JP2020504087A - 4−1bb結合タンパク質及びその使用 - Google Patents
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- 229910052700 potassium Inorganic materials 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
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- 239000002453 shampoo Substances 0.000 description 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000009097 single-agent therapy Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
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- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
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- 235000002906 tartaric acid Nutrition 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 1
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- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
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- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
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- 229960004528 vincristine Drugs 0.000 description 1
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- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
VH ZW103 CDRセット
CDR−H1: SEQ ID NO:11
CDR−H2: SEQ ID NO:12
CDR−H3: SEQ ID NO:13
VL ZW103 CDRセット
CDR−L1: SEQ ID NO:14
CDR−L2: SEQ ID NO:15
CDR−L3: SEQ ID NO:16
VH ZW104 CDRセット
CDR−H1: SEQ ID NO:17
CDR−H2: SEQ ID NO:18
CDR−H3: SEQ ID NO:19
VL ZW104 CDRセット
CDR−L1: SEQ ID NO:20
CDR−L2: SEQ ID NO:21
CDR−L3: SEQ ID NO:22
VH ZW105 CDRセット
CDR−H1: SEQ ID NO:23
CDR−H2: SEQ ID NO:24
CDR−H3: SEQ ID NO:25
VL ZW105 CDRセット
CDR−L1: SEQ ID NO:26
CDR−L2: SEQ ID NO:27
CDR−L3: SEQ ID NO:28
VH ZW106 CDRセット
CDR−H1: SEQ ID NO:29
CDR−H2: SEQ ID NO:30
CDR−H3: SEQ ID NO:31
VL ZW106 CDRセット
CDR−L1: SEQ ID NO:32
CDR−L2: SEQ ID NO:33
CDR−L3: SEQ ID NO:34
VH ZW107 CDRセット
CDR−H1: SEQ ID NO:35
CDR−H2: SEQ ID NO:36
CDR−H3: SEQ ID NO:37
VL ZW107 CDRセット
CDR−L1: SEQ ID NO:38
CDR−L2: SEQ ID NO:39
CDR−L3: SEQ ID NO:40。
SEQ ID NO:1と2、
SEQ ID NO:3と4、
SEQ ID NO:5と6、
SEQ ID NO:7と8、
SEQ ID NO:9と10、
SEQ ID NO:52と53、又は
SEQ ID NO:56と57。
別の実施形態において、結合タンパク質を放出する組成物が開示されており、前記組成物は、製剤及び少なくとも1種の重合体担体を含み、前記製剤はさらに、以上開示された結晶化結合タンパク質、結晶化抗体構築物又は結晶化抗体コンジュゲート、及び成分を含む。別の実施形態において、前記重合体担体は、ポリ(アクリル酸)、ポリ(シアノアクリレート)、ポリ(アミノ酸)、ポリ(無水物)、ポリ(デプシペプチド)、ポリ(エステル)、ポリ(乳酸)、ポリ(乳酸−コ−グリコール酸)又はPLGA、ポリ(b−ヒドロキシブチラート)、ポリ(カプロラクトン)、ポリ(ジオキサノン)、ポリ(エチレングリコール)、ポリ((ヒドロキシプロピル)メタクリルアミド、ポリ[(オルガノ)ホスファゼン]、ポリ(オルトエステル)、ポリ(ビニルアルコール)、ポリ(ビニルピロリドン)、無水マレイン酸−アルキルビニルエーテルコポリマー、プルロニックポリオール(pluronic polyol)、アルブミン、アルギン酸塩、セルロース及びセルロース誘導体、コラーゲン、フィブリン、ゼラチン、ヒアルロン酸、オリゴ糖、グリコサミノグリカン(glycaminoglycan)、硫酸化多糖、及びそれらのブレンドと共重合体からなる群より選ばれる1種又は複数種の重合体である。別の実施形態において、前記成分は、アルブミン、蔗糖、トレハロース、ラクチトール、ゼラチン、ヒドロキシプロピル−β−シクロデキストリン、メトキシポリエチレングリコール、及びポリエチレングリコールからなる群より選ばれる。
e)、特発性パーキンソン病、特発性間質性肺炎、IgE媒介性アレルギー、免疫性溶血性貧血、封入体筋炎、感染性眼炎症疾患、炎症性脱髄疾患、炎症性心疾患、炎症性腎疾患、IPF/UIP、虹彩炎、角膜炎、乾性角結膜炎(keratojunctivitis sicca)、クスマウル病又はクスマウル−マイヤー病、ランドリー麻痺(Landry’s Paralysis)、ランゲルハンス細胞性組織球症、網状皮斑、黄斑変性、顕微鏡的多発性血管炎、モルブス・ベヒテレフ(morbus bechterev)、運動ニューロン疾患、粘膜性類天疱瘡、多臓器不全、重症筋無力症、骨髄異形成症候群、心筋炎、神経根障害、神経障害、非A非B型肝炎、視神経炎、骨溶解、小関節性JRA、末梢動脈閉塞疾患(PAOD)、末梢血管疾患(PVD)、末梢動脈疾患(PAD)、静脈炎、結節性多発性動脈炎(又は結節性動脈周囲炎)、多発性軟骨炎、リウマチ性多発性筋痛、白毛症、多関節性JRA、多内分泌欠損症候群、多発性筋炎、リウマチ性多発性筋痛(PMR)、ポンプ後症候群、原発性パーキンソニズム、前立腺癌、赤芽球癆、原発性副腎不全、再発性視神経脊髄炎、再狭窄、リウマチ性心疾患、SAPHO(滑膜炎、アクネ、膿疱症、骨過形成及び骨髄炎)、強皮症、続発性アミロイドーシス、ショック肺、強膜炎、坐骨神経痛、二次性副腎不全、シリコーン関連結合組織病、スネドン−ウィルキンソン皮膚症、強直性脊椎炎、スティーブンス・ジョンソン症候群(SJS)、全身性炎症反応症候群、側頭動脈炎、トキソプラスマ性網膜炎、概要中毒性表皮壊死症、横断性脊髄炎、TRAPS(腫瘍壊死因子受容体)、I型アレルギー反応、II型糖尿病、じんましん、通常型間質性肺炎(UIP)、血管炎、春季結膜炎、ウイルス性網膜炎、フォークト・小柳・原田症候群(VKH症候群)、滲出型黄斑変性、および創傷治癒からなる群より選ばれる障害を治療できる。
本明細書において、特に断らない限り、本開示について使用される科学及び技術用語は、当業者が通常理解しうる意味を有する。用語の意味及び範囲が明瞭であるが、潜在的なあいまいさがある場合、本明細書において提供される定義は辞書又は外部定義よりも優先される。さらに、文脈によって別段の要求がない限り、単数形の用語は複数形を含み、且つ、複数形の用語は単数形を含むものとする。本開示において、特に明記しない限り、「又は」の使用は、「及び/又は」を意味する。さらに、用語「含み/含む/含まれる/含有する/〜からなる(英語の「including」、及び「includes」や「included」)などの他の形態の使用は限定的ではない。さらに、特に明記しない限り、「要素」又は「コンポーネント」などの用語は、1つ/1種の単位を含む要素及びコンポーネント、ならびに複数/複数種のサブ単位を含む要素及びコンポーネントの両方を包含する。
一般に、本明細書に記載の細胞及び組織培養、分子生物学、免疫学、微生物学、遺伝学、タンパク質及び核酸化学、ならびにハイブリダイゼーションに関連して使用される用語は、当技術分野で一般的に使用されるものである。他に示さない限り、本開示の方法及び技術は、一般的に、当該分野で周知の常法に従って、そして、本開示を通して引用・考察される種々の一般的なそしてより具体的な参考文献に記載されるように行われる。酵素反応及び精製技術は、当技術分野において一般的に達成されているように、又は本明細書に記載されているように、製造業者の仕様書に従って行われる。本明細書に記載の分析化学、合成有機化学及び医薬化学に関連して使用される用語、及びそれらの実験室手順及び技法は、当技術分野において周知であり一般的に使用されているものである。カノニカル技術は、化学合成、化学分析、医薬調製、製剤化、送達及び患者の治療に使用される。
本明細書に使用されている用語「ポリペプチド」とは、アミノ酸の任意の高分子鎖である。用語「ペプチド」、「タンパク質」及び用語ポリペプチドは、交換して使用でき、且つ、アミノ酸の高分子鎖をも意味する。用語「ポリペプチド」は、タンパク質配列の天然又は人工タンパク質、タンパク質断片及びポリペプチドのアナログを含む。ポリペプチドは、単量体又は重合体であり得る。
本明細書で使用される用語「抗体構築物」は、リンカーポリペプチド又は免疫グロブリン定常ドメインに連結された本開示の1つ又は複数の抗原結合部分を含むポリペプチドを指す。リンカーポリペプチドは、ペプチド結合を介して連結された2つ以上のアミノ酸残基を含み、そして1つ以上の抗原結合部分を連結するために使用される。そのようなリンカーポリペプチドは、当技術分野において周知である(例えば、Holliger,P.ら(1993)Proc.Natl.Acad.Sci.USA 90:6444−6448と、Poljak,R.J.ら(1994)Structure2:1121〜1123などを参照)。免疫グロブリン定常ドメインは、重鎖又は軽鎖定常ドメインを指す。ヒトIgG重鎖及び軽鎖定常ドメインアミノ酸配列及びそれらの機能的変化は、当技術分野において公知である。
キメラ抗体は、抗体の異なる部分が異なる起源又は動物種に由来する分子である。キメラ抗体を産生するための方法は当技術分野において公知である。例えば、Morrison,Science 229:1202(1985)と、Oiら、BioTechniques 4:214(1986)と、Gilliesら、(1989)J.Immunol.Methods 125:191−202と、米国特許第5,807,715号、第4,816,567号及び第4,816,379号とを参照でき、これらは、参照によりその全体が本明細書に組み込まれる。さらに、「キメラ抗体」を産生するために開発された、適切な抗原特異性を有するマウス抗体分子由来の遺伝子を適切な生物学的活性を有するヒト抗体分子由来の遺伝子と共にスプライシングする技術が使用できる(Morrisonら、1984, Proc. Natl. Acad. Sci. 81:851−855;Neubergerら、1984, Nature 312:604−608;Takedaら、1985, Nature 314:452−454;これらは、参照によりその全体が本明細書に組み込まれる。)。
www.ncbi.nlm.nih.gov/entrez−/query.fcgi;www.atcc.org/phage/hdb.html;www.sciquest.com/;www.abcam.com/;www.antibodyresource.com/onlinecomp.html;www.public.iastate.edu/.about.pedro/research_tools.html;www.mgen.uni−heidelberg.de/SD/IT/IT.html;www.whfreeman.com/immunology/CH−05/kuby05.htm;www.library.thinkquest.org/12429/Immune/Antibody.html;www.hhmi.org/grants/lectures/1996/vlab/;www.path.cam.ac.uk/.about.mrc7/m−ikeimages.html;www.antibodyresource.com/;mcb.harvard.edu/BioLinks/Immunology.html.www.immunologylink.com/;pathbox.wustl.edu/.about.hcenter/index.−html;www.biotech.ufl.edu/.about.hcl/;www.pebio.com/pa/340913/340913.html−;www.nal.usda.gov/awic/pubs/antibody/;www.m.ehime−u.acjp/.about.yasuhito−/Elisa.html;www.biodesign.con/table.asp;www.icnet.uk/axp/facs/davies/links.html;www.biotech.ufl.edu/.about.fccl/protocol.html;www.isac−net.org/sites_geo.html;aximtl.imt.uni−marburg.de/.about.rek/AEP−Start.html;baserv.uci.kun.nl/.aboutjraats/linksl.html;www.recab.uni−hd.de/immuno.bme.nwu.edu/;www.mrc−cpe.cam.ac.uk/imt−doc/public/INTRO.html;www.ibt.unam.mx/vir/V_mice.html;imgt.cnusc.fr:8104/;www.biochem.uct.ac.uk/.about.martin/abs/index.html;antibody.bath.ac.uk/;abgen.cvm.tamu.edu/lab/wwwabgen.html;www.unizh.ch/.about.honegger/AHOseminar/Slide01.html;www.cryst.bbk.ac.uk/.about.ubcg07s/;www.nimr.mrc.ac.uk/CC/ccaewg/ccaewg.htm;www.path.cam.ac.uk/.about.mrc7/humanisation/TAHHP.html;www.ibt.unam.mx/vir/structure/stat_aim.html;www.biosci.missouri.edu/smithgp/index.html;www.cryst.bioc.cam.ac.uk/.abo−ut.fmolina/Web−pages/Pept/spottech.html;www.jerini.de/fr roducts.htm;www.patents.ibm.com/ibm.html.Kabatら、Sequences of Proteins of Immunological Interest, U.S. Dept. Health (1983)。これらは、それぞれ参照により本明細書に完全に組み込まれる。当該分野において公知するように、そのような導入された配列は、免疫原性を低下させるか、又は結合、親和性、オンレート、オフレート、結合力、特異性、半減期、又は他の任意の適切な特徴を低下、増強又は改変するために使用され得る。
て、徐放性製剤に使用されるポリマーは、不活性であり、浸出性不純物がなく、貯蔵安定性に優れて、無菌性、及び生分解性を有する。別の実施形態において、制御又は持続放出系を予防又は治療標的の近くに配置することができ、したがって全身投与量のほんの一部しか必要としない(例えば、Goodson, in Medical Applications of Controlled Release,同 vol. 2, pp. 115−138 (1984)を参照)。
VH ZW103 CDRセット
CDR−H1: SEQ ID NO:9
CDR−H2: SEQ ID NO:10
CDR−H3: SEQ ID NO:11
VL ZW103 CDRセット
CDR−L1: SEQ ID NO:12
CDR−L2: SEQ ID NO:13
CDR−L3: SEQ ID NO:14
VH ZW104 CDRセット
CDR−H1: SEQ ID NO:15
CDR−H2: SEQ ID NO:16
CDR−H3: SEQ ID NO:17
VL ZW104 CDRセット
CDR−L1: SEQ ID NO:18
CDR−L2: SEQ ID NO:19
CDR−L3: SEQ ID NO:20
VH ZW106 CDRセット
CDR−H1: SEQ ID NO:21
CDR−H2: SEQ ID NO:22
CDR−H3: SEQ ID NO:23
VL ZW106 CDRセット
CDR−L1: SEQ ID NO:24
CDR−L2: SEQ ID NO:25
CDR−L3: SEQ ID NO:26
VH ZW107 CDRセット
CDR−H1: SEQ ID NO:27
CDR−H2: SEQ ID NO:28
CDR−H3: SEQ ID NO:29
VL ZW107 CDRセット
CDR−L1: SEQ ID NO:30
CDR−L2: SEQ ID NO:31
CDR−L3: SEQ ID NO:32。
SEQ ID NO:1と2、
SEQ ID NO:3と4、
SEQ ID NO:5と6、
SEQ ID NO:7と8、又は
SEQ ID NO:42と43。
別の実施形態において、結合タンパク質を放出する組成物が開示されており、前記組成物は、製剤及び少なくとも1種の重合体担体を含み、前記製剤はさらに、以上開示された結晶化結合タンパク質、結晶化抗体構築物又は結晶化抗体コンジュゲート、及び成分を含む。別の実施形態において、前記重合体担体は、ポリ(アクリル酸)、ポリ(シアノアクリレート)、ポリ(アミノ酸)、ポリ(無水物)、ポリ(デプシペプチド)、ポリ(エステル)、ポリ(乳酸)、ポリ(乳酸−コ−グリコール酸)又はPLGA、ポリ(b−ヒドロキシブチラート)、ポリ(カプロラクトン)、ポリ(ジオキサノン)、ポリ(エチレングリコール)、ポリ((ヒドロキシプロピル)メタクリルアミド、ポリ[(オルガノ)ホスファゼン]、ポリ(オルトエステル)、ポリ(ビニルアルコール)、ポリ(ビニルピロリドン)、無水マレイン酸−アルキルビニルエーテルコポリマー、プルロニックポリオール(pluronic polyol)、アルブミン、アルギン酸塩、セルロース及びセルロース誘導体、コラーゲン、フィブリン、ゼラチン、ヒアルロン酸、オリゴ糖、グリコサミノグリカン(glycaminoglycan)、硫酸化多糖、及びそれらのブレンドと共重合体からなる群より選ばれる1種又は複数種の重合体である。別の実施形態において、前記成分は、アルブミン、蔗糖、トレハロース、ラクチトール、ゼラチン、ヒドロキシプロピル−β−シクロデキストリン、メトキシポリエチレングリコール、及びポリエチレングリコールからなる群より選ばれる。
e)、特発性パーキンソン病、特発性間質性肺炎、IgE媒介性アレルギー、免疫性溶血性貧血、封入体筋炎、感染性眼炎症疾患、炎症性脱髄疾患、炎症性心疾患、炎症性腎疾患、IPF/UIP、虹彩炎、角膜炎、乾性角結膜炎(keratojunctivitis sicca)、クスマウル病又はクスマウル−マイヤー病、ランドリー麻痺(Landry’s Paralysis)、ランゲルハンス細胞性組織球症、網状皮斑、黄斑変性、顕微鏡的多発性血管炎、モルブス・ベヒテレフ(morbus bechterev)、運動ニューロン疾患、粘膜性類天疱瘡、多臓器不全、重症筋無力症、骨髄異形成症候群、心筋炎、神経根障害、神経障害、非A非B型肝炎、視神経炎、骨溶解、小関節性JRA、末梢動脈閉塞疾患(PAOD)、末梢血管疾患(PVD)、末梢動脈疾患(PAD)、静脈炎、結節性多発性動脈炎(又は結節性動脈周囲炎)、多発性軟骨炎、リウマチ性多発性筋痛、白毛症、多関節性JRA、多内分泌欠損症候群、多発性筋炎、リウマチ性多発性筋痛(PMR)、ポンプ後症候群、原発性パーキンソニズム、前立腺癌、赤芽球癆、原発性副腎不全、再発性視神経脊髄炎、再狭窄、リウマチ性心疾患、SAPHO(滑膜炎、アクネ、膿疱症、骨過形成及び骨髄炎)、強皮症、続発性アミロイドーシス、ショック肺、強膜炎、坐骨神経痛、二次性副腎不全、シリコーン関連結合組織病、スネドン−ウィルキンソン皮膚症、強直性脊椎炎、スティーブンス・ジョンソン症候群(SJS)、全身性炎症反応症候群、側頭動脈炎、トキソプラスマ性網膜炎、概要中毒性表皮壊死症、横断性脊髄炎、TRAPS(腫瘍壊死因子受容体)、I型アレルギー反応、II型糖尿病、じんましん、通常型間質性肺炎(UIP)、血管炎、春季結膜炎、ウイルス性網膜炎、フォークト・小柳・原田症候群(VKH症候群)、滲出型黄斑変性、および創傷治癒からなる群より選ばれる障害を治療できる。
本明細書において、特に断らない限り、本開示について使用される科学及び技術用語は、当業者が通常理解しうる意味を有する。用語の意味及び範囲が明瞭であるが、潜在的なあいまいさがある場合、本明細書において提供される定義は辞書又は外部定義よりも優先される。さらに、文脈によって別段の要求がない限り、単数形の用語は複数形を含み、且つ、複数形の用語は単数形を含むものとする。本開示において、特に明記しない限り、「又は」の使用は、「及び/又は」を意味する。さらに、用語「含み/含む/含まれる/含有する/〜からなる(英語の「including」、及び「includes」や「included」)などの他の形態の使用は限定的ではない。さらに、特に明記しない限り、「要素」又は「コンポーネント」などの用語は、1つ/1種の単位を含む要素及びコンポーネント、ならびに複数/複数種のサブ単位を含む要素及びコンポーネントの両方を包含する。
一般に、本明細書に記載の細胞及び組織培養、分子生物学、免疫学、微生物学、遺伝学、タンパク質及び核酸化学、ならびにハイブリダイゼーションに関連して使用される用語は、当技術分野で一般的に使用されるものである。他に示さない限り、本開示の方法及び技術は、一般的に、当該分野で周知の常法に従って、そして、本開示を通して引用・考察される種々の一般的なそしてより具体的な参考文献に記載されるように行われる。酵素反応及び精製技術は、当技術分野において一般的に達成されているように、又は本明細書に記載されているように、製造業者の仕様書に従って行われる。本明細書に記載の分析化学、合成有機化学及び医薬化学に関連して使用される用語、及びそれらの実験室手順及び技法は、当技術分野において周知であり一般的に使用されているものである。カノニカル技術は、化学合成、化学分析、医薬調製、製剤化、送達及び患者の治療に使用される。
本明細書に使用されている用語「ポリペプチド」とは、アミノ酸の任意の高分子鎖である。用語「ペプチド」、「タンパク質」及び用語ポリペプチドは、交換して使用でき、且つ、アミノ酸の高分子鎖をも意味する。用語「ポリペプチド」は、タンパク質配列の天然又は人工タンパク質、タンパク質断片及びポリペプチドのアナログを含む。ポリペプチドは、単量体又は重合体であり得る。
本明細書で使用される用語「抗体構築物」は、リンカーポリペプチド又は免疫グロブリン定常ドメインに連結された本開示の1つ又は複数の抗原結合部分を含むポリペプチドを指す。リンカーポリペプチドは、ペプチド結合を介して連結された2つ以上のアミノ酸残基を含み、そして1つ以上の抗原結合部分を連結するために使用される。そのようなリンカーポリペプチドは、当技術分野において周知である(例えば、Holliger,P.ら(1993)Proc.Natl.Acad.Sci.USA 90:6444−6448と、Poljak,R.J.ら(1994)Structure2:1121〜1123などを参照)。免疫グロブリン定常ドメインは、重鎖又は軽鎖定常ドメインを指す。ヒトIgG重鎖及び軽鎖定常ドメインアミノ酸配列及びそれらの機能的変化は、当技術分野において公知である。
キメラ抗体は、抗体の異なる部分が異なる起源又は動物種に由来する分子である。キメラ抗体を産生するための方法は当技術分野において公知である。例えば、Morrison,Science 229:1202(1985)と、Oiら、BioTechniques 4:214(1986)と、Gilliesら、(1989)J.Immunol.Methods 125:191−202と、米国特許第5,807,715号、第4,816,567号及び第4,816,379号とを参照でき、これらは、参照によりその全体が本明細書に組み込まれる。さらに、「キメラ抗体」を産生するために開発された、適切な抗原特異性を有するマウス抗体分子由来の遺伝子を適切な生物学的活性を有するヒト抗体分子由来の遺伝子と共にスプライシングする技術が使用できる(Morrisonら、1984, Proc. Natl. Acad. Sci. 81:851−855;Neubergerら、1984, Nature 312:604−608;Takedaら、1985, Nature 314:452−454;これらは、参照によりその全体が本明細書に組み込まれる。)。
www.ncbi.nlm.nih.gov/entrez−/query.fcgi;www.atcc.org/phage/hdb.html;www.sciquest.com/;www.abcam.com/;www.antibodyresource.com/onlinecomp.html;www.public.iastate.edu/.about.pedro/research_tools.html;www.mgen.uni−heidelberg.de/SD/IT/IT.html;www.whfreeman.com/immunology/CH−05/kuby05.htm;www.library.thinkquest.org/12429/Immune/Antibody.html;www.hhmi.org/grants/lectures/1996/vlab/;www.path.cam.ac.uk/.about.mrc7/m−ikeimages.html;www.antibodyresource.com/;mcb.harvard.edu/BioLinks/Immunology.html.www.immunologylink.com/;pathbox.wustl.edu/.about.hcenter/index.−html;www.biotech.ufl.edu/.about.hcl/;www.pebio.com/pa/340913/340913.html−;www.nal.usda.gov/awic/pubs/antibody/;www.m.ehime−u.acjp/.about.yasuhito−/Elisa.html;www.biodesign.con/table.asp;www.icnet.uk/axp/facs/davies/links.html;www.biotech.ufl.edu/.about.fccl/protocol.html;www.isac−net.org/sites_geo.html;aximtl.imt.uni−marburg.de/.about.rek/AEP−Start.html;baserv.uci.kun.nl/.aboutjraats/linksl.html;www.recab.uni−hd.de/immuno.bme.nwu.edu/;www.mrc−cpe.cam.ac.uk/imt−doc/public/INTRO.html;www.ibt.unam.mx/vir/V_mice.html;imgt.cnusc.fr:8104/;www.biochem.uct.ac.uk/.about.martin/abs/index.html;antibody.bath.ac.uk/;abgen.cvm.tamu.edu/lab/wwwabgen.html;www.unizh.ch/.about.honegger/AHOseminar/Slide01.html;www.cryst.bbk.ac.uk/.about.ubcg07s/;www.nimr.mrc.ac.uk/CC/ccaewg/ccaewg.htm;www.path.cam.ac.uk/.about.mrc7/humanisation/TAHHP.html;www.ibt.unam.mx/vir/structure/stat_aim.html;www.biosci.missouri.edu/smithgp/index.html;www.cryst.bioc.cam.ac.uk/.abo−ut.fmolina/Web−pages/Pept/spottech.html;www.jerini.de/fr roducts.htm;www.patents.ibm.com/ibm.html.Kabatら、Sequences of Proteins of Immunological Interest, U.S. Dept. Health (1983)。これらは、それぞれ参照により本明細書に完全に組み込まれる。当該分野において公知するように、そのような導入された配列は、免疫原性を低下させるか、又は結合、親和性、オンレート、オフレート、結合力、特異性、半減期、又は他の任意の適切な特徴を低下、増強又は改変するために使用され得る。
て、徐放性製剤に使用されるポリマーは、不活性であり、浸出性不純物がなく、貯蔵安定性に優れて、無菌性、及び生分解性を有する。別の実施形態において、制御又は持続放出系を予防又は治療標的の近くに配置することができ、したがって全身投与量のほんの一部しか必要としない(例えば、Goodson, in Medical Applications of Controlled Release,同 vol. 2, pp. 115−138 (1984)を参照)。
Claims (27)
- ヒト4−1BBに特異的に結合可能な結合タンパク質であって、
CDR−H1、CDR−H2、CDR−H3、CDR−L1、CDR−L2及びCDR−L3の6種類のCDRを含む抗原結合ドメインを含み、
CDR−H1は、SEQ ID NO:11、SEQ ID NO:17、SEQ ID NO:23、SEQ ID NO:29、及びSEQ ID NO:35からなる群より選ばれ、
CDR−H2は、SEQ ID NO:12、SEQ ID NO:18、SEQ ID NO:24、SEQ ID NO:30、及びSEQ ID NO:36からなる群より選ばれ、
CDR−H3は、SEQ ID NO:13、SEQ ID NO:19、SEQ ID NO:25、SEQ ID NO:31、及びSEQ ID NO:37からなる群より選ばれ、
CDR−L1は、SEQ ID NO:14、SEQ ID NO:20、SEQ ID NO:26、SEQ ID NO:32、及びSEQ ID NO:38からなる群より選ばれ、
CDR−L2は、SEQ ID NO:15、SEQ ID NO:21、SEQ ID NO:27、SEQ ID NO:33、及びSEQ ID NO:39からなる群より選ばれ、かつ
CDR−L3は、SEQ ID NO:16、SEQ ID NO:22、SEQ ID NO:28、SEQ ID NO:34、及びSEQ ID NO:40からなる群より選ばれる、結合タンパク質。 - 請求項1に記載の結合タンパク質であって、前記6種類のCDRのうち、3種類は、下記可変ドメインCDRセットからなる群より選ばれる、結合タンパク質。
VH ZW103 CDRセット
CDR−H1: SEQ ID NO:11
CDR−H2: SEQ ID NO:12
CDR−H3: SEQ ID NO:13
VL ZW103 CDRセット
CDR−L1: SEQ ID NO:14
CDR−L2: SEQ ID NO:15
CDR−L3: SEQ ID NO:16
VH ZW104 CDRセット
CDR−H1: SEQ ID NO:17
CDR−H2: SEQ ID NO:18
CDR−H3: SEQ ID NO:19
VL ZW104 CDRセット
CDR−L1: SEQ ID NO:20
CDR−L2: SEQ ID NO:21
CDR−L3: SEQ ID NO:22
VH ZW105 CDRセット
CDR−H1: SEQ ID NO:23
CDR−H2: SEQ ID NO:24
CDR−H3: SEQ ID NO:25
VL ZW105 CDRセット
CDR−L1: SEQ ID NO:26
CDR−L2: SEQ ID NO:27
CDR−L3: SEQ ID NO:28
VH ZW106 CDRセット
CDR−H1: SEQ ID NO:29
CDR−H2: SEQ ID NO:30
CDR−H3: SEQ ID NO:31
VL ZW106 CDRセット
CDR−L1: SEQ ID NO:32
CDR−L2: SEQ ID NO:33
CDR−L3: SEQ ID NO:34
VH ZW107 CDRセット
CDR−H1: SEQ ID NO:35
CDR−H2: SEQ ID NO:36
CDR−H3: SEQ ID NO:37
VL ZW107 CDRセット
CDR−L1: SEQ ID NO:38
CDR−L2: SEQ ID NO:39
CDR−L3: SEQ ID NO:40。 - 請求項2に記載の結合タンパク質であって、少なくとも2種の可変ドメインCDRセットを含む、結合タンパク質。
- 請求項3に記載の結合タンパク質であって、前記少なくとも2種の可変ドメインCDRセットは、下記のものからなる群より選ばれる、結合タンパク質。
VH ZW103 CDRセットとVL ZW103 CDRセット、
VH ZW104 CDRセットとVL ZW104 CDRセット、
VH ZW105 CDRセットとVL ZW105 CDRセット、
VH ZW106 CDRセットとVL ZW106 CDRセット、及び
VH ZW107 CDRセットとVL ZW107 CDRセット。 - 前記請求項のいずれか1項に記載の結合タンパク質であって、ヒト受容体フレームワークをさらに含む、結合タンパク質。
- 前記請求項のいずれか1項に記載の結合タンパク質であって、前記結合タンパク質は、少なくとも1種の可変ドメインを含み、かつ、前記可変ドメインは、SEQ ID NO:1〜10からなる群より選ばれるアミノ酸配列を有する、結合タンパク質。
- 前記請求項のいずれか1項に記載の結合タンパク質であって、前記結合タンパク質は、少なくとも1種の重鎖可変ドメイン及び少なくとも1種の軽鎖可変ドメインを含み、かつ、前記重鎖可変ドメインがSEQ ID NO:1、3、5、7、9、52及び56からなる群より選ばれるアミノ酸配列を含み、前記軽鎖可変ドメインがSEQ ID NO:2、4、6、8、10、53及び57からなる群より選ばれるアミノ酸配列を有する、結合タンパク質。
- 請求項7に記載の結合タンパク質であって、前記結合タンパク質は、2種の可変ドメインを含み、前記2種の可変ドメインは、下記のものからなる群より選ばれるアミノ酸配列を有する、結合タンパク質。
SEQ ID NO:1と2、
SEQ ID NO:3と4、
SEQ ID NO:5と6、
SEQ ID NO:7と8、
SEQ ID NO:9と10、
SEQ ID NO:52と53、及び
SEQ ID NO:56と57。 - 前記請求項のいずれか1項に記載の結合タンパク質であって、ヒトIgM定常ドメイン、ヒトIgG1定常ドメイン、ヒトIgG2定常ドメイン、ヒトIgG3定常ドメイン、ヒトIgG4定常ドメイン、ヒトIgE定常ドメイン、及びヒトIgA定常ドメインからなる群より選ばれる重鎖免疫グロブリン定常ドメインをさらに含む、結合タンパク質。
- 前記請求項のいずれか1項に記載の結合タンパク質であって、前記重鎖免疫グロブリン定常ドメインは、ヒトIgG1定常ドメインである、結合タンパク質。
- 前記請求項のいずれか1項に記載の結合タンパク質であって、軽鎖免疫グロブリン定常ドメインをさらに含み、前記軽鎖免疫グロブリン定常ドメインは、ヒトIg κ定常ドメインである、結合タンパク質。
- 前記請求項のいずれか1項に記載の結合タンパク質であって、軽鎖免疫グロブリン定常ドメインをさらに含み、前記軽鎖免疫グロブリン定常ドメインは、ヒトIg λ定常ドメインである、結合タンパク質。
- 前記請求項のいずれか1項に記載の結合タンパク質であって、前記結合タンパク質は、免疫グロブリン分子、scFv、モノクローナル抗体、ヒト抗体、キメラ抗体、ヒト化抗体、単一ドメイン抗体、Fab断片、Fab’断片、F(ab’)2、Fv、ジスルフィド結合Fv、単一ドメイン抗体、ダイアボディ、多重特異性抗体、二重特異性抗体(bispecific antibody)及び二重特異抗体(dual specific antibody)からなる群より選ばれる、結合タンパク質。
- 前記請求項のいずれか1項に記載の結合タンパク質であって、前記結合タンパク質は、ヒト抗体である、結合タンパク質。
- 前記請求項のいずれか1項に記載の結合タンパク質であって、前記結合タンパク質は、4−1BBの生物学的機能又はレベルを調整できる、結合タンパク質。
- 前記請求項のいずれか1項に記載の結合タンパク質であって、前記4−1BBは、ヒト4−1BBである、結合タンパク質。
- 前記請求項のいずれか1項に記載の結合タンパク質を含むとともに、リンカーポリペプチド又は免疫グロブリン定常ドメインを含む、抗体構築物。
- 請求項17に記載の抗体構築物であって、免疫グロブリン分子、モノクローナル抗体、キメラ抗体、CDR移植抗体、ヒト化抗体、Fab、Fab’、F(ab’)2、Fv、ジスルフィド結合Fv、scFv、単一ドメイン抗体、ダイアボディ、多重特異性抗体、二重特異抗体(dual specific antibody)、及び二重特異性抗体(bispecific antibody)からなる群より選ばれる、抗体構築物。
- 請求項18に記載の抗体構築物であって、前記抗体構築物は、
ヒトIgM定常ドメイン、ヒトIgG1定常ドメイン、ヒトIgG2定常ドメイン、ヒトIgG3定常ドメイン、ヒトIgG4定常ドメイン、ヒトIgE定常ドメイン、ヒトIgA定常ドメイン、及び
Fc新生児受容体、Fc γ受容体又はC1qとの結合強度を変える1種又は複数種の突然変異を含むIgG定常ドメイン変異体
からなる群より選ばれる重鎖免疫グロブリン定常ドメインを含む、抗体構築物。 - 前記請求項のいずれか1項に記載の結合タンパク質と薬学的に許容される担体とを含む、医薬組成物。
- ヒト4−1BBの活性を向上させる方法であって、
ヒト4−1BBと、ヒト4−1BB活性を効果的に向上させる用量の前記請求項のいずれか1項に記載の結合タンパク質とを接触させるステップを含む、方法。 - 障害に罹患しているヒト対象におけるヒト4−1BB活性を変化させる方法であって、
前記ヒト対象に前記請求項のいずれか1項に記載の結合タンパク質を投与することで、前記ヒト対象におけるヒト4−1BBの活性を向上させるステップを含む、方法。 - 請求項22に記載の方法であって、前記障害が癌である方法。
- 請求項1〜16のいずれか1項に記載の結合タンパク質であって、前記重鎖は、SEQ ID No. 54及びSEQ ID No. 58からなる群より選ばれる配列を有するポリペプチドを含む、結合タンパク質。
- 請求項1〜16のいずれか1項に記載の結合タンパク質であって、前記軽鎖は、SEQ ID No. 55及びSEQ ID No. 59からなる群より選ばれる配列を有するポリペプチドを含む、結合タンパク質。
- ヒト4−1BBに特異的に結合可能な結合タンパク質であって、
前記結合タンパク質は、SEQ ID No. 52の配列を有するポリペプチド、SEQ ID No. 53の配列を有するポリペプチド、SEQ ID No. 54の配列を有するポリペプチド、及びSEQ ID No. 55の配列を有するポリペプチドを含む、結合タンパク質。 - ヒト4−1BBに特異的に結合可能な結合タンパク質であって、
前記結合タンパク質は、SEQ ID No. 56の配列を有するポリペプチド、SEQ ID No. 57の配列を有するポリペプチド、SEQ ID No. 58の配列を有するポリペプチド、及びSEQ ID No. 59の配列を有するポリペプチドを含む、結合タンパク質。
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002531383A (ja) * | 1998-11-17 | 2002-09-24 | エルジ ケミカル リミテッド | ヒト4−1bbに特異的なヒト化抗体およびそれを含む医薬組成物 |
JP2007532095A (ja) * | 2003-10-10 | 2007-11-15 | ブリストル−マイヤーズ スクイブ カンパニー | ヒト4−1bb(cd137)に対する完全ヒト抗体 |
JP2013544756A (ja) * | 2010-09-09 | 2013-12-19 | ファイザー・インク | 4−1bb結合分子 |
WO2016134358A1 (en) * | 2015-02-22 | 2016-08-25 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind cd137 |
Family Cites Families (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0092918B1 (en) | 1982-04-22 | 1988-10-19 | Imperial Chemical Industries Plc | Continuous release formulations |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
US5128326A (en) | 1984-12-06 | 1992-07-07 | Biomatrix, Inc. | Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same |
DE3587814T2 (de) | 1985-03-30 | 1994-11-10 | Marc Ballivet | Verfahren zum erhalten von dns, rns, peptiden, polypeptiden oder proteinen durch dns-rekombinant-verfahren. |
US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5763192A (en) | 1986-11-20 | 1998-06-09 | Ixsys, Incorporated | Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique |
WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
US4880078A (en) | 1987-06-29 | 1989-11-14 | Honda Giken Kogyo Kabushiki Kaisha | Exhaust muffler |
JP2919890B2 (ja) | 1988-11-11 | 1999-07-19 | メディカル リサーチ カウンスル | 単一ドメインリガンド、そのリガンドからなる受容体、その製造方法、ならびにそのリガンドおよび受容体の使用 |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
WO1990014443A1 (en) | 1989-05-16 | 1990-11-29 | Huse William D | Co-expression of heteromeric receptors |
CA2016842A1 (en) | 1989-05-16 | 1990-11-16 | Richard A. Lerner | Method for tapping the immunological repertoire |
CA2016841C (en) | 1989-05-16 | 1999-09-21 | William D. Huse | A method for producing polymers having a preselected activity |
WO1991005548A1 (en) | 1989-10-10 | 1991-05-02 | Pitman-Moore, Inc. | Sustained release composition for macromolecular proteins |
CA2071867A1 (en) | 1989-11-06 | 1991-05-07 | Edith Mathiowitz | Method for producing protein microspheres |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
WO1992003461A1 (en) | 1990-08-24 | 1992-03-05 | Ixsys, Inc. | Methods of synthesizing oligonucleotides with random codons |
CA2098824A1 (en) | 1990-12-20 | 1992-06-21 | William D. Huse | Optimization of binding proteins |
CA2109528A1 (en) | 1991-05-01 | 1992-11-02 | Gregory A. Prince | A method for treating infectious respiratory diseases |
WO1993006213A1 (en) | 1991-09-23 | 1993-04-01 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
JP4157160B2 (ja) | 1991-12-13 | 2008-09-24 | ゾーマ テクノロジー リミテッド | 改変抗体可変領域の調製のための方法 |
US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
US5912015A (en) | 1992-03-12 | 1999-06-15 | Alkermes Controlled Therapeutics, Inc. | Modulated release from biocompatible polymers |
US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
US5934272A (en) | 1993-01-29 | 1999-08-10 | Aradigm Corporation | Device and method of creating aerosolized mist of respiratory drug |
WO1994018219A1 (en) | 1993-02-02 | 1994-08-18 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
ATE252894T1 (de) | 1995-01-05 | 2003-11-15 | Univ Michigan | Oberflächen-modifizierte nanopartikel und verfahren für ihre herstellung und verwendung |
US6019968A (en) | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
US6127977A (en) | 1996-11-08 | 2000-10-03 | Cohen; Nathan | Microstrip patch antenna with fractal structure |
EP0850051A2 (en) | 1995-08-31 | 1998-07-01 | Alkermes Controlled Therapeutics, Inc. | Composition for sustained release of an agent |
US6331431B1 (en) | 1995-11-28 | 2001-12-18 | Ixsys, Inc. | Vacuum device and method for isolating periplasmic fraction from cells |
AU2063197A (en) | 1996-03-04 | 1997-09-22 | Massachusetts Institute Of Technology | Materials and methods for enhancing cellular internalization |
US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
ATE287257T1 (de) | 1997-01-16 | 2005-02-15 | Massachusetts Inst Technology | Zubereitung von partikelhaltigen arzneimitteln zur inhalation |
AU8691398A (en) | 1997-08-04 | 1999-02-22 | Ixsys, Incorporated | Methods for identifying ligand specific binding molecules |
US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
SE512663C2 (sv) | 1997-10-23 | 2000-04-17 | Biogram Ab | Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer |
JP2002518432A (ja) | 1998-06-24 | 2002-06-25 | アドバンスト インハレーション リサーチ,インコーポレイテッド | 吸入器から放出される大多孔性粒子 |
US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
CA2704600C (en) | 1999-04-09 | 2016-10-25 | Kyowa Hakko Kirin Co., Ltd. | A method for producing antibodies with increased adcc activity |
WO2001083525A2 (en) | 2000-05-03 | 2001-11-08 | Amgen Inc. | Modified peptides, comprising an fc domain, as therapeutic agents |
US7449308B2 (en) | 2000-06-28 | 2008-11-11 | Glycofi, Inc. | Combinatorial DNA library for producing modified N-glycans in lower eukaryotes |
US7029872B2 (en) | 2000-06-28 | 2006-04-18 | Glycofi, Inc | Methods for producing modified glycoproteins |
AU2002256971B2 (en) | 2000-12-28 | 2008-04-03 | Altus Pharmaceuticals Inc. | Crystals of whole antibodies and fragments thereof and methods for making and using them |
US20040192898A1 (en) | 2001-08-17 | 2004-09-30 | Jia Audrey Yunhua | Anti-abeta antibodies |
HUP0600342A3 (en) | 2001-10-25 | 2011-03-28 | Genentech Inc | Glycoprotein compositions |
WO2004078140A2 (en) | 2003-03-05 | 2004-09-16 | Halozyme, Inc. | SOLUBLE HYALURONIDASE GLYCOPROTEIN (sHASEGP), PROCESS FOR PREPARING THE SAME, USES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF |
US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
GB0407315D0 (en) | 2003-07-15 | 2004-05-05 | Cambridge Antibody Tech | Human antibody molecules |
US20050042664A1 (en) | 2003-08-22 | 2005-02-24 | Medimmune, Inc. | Humanization of antibodies |
JP2007535317A (ja) | 2004-04-15 | 2007-12-06 | グライコフィ, インコーポレイテッド | 下等真核生物におけるガラクトシル化された糖タンパク質の産生 |
AR049390A1 (es) | 2004-06-09 | 2006-07-26 | Wyeth Corp | Anticuerpos contra la interleuquina-13 humana y usos de los mismos |
WO2006117910A1 (ja) | 2005-04-28 | 2006-11-09 | Mochida Pharmaceutical Co., Ltd. | 抗血小板膜糖蛋白質ⅵモノクローナル抗体 |
CA2615983A1 (en) | 2005-07-21 | 2007-02-01 | Abbott Laboratories | Multiple gene expression including sorf constructs and methods with polyproteins, pro-proteins, and proteolysis |
ES2624835T3 (es) | 2009-08-06 | 2017-07-17 | Immunas Pharma, Inc. | Anticuerpos que se unen específicamente a los oligómeros A beta y uso de los mismos |
WO2016123143A1 (en) * | 2015-01-26 | 2016-08-04 | The University Of Chicago | CAR T-CELLS RECOGNIZING CANCER-SPECIFIC IL 13Rα2 |
-
2017
- 2017-11-22 CN CN201780003998.2A patent/CN108367075B/zh active Active
- 2017-11-22 JP JP2019528446A patent/JP7274417B2/ja active Active
- 2017-11-22 EP EP17873941.3A patent/EP3544628A4/en active Pending
- 2017-11-22 US US16/463,580 patent/US10899842B2/en active Active
- 2017-11-22 WO PCT/US2017/063142 patent/WO2018098370A1/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002531383A (ja) * | 1998-11-17 | 2002-09-24 | エルジ ケミカル リミテッド | ヒト4−1bbに特異的なヒト化抗体およびそれを含む医薬組成物 |
JP2007532095A (ja) * | 2003-10-10 | 2007-11-15 | ブリストル−マイヤーズ スクイブ カンパニー | ヒト4−1bb(cd137)に対する完全ヒト抗体 |
JP2013544756A (ja) * | 2010-09-09 | 2013-12-19 | ファイザー・インク | 4−1bb結合分子 |
WO2016134358A1 (en) * | 2015-02-22 | 2016-08-25 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind cd137 |
Non-Patent Citations (1)
Title |
---|
CANCER IMMUNOLOGY IMMUNOTHERAPY, vol. 61, JPN6021040750, 2012, pages 1721 - 1733, ISSN: 0004941506 * |
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US20190284292A1 (en) | 2019-09-19 |
US10899842B2 (en) | 2021-01-26 |
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