JP2008540549A5 - - Google Patents

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Publication number
JP2008540549A5
JP2008540549A5 JP2008511295A JP2008511295A JP2008540549A5 JP 2008540549 A5 JP2008540549 A5 JP 2008540549A5 JP 2008511295 A JP2008511295 A JP 2008511295A JP 2008511295 A JP2008511295 A JP 2008511295A JP 2008540549 A5 JP2008540549 A5 JP 2008540549A5
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JP
Japan
Prior art keywords
compound
atom
lower alkyl
hydrogen atom
trpv3
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Pending
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JP2008511295A
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English (en)
Japanese (ja)
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JP2008540549A (ja
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Priority claimed from PCT/US2006/017995 external-priority patent/WO2006122156A2/en
Publication of JP2008540549A publication Critical patent/JP2008540549A/ja
Publication of JP2008540549A5 publication Critical patent/JP2008540549A5/ja
Pending legal-status Critical Current

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JP2008511295A 2005-05-09 2006-05-09 Trpv3機能調節用化合物 Pending JP2008540549A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US67943805P 2005-05-09 2005-05-09
US67943605P 2005-05-09 2005-05-09
US70258405P 2005-07-25 2005-07-25
PCT/US2006/017995 WO2006122156A2 (en) 2005-05-09 2006-05-09 Compounds for modulating trpv3 function

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013023822A Division JP2013082755A (ja) 2005-05-09 2013-02-08 Trpv3機能調節用化合物

Publications (2)

Publication Number Publication Date
JP2008540549A JP2008540549A (ja) 2008-11-20
JP2008540549A5 true JP2008540549A5 (https=) 2009-06-25

Family

ID=36930222

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008511295A Pending JP2008540549A (ja) 2005-05-09 2006-05-09 Trpv3機能調節用化合物
JP2013023822A Abandoned JP2013082755A (ja) 2005-05-09 2013-02-08 Trpv3機能調節用化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013023822A Abandoned JP2013082755A (ja) 2005-05-09 2013-02-08 Trpv3機能調節用化合物

Country Status (8)

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US (3) US7803790B2 (https=)
EP (2) EP2392328A1 (https=)
JP (2) JP2008540549A (https=)
CN (1) CN101233132A (https=)
AU (1) AU2006244074B2 (https=)
CA (1) CA2608194A1 (https=)
TW (1) TWI401254B (https=)
WO (1) WO2006122156A2 (https=)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030219806A1 (en) * 2000-02-22 2003-11-27 Millennium Pharmaceuticals, Inc. Novel 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 molecules and uses therefor
US8916550B2 (en) * 2005-05-09 2014-12-23 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
EP2392328A1 (en) * 2005-05-09 2011-12-07 Hydra Biosciences, Inc. Compounds for modulating TRPV3 Function
US7893260B2 (en) * 2005-11-04 2011-02-22 Hydra Biosciences, Inc. Substituted quinazolin-4-one compounds for antagonizing TRPV3 function
DE602006015700D1 (de) 2005-11-21 2010-09-02 Anadys Pharmaceuticals Inc Neues verfahren zur herstellung von 5-amino-3h-thiazoloä4,5-düpyrimidin-2-on
WO2007092610A2 (en) 2006-02-07 2007-08-16 Tivamed, Inc. Vaginal remodeling device and methods
CN101096363B (zh) * 2006-06-27 2011-05-11 中国人民解放军军事医学科学院毒物药物研究所 2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途
US8481161B2 (en) * 2006-06-28 2013-07-09 Samsung Electronics Co., Ltd. Functionalized metal nanoparticle and method for formation of conductive pattern using the same
US7998980B2 (en) 2006-09-15 2011-08-16 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
EP2120557A4 (en) * 2006-12-08 2010-02-10 Roskamp Res Llc POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION
WO2008140750A1 (en) * 2007-05-10 2008-11-20 Hydra Biosciences Inc. Compounds for modulating trpv3 function
WO2009006580A1 (en) * 2007-07-05 2009-01-08 Cv Therapeutics, Inc. Optionally condensed dihydropyridine, dihydropyrimidine and dihydropyrane derivatives acting as late sodium channel blockers
US20090012103A1 (en) 2007-07-05 2009-01-08 Matthew Abelman Substituted heterocyclic compounds
WO2009102864A1 (en) 2008-02-12 2009-08-20 Stanford University Hedgehog pathway antagonists and methods of use
AP2010005480A0 (en) * 2008-06-03 2010-12-31 Siga Technologies Inc Small molecule inhibitors for the treatment or prevention of denque virus infection.
WO2010055384A1 (en) * 2008-11-17 2010-05-20 Glenmark Pharmaceuticals S.A. Chromenone derivatives as trpv3 antagonists
KR101034299B1 (ko) 2008-12-02 2011-05-16 고려대학교 산학협력단 Trpv3 활성 조절 약물 및 이의 활용
KR101034300B1 (ko) * 2008-12-02 2011-05-16 고려대학교 산학협력단 Trpv3 활성 억제 약물 및 이의 활용
TW201105681A (en) * 2009-06-10 2011-02-16 Janssen Pharmaceutica Nv Benzimidazole derivatives useful as TRPM8 channel modulators
KR101643799B1 (ko) 2009-09-18 2016-07-28 비베베, 아이엔씨. 질 재건 기구 및 방법
CN102802632A (zh) 2010-03-22 2012-11-28 格兰马克药品股份有限公司 含有嘧啶酮衍生物的药物组合物
PT2593452T (pt) 2010-07-14 2017-04-24 Novartis Ag Compostos heterocíclicos agonistas do receptor ip
MX2013001612A (es) * 2010-08-10 2013-07-05 Abbvie Inc Moduladores de trpv3 novedosos.
JP5951625B2 (ja) 2010-11-24 2016-07-13 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨークThe Trustees Of Columbia University In The City Of New York 加齢性黄斑変性症およびシュタルガルト病の処置のための非レチノイドrbp4アンタゴニスト
US20140031341A1 (en) * 2010-12-22 2014-01-30 Universitat Munster Modulators and methods for the treatment of rosacea
SG193331A1 (en) * 2011-03-18 2013-10-30 Lupin Ltd Benzo [b] [1, 4] oxazin derivatives as calcium sensing receptor modulators
US9012651B2 (en) 2011-03-24 2015-04-21 Abbvie Inc. TRPV3 modulators
WO2013003112A1 (en) 2011-06-27 2013-01-03 The Jackson Laboratory Methods and compositions for treatment of cancer and autoimmune disease
CN102994508B (zh) * 2011-09-14 2015-04-01 深圳华大基因科技有限公司 Olmsted综合征相关基因的鉴别以及与其相关的产品、方法及用途
WO2013062964A2 (en) 2011-10-24 2013-05-02 Abbvie Inc. Novel trpv3 modulators
UY34572A (es) 2012-01-13 2013-09-02 Novartis Ag Compuestos heterocíclicos agonistas del receptor ip
WO2013152109A1 (en) * 2012-04-04 2013-10-10 Dana-Farber Cancer Institute, Inc. Trpv4 antagonist and methods of use thereof
US9333202B2 (en) 2012-05-01 2016-05-10 The Trustees Of Columbia University In The City Of New York Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease
CN102747128A (zh) * 2012-05-24 2012-10-24 北京海威磐石生物医药科技有限公司 Trpv3通道蛋白在筛选用于皮肤病治疗或皮肤护理的药物中的应用
WO2013178782A1 (en) * 2012-05-30 2013-12-05 Universidad De Zaragoza Allosteric inhibitors of ns3 protease from hepatitis c virus
EP2869897A4 (en) 2012-07-06 2016-09-28 Univ Duke ACTIVATION OF THE TRPV4 ION CHANNEL BY PHYSICAL STIMULI AND IMPORTANT ROLE FOR TRPV4 IN ORGANIC INFLAMMATION AND JUCKREIZ
CN105189500A (zh) 2013-02-13 2015-12-23 诺华股份有限公司 Ip受体激动剂杂环化合物
EP3495357B1 (en) 2013-03-14 2021-05-05 The Trustees of Columbia University in the City of New York 4-phenylpiperidines, their preparation and use
WO2014152018A1 (en) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York Octahydrocyclopentapyrroles, their preparation and use
US9938291B2 (en) 2013-03-14 2018-04-10 The Trustess Of Columbia University In The City Of New York N-alkyl-2-phenoxyethanamines, their preparation and use
US9944644B2 (en) 2013-03-14 2018-04-17 The Trustees Of Columbia University In The City Of New York Octahydropyrrolopyrroles their preparation and use
CN103349786B (zh) * 2013-06-04 2015-03-25 北京大学第一医院 一种以trpv3通道蛋白为靶点的用于治疗皮肤瘙痒药物的筛选方法
CN110627770A (zh) 2013-11-18 2019-12-31 福马疗法公司 作为bet溴域抑制剂的四氢喹啉组成物
RU2720237C2 (ru) 2013-11-18 2020-04-28 Форма Терапеутикс, Инк. Композиции, содержащие бензопиперазин, в качестве ингибиторов бромодоменов вет
SG11201608943VA (en) 2014-04-30 2016-11-29 Univ Columbia Substituted 4-phenylpiperidines, their preparaiton and use
WO2016028325A1 (en) 2014-08-22 2016-02-25 Duke University Trpa1 and trpv4 inhibitors and methods of using the same for organ-specific inflammation and itch
TW201702218A (zh) * 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
US11229628B2 (en) 2015-01-09 2022-01-25 Duke University TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch
WO2016121433A1 (ja) * 2015-01-28 2016-08-04 シャープ株式会社 端末装置、基地局装置、通信方法および集積回路
WO2016160938A1 (en) * 2015-04-02 2016-10-06 Abbvie Inc. N-(1,3-thiazol-2-yl)pyrimidine-5-carboxamides as trpv3 modulators
CN109310683A (zh) 2016-04-07 2019-02-05 杜克大学 用于消毒和麻醉的trpv4和trpa1的小分子双重抑制剂
CN114748624A (zh) * 2016-06-13 2022-07-15 田边三菱制药株式会社 用于治疗或预防血管舒缩症状的组合物
WO2018129609A1 (en) * 2017-01-10 2018-07-19 Owen-Barry Pharmaceuticals Inc. Anticonvulsant compounds
KR20190063746A (ko) * 2017-11-30 2019-06-10 (주)인핸스드바이오 p34 단백질 및 NEDD4-1 단백질의 결합 억제제로서의 신규 화합물 및 이의 용도
CN110339360B (zh) * 2018-04-02 2024-04-19 苏中药业集团股份有限公司 瞬时受体电位阳离子通道trpv3在研制预防或治疗银屑病药物中的应用
US12337064B2 (en) * 2018-09-05 2025-06-24 Sensory Cloud, Inc. Formulations and compositions for ortho- and/or retro-nasal delivery and associated systems, methods and articles
WO2021154966A1 (en) 2020-01-29 2021-08-05 Kamari Pharma Ltd. Compounds and compositions for use in treating skin disorders
US11691971B2 (en) 2020-06-19 2023-07-04 Incyte Corporation Naphthyridinone compounds as JAK2 V617F inhibitors
WO2021257863A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Pyrrolotriazine compounds as jak2 v617f inhibitors
US11891403B2 (en) * 2020-06-29 2024-02-06 Boehringer Ingelheim International Gmbh Tetrazole derivatives as TRPA1 inhibitors
CR20230057A (es) 2020-07-02 2023-08-15 Incyte Corp Compuestos tríciclicos de urea como inhibidores de jak2 v617f
US11767323B2 (en) 2020-07-02 2023-09-26 Incyte Corporation Tricyclic pyridone compounds as JAK2 V617F inhibitors
WO2022026548A1 (en) * 2020-07-29 2022-02-03 Ideaya Biosciences, Inc. Acetamido-amino and acetamido-sulfur derivatives as dna polymerase theta inhibitors
US11661422B2 (en) 2020-08-27 2023-05-30 Incyte Corporation Tricyclic urea compounds as JAK2 V617F inhibitors
WO2022112352A1 (en) * 2020-11-24 2022-06-02 Katholieke Universiteit Leuven Heterocycle derivatives for treating trpm3 mediated disorders
US20230391739A1 (en) * 2020-11-24 2023-12-07 Katholieke Universiteit Leuven Aryl derivatives for treating trpm3 mediated disorders
US11919908B2 (en) 2020-12-21 2024-03-05 Incyte Corporation Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors
AR125273A1 (es) 2021-02-25 2023-07-05 Incyte Corp Lactamas espirocíclicas como inhibidores de jak2 v617f
AU2023235313A1 (en) 2022-03-17 2024-10-03 Incyte Corporation Tricyclic urea compounds as jak2 v617f inhibitors
CN120202189A (zh) 2022-09-30 2025-06-24 巴塞尔大学 免疫抑制化合物
CN119930563B (zh) * 2023-12-20 2026-03-17 苏中药业集团股份有限公司 一种瞬时受体电位阳离子通道trpv3抑制剂及其用途
CN120398870A (zh) * 2024-01-31 2025-08-01 深圳晶蛋生物医药科技有限公司 一种苯并吗啉类化合物及其应用

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005501B1 (de) 1978-05-20 1981-11-25 Bayer Ag Heteroaryl-oxyessigsäureamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide
US4461896A (en) 1979-02-07 1984-07-24 Norwich Eaton Pharmaceuticals, Inc. 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
DE3018075A1 (de) 1980-05-10 1981-11-12 Bayer Ag, 5090 Leverkusen Mittel zur regulierung des pflanzenwachstums, deren herstellung und deren verwendung
JPS56158702A (en) 1980-05-12 1981-12-07 Nippon Tokushu Noyaku Seizo Kk Herbicide
US4273927A (en) 1980-08-14 1981-06-16 Morton-Norwich Products, Inc. Converting enzyme inhibitor
DE3038599A1 (de) 1980-10-13 1982-05-19 Bayer Ag, 5090 Leverkusen Substituierte benzazol-2-yl-oxyessigsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide
DE3038652A1 (de) 1980-10-13 1982-05-19 Bayer Ag, 5090 Leverkusen 5-chlor-benzoxazol-2-yl-oxyessigsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide
DE3418168A1 (de) 1984-05-16 1985-11-21 Bayer Ag, 5090 Leverkusen 6-chlorbenzazolyloxyacetamide
DE3422861A1 (de) 1984-06-20 1986-01-02 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von heteroaryloxyacetamiden
EP0318859A3 (en) * 1987-12-03 1990-08-16 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
WO1991007087A1 (en) 1989-11-13 1991-05-30 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
DE69132531T2 (de) 1990-12-06 2001-09-13 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Verbindungen und ihre Verwendung in einer binären Synthesestrategie
CA2124087C (en) 1991-11-22 2002-10-01 James L. Winkler Combinatorial strategies for polymer synthesis
US5359115A (en) 1992-03-26 1994-10-25 Affymax Technologies, N.V. Methods for the synthesis of phosphonate esters
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
DE4218433A1 (de) 1992-06-04 1993-12-09 Bayer Ag Fluorbenzoxazolyloxyacetamide
DE4219246A1 (de) 1992-06-12 1993-12-16 Bayer Ag Neue 2-(7-Chlor-2-benzoxazolyloxy)-acetamide
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
DE4230903A1 (de) 1992-09-16 1994-03-17 Bayer Ag Fluorbenzthiazolyloxyacetamide
KR100310939B1 (ko) 1992-10-01 2002-06-20 추후제출 태그로암호화한복합조합화학라이브러리
GB9318935D0 (en) * 1992-10-20 1993-10-27 Zeneca Ltd Heterocyclic derivatives
FR2707639B1 (fr) 1993-06-30 1995-10-13 Pf Medicament Nouveaux composés indoliques dérivés d'arylamines comme ligands sélectifs des récepteurs 5HT1D et 5HT1B.
US5362899A (en) 1993-09-09 1994-11-08 Affymax Technologies, N.V. Chiral synthesis of alpha-aminophosponic acids
DE4430092A1 (de) * 1994-08-25 1996-02-29 Bayer Ag 2,3-Cyclisch kondensierte 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US5712171A (en) 1995-01-20 1998-01-27 Arqule, Inc. Method of generating a plurality of chemical compounds in a spatially arranged array
GB9524812D0 (en) 1995-12-05 1996-02-07 Leo Pharm Prod Ltd Chemical compounds
US6245817B1 (en) * 1997-02-14 2001-06-12 Bayer Corporation NPY5 receptor antagonists and methods for using same
DE69809827D1 (de) 1997-03-31 2003-01-16 Korea Res Inst Chem Tech Chinolinische Sulfid-Derivate als NMDA Rezeptor-Antagonisten und Verfahren zu ihrer Herstellung
ES2262248T3 (es) * 1997-11-14 2006-11-16 Kowa Company. Ltd. Nuevos compuestos amida y medicamente que los contienen.
JP4327915B2 (ja) 1998-03-30 2009-09-09 株式会社デ・ウエスタン・セラピテクス研究所 スルフォンアミド誘導体
EP1070054A1 (en) * 1998-04-08 2001-01-24 Takeda Chemical Industries, Ltd. Amine compounds, their production and their use as somatostatin receptor antagonists or agonists
US20030219806A1 (en) 2000-02-22 2003-11-27 Millennium Pharmaceuticals, Inc. Novel 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 molecules and uses therefor
EP1288202A4 (en) * 2000-05-11 2003-07-02 Banyu Pharma Co Ltd N-acyltetrahydroisoquinoline derivatives
AU2001270240A1 (en) 2000-06-26 2002-01-08 Millennium Pharmaceuticals, Inc. Human calcium channels (48000; 52920) and uses thereof
ES2385931T3 (es) * 2000-07-07 2012-08-03 Spectrum Pharmaceuticals, Inc. MÉTODOS PARA EL TRATAMIENTO DE NEUROPATíA PERIFÉRICA INDUCIDA POR UNA ENFERMEDAD Y AFECCIONES RELACIONADAS.
GB2372993A (en) 2000-11-03 2002-09-11 Smithkline Beecham Plc Vanilloid Receptor 6
US20030027164A1 (en) 2000-12-01 2003-02-06 Gaughan Glen T. Novel human nucleic acid molecules and polypeptides encoding a novel human ion channel expressed in spinal cord and brain
EP1399558A2 (en) 2001-06-13 2004-03-24 Novartis AG Vanilloid receptor-related nucleic acids and polypeptides
US20040009537A1 (en) 2002-01-11 2004-01-15 Jack Roos Methods of modulating and of identifying agents that modulate intracellular calcium
US20040192728A1 (en) * 2003-02-03 2004-09-30 Ellen Codd Quinoline-derived amide modulators of vanilloid VR1 receptor
SE0301446D0 (sv) * 2003-05-16 2003-05-16 Astrazeneca Ab New Compounds
US20050070570A1 (en) * 2003-06-18 2005-03-31 4Sc Ag Novel potassium channels modulators
AU2004272104B2 (en) * 2003-09-10 2011-09-08 Icagen, Inc Fused ring heterocycles as potassium channel modulators
ATE532509T1 (de) 2003-09-11 2011-11-15 Tibotec Pharm Ltd Mittel zur hemmung des eintritts des hiv-virus
DE10351087A1 (de) 2003-10-31 2005-05-25 Bayer Technology Services Gmbh Feste Wirkstoff-Formulierung
CA2545725A1 (en) * 2003-11-14 2005-06-02 Merck Sharp & Dohme Limited Bicyclic pyrimidin-4-(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (vr1)
US20080139560A1 (en) * 2004-03-08 2008-06-12 Scion Pharmaceuticals, Inc. Ion Channel Modulators
EP1723123A4 (en) * 2004-03-08 2009-12-02 Wyeth Corp ION CHANNEL MODULATORS
EP1722783A4 (en) 2004-03-08 2009-08-12 Wyeth Corp MODULATORS OF THE ION CHANNEL FUNCTION
EP1790131B1 (en) 2004-09-09 2012-12-05 Avaya Inc. Methods of and systems for network traffic security
WO2006102645A1 (en) * 2005-03-24 2006-09-28 Janssen Pharmaceutica, N.V. Biaryl derived amide modulators of vanilloid vr1 receptor
EP2392328A1 (en) * 2005-05-09 2011-12-07 Hydra Biosciences, Inc. Compounds for modulating TRPV3 Function
US8916550B2 (en) 2005-05-09 2014-12-23 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
US7893260B2 (en) 2005-11-04 2011-02-22 Hydra Biosciences, Inc. Substituted quinazolin-4-one compounds for antagonizing TRPV3 function
US7998980B2 (en) * 2006-09-15 2011-08-16 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
WO2008140750A1 (en) * 2007-05-10 2008-11-20 Hydra Biosciences Inc. Compounds for modulating trpv3 function

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