Ltd. | Antibodies to EGF receptor epitope peptides |
| GB0410627D0 (en) | 2004-05-12 | 2004-06-16 | Scancell Ltd | Specific binding members |
| JP4898691B2 (ja) | 2004-10-22 | 2012-03-21 | ザイモジェネティクス， インコーポレイテッド | 抗ｉｌ−２２ｒａ抗体および結合パートナー、ならびに炎症における使用法 |
| NZ556286A (en) * | 2005-02-07 | 2010-11-26 | Glycart Biotechnology Ag | Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof |
| CA2964111A1 (en) * | 2005-03-29 | 2006-10-05 | The Trustees Of The University Of Pennsylvania | Methods for generating new hair folicles, treating baldness, and hair removal |
| JP2006284330A (ja) * | 2005-03-31 | 2006-10-19 | Gunma Univ | アシアロｇｍ１の免疫学的測定キット並びに抗アシアロｇｍ１抗体の免疫学的測定キット |
| WO2007041397A2 (en) * | 2005-09-30 | 2007-04-12 | California Pacific Medical Center | Targeted pharmaceuticals and ligands |
| AU2007218959A1 (en) * | 2006-02-24 | 2007-08-30 | F. Hoffmann-La Roche Ag | Cancerous disease modifying antibodies |
| US20090280503A1 (en) * | 2006-09-15 | 2009-11-12 | James Fiore | Method for detecting and treating skin disorders |
| AU2007305423A1 (en) | 2006-09-28 | 2008-04-10 | Follica, Inc. | Methods, kits, and compositions for generating new hair follicles and growing hair |
| CN104043123B (zh) | 2007-01-25 | 2019-08-13 | 达娜-法勃肿瘤研究所公司 | 抗egfr抗体在治疗egfr突变体介导的疾病中的用途 |
| EP2132229B1 (en) | 2007-03-01 | 2016-05-11 | Symphogen A/S | Recombinant anti-epidermal growth factor receptor antibody compositions |
| CN101688229B (zh) | 2007-03-15 | 2013-06-12 | 路德维格癌症研究所 | 包含egfr抗体和src抑制剂的组合物及其在制备用于治疗哺乳动物癌症的药物中的用途 |
| US8900816B2 (en) * | 2007-07-19 | 2014-12-02 | Duke University | Assay for anti-EGFRvIII antibodies |
| CN108424454B (zh) * | 2007-08-14 | 2022-05-31 | 路德维格癌症研究所有限公司 | 靶向egf受体的单克隆抗体175及其衍生物和用途 |
| US20110256142A1 (en) * | 2007-09-06 | 2011-10-20 | Genmab A/S | Novel methods and antibodies for treating cancer |
| WO2009068649A2 (en) | 2007-11-30 | 2009-06-04 | Glaxo Group Limited | Antigen-binding constructs |
| EP2331577B1 (en) | 2008-08-29 | 2017-06-07 | Symphogen A/S | Recombinant anti-epidermal growth factor receptor antibody compositions |
| PL3023438T3 (pl) | 2009-09-03 | 2020-07-27 | Merck Sharp & Dohme Corp. | Przeciwciała anty-gitr |
| KR101477762B1 (ko) * | 2009-09-22 | 2014-12-30 | 상하이 캔서 인스티튜트 | 특이성 결합 단백질 및 용도 |
| US20110076232A1 (en) | 2009-09-29 | 2011-03-31 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
| JP2011144124A (ja) * | 2010-01-13 | 2011-07-28 | Fujirebio Inc | 活性型ｅｇｆｒ特異抗体 |
| EP2544680B1 (en) | 2010-03-11 | 2015-01-14 | Merrimack Pharmaceuticals, Inc. | Use of erbb3 inhibitors in the treatment of triple negative breast cancer |
| JP2013534515A (ja) | 2010-06-01 | 2013-09-05 | モナシュ ユニバーシティ | プロセシングされていない受容体型チロシンキナーゼｃ−ＭＥＴに対する抗体 |
| BR112013010569A2 (pt) | 2010-10-29 | 2017-07-04 | Immunogen Inc | moléculas de ligação de egfr não antagonísticas e imunoconjugados das mesma |
| AU2011320314B2 (en) | 2010-10-29 | 2015-08-06 | Immunogen, Inc. | Novel EGFR-binding molecules and immunoconjugates thereof |
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| EP2655413B1 (en) | 2010-12-23 | 2019-01-16 | F.Hoffmann-La Roche Ag | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| PL2668209T3 (pl) | 2011-01-24 | 2021-11-02 | Gilead Sciences, Inc. | Przeciwciało selektywne dla komórek z wysoką gęstością egfr |
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| PE20160996A1 (es) | 2013-12-23 | 2016-11-09 | Bayer Pharma AG | Conjugados de farmacos anticuerpo (adcs) con inhibidores de ksp |
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- 2002-05-13 DE DE60234094T patent/DE60234094D1/de not_active Expired - Lifetime
- 2002-05-13 PT PT02739258T patent/PT1392359E/pt unknown
- 2002-05-13 EP EP10186053A patent/EP2335728A1/en not_active Withdrawn
- 2002-05-13 US US10/145,598 patent/US7589180B2/en not_active Expired - Lifetime
- 2002-05-13 AU AU2002311919A patent/AU2002311919B8/en not_active Expired
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2007
- 2007-07-05 JP JP2007177834A patent/JP2007306933A/ja not_active Withdrawn
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2008
- 2008-11-14 JP JP2008292842A patent/JP5384912B2/ja not_active Expired - Lifetime
- 2008-12-23 US US12/317,683 patent/US20090220510A1/en not_active Abandoned
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2010
- 2010-01-15 CY CY20101100049T patent/CY1109725T1/el unknown
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2012
- 2012-12-11 US US13/711,368 patent/US9562102B2/en not_active Expired - Fee Related
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2013
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5401828A (en) * | 1989-09-08 | 1995-03-28 | The Johns Hopkins University | Structural alterations of the EGF receptor gene in human gliomas |
| US5795965A (en) * | 1991-04-25 | 1998-08-18 | Chugai Seiyaku Kabushiki Kaisha | Reshaped human to human interleukin-6 receptor |
| US5942602A (en) * | 1997-02-13 | 1999-08-24 | Schering Aktiengessellschaft | Growth factor receptor antibodies |
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