MX2014008420A - Inhibidor de dipeptidil peptidasa-iv. - Google Patents
Inhibidor de dipeptidil peptidasa-iv.Info
- Publication number
- MX2014008420A MX2014008420A MX2014008420A MX2014008420A MX2014008420A MX 2014008420 A MX2014008420 A MX 2014008420A MX 2014008420 A MX2014008420 A MX 2014008420A MX 2014008420 A MX2014008420 A MX 2014008420A MX 2014008420 A MX2014008420 A MX 2014008420A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitor
- amino acids
- dipeptidyl peptidase
- neutral
- peptide
- Prior art date
Links
- 229940124213 Dipeptidyl peptidase 4 (DPP IV) inhibitor Drugs 0.000 title abstract 3
- 239000003603 dipeptidyl peptidase IV inhibitor Substances 0.000 title abstract 3
- 229940024606 amino acid Drugs 0.000 abstract 4
- 235000001014 amino acid Nutrition 0.000 abstract 4
- 230000007935 neutral effect Effects 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- -1 aliphatic amino acids Chemical class 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- 239000005541 ACE inhibitor Substances 0.000 abstract 1
- 101710129690 Angiotensin-converting enzyme inhibitor Proteins 0.000 abstract 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 1
- 101710086378 Bradykinin-potentiating and C-type natriuretic peptides Proteins 0.000 abstract 1
- 206010048554 Endothelial dysfunction Diseases 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 abstract 1
- 239000003472 antidiabetic agent Substances 0.000 abstract 1
- 229960001230 asparagine Drugs 0.000 abstract 1
- 235000009582 asparagine Nutrition 0.000 abstract 1
- 230000008694 endothelial dysfunction Effects 0.000 abstract 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 1
- 235000004554 glutamine Nutrition 0.000 abstract 1
- 229940126904 hypoglycaemic agent Drugs 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- 235000006109 methionine Nutrition 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8103—Exopeptidase (E.C. 3.4.11-19) inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/485—Exopeptidases (3.4.11-3.4.19)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Food Science & Technology (AREA)
- Vascular Medicine (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
Abstract
Se proporcionan un inhibidor de dipeptidil peptidasa-IV excelente y los similares. Un péptido que consiste de Val-Pro-X en donde X representa un residuo de aminoácido (excepto para el residuo de L-prolina); el X mencionado en lo anterior de preferencia es uno seleccionado de un residuo de aminoácido básico, un residuo de aminoácido neutro alifático, un residuo de aminoácido neutro que lleva grupo amida o un residuo de aminoácido neutro que lleva grupo aromático; el X mencionado en lo anterior de preferencia es uno seleccionado de un residuo de alanina, un residuo de glutamina, un residuo de metionina, un residuo de asparagina, un residuo de glicina, un residuo de valina, un residuo de tirosina, un residuo de serina y un residuo de lisina; un inhibidor de dipeptidil peptidasa-IV, un agente supresor de elevación de azúcar en la sangre, un agente supresor de trastorno endotelial vascular y un inhibidor de la enzima convertidora de angiotensina que contiene el péptido mencionado en lo anterior como un ingrediente activo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012053855 | 2012-03-09 | ||
PCT/JP2013/054291 WO2013133031A1 (ja) | 2012-03-09 | 2013-02-21 | ジペプチジルペプチダーゼ-iv阻害剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2014008420A true MX2014008420A (es) | 2015-03-03 |
Family
ID=49116514
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014008420A MX2014008420A (es) | 2012-03-09 | 2013-02-21 | Inhibidor de dipeptidil peptidasa-iv. |
Country Status (6)
Country | Link |
---|---|
US (1) | US9617300B2 (es) |
EP (1) | EP2824110A4 (es) |
JP (1) | JP5832049B2 (es) |
CN (2) | CN105833256A (es) |
MX (1) | MX2014008420A (es) |
WO (1) | WO2013133031A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106317172A (zh) * | 2015-06-23 | 2017-01-11 | 首都医科大学 | Pro-Ser,其合成,活性和应用 |
JP7115310B2 (ja) * | 2015-12-16 | 2022-08-09 | ディーエスエム アイピー アセッツ ビー.ブイ. | 新規な使用 |
CN107337710A (zh) * | 2017-07-26 | 2017-11-10 | 盐城卫生职业技术学院 | 一种抗高血压活性肽The‑The‑Pro及应用和药物组合物 |
JP7068942B2 (ja) * | 2018-06-25 | 2022-05-17 | サンスター株式会社 | トリペプチド含有組成物 |
JP7453665B2 (ja) | 2019-01-29 | 2024-03-21 | 国立大学法人鳥取大学 | ジペプチジルペプチダーゼiv阻害活性が高い発酵乳およびその製造方法 |
CN113801192B (zh) * | 2021-08-31 | 2023-06-20 | 华南理工大学 | 一种抑制二肽基肽酶iv的四肽及其应用 |
CN114349818A (zh) * | 2021-12-31 | 2022-04-15 | 华南理工大学 | 一类具有双靶点降糖功能的三肽及其应用 |
WO2024038888A1 (ja) * | 2022-08-19 | 2024-02-22 | 森永乳業株式会社 | 組成物 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2782142B2 (ja) | 1992-07-23 | 1998-07-30 | カルピス株式会社 | アンジオテンシン変換酵素阻害剤及びその製造法 |
JP3483212B2 (ja) | 1993-10-06 | 2004-01-06 | 日本合成化学工業株式会社 | 新規ペプチド、それを製造する方法及び用途 |
JP3665663B2 (ja) * | 1994-08-02 | 2005-06-29 | カルピス株式会社 | 血圧降下剤及びその製造法 |
DE19605039A1 (de) | 1996-02-12 | 1997-08-14 | Hoechst Ag | Verfahren zur Herstellung von Oligopeptid-Aldehyden |
CA2323063A1 (en) | 1998-03-26 | 1999-09-30 | University Of Dundee | Use of inhibitors of mammalian asparaginyl endopeptidase for therapy of autoimmune disease |
US20030176357A1 (en) * | 1998-10-06 | 2003-09-18 | Pospisilik Andrew J. | Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels |
JP4633876B2 (ja) | 1999-11-11 | 2011-02-16 | カルピス株式会社 | トリペプチドの製造方法 |
US20030130199A1 (en) * | 2001-06-27 | 2003-07-10 | Von Hoersten Stephan | Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents |
WO2003002593A2 (en) * | 2001-06-27 | 2003-01-09 | Probiodrug Ag | Peptide structures useful for competitive modulation of dipeptidyl peptidase iv catalysis |
JP4840837B2 (ja) | 2001-09-28 | 2011-12-21 | 日本たばこ産業株式会社 | 旨味を有する新規ペプチド、及びそれを旨味成分とする調味料 |
EP1298210A1 (en) * | 2001-10-01 | 2003-04-02 | Societe Des Produits Nestle S.A. | Cocoa flavour precursor peptides |
US20030069187A1 (en) * | 2001-10-05 | 2003-04-10 | Rao Srinivasa K. | Elastase inhibitors |
KR100615844B1 (ko) | 2001-11-21 | 2006-08-25 | 모리나가 뉴교 가부시키가이샤 | 안지오텐신 변환효소 저해작용을 갖는 신규 펩타이드 |
EP1831361B1 (en) | 2004-12-23 | 2012-01-25 | Campina Nederland Holding B.V. | Protein hydrolysate enriched in peptides inhibiting dpp-iv and their use |
CN1331882C (zh) * | 2004-12-29 | 2007-08-15 | 山东大学 | 中国毛虾蛋白降压肽及其制备方法与应用 |
JP5094412B2 (ja) | 2005-01-19 | 2012-12-12 | メルク・シャープ・エンド・ドーム・コーポレイション | 糖尿病治療用又は予防用のジペプチジルペプチダーゼ−iv阻害剤としての二環系ピリミジン |
JP5114826B2 (ja) | 2005-02-04 | 2013-01-09 | ダイキン工業株式会社 | 架橋性組成物およびそれからなる積層体 |
WO2006108211A1 (en) * | 2005-02-25 | 2006-10-19 | The Murdoch Childrens Research Institute | Fragments of von willebrand factor a-related protein |
JP4915833B2 (ja) | 2005-07-01 | 2012-04-11 | 雪印メグミルク株式会社 | ジペプチジルペプチダーゼiv阻害剤 |
JP5061710B2 (ja) | 2007-05-10 | 2012-10-31 | ユーハ味覚糖株式会社 | ジペプチジルペプチダーゼiv阻害剤 |
US8785374B2 (en) * | 2007-10-19 | 2014-07-22 | Alba Therapeutics Corporation | Inhibitors of mammalian tight junction opening |
DE102008062136B4 (de) * | 2008-12-16 | 2012-05-03 | Kamamed Ug | Pharmazeutische Zusammensetzung auf Basis von Peptid aus Kamelmilch |
WO2010077988A2 (en) * | 2008-12-16 | 2010-07-08 | Jerzy Alexander Georgiades | Role of proline rich peptides in cellular communication mechanisms and treatment of diseases |
JP5729297B2 (ja) * | 2009-07-13 | 2015-06-03 | 不二製油株式会社 | 経口性抗炎症剤及び経口性抗炎症ペプチド |
JP6026720B2 (ja) | 2009-12-18 | 2016-11-16 | 株式会社明治 | 血糖値降下剤及び血糖値降下飲食品組成物 |
-
2013
- 2013-02-21 EP EP13758259.9A patent/EP2824110A4/en not_active Withdrawn
- 2013-02-21 US US14/383,618 patent/US9617300B2/en active Active
- 2013-02-21 CN CN201610269709.0A patent/CN105833256A/zh active Pending
- 2013-02-21 WO PCT/JP2013/054291 patent/WO2013133031A1/ja active Application Filing
- 2013-02-21 JP JP2014503756A patent/JP5832049B2/ja active Active
- 2013-02-21 MX MX2014008420A patent/MX2014008420A/es unknown
- 2013-02-21 CN CN201380013217.XA patent/CN104159912B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
EP2824110A1 (en) | 2015-01-14 |
JP5832049B2 (ja) | 2015-12-16 |
WO2013133031A1 (ja) | 2013-09-12 |
CN105833256A (zh) | 2016-08-10 |
US9617300B2 (en) | 2017-04-11 |
JPWO2013133031A1 (ja) | 2015-07-30 |
EP2824110A4 (en) | 2015-12-30 |
CN104159912B (zh) | 2016-11-09 |
CN104159912A (zh) | 2014-11-19 |
US20150232510A1 (en) | 2015-08-20 |
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