NO20073878L - Kinazolinderivater som tyrosin kinase inhibitorer - Google Patents

Kinazolinderivater som tyrosin kinase inhibitorer

Info

Publication number
NO20073878L
NO20073878L NO20073878A NO20073878A NO20073878L NO 20073878 L NO20073878 L NO 20073878L NO 20073878 A NO20073878 A NO 20073878A NO 20073878 A NO20073878 A NO 20073878A NO 20073878 L NO20073878 L NO 20073878L
Authority
NO
Norway
Prior art keywords
quinazoline derivatives
tyrosine kinase
kinase inhibitors
formula
medicament
Prior art date
Application number
NO20073878A
Other languages
English (en)
Inventor
Richard Anthony Storey
Alleyn Plowright
Christopher Thomas Halsall
Laurent Francois And Hennequin
Kieran Lennon
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36390222&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20073878(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0504018A external-priority patent/GB0504018D0/en
Priority claimed from GB0506657A external-priority patent/GB0506657D0/en
Priority claimed from GB0524001A external-priority patent/GB0524001D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20073878L publication Critical patent/NO20073878L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

I Oppfinnelsen angår kinazolinderivater med Forme l I eller farmasøytisk akseptable salter derav: hvor hver av R1, R2, R3, R4 og m er som definert i beskrivelsen; fremgangsmåter for deres fremstilling; farmasøytiske preparater inneholdende dem og anvendelse av dem ved fremstilling av et medikament for å gi en anti-proliferativ effekt. Kinazolinderivatene med formel I er forventet å være anvendelige ved behandling av sykdommer så som visse kreftformer mediert av erbB-reseptor-tyrosinkinaser, spesielt EGFR-tyrosinkinase.
NO20073878A 2005-02-26 2007-07-24 Kinazolinderivater som tyrosin kinase inhibitorer NO20073878L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0504018A GB0504018D0 (en) 2005-02-26 2005-02-26 Quinazoline derivatives
GB0506657A GB0506657D0 (en) 2005-03-31 2005-03-31 Quinazoline derivatives
GB0524001A GB0524001D0 (en) 2005-11-25 2005-11-25 Quinazoline derivatives
PCT/GB2006/000656 WO2006090163A1 (en) 2005-02-26 2006-02-24 Quinazoline derivatives as tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
NO20073878L true NO20073878L (no) 2007-10-23

Family

ID=36390222

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073878A NO20073878L (no) 2005-02-26 2007-07-24 Kinazolinderivater som tyrosin kinase inhibitorer

Country Status (15)

Country Link
US (1) US8735410B2 (no)
EP (1) EP1856095B1 (no)
JP (1) JP5054544B2 (no)
KR (1) KR20070107151A (no)
AR (1) AR055564A1 (no)
AT (1) ATE521603T1 (no)
AU (1) AU2006217738A1 (no)
BR (1) BRPI0607432A2 (no)
CA (1) CA2599210A1 (no)
IL (1) IL184798A0 (no)
MX (1) MX2007010399A (no)
NO (1) NO20073878L (no)
TW (1) TW200640904A (no)
UY (1) UY29398A1 (no)
WO (1) WO2006090163A1 (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
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US8629153B2 (en) 2008-09-03 2014-01-14 Boehringer Ingelheim International Gmbh Use of quinazoline derivatives for the treatment of viral diseases
KR20140096571A (ko) * 2013-01-28 2014-08-06 한미약품 주식회사 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법
CN103288759B (zh) * 2013-05-16 2015-05-20 苏州明锐医药科技有限公司 达克米替尼的制备方法
WO2016123706A1 (en) * 2015-02-03 2016-08-11 Trillium Therapeutics Inc. Novel fluorinated derivatives as egfr inhibitors useful for treating cancers
EP3689351B1 (en) 2017-09-28 2022-11-02 Chongqing Pharmaceutical Industrial Research Institute Co. Ltd. Quinoline derivative and application thereof as tyrosine kinase inhibitor
MX2021002876A (es) * 2018-09-14 2021-06-04 Spectrum Pharmaceuticals Inc Kits y metodos para tratar canceres.

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Also Published As

Publication number Publication date
JP5054544B2 (ja) 2012-10-24
WO2006090163A1 (en) 2006-08-31
CA2599210A1 (en) 2006-08-31
US8735410B2 (en) 2014-05-27
UY29398A1 (es) 2006-10-02
MX2007010399A (es) 2007-09-25
AU2006217738A1 (en) 2006-08-31
EP1856095B1 (en) 2011-08-24
US20110152297A1 (en) 2011-06-23
JP2008531536A (ja) 2008-08-14
KR20070107151A (ko) 2007-11-06
ATE521603T1 (de) 2011-09-15
BRPI0607432A2 (pt) 2009-09-01
TW200640904A (en) 2006-12-01
IL184798A0 (en) 2007-12-03
EP1856095A1 (en) 2007-11-21
AR055564A1 (es) 2007-08-22

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