AU2006244074B2 - Compounds for modulating TRPV3 function - Google Patents

Compounds for modulating TRPV3 function Download PDF

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Publication number
AU2006244074B2
AU2006244074B2 AU2006244074A AU2006244074A AU2006244074B2 AU 2006244074 B2 AU2006244074 B2 AU 2006244074B2 AU 2006244074 A AU2006244074 A AU 2006244074A AU 2006244074 A AU2006244074 A AU 2006244074A AU 2006244074 B2 AU2006244074 B2 AU 2006244074B2
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Australia
Prior art keywords
lower alkyl
compound
alkoxy
independently
absent
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AU2006244074A
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AU2006244074A1 (en
Inventor
Jayhong A. Chong
Christopher Fanger
Glenn R. Larsen
William C. Lumma Jr.
Anu Mahadevan
Peter Meltzer
Magdalena M. Moran
Amy Ripka
Dennis John Underwood
Manfred Weigele
Xiaoguang Zhen
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Hydra Biosciences LLC
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Hydra Biosciences LLC
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Priority to AU2012244254A priority Critical patent/AU2012244254A1/en
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Publication of AU2006244074B2 publication Critical patent/AU2006244074B2/en
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AU2006244074A 2005-05-09 2006-05-09 Compounds for modulating TRPV3 function Ceased AU2006244074B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2012244254A AU2012244254A1 (en) 2005-05-09 2012-10-22 Compounds for modulating TRPV3 function

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US67943805P 2005-05-09 2005-05-09
US67943605P 2005-05-09 2005-05-09
US60/679,438 2005-05-09
US60/679,436 2005-05-09
US70258405P 2005-07-25 2005-07-25
US60/702,584 2005-07-25
PCT/US2006/017995 WO2006122156A2 (en) 2005-05-09 2006-05-09 Compounds for modulating trpv3 function

Related Child Applications (1)

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AU2012244254A Division AU2012244254A1 (en) 2005-05-09 2012-10-22 Compounds for modulating TRPV3 function

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AU2006244074A1 AU2006244074A1 (en) 2006-11-16
AU2006244074B2 true AU2006244074B2 (en) 2012-12-13

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US (3) US7803790B2 (https=)
EP (2) EP2392328A1 (https=)
JP (2) JP2008540549A (https=)
CN (1) CN101233132A (https=)
AU (1) AU2006244074B2 (https=)
CA (1) CA2608194A1 (https=)
TW (1) TWI401254B (https=)
WO (1) WO2006122156A2 (https=)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030219806A1 (en) * 2000-02-22 2003-11-27 Millennium Pharmaceuticals, Inc. Novel 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 molecules and uses therefor
US8916550B2 (en) * 2005-05-09 2014-12-23 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
EP2392328A1 (en) * 2005-05-09 2011-12-07 Hydra Biosciences, Inc. Compounds for modulating TRPV3 Function
US7893260B2 (en) * 2005-11-04 2011-02-22 Hydra Biosciences, Inc. Substituted quinazolin-4-one compounds for antagonizing TRPV3 function
DE602006015700D1 (de) 2005-11-21 2010-09-02 Anadys Pharmaceuticals Inc Neues verfahren zur herstellung von 5-amino-3h-thiazoloä4,5-düpyrimidin-2-on
WO2007092610A2 (en) 2006-02-07 2007-08-16 Tivamed, Inc. Vaginal remodeling device and methods
CN101096363B (zh) * 2006-06-27 2011-05-11 中国人民解放军军事医学科学院毒物药物研究所 2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途
US8481161B2 (en) * 2006-06-28 2013-07-09 Samsung Electronics Co., Ltd. Functionalized metal nanoparticle and method for formation of conductive pattern using the same
US7998980B2 (en) 2006-09-15 2011-08-16 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
EP2120557A4 (en) * 2006-12-08 2010-02-10 Roskamp Res Llc POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION
WO2008140750A1 (en) * 2007-05-10 2008-11-20 Hydra Biosciences Inc. Compounds for modulating trpv3 function
WO2009006580A1 (en) * 2007-07-05 2009-01-08 Cv Therapeutics, Inc. Optionally condensed dihydropyridine, dihydropyrimidine and dihydropyrane derivatives acting as late sodium channel blockers
US20090012103A1 (en) 2007-07-05 2009-01-08 Matthew Abelman Substituted heterocyclic compounds
WO2009102864A1 (en) 2008-02-12 2009-08-20 Stanford University Hedgehog pathway antagonists and methods of use
AP2010005480A0 (en) * 2008-06-03 2010-12-31 Siga Technologies Inc Small molecule inhibitors for the treatment or prevention of denque virus infection.
WO2010055384A1 (en) * 2008-11-17 2010-05-20 Glenmark Pharmaceuticals S.A. Chromenone derivatives as trpv3 antagonists
KR101034299B1 (ko) 2008-12-02 2011-05-16 고려대학교 산학협력단 Ｔｒｐｖ３ 활성 조절 약물 및 이의 활용
KR101034300B1 (ko) * 2008-12-02 2011-05-16 고려대학교 산학협력단 Ｔｒｐｖ３ 활성 억제 약물 및 이의 활용
TW201105681A (en) * 2009-06-10 2011-02-16 Janssen Pharmaceutica Nv Benzimidazole derivatives useful as TRPM8 channel modulators
KR101643799B1 (ko) 2009-09-18 2016-07-28 비베베, 아이엔씨. 질 재건 기구 및 방법
CN102802632A (zh) 2010-03-22 2012-11-28 格兰马克药品股份有限公司 含有嘧啶酮衍生物的药物组合物
PT2593452T (pt) 2010-07-14 2017-04-24 Novartis Ag Compostos heterocíclicos agonistas do receptor ip
MX2013001612A (es) * 2010-08-10 2013-07-05 Abbvie Inc Moduladores de trpv3 novedosos.
JP5951625B2 (ja) 2010-11-24 2016-07-13 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨークＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｃｏｌｕｍｂｉａ Ｕｎｉｖｅｒｓｉｔｙ Ｉｎ Ｔｈｅ Ｃｉｔｙ Ｏｆ Ｎｅｗ Ｙｏｒｋ 加齢性黄斑変性症およびシュタルガルト病の処置のための非レチノイドｒｂｐ４アンタゴニスト
US20140031341A1 (en) * 2010-12-22 2014-01-30 Universitat Munster Modulators and methods for the treatment of rosacea
SG193331A1 (en) * 2011-03-18 2013-10-30 Lupin Ltd Benzo [b] [1, 4] oxazin derivatives as calcium sensing receptor modulators
US9012651B2 (en) 2011-03-24 2015-04-21 Abbvie Inc. TRPV3 modulators
WO2013003112A1 (en) 2011-06-27 2013-01-03 The Jackson Laboratory Methods and compositions for treatment of cancer and autoimmune disease
CN102994508B (zh) * 2011-09-14 2015-04-01 深圳华大基因科技有限公司 Olmsted综合征相关基因的鉴别以及与其相关的产品、方法及用途
WO2013062964A2 (en) 2011-10-24 2013-05-02 Abbvie Inc. Novel trpv3 modulators
UY34572A (es) 2012-01-13 2013-09-02 Novartis Ag Compuestos heterocíclicos agonistas del receptor ip
WO2013152109A1 (en) * 2012-04-04 2013-10-10 Dana-Farber Cancer Institute, Inc. Trpv4 antagonist and methods of use thereof
US9333202B2 (en) 2012-05-01 2016-05-10 The Trustees Of Columbia University In The City Of New York Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease
CN102747128A (zh) * 2012-05-24 2012-10-24 北京海威磐石生物医药科技有限公司 Trpv3通道蛋白在筛选用于皮肤病治疗或皮肤护理的药物中的应用
WO2013178782A1 (en) * 2012-05-30 2013-12-05 Universidad De Zaragoza Allosteric inhibitors of ns3 protease from hepatitis c virus
EP2869897A4 (en) 2012-07-06 2016-09-28 Univ Duke ACTIVATION OF THE TRPV4 ION CHANNEL BY PHYSICAL STIMULI AND IMPORTANT ROLE FOR TRPV4 IN ORGANIC INFLAMMATION AND JUCKREIZ
CN105189500A (zh) 2013-02-13 2015-12-23 诺华股份有限公司 Ip受体激动剂杂环化合物
EP3495357B1 (en) 2013-03-14 2021-05-05 The Trustees of Columbia University in the City of New York 4-phenylpiperidines, their preparation and use
WO2014152018A1 (en) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York Octahydrocyclopentapyrroles, their preparation and use
US9938291B2 (en) 2013-03-14 2018-04-10 The Trustess Of Columbia University In The City Of New York N-alkyl-2-phenoxyethanamines, their preparation and use
US9944644B2 (en) 2013-03-14 2018-04-17 The Trustees Of Columbia University In The City Of New York Octahydropyrrolopyrroles their preparation and use
CN103349786B (zh) * 2013-06-04 2015-03-25 北京大学第一医院 一种以trpv3通道蛋白为靶点的用于治疗皮肤瘙痒药物的筛选方法
CN110627770A (zh) 2013-11-18 2019-12-31 福马疗法公司 作为bet溴域抑制剂的四氢喹啉组成物
RU2720237C2 (ru) 2013-11-18 2020-04-28 Форма Терапеутикс, Инк. Композиции, содержащие бензопиперазин, в качестве ингибиторов бромодоменов вет
SG11201608943VA (en) 2014-04-30 2016-11-29 Univ Columbia Substituted 4-phenylpiperidines, their preparaiton and use
WO2016028325A1 (en) 2014-08-22 2016-02-25 Duke University Trpa1 and trpv4 inhibitors and methods of using the same for organ-specific inflammation and itch
TW201702218A (zh) * 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
US11229628B2 (en) 2015-01-09 2022-01-25 Duke University TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch
WO2016121433A1 (ja) * 2015-01-28 2016-08-04 シャープ株式会社 端末装置、基地局装置、通信方法および集積回路
WO2016160938A1 (en) * 2015-04-02 2016-10-06 Abbvie Inc. N-(1,3-thiazol-2-yl)pyrimidine-5-carboxamides as trpv3 modulators
CN109310683A (zh) 2016-04-07 2019-02-05 杜克大学 用于消毒和麻醉的trpv4和trpa1的小分子双重抑制剂
CN114748624A (zh) * 2016-06-13 2022-07-15 田边三菱制药株式会社 用于治疗或预防血管舒缩症状的组合物
WO2018129609A1 (en) * 2017-01-10 2018-07-19 Owen-Barry Pharmaceuticals Inc. Anticonvulsant compounds
KR20190063746A (ko) * 2017-11-30 2019-06-10 (주)인핸스드바이오 p34 단백질 및 NEDD4-1 단백질의 결합 억제제로서의 신규 화합물 및 이의 용도
CN110339360B (zh) * 2018-04-02 2024-04-19 苏中药业集团股份有限公司 瞬时受体电位阳离子通道trpv3在研制预防或治疗银屑病药物中的应用
US12337064B2 (en) * 2018-09-05 2025-06-24 Sensory Cloud, Inc. Formulations and compositions for ortho- and/or retro-nasal delivery and associated systems, methods and articles
WO2021154966A1 (en) 2020-01-29 2021-08-05 Kamari Pharma Ltd. Compounds and compositions for use in treating skin disorders
US11691971B2 (en) 2020-06-19 2023-07-04 Incyte Corporation Naphthyridinone compounds as JAK2 V617F inhibitors
WO2021257863A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Pyrrolotriazine compounds as jak2 v617f inhibitors
US11891403B2 (en) * 2020-06-29 2024-02-06 Boehringer Ingelheim International Gmbh Tetrazole derivatives as TRPA1 inhibitors
CR20230057A (es) 2020-07-02 2023-08-15 Incyte Corp Compuestos tríciclicos de urea como inhibidores de jak2 v617f
US11767323B2 (en) 2020-07-02 2023-09-26 Incyte Corporation Tricyclic pyridone compounds as JAK2 V617F inhibitors
WO2022026548A1 (en) * 2020-07-29 2022-02-03 Ideaya Biosciences, Inc. Acetamido-amino and acetamido-sulfur derivatives as dna polymerase theta inhibitors
US11661422B2 (en) 2020-08-27 2023-05-30 Incyte Corporation Tricyclic urea compounds as JAK2 V617F inhibitors
WO2022112352A1 (en) * 2020-11-24 2022-06-02 Katholieke Universiteit Leuven Heterocycle derivatives for treating trpm3 mediated disorders
US20230391739A1 (en) * 2020-11-24 2023-12-07 Katholieke Universiteit Leuven Aryl derivatives for treating trpm3 mediated disorders
US11919908B2 (en) 2020-12-21 2024-03-05 Incyte Corporation Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors
AR125273A1 (es) 2021-02-25 2023-07-05 Incyte Corp Lactamas espirocíclicas como inhibidores de jak2 v617f
AU2023235313A1 (en) 2022-03-17 2024-10-03 Incyte Corporation Tricyclic urea compounds as jak2 v617f inhibitors
CN120202189A (zh) 2022-09-30 2025-06-24 巴塞尔大学 免疫抑制化合物
CN119930563B (zh) * 2023-12-20 2026-03-17 苏中药业集团股份有限公司 一种瞬时受体电位阳离子通道trpv3抑制剂及其用途
CN120398870A (zh) * 2024-01-31 2025-08-01 深圳晶蛋生物医药科技有限公司 一种苯并吗啉类化合物及其应用

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4509971A (en) * 1978-05-20 1985-04-09 Bayer Aktiengesellschaft Benzothiazole substituted carboxylic acid amide compounds and herbicidal methods compositions thereof
EP0318859A2 (en) * 1987-12-03 1989-06-07 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
WO1999052875A1 (en) * 1998-04-08 1999-10-21 Takeda Chemical Industries, Ltd. Amine compounds, their production and their use as somatostatin receptor antagonists or agonists
EP0979823A1 (en) * 1997-11-14 2000-02-16 Kowa Company Ltd. Novel amide compounds and drugs containing the same
WO2002004448A2 (en) * 2000-07-07 2002-01-17 Neotherapeutics, Inc. Methods for treatment of drug-induced peripheral neuropathy and related conditions
WO2002101045A2 (en) * 2001-06-13 2002-12-19 Novartis Ag Vanilloid receptor-related nucleic acids and polypeptides
US20040044031A1 (en) * 2000-05-11 2004-03-04 Koji Yamada N-acyltetrahydroisoquinoline derivatives
WO2004069792A2 (en) * 2003-02-03 2004-08-19 Janssen Pharmaceutica N.V. Quinoline-derived amide modulators of vanilloid vr1 receptor
WO2004100865A2 (en) * 2003-05-16 2004-11-25 Astrazeneca Ab New benzimidazole derivatives
US20050059823A1 (en) * 2003-09-10 2005-03-17 Icagen, Inc. Fused ring heterocycles as potassium channel modulators
US20050070570A1 (en) * 2003-06-18 2005-03-31 4Sc Ag Novel potassium channels modulators
WO2005049613A1 (en) * 2003-11-14 2005-06-02 Merck Sharp & Dohme Limited Bicyclic pyrimidin-4-(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (vr1)
AU2005222402A1 (en) * 2004-03-08 2005-09-22 Wyeth Ion channel modulators
WO2005097112A2 (en) * 2004-03-08 2005-10-20 Wyeth Ion channel modulators
AU2006226775A1 (en) * 2005-03-24 2006-09-28 Janssen Pharmaceutica, N.V. Biaryl derived amide modulators of vanilloid VR1 receptor

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4461896A (en) 1979-02-07 1984-07-24 Norwich Eaton Pharmaceuticals, Inc. 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
DE3018075A1 (de) 1980-05-10 1981-11-12 Bayer Ag, 5090 Leverkusen Mittel zur regulierung des pflanzenwachstums, deren herstellung und deren verwendung
JPS56158702A (en) 1980-05-12 1981-12-07 Nippon Tokushu Noyaku Seizo Kk Herbicide
US4273927A (en) 1980-08-14 1981-06-16 Morton-Norwich Products, Inc. Converting enzyme inhibitor
DE3038599A1 (de) 1980-10-13 1982-05-19 Bayer Ag, 5090 Leverkusen Substituierte benzazol-2-yl-oxyessigsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide
DE3038652A1 (de) 1980-10-13 1982-05-19 Bayer Ag, 5090 Leverkusen 5-chlor-benzoxazol-2-yl-oxyessigsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide
DE3418168A1 (de) 1984-05-16 1985-11-21 Bayer Ag, 5090 Leverkusen 6-chlorbenzazolyloxyacetamide
DE3422861A1 (de) 1984-06-20 1986-01-02 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von heteroaryloxyacetamiden
WO1991007087A1 (en) 1989-11-13 1991-05-30 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
DE69132531T2 (de) 1990-12-06 2001-09-13 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Verbindungen und ihre Verwendung in einer binären Synthesestrategie
CA2124087C (en) 1991-11-22 2002-10-01 James L. Winkler Combinatorial strategies for polymer synthesis
US5359115A (en) 1992-03-26 1994-10-25 Affymax Technologies, N.V. Methods for the synthesis of phosphonate esters
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
DE4218433A1 (de) 1992-06-04 1993-12-09 Bayer Ag Fluorbenzoxazolyloxyacetamide
DE4219246A1 (de) 1992-06-12 1993-12-16 Bayer Ag Neue 2-(7-Chlor-2-benzoxazolyloxy)-acetamide
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
DE4230903A1 (de) 1992-09-16 1994-03-17 Bayer Ag Fluorbenzthiazolyloxyacetamide
KR100310939B1 (ko) 1992-10-01 2002-06-20 추후제출 태그로암호화한복합조합화학라이브러리
GB9318935D0 (en) * 1992-10-20 1993-10-27 Zeneca Ltd Heterocyclic derivatives
FR2707639B1 (fr) 1993-06-30 1995-10-13 Pf Medicament Nouveaux composés indoliques dérivés d'arylamines comme ligands sélectifs des récepteurs 5HT1D et 5HT1B.
US5362899A (en) 1993-09-09 1994-11-08 Affymax Technologies, N.V. Chiral synthesis of alpha-aminophosponic acids
DE4430092A1 (de) * 1994-08-25 1996-02-29 Bayer Ag 2,3-Cyclisch kondensierte 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US5712171A (en) 1995-01-20 1998-01-27 Arqule, Inc. Method of generating a plurality of chemical compounds in a spatially arranged array
GB9524812D0 (en) 1995-12-05 1996-02-07 Leo Pharm Prod Ltd Chemical compounds
US6245817B1 (en) * 1997-02-14 2001-06-12 Bayer Corporation NPY5 receptor antagonists and methods for using same
DE69809827D1 (de) 1997-03-31 2003-01-16 Korea Res Inst Chem Tech Chinolinische Sulfid-Derivate als NMDA Rezeptor-Antagonisten und Verfahren zu ihrer Herstellung
JP4327915B2 (ja) 1998-03-30 2009-09-09 株式会社デ・ウエスタン・セラピテクス研究所 スルフォンアミド誘導体
US20030219806A1 (en) 2000-02-22 2003-11-27 Millennium Pharmaceuticals, Inc. Novel 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 molecules and uses therefor
AU2001270240A1 (en) 2000-06-26 2002-01-08 Millennium Pharmaceuticals, Inc. Human calcium channels (48000; 52920) and uses thereof
GB2372993A (en) 2000-11-03 2002-09-11 Smithkline Beecham Plc Vanilloid Receptor 6
US20030027164A1 (en) 2000-12-01 2003-02-06 Gaughan Glen T. Novel human nucleic acid molecules and polypeptides encoding a novel human ion channel expressed in spinal cord and brain
US20040009537A1 (en) 2002-01-11 2004-01-15 Jack Roos Methods of modulating and of identifying agents that modulate intracellular calcium
ATE532509T1 (de) 2003-09-11 2011-11-15 Tibotec Pharm Ltd Mittel zur hemmung des eintritts des hiv-virus
DE10351087A1 (de) 2003-10-31 2005-05-25 Bayer Technology Services Gmbh Feste Wirkstoff-Formulierung
EP1722783A4 (en) 2004-03-08 2009-08-12 Wyeth Corp MODULATORS OF THE ION CHANNEL FUNCTION
EP1790131B1 (en) 2004-09-09 2012-12-05 Avaya Inc. Methods of and systems for network traffic security
EP2392328A1 (en) * 2005-05-09 2011-12-07 Hydra Biosciences, Inc. Compounds for modulating TRPV3 Function
US8916550B2 (en) 2005-05-09 2014-12-23 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
US7893260B2 (en) 2005-11-04 2011-02-22 Hydra Biosciences, Inc. Substituted quinazolin-4-one compounds for antagonizing TRPV3 function
US7998980B2 (en) * 2006-09-15 2011-08-16 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
WO2008140750A1 (en) * 2007-05-10 2008-11-20 Hydra Biosciences Inc. Compounds for modulating trpv3 function

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4509971A (en) * 1978-05-20 1985-04-09 Bayer Aktiengesellschaft Benzothiazole substituted carboxylic acid amide compounds and herbicidal methods compositions thereof
EP0318859A2 (en) * 1987-12-03 1989-06-07 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
EP0979823A1 (en) * 1997-11-14 2000-02-16 Kowa Company Ltd. Novel amide compounds and drugs containing the same
WO1999052875A1 (en) * 1998-04-08 1999-10-21 Takeda Chemical Industries, Ltd. Amine compounds, their production and their use as somatostatin receptor antagonists or agonists
US20040044031A1 (en) * 2000-05-11 2004-03-04 Koji Yamada N-acyltetrahydroisoquinoline derivatives
WO2002004448A2 (en) * 2000-07-07 2002-01-17 Neotherapeutics, Inc. Methods for treatment of drug-induced peripheral neuropathy and related conditions
WO2002101045A2 (en) * 2001-06-13 2002-12-19 Novartis Ag Vanilloid receptor-related nucleic acids and polypeptides
WO2004069792A2 (en) * 2003-02-03 2004-08-19 Janssen Pharmaceutica N.V. Quinoline-derived amide modulators of vanilloid vr1 receptor
WO2004100865A2 (en) * 2003-05-16 2004-11-25 Astrazeneca Ab New benzimidazole derivatives
US20050070570A1 (en) * 2003-06-18 2005-03-31 4Sc Ag Novel potassium channels modulators
US20050059823A1 (en) * 2003-09-10 2005-03-17 Icagen, Inc. Fused ring heterocycles as potassium channel modulators
WO2005049613A1 (en) * 2003-11-14 2005-06-02 Merck Sharp & Dohme Limited Bicyclic pyrimidin-4-(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (vr1)
AU2005222402A1 (en) * 2004-03-08 2005-09-22 Wyeth Ion channel modulators
WO2005097112A2 (en) * 2004-03-08 2005-10-20 Wyeth Ion channel modulators
AU2006226775A1 (en) * 2005-03-24 2006-09-28 Janssen Pharmaceutica, N.V. Biaryl derived amide modulators of vanilloid VR1 receptor

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
CAplus Accession No. 1970:443484 *
CAplus Accession No. 1986:14516 *
CAS Registry No. 311789-03-4 *
CAS Registry No. 346635-88-9 *
CAS Registry No. 350500-40-2 *
CAS Registry No. 399010-02-7 *
CAS Registry No. 448254-55-5 *
CAS Registry No. 454198-89-1 *
CAS Registry No. 457082-86-9 *
CAS Registry No. 482356-45-6 *
CAS Registry No. 502891-02-3 *
CAS Registry No. 722480-97-9 *
CAS Registry No. 748783-90-6 *

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