JP7211961B2 - 酸性ｐＨでＶＩＳＴＡに結合する抗体 - Google Patents

酸性ｐＨでＶＩＳＴＡに結合する抗体 Download PDF

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JP7211961B2
JP7211961B2 JP2019549389A JP2019549389A JP7211961B2 JP 7211961 B2 JP7211961 B2 JP 7211961B2 JP 2019549389 A JP2019549389 A JP 2019549389A JP 2019549389 A JP2019549389 A JP 2019549389A JP 7211961 B2 JP7211961 B2 JP 7211961B2
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amino acid
acid sequence
light chain
seq
e100ff
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JP2020509756A (ja
JP2020509756A5 (https=
Inventor
ロバート ジェー． ジョンストン，
アルビンド ラジパール，
ポール オー． シェパード，
ルイス ボルヘス，
アンドリュー ランキン，
キース サアドゥン バハジャト，
アラン ジェー． コーマン，
アンディ エックス． トン，
リン ホイ スー，
ジンジャー レイクストロー，
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2019549389A 2017-03-14 2018-03-13 酸性ｐＨでＶＩＳＴＡに結合する抗体 Active JP7211961B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023002879A JP7573659B2 (ja) 2017-03-14 2023-01-12 酸性ｐＨでＶＩＳＴＡに結合する抗体
JP2024179648A JP2025023919A (ja) 2017-03-14 2024-10-15 酸性ｐＨでＶＩＳＴＡに結合する抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762471196P 2017-03-14 2017-03-14
US62/471,196 2017-03-14
US201862636746P 2018-02-28 2018-02-28
US62/636,746 2018-02-28
PCT/US2018/022230 WO2018169993A1 (en) 2017-03-14 2018-03-13 Antibodies binding to vista at acidic ph

Related Child Applications (1)

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JP2023002879A Division JP7573659B2 (ja) 2017-03-14 2023-01-12 酸性ｐＨでＶＩＳＴＡに結合する抗体

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JP2020509756A JP2020509756A (ja) 2020-04-02
JP2020509756A5 JP2020509756A5 (https=) 2021-04-30
JP7211961B2 true JP7211961B2 (ja) 2023-01-24

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JP2019549389A Active JP7211961B2 (ja) 2017-03-14 2018-03-13 酸性ｐＨでＶＩＳＴＡに結合する抗体
JP2023002879A Active JP7573659B2 (ja) 2017-03-14 2023-01-12 酸性ｐＨでＶＩＳＴＡに結合する抗体
JP2024179648A Pending JP2025023919A (ja) 2017-03-14 2024-10-15 酸性ｐＨでＶＩＳＴＡに結合する抗体

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JP2023002879A Active JP7573659B2 (ja) 2017-03-14 2023-01-12 酸性ｐＨでＶＩＳＴＡに結合する抗体
JP2024179648A Pending JP2025023919A (ja) 2017-03-14 2024-10-15 酸性ｐＨでＶＩＳＴＡに結合する抗体

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US (3) US11603406B2 (https=)
EP (1) EP3595720A4 (https=)
JP (3) JP7211961B2 (https=)
KR (2) KR102715540B1 (https=)
CN (2) CN118894937A (https=)
AU (2) AU2018236218B2 (https=)
BR (1) BR112019019108A2 (https=)
CA (1) CA3054067A1 (https=)
CL (2) CL2019002610A1 (https=)
CO (1) CO2019010943A2 (https=)
IL (2) IL269240B1 (https=)
MX (1) MX2024003316A (https=)
MY (1) MY200609A (https=)
PE (2) PE20250933A1 (https=)
SG (1) SG11201907848YA (https=)
TW (2) TWI890190B (https=)
WO (1) WO2018169993A1 (https=)
ZA (1) ZA201905525B (https=)

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TWI812066B (zh) 2010-11-30 2023-08-11 日商中外製藥股份有限公司 具有鈣依存性的抗原結合能力之抗體
CN112812184A (zh) 2011-02-25 2021-05-18 中外制药株式会社 FcγRIIb特异性Fc抗体
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JP6124800B2 (ja) 2011-11-30 2017-05-10 中外製薬株式会社 免疫複合体を形成する細胞内への運搬体（キャリア）を含む医薬
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