WO2003062266A3 - Hybrid synthetic method for antimicrobial peptides - Google Patents

Hybrid synthetic method for antimicrobial peptides Download PDF

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Publication number
WO2003062266A3
WO2003062266A3 PCT/US2003/001998 US0301998W WO03062266A3 WO 2003062266 A3 WO2003062266 A3 WO 2003062266A3 US 0301998 W US0301998 W US 0301998W WO 03062266 A3 WO03062266 A3 WO 03062266A3
Authority
WO
WIPO (PCT)
Prior art keywords
solid
synthetic method
antimicrobial peptides
synthesis
relates
Prior art date
Application number
PCT/US2003/001998
Other languages
French (fr)
Other versions
WO2003062266A2 (en
Inventor
Gene Merutka
Zoulin Zhu
Sheri A Almeda
Original Assignee
Intrabiotics Pharmaceuticals
Gene Merutka
Zoulin Zhu
Sheri A Almeda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intrabiotics Pharmaceuticals, Gene Merutka, Zoulin Zhu, Sheri A Almeda filed Critical Intrabiotics Pharmaceuticals
Priority to AU2003216091A priority Critical patent/AU2003216091A1/en
Publication of WO2003062266A2 publication Critical patent/WO2003062266A2/en
Publication of WO2003062266A3 publication Critical patent/WO2003062266A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to methods for the synthesis and isolation of the protegrin IB 367; as well as analogs and derivatives thereof. The present method utilizes both solid phase and liquid phase peptide synthesis procedures to synthesize and combine specific peptide fragment intermediates. This invention relates to processes comprising solid phase peptide synthesis procedures in which glycine is the amino acid attached to the solid support, and both solid and liquid phase synthesis methods that use side-chain-unprotected arginine residues.
PCT/US2003/001998 2002-01-22 2003-01-22 Hybrid synthetic method for antimicrobial peptides WO2003062266A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003216091A AU2003216091A1 (en) 2002-01-22 2003-01-22 Hybrid synthetic method for antimicrobial peptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35044902P 2002-01-22 2002-01-22
US60/350,449 2002-01-22

Publications (2)

Publication Number Publication Date
WO2003062266A2 WO2003062266A2 (en) 2003-07-31
WO2003062266A3 true WO2003062266A3 (en) 2003-12-11

Family

ID=27613393

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/001998 WO2003062266A2 (en) 2002-01-22 2003-01-22 Hybrid synthetic method for antimicrobial peptides

Country Status (2)

Country Link
AU (1) AU2003216091A1 (en)
WO (1) WO2003062266A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE410437T1 (en) 2003-12-31 2008-10-15 Hoffmann La Roche METHOD AND SYSTEMS FOR RECOVERING PEPTIDES
DE102007036128A1 (en) * 2007-07-23 2009-02-12 Universität Leipzig Antibiotic peptides
DE102009007381A1 (en) 2009-01-29 2010-08-05 Amp-Therapeutics Gmbh & Co. Kg Antibiotic peptides
JP6011528B2 (en) * 2011-05-31 2016-10-19 味の素株式会社 Method for producing peptide
CN102336813B (en) * 2011-07-01 2016-01-06 上海苏豪逸明制药有限公司 A kind of preparation method of synthesizing proteidin with solid phase polypeptide
CN103012563A (en) * 2012-12-13 2013-04-03 南京工业大学 Solid-phase synthesis method of antibacterial peptide Iseganan
CN105982825B (en) * 2015-02-13 2018-12-14 沛进生命科学公司 A kind of purposes of composition in the cosmetics that preparation has moisture-keeping functions
CN112500453A (en) * 2020-12-13 2021-03-16 江苏新瑞药业有限公司 Solid-phase synthesis method of fragment of antibacterial peptide Iseganan

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5804558A (en) * 1993-07-20 1998-09-08 University Of California Protegrins
US5994306A (en) * 1995-11-22 1999-11-30 Intrabiotics Pharmaceuticals, Inc. Fine-tuned protegrins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5804558A (en) * 1993-07-20 1998-09-08 University Of California Protegrins
US5994306A (en) * 1995-11-22 1999-11-30 Intrabiotics Pharmaceuticals, Inc. Fine-tuned protegrins

Also Published As

Publication number Publication date
WO2003062266A2 (en) 2003-07-31
AU2003216091A1 (en) 2003-09-02

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