JP2008541711A5 - - Google Patents
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- JP2008541711A5 JP2008541711A5 JP2008512701A JP2008512701A JP2008541711A5 JP 2008541711 A5 JP2008541711 A5 JP 2008541711A5 JP 2008512701 A JP2008512701 A JP 2008512701A JP 2008512701 A JP2008512701 A JP 2008512701A JP 2008541711 A5 JP2008541711 A5 JP 2008541711A5
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- 239000000427 antigen Substances 0.000 claims 15
- 108091007172 antigens Proteins 0.000 claims 15
- 102000038129 antigens Human genes 0.000 claims 15
- 102000005614 monoclonal antibodies Human genes 0.000 claims 14
- 108010045030 monoclonal antibodies Proteins 0.000 claims 14
- 210000004881 tumor cells Anatomy 0.000 claims 6
- 210000004027 cells Anatomy 0.000 claims 3
- IAKHMKGGTNLKSZ-INIZCTEOSA-N Colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 claims 2
- 102100008453 FOLH1 Human genes 0.000 claims 2
- 101700036477 FOLH1 Proteins 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 238000003260 fluorescence intensity Methods 0.000 claims 2
- NRUKOCRGYNPUPR-QBPJDGROSA-N (5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 claims 1
- AOJJSUZBOXZQNB-TZSSRYMLSA-N ADRIAMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 1
- RSIHSRDYCUFFLA-DYKIIFRCSA-N Boldenone Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 RSIHSRDYCUFFLA-DYKIIFRCSA-N 0.000 claims 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N DAUNOMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 1
- 229960000640 Dactinomycin Drugs 0.000 claims 1
- 108010092160 Dactinomycin Proteins 0.000 claims 1
- 229960000975 Daunorubicin Drugs 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- 229960004679 Doxorubicin Drugs 0.000 claims 1
- AUVVAXYIELKVAI-CKBKHPSWSA-N Emetine Chemical compound N1CCC2=CC(OC)=C(OC)C=C2[C@H]1C[C@H]1C[C@H]2C3=CC(OC)=C(OC)C=C3CCN2C[C@@H]1CC AUVVAXYIELKVAI-CKBKHPSWSA-N 0.000 claims 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N Ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 claims 1
- 229960005420 Etoposide Drugs 0.000 claims 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N Etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 1
- 231100000776 Exotoxin Toxicity 0.000 claims 1
- IUAYMJGZBVDSGL-UHFFFAOYSA-N Gramicidin Chemical compound N1C(=O)C(CC(C)C)NC(=O)C(CCCN)NC(=O)C(C(C)C)NC(=O)C2CCCN2C(=O)C(CC=2C=CC=CC=2)NC(=O)C(CC(C)C)NC(=O)C(CCCN)NC(=O)C(C(C)C)NC(=O)C2CCCN2C(=O)C1CC1=CC=CC=C1 IUAYMJGZBVDSGL-UHFFFAOYSA-N 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N Intaxel Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 229960004857 Mitomycin Drugs 0.000 claims 1
- 229960001156 Mitoxantrone Drugs 0.000 claims 1
- KKZJGLLVHKMTCM-UHFFFAOYSA-N Mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims 1
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims 1
- 101700008337 PSMA Proteins 0.000 claims 1
- RXWNCPJZOCPEPQ-NVWDDTSBSA-N PUROMYCIN Chemical compound C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 claims 1
- 229950010131 PUROMYCIN Drugs 0.000 claims 1
- 229960001592 Paclitaxel Drugs 0.000 claims 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N Procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 claims 1
- AQHHHDLHHXJYJD-UHFFFAOYSA-N Proprasylyt Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 claims 1
- 210000002307 Prostate Anatomy 0.000 claims 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 1
- 229940055023 Pseudomonas aeruginosa Drugs 0.000 claims 1
- 229960001278 Teniposide Drugs 0.000 claims 1
- 229960002372 Tetracaine Drugs 0.000 claims 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N Tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims 1
- 231100000765 Toxin Toxicity 0.000 claims 1
- 229960003048 Vinblastine Drugs 0.000 claims 1
- HOFQVRTUGATRFI-XQKSVPLYSA-N Vinblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 HOFQVRTUGATRFI-XQKSVPLYSA-N 0.000 claims 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims 1
- 229960004528 Vincristine Drugs 0.000 claims 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Xylocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 1
- RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229960001338 colchicine Drugs 0.000 claims 1
- GBOGMAARMMDZGR-TYHYBEHESA-N cytochalasin B Chemical compound C([C@H]1[C@@H]2[C@@H](C([C@@H](O)[C@@H]3/C=C/C[C@H](C)CCC[C@@H](O)/C=C/C(=O)O[C@@]23C(=O)N1)=C)C)C1=CC=CC=C1 GBOGMAARMMDZGR-TYHYBEHESA-N 0.000 claims 1
- 230000001472 cytotoxic Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229960002694 emetine Drugs 0.000 claims 1
- AUVVAXYIELKVAI-UWBTVBNJSA-N emetine Natural products N1CCC2=CC(OC)=C(OC)C=C2[C@H]1C[C@H]1C[C@H]2C3=CC(OC)=C(OC)C=C3CCN2C[C@H]1CC AUVVAXYIELKVAI-UWBTVBNJSA-N 0.000 claims 1
- 239000002095 exotoxin Substances 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 229960004194 lidocaine Drugs 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- -1 mythromycin Chemical compound 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 229920000023 polynucleotide Polymers 0.000 claims 1
- 229960004919 procaine Drugs 0.000 claims 1
- 229960003712 propranolol Drugs 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229930003347 taxol Natural products 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 108020003112 toxins Proteins 0.000 claims 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
Claims (13)
- a)腫瘍細胞の表面上に存在するネイティブ形態の前立腺特異的膜抗原に結合し、
b)腫瘍細胞によって内在化でき、
c)LNCAP細胞には強力に結合するが、前立腺膜特異的抗原の発現を欠く細胞には結合しないかごくわずかにのみ結合し、そして
d)標識または細胞傷害性薬物と連結され、
e)配列番号:1および/または配列番号:10および/または配列番号:20および/または配列番号:22のうちの少なくとも10個の連続アミノ酸の部分アミノ酸配列を含むことを特徴とする、
単離されたモノクローナル抗体またはその抗原結合部分。 - 前記モノクローナル抗体(mAb)のPE蛍光強度(MFI)が抗原飽和において1000より高く、かつscFvのPE蛍光強度が抗原飽和において40より高いことを特徴とする、請求項1に記載の単離されたモノクローナル抗体またはその抗原結合部分。
- 1nM〜120nMの間の濃度でPSMA部位のうち50%飽和に達するLNCAP細胞に対する高結合活性を示す、請求項1または2に記載の単離されたモノクローナル抗体またはその抗原結合部分。
- 前記標識が放射線または蛍光線を放射する粒子であることを特徴とする、請求項1〜3のいずれかに記載の単離されたモノクローナル抗体またはその抗原結合部分。
- 前記細胞傷害性薬物が、毒素からなる群、特にタキソール、緑膿菌外毒素の断片、サイトカラシンB、グラミシジンD、臭化エチジウム、エメチン、マイトマイシン、エトポシド、テノポシド、ビンクリスチン、ビンブラスチン、コルヒチン、ドキソルビシン、ダウノルビシン、ジヒドロキシアントラシンジオン、ミトキサントロン、ミスラマイシン、アクチノマイシンD、1−デヒドロテストステロン、グルココルチコイド、プロカイン、テトラカイン、リドカイン、プロプラノロール、および/またはピューロマイシンからなる群より選択される細胞毒性物質であることを特徴とする、請求項1〜4に記載の単離されたモノクローナル抗体またはその抗原結合部分。
- さらに、配列番号:2〜配列番号:7のうちの少なくとも1つを含むことを特徴とする、請求項1に記載の単離されたモノクローナル抗体またはその抗原結合部分。
- さらに、配列番号:11〜配列番号:16のうちの少なくとも1つを含むことを特徴とする、請求項1に記載の単離されたモノクローナル抗体またはその抗原結合部分。
- 請求項1〜7のいずれかに記載の単離されたモノクローナル抗体またはその抗原結合部分を含む、医薬組成物。
- 癌の処置のための医薬調製のための、請求項1〜7いずれかに記載の単離されたモノクローナル抗体またはその抗原結合部分の使用。
- 請求項1〜7のいずれかに記載の単離されたモノクローナル抗体またはその抗原結合部分を含む、腫瘍細胞検出のための診断キット。
- 請求項1〜7のいずれかに記載の単離されたモノクローナル抗体またはその抗原結合部分と、識別されるべき腫瘍細胞とが接触されることを特徴とする、腫瘍細胞のインビトロ識別のための方法。
- 腫瘍細胞の診断識別のための、請求項1〜7のいずれかに記載の単離されたモノクローナル抗体またはその抗原結合部分の使用。
- 配列番号:8、9、17、18、19、21、23および24からなる群のいずれかの配列のうちの少なくとも20ヌクレオチドの連続配列を含むことを特徴とする、単離されたポリヌクレオチド。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05011536A EP1726650A1 (en) | 2005-05-27 | 2005-05-27 | Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen |
EP05011536.9 | 2005-05-27 | ||
PCT/EP2006/001917 WO2006125481A1 (en) | 2005-05-27 | 2006-03-02 | Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012091882A Division JP5524270B2 (ja) | 2005-05-27 | 2012-04-13 | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2008541711A JP2008541711A (ja) | 2008-11-27 |
JP2008541711A5 true JP2008541711A5 (ja) | 2009-02-26 |
JP5038297B2 JP5038297B2 (ja) | 2012-10-03 |
Family
ID=34937022
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008512701A Active JP5038297B2 (ja) | 2005-05-27 | 2006-03-02 | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
JP2012091882A Active JP5524270B2 (ja) | 2005-05-27 | 2012-04-13 | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
JP2014017392A Active JP6110321B2 (ja) | 2005-05-27 | 2014-01-31 | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
JP2016063219A Pending JP2016190839A (ja) | 2005-05-27 | 2016-03-28 | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012091882A Active JP5524270B2 (ja) | 2005-05-27 | 2012-04-13 | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
JP2014017392A Active JP6110321B2 (ja) | 2005-05-27 | 2014-01-31 | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
JP2016063219A Pending JP2016190839A (ja) | 2005-05-27 | 2016-03-28 | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
Country Status (16)
Country | Link |
---|---|
US (3) | US8198416B2 (ja) |
EP (3) | EP1726650A1 (ja) |
JP (4) | JP5038297B2 (ja) |
CN (1) | CN101233236B (ja) |
AT (1) | ATE505544T1 (ja) |
AU (1) | AU2006251445B2 (ja) |
CA (1) | CA2609682C (ja) |
CY (1) | CY1111409T1 (ja) |
DE (1) | DE602006021296D1 (ja) |
DK (1) | DK1883698T4 (ja) |
ES (1) | ES2362795T5 (ja) |
PL (1) | PL1883698T5 (ja) |
PT (1) | PT1883698E (ja) |
RU (1) | RU2458073C2 (ja) |
SI (1) | SI1883698T2 (ja) |
WO (1) | WO2006125481A1 (ja) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7105159B1 (en) | 1992-11-05 | 2006-09-12 | Sloan-Kettering Institute For Cancer Research | Antibodies to prostate-specific membrane antigen |
US20050215472A1 (en) | 2001-10-23 | 2005-09-29 | Psma Development Company, Llc | PSMA formulations and uses thereof |
EP1448588A4 (en) | 2001-10-23 | 2006-10-25 | Psma Dev Company L L C | ANTIBODIES AND MULTIMERS OF PSMA PROTEINS |
EP1726650A1 (en) * | 2005-05-27 | 2006-11-29 | Universitätsklinikum Freiburg | Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen |
GB0715542D0 (en) * | 2007-08-09 | 2007-09-19 | Imp Innovations Ltd | Methods |
AU2008333985B2 (en) | 2007-11-30 | 2015-02-05 | Kalobios Pharmaceuticals, Inc. | Antibodies to the PcrV antigen of pseudomonas aeruginosa |
US20110189093A1 (en) * | 2008-04-14 | 2011-08-04 | Proscan Rx Pharma | Prostate specific membrane antigen antibodies and antigen binding fragments |
ITTO20080313A1 (it) * | 2008-04-22 | 2009-10-23 | Marco Colombatti | Anticorpo monoclonale isolato o suo frammento legante l'antigene specifico di membrana della prostata, suoi coniugati e suoi usi |
ME02485B (me) | 2008-10-01 | 2017-02-20 | Amgen Res Munich Gmbh | Bispecifično jednolančano protutijelo psmaxcd3 s međuvrsnom specifičnošću |
EP2352763B2 (en) | 2008-10-01 | 2022-09-21 | Amgen Research (Munich) GmbH | Bispecific single chain antibodies with specificity for high molecular weight target antigens |
JP5906090B2 (ja) | 2009-02-17 | 2016-04-20 | コーネル・リサーチ・ファンデーション・インコーポレイテッドCornell Research Foundation, Incorporated | 癌の診断のための方法およびキットならびに治療価の推定 |
TWI629357B (zh) * | 2009-10-02 | 2018-07-11 | 安進研究(慕尼黑)有限責任公司 | 跨物種特異性的PSMAxCD3雙特異性單鏈抗體 |
CA2782333C (en) * | 2009-12-02 | 2019-06-04 | Imaginab, Inc. | J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use |
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