|
US5097A
(en)
|
|
1847-05-01 |
|
N peters photo lithogr peer wasringto d o |
|
US659684A
(en)
|
1899-10-14 |
1900-10-16 |
John A W Lundborg |
Dental rubber-dam holder.
|
|
US3896111A
(en)
|
1973-02-20 |
1975-07-22 |
Research Corp |
Ansa macrolides
|
|
DE2319495C2
(de)
|
1973-04-17 |
1985-01-10 |
Yeda Research And Development Co., Ltd., Rehovot |
Verfahren zum selektiven, reversiblen Binden von Biomolekülen an ein Adsorbens in einer chromatographischen Säule
|
|
US4000098A
(en)
|
1974-08-16 |
1976-12-28 |
Palo Alto Medical Research Foundation |
Separation of proteins by hydrophobic adsorption
|
|
US4151042A
(en)
|
1977-03-31 |
1979-04-24 |
Takeda Chemical Industries, Ltd. |
Method for producing maytansinol and its derivatives
|
|
US4563304A
(en)
|
1981-02-27 |
1986-01-07 |
Pharmacia Fine Chemicals Ab |
Pyridine compounds modifying proteins, polypeptides or polysaccharides
|
|
US4631190A
(en)
|
1981-06-26 |
1986-12-23 |
Shen Wei C |
Acidity-sensitive spacer molecule to control the release of pharmaceuticals from molecular carriers
|
|
AU561343B2
(en)
|
1981-10-19 |
1987-05-07 |
Genentech Inc. |
Human immune interferon by recombinant dna
|
|
US4612282A
(en)
|
1981-12-15 |
1986-09-16 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Monoclonal antibodies reactive with human breast cancer
|
|
US4522918A
(en)
|
1981-12-15 |
1985-06-11 |
Jeffery Schlom |
Process for producing monoclonal antibodies reactive with human breast cancer
|
|
US4542225A
(en)
|
1984-08-29 |
1985-09-17 |
Dana-Farber Cancer Institute, Inc. |
Acid-cleavable compound
|
|
US4889919A
(en)
|
1986-08-13 |
1989-12-26 |
Zymogenetics, Inc. |
Biologically active PDGF derived A-chain homodimers
|
|
US4766073A
(en)
|
1985-02-25 |
1988-08-23 |
Zymogenetics Inc. |
Expression of biologically active PDGF analogs in eucaryotic cells
|
|
US5157021A
(en)
|
1985-03-15 |
1992-10-20 |
Novo Nordisk A/S |
Insulin derivatives and pharmaceutical preparations containing these derivatives
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
IL78444A
(en)
|
1986-04-08 |
1992-05-25 |
Yeda Res & Dev |
Human gamma interferon-specific receptor protein,antibody against said protein,and compositions containing said protein and antibody
|
|
US4831175A
(en)
|
1986-09-05 |
1989-05-16 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
|
|
US5099069A
(en)
|
1986-09-05 |
1992-03-24 |
Gansow Otto A |
Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
|
|
US5246692A
(en)
|
1986-09-05 |
1993-09-21 |
The United States Of America As Represented By The Secretary Of Health And Human Services |
Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
|
|
US5892019A
(en)
|
1987-07-15 |
1999-04-06 |
The United States Of America, As Represented By The Department Of Health And Human Services |
Production of a single-gene-encoded immunoglobulin
|
|
EP0394277B1
(en)
|
1987-07-15 |
1998-01-14 |
THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce |
Second generation monoclonal antibodies having binding specificity to tag-72 and human carcinomas and methods for employing the same
|
|
AU643427B2
(en)
|
1988-10-31 |
1993-11-18 |
Immunex Corporation |
Interleukin-4 receptors
|
|
DE68913658T3
(de)
|
1988-11-11 |
2005-07-21 |
Stratagene, La Jolla |
Klonierung von Immunglobulin Sequenzen aus den variablen Domänen
|
|
US5175384A
(en)
|
1988-12-05 |
1992-12-29 |
Genpharm International |
Transgenic mice depleted in mature t-cells and methods for making transgenic mice
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5116964A
(en)
|
1989-02-23 |
1992-05-26 |
Genentech, Inc. |
Hybrid immunoglobulins
|
|
US5225538A
(en)
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
|
JPH04505260A
(ja)
|
1989-05-22 |
1992-09-17 |
ザイモジェネティクス,インコーポレイティド |
PDGFα―受容体
|
|
US5061786A
(en)
|
1989-05-25 |
1991-10-29 |
Genentech, Inc. |
Biologically active polypeptides based on transforming growth factor-β
|
|
US5194596A
(en)
|
1989-07-27 |
1993-03-16 |
California Biotechnology Inc. |
Production of vascular endothelial cell growth factor
|
|
US5460785A
(en)
|
1989-08-09 |
1995-10-24 |
Rhomed Incorporated |
Direct labeling of antibodies and other protein with metal ions
|
|
JPH0396383A
(ja)
|
1989-09-08 |
1991-04-22 |
Riso Kagaku Corp |
画像形成装置
|
|
EP0417563B1
(de)
|
1989-09-12 |
2000-07-05 |
F. Hoffmann-La Roche Ag |
TNF-bindende Proteine
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
US5648273A
(en)
|
1989-12-27 |
1997-07-15 |
The United States Of America, As Represented By The Department Of Health And Human Services |
Hepatic growth factor receptor is the MET proto-oncogene
|
|
JP3068180B2
(ja)
|
1990-01-12 |
2000-07-24 |
アブジェニックス インコーポレイテッド |
異種抗体の生成
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5124471A
(en)
|
1990-03-26 |
1992-06-23 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Bifunctional dtpa-type ligand
|
|
CA2040099A1
(en)
|
1990-05-01 |
1991-11-02 |
Mariano Barbacid |
Tyrosine kinase negative trkb
|
|
US5256643A
(en)
|
1990-05-29 |
1993-10-26 |
The Government Of The United States |
Human cripto protein
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5453491A
(en)
|
1990-09-11 |
1995-09-26 |
Kiyoshi Takatsu |
Murine interleukin-5 receptor
|
|
ES2113940T3
(es)
|
1990-12-03 |
1998-05-16 |
Genentech Inc |
Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas.
|
|
JPH04334377A
(ja)
|
1990-12-31 |
1992-11-20 |
Akzo Nv |
酸−不安定性リンカー分子
|
|
EP0580751A1
(en)
|
1991-04-19 |
1994-02-02 |
Schering Corporation |
Subunit of the human interleukin-3 receptor
|
|
US5227158A
(en)
|
1991-06-10 |
1993-07-13 |
Genentech, Inc. |
Method of stimulating hepatocyte proliferation by administration of hepatocyte growth factor and gamma-interferon
|
|
US5346991A
(en)
|
1991-06-13 |
1994-09-13 |
Genentech, Inc. |
Tissue factor mutants useful for the treatment of myocardial infarction and coagulopathic disorders
|
|
WO1992022653A1
(en)
|
1991-06-14 |
1992-12-23 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
US5348856A
(en)
|
1991-07-08 |
1994-09-20 |
E. R. Squibb & Sons, Inc. |
DNA encoding TRKC protein
|
|
US5756096A
(en)
|
1991-07-25 |
1998-05-26 |
Idec Pharmaceuticals Corporation |
Recombinant antibodies for human therapy
|
|
IE922437A1
(en)
|
1991-07-25 |
1993-01-27 |
Idec Pharma Corp |
Recombinant antibodies for human therapy
|
|
US5264557A
(en)
|
1991-08-23 |
1993-11-23 |
The United States Of America As Represented By The Department Of Health And Human Services |
Polypeptide of a human cripto-related gene, CR-3
|
|
ATE244763T1
(de)
|
1992-02-11 |
2003-07-15 |
Cell Genesys Inc |
Erzielen von homozygotem durch zielgerichtete genetische ereignisse
|
|
GB9206422D0
(en)
|
1992-03-24 |
1992-05-06 |
Bolt Sarah L |
Antibody preparation
|
|
JP2559093Y2
(ja)
|
1992-05-08 |
1998-01-14 |
ワイケイケイ株式会社 |
面ファスナー
|
|
EP0627932B1
(en)
|
1992-11-04 |
2002-05-08 |
City Of Hope |
Antibody construct
|
|
DE122004000036I1
(de)
|
1992-11-13 |
2005-07-07 |
Biogen Idec Inc |
Therapeutische Verwendung von chimerischen und markierten Antik¦rper gegen menschlichen B Lymphozyt beschr{nkter Differenzierung antigen f}r die Behandlung von B-Zell-Lymphoma.
|
|
PT669986E
(pt)
|
1992-11-13 |
2003-08-29 |
Idec Pharma Corp |
Sequencia do marcador de seleccao dominante alterada e estrategias de insercao intronica para melhoria de expressao de produto genico e sistemas de vector de expressao que o compreendem
|
|
US5736137A
(en)
|
1992-11-13 |
1998-04-07 |
Idec Pharmaceuticals Corporation |
Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
|
|
US5556623A
(en)
|
1993-03-30 |
1996-09-17 |
Eli Lilly And Company |
Antibody-drug conjugates
|
|
AU7050994A
(en)
|
1993-06-01 |
1994-12-20 |
Scripps Research Institute, The |
Human mutant tissue factor compositions useful as tissue factor antagonists
|
|
US5877016A
(en)
|
1994-03-18 |
1999-03-02 |
Genentech, Inc. |
Human trk receptors and neurotrophic factor inhibitors
|
|
US5686292A
(en)
|
1995-06-02 |
1997-11-11 |
Genentech, Inc. |
Hepatocyte growth factor receptor antagonist antibodies and uses thereof
|
|
US5981215A
(en)
|
1995-06-06 |
1999-11-09 |
Human Genome Sciences, Inc. |
Human criptin growth factor
|
|
US5811524A
(en)
|
1995-06-07 |
1998-09-22 |
Idec Pharmaceuticals Corporation |
Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof
|
|
DE69628652T3
(de)
|
1995-09-08 |
2012-05-03 |
Genentech, Inc. |
Vegf-verwandtes protein
|
|
GB9524973D0
(en)
|
1995-12-06 |
1996-02-07 |
Lynxvale Ltd |
Viral vectors
|
|
CN1201005C
(zh)
|
1996-05-22 |
2005-05-11 |
维文蒂阿生物技术股份有限公司 |
特异性检测癌细胞的抗原结合片段、编码所述片段的dna、以及它们在预防和检测癌症上的用途
|
|
ATE465257T1
(de)
|
1996-07-03 |
2010-05-15 |
Genentech Inc |
Agonisten für den rezeptor des hepatozyten- wachstumsfaktors und deren anwendungen
|
|
CA2262405A1
(en)
*
|
1996-08-02 |
1998-02-12 |
Bristol-Myers Squibb Company |
A method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
|
|
US6159462A
(en)
|
1996-08-16 |
2000-12-12 |
Genentech, Inc. |
Uses of Wnt polypeptides
|
|
CA2264610A1
(en)
|
1996-11-05 |
1998-05-14 |
Bristol-Myers Squibb Company |
Branched peptide linkers
|
|
US6011138A
(en)
|
1997-02-20 |
2000-01-04 |
Idec Pharmaceuticals Corporation |
Gamma-1 anti-human CD23 monoclonal antibodies
|
|
AU737155B2
(en)
|
1997-03-14 |
2001-08-09 |
Biogen Idec Inc. |
Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same
|
|
GB9720054D0
(en)
|
1997-09-19 |
1997-11-19 |
Celltech Therapeutics Ltd |
Biological products
|
|
IL125608A0
(en)
|
1998-07-30 |
1999-03-12 |
Yeda Res & Dev |
Tumor associated antigen peptides and use of same as anti-tumor vaccines
|
|
JP3971108B2
(ja)
|
1999-01-06 |
2007-09-05 |
ジェネンテック・インコーポレーテッド |
インシュリン様成長因子(igf)i突然変異体
|
|
DE60042550D1
(de)
|
1999-01-06 |
2009-08-27 |
Genentech Inc |
Mutierte varianten des insulin-ähnlichen wachstumsfaktor i (igf-i)
|
|
CA2356401A1
(en)
|
1999-01-07 |
2000-07-13 |
Lexigen Pharmaceuticals, Corp. |
Expression and export of anti-obesity proteins as fc fusion proteins
|
|
AU3316600A
(en)
*
|
1999-02-22 |
2000-09-21 |
Torben F. Orntoft |
Gene expression in bladder tumors
|
|
CA2370760A1
(en)
|
1999-04-20 |
2000-10-26 |
William J. Kokolus |
Improved method of identifying and locating immunobiologically-active linear peptides
|
|
CA2372400C
(en)
|
1999-05-19 |
2010-04-27 |
Lexigen Pharmaceuticals Corp. |
Expression and export of interferon-alpha proteins as fc fusion proteins
|
|
US6949245B1
(en)
|
1999-06-25 |
2005-09-27 |
Genentech, Inc. |
Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
|
|
JP2001046066A
(ja)
|
1999-08-03 |
2001-02-20 |
Kyowa Hakko Kogyo Co Ltd |
新規な相補性決定領域を有するヒトvegf受容体kdrに対する抗体
|
|
KR100490077B1
(ko)
|
1999-10-29 |
2005-05-17 |
제넨테크, 인크. |
항-전립선 줄기세포 항원 (psca) 항체 조성물 및 그의사용 방법
|
|
ES2309050T3
(es)
|
2000-03-03 |
2008-12-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Anticuerpo anti-ccr4 y su fragmento.
|
|
US6333410B1
(en)
|
2000-08-18 |
2001-12-25 |
Immunogen, Inc. |
Process for the preparation and purification of thiol-containing maytansinoids
|
|
GB0020953D0
(en)
|
2000-08-24 |
2000-10-11 |
Smithkline Beecham Biolog |
Vaccine
|
|
CA2422814A1
(en)
|
2000-09-18 |
2002-03-21 |
Biogen, Inc. |
Cripto mutant and uses thereof
|
|
JP3821779B2
(ja)
|
2001-01-26 |
2006-09-13 |
アメリカ合衆国 |
Cripto−1の検出及び定量
|
|
AU2002327164A1
(en)
*
|
2001-01-29 |
2002-12-09 |
Idec Pharmaceuticals Corporation |
Engineered tetravalent antibodies and methods of use
|
|
NZ545176A
(en)
|
2001-01-29 |
2008-05-30 |
Biogen Idec Inc |
Modified antibodies reactive with CD20 and methods of use
|
|
AUPR395801A0
(en)
*
|
2001-03-26 |
2001-04-26 |
Austin Research Institute, The |
Antibodies against cancer
|
|
EP1390389B1
(en)
*
|
2001-04-26 |
2009-01-14 |
Biogen Idec MA Inc. |
Cripto blocking antibodies and uses thereof
|
|
US7582299B2
(en)
|
2001-04-26 |
2009-09-01 |
Biogen Idec Ma Inc. |
Cripto-specific antibodies
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
CA2460120A1
(en)
|
2001-09-18 |
2003-03-27 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
US20040014690A1
(en)
*
|
2002-02-13 |
2004-01-22 |
Zhenkun Ma |
Macrolides with activity against methicillin-resistant staphylococcus aureus
|
|
MY139983A
(en)
*
|
2002-03-12 |
2009-11-30 |
Janssen Alzheimer Immunotherap |
Humanized antibodies that recognize beta amyloid peptide
|
|
EP1494693B1
(en)
|
2002-03-22 |
2010-12-08 |
Biogen Idec MA Inc. |
Cripto-specific antibodies
|
|
EP1517921B1
(en)
*
|
2002-06-28 |
2006-06-07 |
Domantis Limited |
Dual specific ligands with increased serum half-life
|
|
EP1641826A2
(en)
|
2003-06-27 |
2006-04-05 |
Biogen Idec MA Inc. |
Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions
|
|
EP2135952A3
(en)
*
|
2003-09-15 |
2010-09-29 |
Research Development Foundation |
Cripto antagonism of activin and TGF-beta signaling
|
|
AU2006203889A1
(en)
|
2005-01-05 |
2006-07-13 |
Biogen Idec Ma Inc. |
CRIPTO binding molecules
|
|
CA2650379A1
(en)
*
|
2006-04-28 |
2007-11-08 |
Biogen Idec Ma Inc. |
Composition and methods for the detection of cripto-3
|
|
EP2988959B1
(en)
|
2013-04-23 |
2020-08-05 |
ClearMotion, Inc. |
Active suspension with structural actuator
|
|
US9925552B2
(en)
|
2015-03-09 |
2018-03-27 |
Nordson Corporation |
Liquid dispensing applicators having backpressure control devices, and related methods
|