JP2008531536A5 - - Google Patents
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- Publication number
- JP2008531536A5 JP2008531536A5 JP2007556662A JP2007556662A JP2008531536A5 JP 2008531536 A5 JP2008531536 A5 JP 2008531536A5 JP 2007556662 A JP2007556662 A JP 2007556662A JP 2007556662 A JP2007556662 A JP 2007556662A JP 2008531536 A5 JP2008531536 A5 JP 2008531536A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- pharmaceutically acceptable
- chloro
- acceptable salt
- methoxyquinazolin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 26
- 150000003246 quinazolines Chemical class 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- -1 3-chloro-2-fluoroanilino, 3-chloro-4-fluoroanilino Chemical group 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 125000000524 functional group Chemical group 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 241000282412 Homo Species 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 238000000634 powder X-ray diffraction Methods 0.000 claims 3
- KZPCCHWWIXHAPW-FZKQIMNGSA-N (2r,4r)-4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy-n,1-dimethylpiperidine-2-carboxamide Chemical compound C1CN(C)[C@@H](C(=O)NC)C[C@@H]1OC(C(=CC1=NC=N2)OC)=CC1=C2NC1=CC=CC(Cl)=C1F KZPCCHWWIXHAPW-FZKQIMNGSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 2
- HGKSSYGJWQWSLQ-SJKOYZFVSA-N (2r,4r)-4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy-1-methylpiperidine-2-carboxamide Chemical compound C=12C=C(O[C@H]3C[C@@H](N(C)CC3)C(N)=O)C(OC)=CC2=NC=NC=1NC1=CC=CC(Cl)=C1F HGKSSYGJWQWSLQ-SJKOYZFVSA-N 0.000 claims 1
- ZFIWABPVEBYZAM-SJKOYZFVSA-N (2r,4r)-4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy-n-methylpiperidine-2-carboxamide Chemical compound C1CN[C@@H](C(=O)NC)C[C@@H]1OC(C(=CC1=NC=N2)OC)=CC1=C2NC1=CC=CC(Cl)=C1F ZFIWABPVEBYZAM-SJKOYZFVSA-N 0.000 claims 1
- KZPCCHWWIXHAPW-SCLBCKFNSA-N (2r,4s)-4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy-n,1-dimethylpiperidine-2-carboxamide Chemical compound C1CN(C)[C@@H](C(=O)NC)C[C@H]1OC(C(=CC1=NC=N2)OC)=CC1=C2NC1=CC=CC(Cl)=C1F KZPCCHWWIXHAPW-SCLBCKFNSA-N 0.000 claims 1
- KZPCCHWWIXHAPW-ACJLOTCBSA-N (2s,4r)-4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy-n,1-dimethylpiperidine-2-carboxamide Chemical compound C1CN(C)[C@H](C(=O)NC)C[C@@H]1OC(C(=CC1=NC=N2)OC)=CC1=C2NC1=CC=CC(Cl)=C1F KZPCCHWWIXHAPW-ACJLOTCBSA-N 0.000 claims 1
- HGKSSYGJWQWSLQ-SJCJKPOMSA-N (2s,4s)-4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy-1-methylpiperidine-2-carboxamide Chemical compound C=12C=C(O[C@@H]3C[C@H](N(C)CC3)C(N)=O)C(OC)=CC2=NC=NC=1NC1=CC=CC(Cl)=C1F HGKSSYGJWQWSLQ-SJCJKPOMSA-N 0.000 claims 1
- KZPCCHWWIXHAPW-UGSOOPFHSA-N (2s,4s)-4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy-n,1-dimethylpiperidine-2-carboxamide Chemical compound C1CN(C)[C@H](C(=O)NC)C[C@H]1OC(C(=CC1=NC=N2)OC)=CC1=C2NC1=CC=CC(Cl)=C1F KZPCCHWWIXHAPW-UGSOOPFHSA-N 0.000 claims 1
- CIOPUONYTJYZKQ-UHFFFAOYSA-N 1,2-dimethylpiperidine-2-carboxamide Chemical compound CN1CCCCC1(C)C(N)=O CIOPUONYTJYZKQ-UHFFFAOYSA-N 0.000 claims 1
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 1
- KZPCCHWWIXHAPW-UHFFFAOYSA-N 4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy-n,1-dimethylpiperidine-2-carboxamide Chemical compound C1CN(C)C(C(=O)NC)CC1OC(C(=CC1=NC=N2)OC)=CC1=C2NC1=CC=CC(Cl)=C1F KZPCCHWWIXHAPW-UHFFFAOYSA-N 0.000 claims 1
- 102000001301 EGF receptor Human genes 0.000 claims 1
- 108060006698 EGF receptor Proteins 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000003463 hyperproliferative effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 150000002688 maleic acid derivatives Chemical class 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0504018.3 | 2005-02-26 | ||
| GB0504018A GB0504018D0 (en) | 2005-02-26 | 2005-02-26 | Quinazoline derivatives |
| GB0506657.6 | 2005-03-21 | ||
| GB0506657A GB0506657D0 (en) | 2005-03-31 | 2005-03-31 | Quinazoline derivatives |
| GB0524001A GB0524001D0 (en) | 2005-11-25 | 2005-11-25 | Quinazoline derivatives |
| GB0524001.5 | 2005-11-25 | ||
| PCT/GB2006/000656 WO2006090163A1 (en) | 2005-02-26 | 2006-02-24 | Quinazoline derivatives as tyrosine kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008531536A JP2008531536A (ja) | 2008-08-14 |
| JP2008531536A5 true JP2008531536A5 (https=) | 2009-04-09 |
| JP5054544B2 JP5054544B2 (ja) | 2012-10-24 |
Family
ID=36390222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007556662A Expired - Fee Related JP5054544B2 (ja) | 2005-02-26 | 2006-02-24 | チロシンキナーゼ阻害剤としてのキナゾリン誘導体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8735410B2 (https=) |
| EP (1) | EP1856095B1 (https=) |
| JP (1) | JP5054544B2 (https=) |
| KR (1) | KR20070107151A (https=) |
| AR (1) | AR055564A1 (https=) |
| AT (1) | ATE521603T1 (https=) |
| AU (1) | AU2006217738A1 (https=) |
| BR (1) | BRPI0607432A2 (https=) |
| CA (1) | CA2599210A1 (https=) |
| IL (1) | IL184798A0 (https=) |
| MX (1) | MX2007010399A (https=) |
| NO (1) | NO20073878L (https=) |
| TW (1) | TW200640904A (https=) |
| UY (1) | UY29398A1 (https=) |
| WO (1) | WO2006090163A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2305844T3 (es) | 2003-09-16 | 2008-11-01 | Astrazeneca Ab | Derivados de quinazolina como inhibidores de tirosina cinasa. |
| GB0326459D0 (en) | 2003-11-13 | 2003-12-17 | Astrazeneca Ab | Quinazoline derivatives |
| JP5032851B2 (ja) | 2004-02-03 | 2012-09-26 | アストラゼネカ アクチボラグ | キナゾリン誘導体 |
| CA2735875A1 (en) | 2008-09-03 | 2010-03-11 | Boehringer Ingelheim International Gmbh | Use of quinazoline derivatives for the treatment of viral diseases |
| KR20140096571A (ko) * | 2013-01-28 | 2014-08-06 | 한미약품 주식회사 | 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법 |
| CN103288759B (zh) * | 2013-05-16 | 2015-05-20 | 苏州明锐医药科技有限公司 | 达克米替尼的制备方法 |
| CA2974442A1 (en) * | 2015-02-03 | 2016-08-11 | Trillium Therapeutics Inc. | Novel fluorinated derivatives as egfr inhibitors useful for treating cancers |
| WO2019062637A1 (zh) * | 2017-09-28 | 2019-04-04 | 南京明德新药研发股份有限公司 | 喹啉衍生物及其作为酪氨酸激酶抑制剂的应用 |
| BR112021004527A2 (pt) | 2018-09-14 | 2021-06-08 | Spectrum Pharmaceuticals, Inc. | kits e métodos para tratamento contra câncer |
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| DE10334226A1 (de) * | 2003-07-28 | 2005-02-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse |
| GB0317665D0 (en) * | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
| JP2007500177A (ja) * | 2003-07-29 | 2007-01-11 | アストラゼネカ アクチボラグ | チロシンキナーゼ阻害剤としてのピペリジルキナゾリン誘導体 |
| WO2005028469A1 (en) * | 2003-09-19 | 2005-03-31 | Astrazeneca Ab | Quinazoline derivatives |
| CN1882570B (zh) * | 2003-09-19 | 2010-12-08 | 阿斯利康(瑞典)有限公司 | 喹唑啉衍生物 |
| KR20060100388A (ko) * | 2003-09-25 | 2006-09-20 | 아스트라제네카 아베 | 퀴나졸린 유도체 |
-
2006
- 2006-02-24 MX MX2007010399A patent/MX2007010399A/es not_active Application Discontinuation
- 2006-02-24 KR KR1020077021853A patent/KR20070107151A/ko not_active Withdrawn
- 2006-02-24 WO PCT/GB2006/000656 patent/WO2006090163A1/en not_active Ceased
- 2006-02-24 TW TW095106212A patent/TW200640904A/zh unknown
- 2006-02-24 AR ARP060100689A patent/AR055564A1/es unknown
- 2006-02-24 AU AU2006217738A patent/AU2006217738A1/en not_active Abandoned
- 2006-02-24 UY UY29398A patent/UY29398A1/es unknown
- 2006-02-24 BR BRPI0607432-4A patent/BRPI0607432A2/pt not_active IP Right Cessation
- 2006-02-24 US US11/884,923 patent/US8735410B2/en not_active Expired - Fee Related
- 2006-02-24 EP EP06709888A patent/EP1856095B1/en not_active Expired - Lifetime
- 2006-02-24 AT AT06709888T patent/ATE521603T1/de not_active IP Right Cessation
- 2006-02-24 JP JP2007556662A patent/JP5054544B2/ja not_active Expired - Fee Related
- 2006-02-24 CA CA002599210A patent/CA2599210A1/en not_active Abandoned
-
2007
- 2007-07-23 IL IL184798A patent/IL184798A0/en unknown
- 2007-07-24 NO NO20073878A patent/NO20073878L/no not_active Application Discontinuation
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