JP2023061927A5 - - Google Patents
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- JP2023061927A5 JP2023061927A5 JP2023002879A JP2023002879A JP2023061927A5 JP 2023061927 A5 JP2023061927 A5 JP 2023061927A5 JP 2023002879 A JP2023002879 A JP 2023002879A JP 2023002879 A JP2023002879 A JP 2023002879A JP 2023061927 A5 JP2023061927 A5 JP 2023061927A5
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- Prior art keywords
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- amino acid
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 19
- 239000000203 mixture Substances 0.000 claims 8
- 230000007935 neutral effect Effects 0.000 claims 6
- 230000004962 physiological condition Effects 0.000 claims 6
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims 5
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 5
- 230000002378 acidificating effect Effects 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 230000006044 T cell activation Effects 0.000 claims 3
- 239000012636 effector Substances 0.000 claims 3
- 102000008055 Heparan Sulfate Proteoglycans Human genes 0.000 claims 2
- 229920002971 Heparan sulfate Polymers 0.000 claims 2
- 108090000054 Syndecan-2 Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 239000000611 antibody drug conjugate Substances 0.000 claims 2
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 210000005259 peripheral blood Anatomy 0.000 claims 2
- 239000011886 peripheral blood Substances 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 241000282567 Macaca fascicularis Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000004236 Ponceau SX Substances 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 238000012506 imaged capillary isoelectric focusing Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024179648A JP2025023919A (ja) | 2017-03-14 | 2024-10-15 | 酸性ｐＨでＶＩＳＴＡに結合する抗体 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762471196P | 2017-03-14 | 2017-03-14 | |
| US62/471,196 | 2017-03-14 | ||
| US201862636746P | 2018-02-28 | 2018-02-28 | |
| US62/636,746 | 2018-02-28 | ||
| JP2019549389A JP7211961B2 (ja) | 2017-03-14 | 2018-03-13 | 酸性ｐＨでＶＩＳＴＡに結合する抗体 |
| PCT/US2018/022230 WO2018169993A1 (en) | 2017-03-14 | 2018-03-13 | Antibodies binding to vista at acidic ph |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019549389A Division JP7211961B2 (ja) | 2017-03-14 | 2018-03-13 | 酸性ｐＨでＶＩＳＴＡに結合する抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024179648A Division JP2025023919A (ja) | 2017-03-14 | 2024-10-15 | 酸性ｐＨでＶＩＳＴＡに結合する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023061927A JP2023061927A (ja) | 2023-05-02 |
| JP2023061927A5 true JP2023061927A5 (https=) | 2023-06-05 |
| JP7573659B2 JP7573659B2 (ja) | 2024-10-25 |
Family
ID=63522565
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019549389A Active JP7211961B2 (ja) | 2017-03-14 | 2018-03-13 | 酸性ｐＨでＶＩＳＴＡに結合する抗体 |
| JP2023002879A Active JP7573659B2 (ja) | 2017-03-14 | 2023-01-12 | 酸性ｐＨでＶＩＳＴＡに結合する抗体 |
| JP2024179648A Pending JP2025023919A (ja) | 2017-03-14 | 2024-10-15 | 酸性ｐＨでＶＩＳＴＡに結合する抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019549389A Active JP7211961B2 (ja) | 2017-03-14 | 2018-03-13 | 酸性ｐＨでＶＩＳＴＡに結合する抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024179648A Pending JP2025023919A (ja) | 2017-03-14 | 2024-10-15 | 酸性ｐＨでＶＩＳＴＡに結合する抗体 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US11603406B2 (https=) |
| EP (1) | EP3595720A4 (https=) |
| JP (3) | JP7211961B2 (https=) |
| KR (2) | KR102715540B1 (https=) |
| CN (2) | CN118894937A (https=) |
| AU (2) | AU2018236218B2 (https=) |
| BR (1) | BR112019019108A2 (https=) |
| CA (1) | CA3054067A1 (https=) |
| CL (2) | CL2019002610A1 (https=) |
| CO (1) | CO2019010943A2 (https=) |
| IL (2) | IL269240B1 (https=) |
| MX (1) | MX2024003316A (https=) |
| MY (1) | MY200609A (https=) |
| PE (2) | PE20250933A1 (https=) |
| SG (1) | SG11201907848YA (https=) |
| TW (2) | TWI890190B (https=) |
| WO (1) | WO2018169993A1 (https=) |
| ZA (1) | ZA201905525B (https=) |
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| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| KR102057826B1 (ko) | 2008-04-11 | 2019-12-20 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| TWI812066B (zh) | 2010-11-30 | 2023-08-11 | 日商中外製藥股份有限公司 | 具有鈣依存性的抗原結合能力之抗體 |
| CN112812184A (zh) | 2011-02-25 | 2021-05-18 | 中外制药株式会社 | FcγRIIb特异性Fc抗体 |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| JP6124800B2 (ja) | 2011-11-30 | 2017-05-10 | 中外製薬株式会社 | 免疫複合体を形成する細胞内への運搬体（キャリア）を含む医薬 |
| JP6226752B2 (ja) | 2012-02-09 | 2017-11-08 | 中外製薬株式会社 | 抗体のＦｃ領域改変体 |
| TW202237660A (zh) | 2012-08-24 | 2022-10-01 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
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| CN107207607B (zh) | 2014-12-19 | 2021-05-04 | 中外制药株式会社 | 抗-c5抗体及使用方法 |
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| CN114773470A (zh) | 2015-02-05 | 2022-07-22 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用 |
| US11359009B2 (en) | 2015-12-25 | 2022-06-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| TWI693940B (zh) | 2016-08-05 | 2020-05-21 | 日商中外製藥股份有限公司 | Ｉｌ-８相關疾病之治療用或預防用組成物 |
| EP3568159A4 (en) | 2017-01-11 | 2020-08-05 | Bristol-Myers Squibb Company | PSGL-1 ANTAGONISTS AND THEIR USES |
| JP7191833B2 (ja) | 2017-01-30 | 2022-12-19 | 中外製薬株式会社 | 抗スクレロスチン抗体およびその使用 |
| KR102715540B1 (ko) * | 2017-03-14 | 2024-10-08 | 파이브 프라임 테라퓨틱스, 인크. | 산성 pH에서 VISTA에 결합하는 항체 |
| WO2018217976A1 (en) | 2017-05-25 | 2018-11-29 | Bristol-Myers Squibb Company | Antagonistic cd40 monoclonal antibodies and uses thereof |
| BR112020019083A2 (pt) | 2018-03-21 | 2020-12-29 | Five Prime Therapeutics, Inc. | Anticorpos, ácido nucleico, composições, célula e métodos para preparar um anticorpo, para tratar câncer, para tratar uma doença infecciosa, para tratar uma inflamação, para a identificação de um anticorpo, para melhorar a eficácia antitumoral de um anticorpo, para melhorar a farmacocinética de um anticorpo, para selecionar um anticorpo, para melhorar a eficácia de anticorpos, para isolar anticorpos, para detectar vista em uma amostra e para tratar câncer |
| GB201814562D0 (en) | 2018-09-07 | 2018-10-24 | Hummingbird Bioscience Pte Ltd | Vista antigen-binding molecules |
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| EP4031575A1 (en) * | 2019-09-19 | 2022-07-27 | Bristol-Myers Squibb Company | Antibodies binding to vista at acidic ph |
| MX2022007479A (es) | 2019-12-18 | 2022-06-29 | Hoffmann La Roche | Anticuerpos anti-ccl2 biespecificos. |
| WO2022178203A1 (en) * | 2021-02-18 | 2022-08-25 | Kineta, Inc. | Anti-vista antibodies and uses thereof |
| IL310292A (en) | 2021-07-22 | 2024-03-01 | Univ Dundee | Medicinal myotains |
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2018
- 2018-03-13 KR KR1020197029923A patent/KR102715540B1/ko active Active
- 2018-03-13 CN CN202410878453.8A patent/CN118894937A/zh active Pending
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- 2018-03-13 EP EP18767615.0A patent/EP3595720A4/en active Pending
- 2018-03-13 US US16/493,712 patent/US11603406B2/en active Active
- 2018-03-13 BR BR112019019108-9A patent/BR112019019108A2/pt unknown
- 2018-03-13 CA CA3054067A patent/CA3054067A1/en active Pending
- 2018-03-13 WO PCT/US2018/022230 patent/WO2018169993A1/en not_active Ceased
- 2018-03-13 CN CN201880031212.2A patent/CN110740749B/zh active Active
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