JP5054544B2 - チロシンキナーゼ阻害剤としてのキナゾリン誘導体 - Google Patents

チロシンキナーゼ阻害剤としてのキナゾリン誘導体 Download PDF

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Publication number
JP5054544B2
JP5054544B2 JP2007556662A JP2007556662A JP5054544B2 JP 5054544 B2 JP5054544 B2 JP 5054544B2 JP 2007556662 A JP2007556662 A JP 2007556662A JP 2007556662 A JP2007556662 A JP 2007556662A JP 5054544 B2 JP5054544 B2 JP 5054544B2
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JP
Japan
Prior art keywords
formula
chloro
pharmaceutically acceptable
acceptable salt
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2007556662A
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English (en)
Japanese (ja)
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JP2008531536A5 (https=
JP2008531536A (ja
Inventor
ハルソール，クリストファー・トーマス
アンネキン，ローラン・フランソワ・アンドレ
プロウライト，アレイン・トーマス
ストレイ，リチャード
レノン，キエラン
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AstraZeneca AB
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AstraZeneca AB
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36390222&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP5054544(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0504018A external-priority patent/GB0504018D0/en
Priority claimed from GB0506657A external-priority patent/GB0506657D0/en
Priority claimed from GB0524001A external-priority patent/GB0524001D0/en
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of JP2008531536A publication Critical patent/JP2008531536A/ja
Publication of JP2008531536A5 publication Critical patent/JP2008531536A5/ja
Application granted granted Critical
Publication of JP5054544B2 publication Critical patent/JP5054544B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2007556662A 2005-02-26 2006-02-24 チロシンキナーゼ阻害剤としてのキナゾリン誘導体 Expired - Fee Related JP5054544B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0504018.3 2005-02-26
GB0504018A GB0504018D0 (en) 2005-02-26 2005-02-26 Quinazoline derivatives
GB0506657.6 2005-03-21
GB0506657A GB0506657D0 (en) 2005-03-31 2005-03-31 Quinazoline derivatives
GB0524001A GB0524001D0 (en) 2005-11-25 2005-11-25 Quinazoline derivatives
GB0524001.5 2005-11-25
PCT/GB2006/000656 WO2006090163A1 (en) 2005-02-26 2006-02-24 Quinazoline derivatives as tyrosine kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2008531536A JP2008531536A (ja) 2008-08-14
JP2008531536A5 JP2008531536A5 (https=) 2009-04-09
JP5054544B2 true JP5054544B2 (ja) 2012-10-24

Family

ID=36390222

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007556662A Expired - Fee Related JP5054544B2 (ja) 2005-02-26 2006-02-24 チロシンキナーゼ阻害剤としてのキナゾリン誘導体

Country Status (15)

Country Link
US (1) US8735410B2 (https=)
EP (1) EP1856095B1 (https=)
JP (1) JP5054544B2 (https=)
KR (1) KR20070107151A (https=)
AR (1) AR055564A1 (https=)
AT (1) ATE521603T1 (https=)
AU (1) AU2006217738A1 (https=)
BR (1) BRPI0607432A2 (https=)
CA (1) CA2599210A1 (https=)
IL (1) IL184798A0 (https=)
MX (1) MX2007010399A (https=)
NO (1) NO20073878L (https=)
TW (1) TW200640904A (https=)
UY (1) UY29398A1 (https=)
WO (1) WO2006090163A1 (https=)

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* Cited by examiner, † Cited by third party
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JP5032851B2 (ja) 2004-02-03 2012-09-26 アストラゼネカ アクチボラグ キナゾリン誘導体
CA2735875A1 (en) 2008-09-03 2010-03-11 Boehringer Ingelheim International Gmbh Use of quinazoline derivatives for the treatment of viral diseases
KR20140096571A (ko) * 2013-01-28 2014-08-06 한미약품 주식회사 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법
CN103288759B (zh) * 2013-05-16 2015-05-20 苏州明锐医药科技有限公司 达克米替尼的制备方法
CA2974442A1 (en) * 2015-02-03 2016-08-11 Trillium Therapeutics Inc. Novel fluorinated derivatives as egfr inhibitors useful for treating cancers
WO2019062637A1 (zh) * 2017-09-28 2019-04-04 南京明德新药研发股份有限公司 喹啉衍生物及其作为酪氨酸激酶抑制剂的应用
BR112021004527A2 (pt) 2018-09-14 2021-06-08 Spectrum Pharmaceuticals, Inc. kits e métodos para tratamento contra câncer

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Also Published As

Publication number Publication date
KR20070107151A (ko) 2007-11-06
BRPI0607432A2 (pt) 2009-09-01
TW200640904A (en) 2006-12-01
US8735410B2 (en) 2014-05-27
CA2599210A1 (en) 2006-08-31
IL184798A0 (en) 2007-12-03
MX2007010399A (es) 2007-09-25
AR055564A1 (es) 2007-08-22
ATE521603T1 (de) 2011-09-15
AU2006217738A1 (en) 2006-08-31
EP1856095B1 (en) 2011-08-24
UY29398A1 (es) 2006-10-02
NO20073878L (no) 2007-10-23
WO2006090163A1 (en) 2006-08-31
US20110152297A1 (en) 2011-06-23
EP1856095A1 (en) 2007-11-21
JP2008531536A (ja) 2008-08-14

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