CY1109725T1 - Ειδικες δεσμευομενες πρωτεϊνες και χρησεις αυτων - Google Patents

Ειδικες δεσμευομενες πρωτεϊνες και χρησεις αυτων

Info

Publication number
CY1109725T1
CY1109725T1 CY20101100049T CY101100049T CY1109725T1 CY 1109725 T1 CY1109725 T1 CY 1109725T1 CY 20101100049 T CY20101100049 T CY 20101100049T CY 101100049 T CY101100049 T CY 101100049T CY 1109725 T1 CY1109725 T1 CY 1109725T1
Authority
CY
Cyprus
Prior art keywords
antibodies
egfr
binded
proteins
special
Prior art date
Application number
CY20101100049T
Other languages
English (en)
Inventor
Lloyd J Old
Terrance Grant Johns
Con Panousis
Andrew Mark Scott
Christoph Renner
Gerd Ritter
Achim Jungbluth
Elisabeth Stockert
Peter Collins
Webster K Cavenee
Huei-Jen Huang
Anthony Wilks Burgess
Edouard Collins Nice
Original Assignee
Ludwig Institute For Cancer Research Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27403978&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1109725(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ludwig Institute For Cancer Research Ltd. filed Critical Ludwig Institute For Cancer Research Ltd.
Publication of CY1109725T1 publication Critical patent/CY1109725T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Η εφεύρεση σχετίζεται με ειδικά δεσμευόμενα μέλη, ιδίως αντισώματα, και ενεργά θραύσματα αυτών, που αναγνωρίζουν παρεκκλίνουσα, μεταφραστικά τροποποιημένη, ιδίως παρεκκλίνουσα γλυκοζυλιωμένη μορφή του EGFR. Τα δεσμευόμενα μέλη, ιδίως αντισώματα και θραύσματα αυτών, της εφεύρεσης δεν δεσμεύονται με EGFR σε φυσιολογικά κύτταρα απουσία ενίσχυσης του γονιδίου φυσικού τύπου και είναι ικανά να δεσμεύουν τον de2-7 EGFR σε επίτοπο που είναι διαφορετικός από το συνδετικό πεπτίδιο. Χαρακτηριστικό αντίσωμα αυτού του τύπου είναι το πρωτότυπο αντίσωμα 806 του οποίου οι αλληλουχίες VH και VL παρατίθενται ως αλληλουχίες αρ. 2 και 4 (SEQ ID Nos: 2 και 4) και χιμαιρικά αντισώματα αυτού των οποίων χαρακτηριστικό παράδειγμα είναι το ch806.
CY20101100049T 2001-05-11 2010-01-15 Ειδικες δεσμευομενες πρωτεϊνες και χρησεις αυτων CY1109725T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29041001P 2001-05-11 2001-05-11
US32601901P 2001-09-28 2001-09-28
US34225801P 2001-12-21 2001-12-21
EP02739258A EP1392359B2 (en) 2001-05-11 2002-05-13 Specific binding proteins and uses thereof

Publications (1)

Publication Number Publication Date
CY1109725T1 true CY1109725T1 (el) 2014-08-13

Family

ID=27403978

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100049T CY1109725T1 (el) 2001-05-11 2010-01-15 Ειδικες δεσμευομενες πρωτεϊνες και χρησεις αυτων

Country Status (13)

Country Link
US (3) US7589180B2 (el)
EP (3) EP2335728A1 (el)
JP (4) JP4414142B2 (el)
AT (1) ATE446317T1 (el)
AU (1) AU2002311919B8 (el)
CA (1) CA2447139C (el)
CY (1) CY1109725T1 (el)
DE (1) DE60234094D1 (el)
DK (2) DK1392359T4 (el)
ES (2) ES2552281T3 (el)
HK (1) HK1142272A1 (el)
PT (2) PT1392359E (el)
WO (1) WO2002092771A2 (el)

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