JP2013519690A5 - - Google Patents
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- Publication number
- JP2013519690A5 JP2013519690A5 JP2012553146A JP2012553146A JP2013519690A5 JP 2013519690 A5 JP2013519690 A5 JP 2013519690A5 JP 2012553146 A JP2012553146 A JP 2012553146A JP 2012553146 A JP2012553146 A JP 2012553146A JP 2013519690 A5 JP2013519690 A5 JP 2013519690A5
- Authority
- JP
- Japan
- Prior art keywords
- immunoglobulin
- pharmaceutical composition
- composition according
- antibody
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108060003951 Immunoglobulin Proteins 0.000 claims description 53
- 102000018358 immunoglobulin Human genes 0.000 claims description 53
- 239000008194 pharmaceutical composition Substances 0.000 claims description 30
- 241000124008 Mammalia Species 0.000 claims description 21
- 210000005134 plasmacytoid dendritic cell Anatomy 0.000 claims description 20
- 210000003651 basophil Anatomy 0.000 claims description 18
- 239000012636 effector Substances 0.000 claims description 10
- 238000006467 substitution reaction Methods 0.000 claims description 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 6
- 206010025135 lupus erythematosus Diseases 0.000 claims description 6
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims description 4
- 230000004540 complement-dependent cytotoxicity Effects 0.000 claims description 4
- 210000004544 dc2 Anatomy 0.000 claims description 4
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 4
- 231100000167 toxic agent Toxicity 0.000 claims description 4
- 239000003440 toxic substance Substances 0.000 claims description 4
- 102000010790 Interleukin-3 Receptors Human genes 0.000 claims description 3
- 108010038452 Interleukin-3 Receptors Proteins 0.000 claims description 3
- 230000001419 dependent effect Effects 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- 102000009490 IgG Receptors Human genes 0.000 claims description 2
- 108010073807 IgG Receptors Proteins 0.000 claims description 2
- 102000002227 Interferon Type I Human genes 0.000 claims description 2
- 108010014726 Interferon Type I Proteins 0.000 claims description 2
- 102000000646 Interleukin-3 Human genes 0.000 claims description 2
- 108010002386 Interleukin-3 Proteins 0.000 claims description 2
- 206010057249 Phagocytosis Diseases 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims description 2
- 230000008782 phagocytosis Effects 0.000 claims description 2
- 230000011664 signaling Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 3
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 101100396742 Homo sapiens IL3RA gene Proteins 0.000 claims 1
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 33
- 239000003085 diluting agent Substances 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/707,297 | 2010-02-17 | ||
| US12/707,297 US20100209341A1 (en) | 2009-02-18 | 2010-02-17 | Treatment of chronic inflammatory conditions |
| US37449710P | 2010-08-17 | 2010-08-17 | |
| US37448910P | 2010-08-17 | 2010-08-17 | |
| US61/374,489 | 2010-08-17 | ||
| US61/374,497 | 2010-08-17 | ||
| PCT/AU2011/000155 WO2011100786A1 (en) | 2010-02-17 | 2011-02-17 | Compositions and methods for targeting type 1 interferon producing cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013519690A JP2013519690A (ja) | 2013-05-30 |
| JP2013519690A5 true JP2013519690A5 (enExample) | 2014-04-03 |
| JP6018507B2 JP6018507B2 (ja) | 2016-11-02 |
Family
ID=44482392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012553146A Active JP6018507B2 (ja) | 2010-02-17 | 2011-02-17 | Ｉ型インターフェロン産生細胞を標的化するための組成物及び方法 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP2536430B1 (enExample) |
| JP (1) | JP6018507B2 (enExample) |
| KR (1) | KR101842907B1 (enExample) |
| CN (1) | CN103002913B (enExample) |
| AU (1) | AU2011217728B2 (enExample) |
| CA (1) | CA2789810C (enExample) |
| ES (1) | ES2618562T3 (enExample) |
| IL (1) | IL221504B (enExample) |
| NZ (2) | NZ601760A (enExample) |
| WO (1) | WO2011100786A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100209341A1 (en) | 2009-02-18 | 2010-08-19 | Csl Limited | Treatment of chronic inflammatory conditions |
| EP2839842A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
| CA2974453A1 (en) | 2015-01-23 | 2016-07-28 | Sanofi | Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123 |
| TW201709932A (zh) * | 2015-06-12 | 2017-03-16 | 西雅圖遺傳學公司 | Ｃｄ１２３抗體及其共軛物 |
| WO2017186718A1 (en) * | 2016-04-25 | 2017-11-02 | Universität Basel | Allele editing and applications thereof |
| US20220002370A1 (en) * | 2018-09-27 | 2022-01-06 | Xilio Development, Inc. | Masked cytokine polypeptides |
| TW202235431A (zh) | 2020-11-25 | 2022-09-16 | 美商艾希利歐發展股份有限公司 | 腫瘤特異性可裂解連接子 |
| MX2023007901A (es) | 2020-12-31 | 2023-07-11 | Sanofi Sa | Acopladores de celulas asesinas naturales (nk) multifuncionales que se unen a nkp46 y a cd123. |
| AU2023274452A1 (en) | 2022-05-27 | 2025-01-16 | Innate Pharma | Natural killer (nk) cell engagers binding to nkp46 and bcma variants with fc-engineering |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002090510A2 (en) * | 2001-05-08 | 2002-11-14 | Emory University | Regulating immine responses using dendritic cells |
| US7612181B2 (en) * | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| DK3207941T6 (da) * | 2006-09-07 | 2020-11-09 | Scott & White Memorial Hospital | Fremgangsmåder og sammensætninger baseret på diphtheritoksin-interleukin-3-konjugater |
| JP2008162954A (ja) * | 2006-12-28 | 2008-07-17 | Kirin Pharma Co Ltd | 形質細胞様樹状細胞特異的膜分子に対する抗体を含む治療剤 |
| WO2008127735A1 (en) * | 2007-04-13 | 2008-10-23 | Stemline Therapeutics, Inc. | Il3ralpha antibody conjugates and uses thereof |
| CN101896200A (zh) * | 2007-12-06 | 2010-11-24 | Csl有限公司 | 抑制白血病干细胞的方法 |
| US20100209341A1 (en) * | 2009-02-18 | 2010-08-19 | Csl Limited | Treatment of chronic inflammatory conditions |
-
2011
- 2011-02-17 AU AU2011217728A patent/AU2011217728B2/en active Active
- 2011-02-17 EP EP11744183.2A patent/EP2536430B1/en active Active
- 2011-02-17 NZ NZ601760A patent/NZ601760A/xx not_active IP Right Cessation
- 2011-02-17 CN CN201180016427.5A patent/CN103002913B/zh active Active
- 2011-02-17 JP JP2012553146A patent/JP6018507B2/ja active Active
- 2011-02-17 CA CA2789810A patent/CA2789810C/en active Active
- 2011-02-17 WO PCT/AU2011/000155 patent/WO2011100786A1/en not_active Ceased
- 2011-02-17 ES ES11744183.2T patent/ES2618562T3/es active Active
- 2011-02-17 KR KR1020127024197A patent/KR101842907B1/ko active Active
- 2011-02-17 NZ NZ610826A patent/NZ610826A/en unknown
-
2012
- 2012-08-16 IL IL221504A patent/IL221504B/en active IP Right Grant
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