JP2008542278A5 - - Google Patents
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- JP2008542278A5 JP2008542278A5 JP2008513580A JP2008513580A JP2008542278A5 JP 2008542278 A5 JP2008542278 A5 JP 2008542278A5 JP 2008513580 A JP2008513580 A JP 2008513580A JP 2008513580 A JP2008513580 A JP 2008513580A JP 2008542278 A5 JP2008542278 A5 JP 2008542278A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- sequence
- variable domain
- chain variable
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims 39
- 102000004169 proteins and genes Human genes 0.000 claims 39
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 5
- 210000004602 germ cell Anatomy 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 101000830598 Homo sapiens Tumor necrosis factor ligand superfamily member 12 Proteins 0.000 claims 3
- 102000058177 human TNFSF12 Human genes 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68514905P | 2005-05-27 | 2005-05-27 | |
| US60/685,149 | 2005-05-27 | ||
| PCT/US2006/019706 WO2006130374A2 (en) | 2005-05-27 | 2006-05-25 | Tweak binding antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012256386A Division JP2013040210A (ja) | 2005-05-27 | 2012-11-22 | Ｔｗｅａｋ結合抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008542278A JP2008542278A (ja) | 2008-11-27 |
| JP2008542278A5 true JP2008542278A5 (https=) | 2009-07-09 |
| JP5175181B2 JP5175181B2 (ja) | 2013-04-03 |
Family
ID=37482143
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008513580A Expired - Fee Related JP5175181B2 (ja) | 2005-05-27 | 2006-05-25 | Ｔｗｅａｋ結合抗体 |
| JP2012256386A Withdrawn JP2013040210A (ja) | 2005-05-27 | 2012-11-22 | Ｔｗｅａｋ結合抗体 |
| JP2014170135A Withdrawn JP2014221837A (ja) | 2005-05-27 | 2014-08-25 | Ｔｗｅａｋ結合抗体 |
| JP2016212746A Expired - Fee Related JP6234535B2 (ja) | 2005-05-27 | 2016-10-31 | Ｔｗｅａｋ結合抗体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012256386A Withdrawn JP2013040210A (ja) | 2005-05-27 | 2012-11-22 | Ｔｗｅａｋ結合抗体 |
| JP2014170135A Withdrawn JP2014221837A (ja) | 2005-05-27 | 2014-08-25 | Ｔｗｅａｋ結合抗体 |
| JP2016212746A Expired - Fee Related JP6234535B2 (ja) | 2005-05-27 | 2016-10-31 | Ｔｗｅａｋ結合抗体 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US8048422B2 (https=) |
| EP (3) | EP2460832A3 (https=) |
| JP (4) | JP5175181B2 (https=) |
| KR (2) | KR101679468B1 (https=) |
| CN (3) | CN102441163A (https=) |
| AU (1) | AU2006252830B2 (https=) |
| BR (1) | BRPI0611414B8 (https=) |
| CA (1) | CA2609600C (https=) |
| CY (1) | CY1118343T1 (https=) |
| DK (2) | DK2460831T3 (https=) |
| EA (1) | EA018255B1 (https=) |
| ES (2) | ES2507069T3 (https=) |
| GE (1) | GEP20115324B (https=) |
| HU (1) | HUE030701T2 (https=) |
| IL (1) | IL187585A (https=) |
| IS (1) | IS8693A (https=) |
| LT (1) | LT2460831T (https=) |
| ME (2) | MEP35408A (https=) |
| MX (1) | MX339015B (https=) |
| NO (1) | NO20076607L (https=) |
| NZ (2) | NZ583636A (https=) |
| PL (3) | PL2460831T3 (https=) |
| PT (2) | PT2460831T (https=) |
| RS (1) | RS55888B1 (https=) |
| SG (1) | SG162728A1 (https=) |
| SI (2) | SI2460831T1 (https=) |
| UA (1) | UA96416C2 (https=) |
| WO (1) | WO2006130374A2 (https=) |
| ZA (1) | ZA200710765B (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7129061B1 (en) * | 1996-08-07 | 2006-10-31 | Biogen Idec Ma Inc. | Tumor necrosis factor related ligand |
| MXPA01007163A (es) * | 1999-01-15 | 2002-03-27 | Biogen Inc | Antagonistas de tweak y de receptores de tweak y su uso para tratar trastornos inmunologicos. |
| MX352180B (es) | 2002-04-09 | 2017-11-13 | Biogen Ma Inc | El uso de antagonistas de tweak para el tratamiento de condiciones relacionadas con tweak. |
| EP1811838A4 (en) * | 2004-11-08 | 2009-07-22 | Univ Maryland | TWEAK AS A THERAPEUTIC TARGET FOR THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM IN CONNECTION WITH CEREBRAL OEDEM AND CELL DEATH |
| US7939490B2 (en) | 2004-12-13 | 2011-05-10 | University Of Maryland, Baltimore | TWEAK as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death |
| US20090068102A1 (en) * | 2005-02-17 | 2009-03-12 | Biogen Idec Ma Inc. | Treating stroke |
| WO2006089095A2 (en) | 2005-02-17 | 2006-08-24 | Biogen Idec Ma Inc. | Treating neurological disorders |
| CA2607697C (en) | 2005-05-10 | 2015-01-06 | Biogen Idec Ma Inc. | Treating and evaluating inflammatory disorders |
| WO2006130429A2 (en) * | 2005-05-27 | 2006-12-07 | Biogen Idec Ma Inc. | Treatment of cancer |
| WO2006138219A2 (en) | 2005-06-13 | 2006-12-28 | Biogen Idec Ma Inc. | Methods of diagnosis / prognosis of inflammatory conditions |
| US20100284933A1 (en) * | 2006-10-16 | 2010-11-11 | Biogen Idec Ma Inc. | Biomarkers of Multiple Sclerosis |
| US8685741B1 (en) * | 2007-03-07 | 2014-04-01 | Nestec S.A. | Methods for diagnosing irritable bowel syndrome |
| SG190572A1 (en) | 2008-04-29 | 2013-06-28 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| CA2726087A1 (en) | 2008-06-03 | 2009-12-10 | Tariq Ghayur | Dual variable domain immunoglobulins and uses thereof |
| TW201006485A (en) | 2008-06-03 | 2010-02-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| CN102149825B (zh) | 2008-07-08 | 2015-07-22 | Abbvie公司 | 前列腺素e2双重可变结构域免疫球蛋白及其用途 |
| US8093006B2 (en) * | 2009-04-02 | 2012-01-10 | Hoffmann-La Roche Inc. | Antibodies against human tweak and uses thereof |
| NZ621170A (en) | 2009-05-13 | 2015-08-28 | Genzyme Corp | Anti-human cd52 immunoglobulins |
| WO2011028811A2 (en) * | 2009-09-01 | 2011-03-10 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
| BR112012008833A2 (pt) * | 2009-10-15 | 2015-09-08 | Abbott Lab | imunoglobulinas de dominio variavel duplo e usos das mesmas |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| US9096879B2 (en) | 2009-11-24 | 2015-08-04 | Biogen Ma Inc. | Method of supplementing culture media to prevent undesirable amino acid substitutions |
| US9068004B2 (en) | 2010-02-04 | 2015-06-30 | University Of Louisville Research Foundation, Inc. | TWEAK/Fn14 system regulates skeletal muscle atrophy and regeneration |
| CA2803392A1 (en) * | 2010-06-24 | 2011-12-29 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| EP3252072A3 (en) | 2010-08-03 | 2018-03-14 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
| JP2013539364A (ja) | 2010-08-26 | 2013-10-24 | アッヴィ・インコーポレイテッド | 二重可変ドメイン免疫グロブリンおよびその使用 |
| AU2011311673B2 (en) | 2010-10-05 | 2015-09-17 | F. Hoffmann-La Roche Ag | Antibodies against human TWEAK and uses thereof |
| TW201333035A (zh) | 2011-12-30 | 2013-08-16 | Abbvie Inc | 針對ｉｌ－１３及／或ｉｌ－１７之雙特異性結合蛋白 |
| WO2013150043A1 (en) | 2012-04-05 | 2013-10-10 | F. Hoffmann-La Roche Ag | Bispecific antibodies against human tweak and human il17 and uses thereof |
| TW202037609A (zh) | 2012-11-01 | 2020-10-16 | 美商艾伯維有限公司 | 抗-vegf/dll4雙重可變區域免疫球蛋白及其用途 |
| AR095199A1 (es) * | 2013-03-15 | 2015-09-30 | Genzyme Corp | Anticuerpos anti-cd52 |
| WO2014144280A2 (en) | 2013-03-15 | 2014-09-18 | Abbvie Inc. | DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1β AND / OR IL-17 |
| JP2016000003A (ja) * | 2013-04-19 | 2016-01-07 | アステラス製薬株式会社 | 新規抗ヒトｔｗｅａｋ抗体 |
| WO2015051234A2 (en) | 2013-10-04 | 2015-04-09 | Biogen Idec Ma Inc. | Tweak antagonists for treating lupus nephritis and muscle atrophy |
| US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白 |
| US20200031895A1 (en) | 2016-12-16 | 2020-01-30 | Biogen Ma Inc. | Stabilized proteolytically activated growth differentiation factor 11 |
| TW202506732A (zh) | 2018-05-07 | 2025-02-16 | 丹麥商珍美寶股份有限公司 | 使用抗ｐｄ－１抗體與抗組織因子抗體－藥物共軛體之組合以治療癌症之方法 |
| WO2020073047A1 (en) | 2018-10-05 | 2020-04-09 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use |
| US20220089704A1 (en) | 2018-10-29 | 2022-03-24 | Biogen Ma Inc. | Humanized and stabilized fc5 variants for enhancement of blood brain barrier transport |
| TWI844571B (zh) | 2018-10-30 | 2024-06-11 | 丹麥商珍美寶股份有限公司 | 使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法 |
| MY204672A (en) * | 2018-10-31 | 2024-09-09 | Astellas Pharma Inc | Anti-human fn14 antibody |
| CN112778372B (zh) * | 2019-11-11 | 2025-09-23 | 苏州泽璟生物制药股份有限公司 | 咪唑并喹啉取代磷酸酯类激动剂及其制备方法和应用 |
| TW202302648A (zh) * | 2021-03-12 | 2023-01-16 | 美商健生生物科技公司 | Cd79b抗體於自體免疫治療應用之用途 |
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| MX352180B (es) | 2002-04-09 | 2017-11-13 | Biogen Ma Inc | El uso de antagonistas de tweak para el tratamiento de condiciones relacionadas con tweak. |
| CA2512729C (en) | 2003-01-09 | 2014-09-16 | Macrogenics, Inc. | Identification and engineering of antibodies with variant fc regions and methods of using same |
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| EP1811838A4 (en) | 2004-11-08 | 2009-07-22 | Univ Maryland | TWEAK AS A THERAPEUTIC TARGET FOR THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM IN CONNECTION WITH CEREBRAL OEDEM AND CELL DEATH |
| US7939490B2 (en) | 2004-12-13 | 2011-05-10 | University Of Maryland, Baltimore | TWEAK as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death |
| WO2006089095A2 (en) | 2005-02-17 | 2006-08-24 | Biogen Idec Ma Inc. | Treating neurological disorders |
| US20090068102A1 (en) | 2005-02-17 | 2009-03-12 | Biogen Idec Ma Inc. | Treating stroke |
| EP1853312B1 (en) | 2005-03-07 | 2014-12-10 | Genentech, Inc. | Methods and compositions for modulating tweak and fn14 activity |
| CA2607697C (en) | 2005-05-10 | 2015-01-06 | Biogen Idec Ma Inc. | Treating and evaluating inflammatory disorders |
| WO2006130429A2 (en) | 2005-05-27 | 2006-12-07 | Biogen Idec Ma Inc. | Treatment of cancer |
| WO2006138219A2 (en) | 2005-06-13 | 2006-12-28 | Biogen Idec Ma Inc. | Methods of diagnosis / prognosis of inflammatory conditions |
| US20100284933A1 (en) | 2006-10-16 | 2010-11-11 | Biogen Idec Ma Inc. | Biomarkers of Multiple Sclerosis |
-
2006
- 2006-05-25 ME MEP-354/08A patent/MEP35408A/xx unknown
- 2006-05-25 CN CN2011103581313A patent/CN102441163A/zh active Pending
- 2006-05-25 CN CN2006800275811A patent/CN101247830B/zh not_active Expired - Fee Related
- 2006-05-25 LT LTEP11191771.2T patent/LT2460831T/lt unknown
- 2006-05-25 NZ NZ583636A patent/NZ583636A/en not_active IP Right Cessation
- 2006-05-25 PL PL11191771T patent/PL2460831T3/pl unknown
- 2006-05-25 JP JP2008513580A patent/JP5175181B2/ja not_active Expired - Fee Related
- 2006-05-25 WO PCT/US2006/019706 patent/WO2006130374A2/en not_active Ceased
- 2006-05-25 ME MEP-2008-354A patent/ME00261B/me unknown
- 2006-05-25 DK DK11191771.2T patent/DK2460831T3/en active
- 2006-05-25 PT PT111917712T patent/PT2460831T/pt unknown
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