JP2008525430A5 - - Google Patents
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- JP2008525430A5 JP2008525430A5 JP2007548113A JP2007548113A JP2008525430A5 JP 2008525430 A5 JP2008525430 A5 JP 2008525430A5 JP 2007548113 A JP2007548113 A JP 2007548113A JP 2007548113 A JP2007548113 A JP 2007548113A JP 2008525430 A5 JP2008525430 A5 JP 2008525430A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- hydrolyzate
- protein
- peptide
- dpp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 29
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 15
- 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 claims description 13
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 claims description 13
- 150000001413 amino acids Chemical class 0.000 claims description 9
- 239000003531 protein hydrolysate Substances 0.000 claims description 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 8
- 230000002401 inhibitory effect Effects 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 6
- 235000018102 proteins Nutrition 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 4
- 102000014171 Milk Proteins Human genes 0.000 claims description 3
- 108010011756 Milk Proteins Proteins 0.000 claims description 3
- 208000008589 Obesity Diseases 0.000 claims description 3
- 208000026278 immune system disease Diseases 0.000 claims description 3
- 230000001404 mediated effect Effects 0.000 claims description 3
- 235000021239 milk protein Nutrition 0.000 claims description 3
- 235000020824 obesity Nutrition 0.000 claims description 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 3
- 235000013361 beverage Nutrition 0.000 claims 6
- 235000015872 dietary supplement Nutrition 0.000 claims 6
- 235000013305 food Nutrition 0.000 claims 6
- 230000002265 prevention Effects 0.000 claims 5
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 229940127557 pharmaceutical product Drugs 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 108010009736 Protein Hydrolysates Proteins 0.000 claims 1
- 239000005018 casein Substances 0.000 claims 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims 1
- 235000021240 caseins Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 description 7
- 235000001014 amino acid Nutrition 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 3
- 230000003389 potentiating effect Effects 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04078502 | 2004-12-23 | ||
| EP04078502.4 | 2004-12-23 | ||
| PCT/NL2005/050056 WO2006068480A2 (en) | 2004-12-23 | 2005-11-30 | Protein hydrolysate enriched in peptides inhibiting dpp-iv and their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008525430A JP2008525430A (ja) | 2008-07-17 |
| JP2008525430A5 true JP2008525430A5 (enExample) | 2009-01-22 |
| JP5068174B2 JP5068174B2 (ja) | 2012-11-07 |
Family
ID=36602170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548113A Expired - Fee Related JP5068174B2 (ja) | 2004-12-23 | 2005-11-30 | Ｄｐｐ−ｉｖを阻害するペプチド中に濃縮されたタンパク質の加水分解物及びその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8273710B2 (enExample) |
| EP (1) | EP1831361B1 (enExample) |
| JP (1) | JP5068174B2 (enExample) |
| KR (1) | KR101331777B1 (enExample) |
| AT (1) | ATE542896T1 (enExample) |
| DK (1) | DK1831361T3 (enExample) |
| ES (1) | ES2381118T3 (enExample) |
| TW (1) | TWI421089B (enExample) |
| WO (1) | WO2006068480A2 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1831361T3 (da) | 2004-12-23 | 2012-05-14 | Campina Nederland Holding Bv | Proteinhydrolysat beriget med peptider, som inhiberer DPP-IV, og deres anvendelse |
| WO2007004876A2 (en) * | 2005-06-30 | 2007-01-11 | Campina Nederland Holding B.V. | Peptides inhibiting angiotensin-converting enzyme |
| JP2009517464A (ja) * | 2005-11-30 | 2009-04-30 | カンピーナ ネーダーランド ホールディング ビー．ブイ． | グルカゴン様ペプチド１の活性を増強するタンパク質加水分解物の使用 |
| EP1840133A1 (en) * | 2006-03-29 | 2007-10-03 | Global Biotech Development Corp. Ltd. | New immunomodulating oligopeptides |
| CN101426513B (zh) * | 2006-04-21 | 2013-05-01 | 株式会社明治 | 含有肽作为有效成分的组合物 |
| CN101432295B (zh) * | 2006-04-28 | 2013-01-30 | 雪印惠乳业株式会社 | 来自乳蛋白质的肽的应用 |
| JP2008189637A (ja) * | 2007-02-08 | 2008-08-21 | Snow Brand Milk Prod Co Ltd | 自己免疫疾患予防剤 |
| GB2451858A (en) * | 2007-08-15 | 2009-02-18 | Sergiy Konovchuk | Methods of reducing body fat and treating obesity |
| JP5385284B2 (ja) * | 2007-09-11 | 2014-01-08 | モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト | 治療剤としてのグルテンエキソルフィンＣ（ＧｌｕｔｅｎＥｘｏｒｐｈｉｎＣ）の使用 |
| WO2009128713A1 (en) * | 2008-04-14 | 2009-10-22 | Newtricious B.V. | Egg protein hydrolysates |
| DE102008062136B4 (de) * | 2008-12-16 | 2012-05-03 | Kamamed Ug | Pharmazeutische Zusammensetzung auf Basis von Peptid aus Kamelmilch |
| WO2010087480A1 (ja) * | 2009-02-02 | 2010-08-05 | 国立大学法人京都大学 | ペプチドを含む医薬または食品 |
| JP5735734B2 (ja) * | 2009-04-16 | 2015-06-17 | 雪印メグミルク株式会社 | 脂質代謝改善剤 |
| JP2011084485A (ja) * | 2009-10-13 | 2011-04-28 | Snow Brand Milk Prod Co Ltd | 脂肪蓄積抑制剤 |
| CA2790996A1 (en) * | 2010-02-24 | 2011-09-01 | Morinaga Milk Industry Co. Ltd. | Therapeutic agent for eating disorders |
| BR112012028906A2 (pt) * | 2010-05-12 | 2016-07-26 | Mapi Pharma Ltd | polimorfos de benzoato de alogliptina |
| JP5927191B2 (ja) * | 2010-08-24 | 2016-06-01 | 武▲漢▼九生堂生物工程有限公司 | 全卵タンパク質ペプチド、その調製方法及び使用 |
| MX2014008420A (es) | 2012-03-09 | 2015-03-03 | Morinaga Milk Industry Co Ltd | Inhibidor de dipeptidil peptidasa-iv. |
| WO2013133032A1 (ja) * | 2012-03-09 | 2013-09-12 | 森永乳業株式会社 | ジペプチジルペプチダーゼ－ｉｖ阻害剤 |
| WO2014060495A1 (en) * | 2012-10-19 | 2014-04-24 | Dsm Ip Assets B.V. | Process for the production of an infant formula |
| CN103232526B (zh) * | 2012-12-12 | 2015-06-24 | 上海交通大学 | 一种生物活性多肽lplp及其制备和应用 |
| US9289461B2 (en) | 2013-03-15 | 2016-03-22 | Mead Johnson Nutrition Company | Reducing the risk of autoimmune disease |
| US9352020B2 (en) * | 2013-03-15 | 2016-05-31 | Mead Johnson Nutrition Company | Reducing proinflammatory response |
| US9345741B2 (en) * | 2013-03-15 | 2016-05-24 | Mead Johnson Nutrition Company | Nutritional composition containing a peptide component with adiponectin simulating properties and uses thereof |
| US9345727B2 (en) | 2013-03-15 | 2016-05-24 | Mead Johnson Nutrition Company | Nutritional compositions containing a peptide component and uses thereof |
| US9138455B2 (en) * | 2013-03-15 | 2015-09-22 | Mead Johnson Nutrition Company | Activating adiponectin by casein hydrolysate |
| US8889633B2 (en) | 2013-03-15 | 2014-11-18 | Mead Johnson Nutrition Company | Nutritional compositions containing a peptide component with anti-inflammatory properties and uses thereof |
| MY165122A (en) | 2013-06-12 | 2018-02-28 | Maruha Nichiro Corp | Dipeptidyl peptidase-iv (dppiv) inhibitory peptide compound, composition containing the same, and production method for the same |
| CN103483418B (zh) * | 2013-09-12 | 2015-04-01 | 陈尚武 | 一种dpp-ⅳ抑制多肽及其应用 |
| US10639334B2 (en) * | 2014-01-07 | 2020-05-05 | Mead Johnson Nutrition Company | Pediatric nutritional composition with milk peptides for healthy growth and development |
| FR3017536B1 (fr) * | 2014-02-18 | 2017-05-26 | Univ La Rochelle | Compositions pour la prevention et/ou le traitement de pathologies liees a l'alpha-glucosidase |
| JP5872725B1 (ja) * | 2015-02-26 | 2016-03-01 | ヤマキ株式会社 | 鰹節由来のジペプチジルペプチダーゼｉｖ阻害組成物 |
| JP2017031105A (ja) * | 2015-08-03 | 2017-02-09 | 森永乳業株式会社 | 食後血糖値の上昇抑制を促進させる剤 |
| CN105341949B (zh) * | 2015-10-09 | 2018-03-27 | 滨州万嘉生物科技有限公司 | 一种具有降血糖功能的鱼肉蛋白肽及其制备方法与应用 |
| WO2017117121A1 (en) * | 2015-12-28 | 2017-07-06 | Abbott Laboratories | Nutritional compositions comprising hydrolyzed protein and a modified fat system and uses thereof |
| CN110381964A (zh) * | 2017-03-03 | 2019-10-25 | 森永乳业株式会社 | Glp-1分泌促进剂和组合物 |
| EA201992175A1 (ru) * | 2017-03-16 | 2020-03-05 | Микросинтесис Инк. | Композиции и способы, включающие пробиотические молекулы |
| EA201992176A1 (ru) | 2017-03-16 | 2020-03-04 | Микросинтесис Инк. | Пробиотические молекулы для снижения вирулентности патогена |
| CN108314705B (zh) * | 2018-01-26 | 2020-07-14 | 海普诺凯营养品有限公司 | 具有dpp-iv抑制功能的羊乳清蛋白肽、其制备方法及其应用 |
| CN108935912B (zh) * | 2018-06-21 | 2021-04-23 | 中国农业大学 | 一种具有dpp-ⅳ抑制和抗疲劳功能的鱼肉蛋白肽及其制备方法 |
| JP7068942B2 (ja) * | 2018-06-25 | 2022-05-17 | サンスター株式会社 | トリペプチド含有組成物 |
| WO2021083958A1 (en) * | 2019-10-29 | 2021-05-06 | Specialites Pet Food | Novel peptides inducing satiety |
| CN114621320B (zh) * | 2020-12-14 | 2024-05-24 | 清华大学 | 一种可用于减缓glp-1酶解的短肽及其组合物 |
| JPWO2022186290A1 (enExample) * | 2021-03-02 | 2022-09-09 | ||
| CN113035291B (zh) * | 2021-04-08 | 2022-04-05 | 广东药科大学 | 计算机辅助药物设计dpp-iv抑制肽的方法、dpp-iv抑制肽及其应用 |
| CN113480605A (zh) * | 2021-07-27 | 2021-10-08 | 中国海洋大学 | 一种牦牛乳酪蛋白dpp-iv抑制肽及其筛选方法 |
| JP2023069271A (ja) | 2021-11-05 | 2023-05-18 | 住友化学株式会社 | Ｄｐｐ－４阻害剤およびその製造方法。 |
| CN114686551B (zh) * | 2022-03-16 | 2023-08-08 | 江南大学 | 一种豌豆蛋白源dpp-iv抑制肽及其筛选方法 |
| CN114836491B (zh) * | 2022-05-30 | 2023-03-14 | 广州恒雅生物化工有限公司 | 一种抗老亮肤的肌肽制备方法及其在化妆品的应用 |
| JP7847653B2 (ja) * | 2022-08-19 | 2026-04-17 | 森永乳業株式会社 | 組成物 |
| CN115252759A (zh) * | 2022-08-24 | 2022-11-01 | 四川大学华西第二医院 | 酸奶衍生多肽在制备延缓端粒缩短药物及抗衰老药物中的应用 |
| CN116284234B (zh) * | 2023-02-09 | 2024-11-08 | 昆明理工大学 | 一种驼乳源小分子肽及其应用 |
| CN117598389A (zh) * | 2023-11-13 | 2024-02-27 | 大连工业大学 | 一种具有增强免疫功能的酪蛋白水解物及其制备方法 |
| CN118620029B (zh) * | 2024-05-27 | 2024-12-20 | 合肥工业大学 | 一种干腌火腿源dpp-iv抑制肽及其制备、鉴定方法和应用 |
| CN118894920B (zh) * | 2024-10-09 | 2025-04-04 | 澳优乳业（中国）有限公司 | 一种具有降血糖作用的功能肽及制备方法和应用 |
| CN120098106B (zh) * | 2025-05-08 | 2025-08-22 | 华南理工大学 | 一种酪蛋白源降血糖肽及其应用 |
| CN120718130B (zh) * | 2025-08-15 | 2025-12-30 | 杭州康源食品科技有限公司 | 一种促钙吸收利用的酪蛋白源七肽及其应用 |
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| US20070015269A1 (en) * | 2002-11-25 | 2007-01-18 | Michael Hennig | Crystals of DPP-IV |
| EP1422293A1 (en) | 2002-11-25 | 2004-05-26 | F. Hoffmann-La Roche Ag | Crystal structure of dipeptidyl peptidase IV |
| EP1599215B1 (en) | 2003-02-07 | 2010-08-18 | Campina B.V. | Use of tryptophan rich peptides from whey protein hydrolysate for treating overweight and obesity |
| GB0310593D0 (en) * | 2003-05-08 | 2003-06-11 | Leuven K U Res & Dev | Peptidic prodrugs |
| WO2005081628A2 (en) | 2004-03-01 | 2005-09-09 | Peptera Pharmaceutical Ltd. | Casein derived peptides and therapeutic uses thereof |
| JP2008500304A (ja) | 2004-05-27 | 2008-01-10 | カンピーナ ネーダーランド ホールディング ビー．ブイ． | Ｄｐｐ−ｉｖ媒介症状の予防及び／又は治療用の薬剤製造のためのタンパク質加水分解物の使用 |
| JP2008505653A (ja) | 2004-07-12 | 2008-02-28 | ディーエスエム アイピー アセッツ ビー．ブイ． | 血圧降下タンパク質加水分解物 |
| DK1831361T3 (da) | 2004-12-23 | 2012-05-14 | Campina Nederland Holding Bv | Proteinhydrolysat beriget med peptider, som inhiberer DPP-IV, og deres anvendelse |
| JP2009517464A (ja) | 2005-11-30 | 2009-04-30 | カンピーナ ネーダーランド ホールディング ビー．ブイ． | グルカゴン様ペプチド１の活性を増強するタンパク質加水分解物の使用 |
-
2005
- 2005-11-30 DK DK05809074.7T patent/DK1831361T3/da active
- 2005-11-30 KR KR1020077014235A patent/KR101331777B1/ko not_active Expired - Fee Related
- 2005-11-30 EP EP05809074A patent/EP1831361B1/en not_active Expired - Lifetime
- 2005-11-30 ES ES05809074T patent/ES2381118T3/es not_active Expired - Lifetime
- 2005-11-30 US US11/722,667 patent/US8273710B2/en not_active Expired - Fee Related
- 2005-11-30 AT AT05809074T patent/ATE542896T1/de active
- 2005-11-30 JP JP2007548113A patent/JP5068174B2/ja not_active Expired - Fee Related
- 2005-11-30 WO PCT/NL2005/050056 patent/WO2006068480A2/en not_active Ceased
- 2005-12-01 TW TW094142261A patent/TWI421089B/zh not_active IP Right Cessation
-
2012
- 2012-09-14 US US13/620,474 patent/US20130096074A1/en not_active Abandoned
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