JP2008524117A - Fviiiの特定部位の変更 - Google Patents

Fviiiの特定部位の変更 Download PDF

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Publication number
JP2008524117A
JP2008524117A JP2007541405A JP2007541405A JP2008524117A JP 2008524117 A JP2008524117 A JP 2008524117A JP 2007541405 A JP2007541405 A JP 2007541405A JP 2007541405 A JP2007541405 A JP 2007541405A JP 2008524117 A JP2008524117 A JP 2008524117A
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Prior art keywords
polypeptide
factor viii
complex
fviii
binding
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Pending
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JP2007541405A
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English (en)
Japanese (ja)
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JP2008524117A5 (enExample
Inventor
パン,クラーク・キユー
マーフイー,ジヨン・イー
メイ,ベイソング
ストラウス,ジヨナサン・エス
ツアンドラ,ヘンドリ
チエン,ジヤンミン
バーネツト,トーマス
タング,リアング
ワング,デキアン
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Bayer Healthcare LLC
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Bayer Healthcare LLC
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Application filed by Bayer Healthcare LLC filed Critical Bayer Healthcare LLC
Publication of JP2008524117A publication Critical patent/JP2008524117A/ja
Publication of JP2008524117A5 publication Critical patent/JP2008524117A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
JP2007541405A 2004-11-12 2005-11-14 Fviiiの特定部位の変更 Pending JP2008524117A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62727704P 2004-11-12 2004-11-12
PCT/US2005/041205 WO2006053299A2 (en) 2004-11-12 2005-11-14 Site-directed modification of fviii

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012231926A Division JP6109523B2 (ja) 2004-11-12 2012-10-19 Fviiiの特定部位の変更

Publications (2)

Publication Number Publication Date
JP2008524117A true JP2008524117A (ja) 2008-07-10
JP2008524117A5 JP2008524117A5 (enExample) 2009-01-08

Family

ID=36337298

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2007541405A Pending JP2008524117A (ja) 2004-11-12 2005-11-14 Fviiiの特定部位の変更
JP2012231926A Expired - Lifetime JP6109523B2 (ja) 2004-11-12 2012-10-19 Fviiiの特定部位の変更
JP2015022993A Expired - Lifetime JP6018238B2 (ja) 2004-11-12 2015-02-09 Fviiiの特定部位の変更
JP2016234757A Expired - Fee Related JP6559642B2 (ja) 2004-11-12 2016-12-02 Fviiiの特定部位の変更
JP2016234756A Expired - Fee Related JP6487895B2 (ja) 2004-11-12 2016-12-02 Fviiiの特定部位の変更

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2012231926A Expired - Lifetime JP6109523B2 (ja) 2004-11-12 2012-10-19 Fviiiの特定部位の変更
JP2015022993A Expired - Lifetime JP6018238B2 (ja) 2004-11-12 2015-02-09 Fviiiの特定部位の変更
JP2016234757A Expired - Fee Related JP6559642B2 (ja) 2004-11-12 2016-12-02 Fviiiの特定部位の変更
JP2016234756A Expired - Fee Related JP6487895B2 (ja) 2004-11-12 2016-12-02 Fviiiの特定部位の変更

Country Status (32)

Country Link
US (4) US7632921B2 (enExample)
EP (9) EP2363414B1 (enExample)
JP (5) JP2008524117A (enExample)
KR (7) KR20120136413A (enExample)
CN (6) CN105753968A (enExample)
AU (1) AU2005304622B2 (enExample)
BE (1) BE2019C523I2 (enExample)
BR (2) BRPI0517795B8 (enExample)
CA (1) CA2586379C (enExample)
CY (3) CY1119292T1 (enExample)
DK (3) DK2371856T3 (enExample)
ES (4) ES2930143T3 (enExample)
FR (1) FR19C1031I2 (enExample)
HN (1) HN2007015683A (enExample)
HR (2) HRP20180481B1 (enExample)
HU (5) HUE060016T2 (enExample)
IL (3) IL182903A (enExample)
LT (5) LT2363414T (enExample)
LU (1) LUC00118I2 (enExample)
MA (1) MA29663B1 (enExample)
MX (3) MX392760B (enExample)
NL (1) NL300989I2 (enExample)
NO (3) NO345800B1 (enExample)
NZ (1) NZ555032A (enExample)
PH (2) PH12014500352B1 (enExample)
PL (4) PL2363414T3 (enExample)
PT (4) PT3130601T (enExample)
RU (1) RU2423380C2 (enExample)
SI (4) SI2363414T1 (enExample)
UA (1) UA95225C2 (enExample)
WO (1) WO2006053299A2 (enExample)
ZA (1) ZA200703696B (enExample)

Cited By (11)

* Cited by examiner, † Cited by third party
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JP2012505917A (ja) * 2008-10-17 2012-03-08 バクスター・インターナショナル・インコーポレイテッド 低度の水溶性ポリマーを含む改変血液因子
JP2012508172A (ja) * 2008-11-03 2012-04-05 バイエル・ヘルスケア・エルエルシー 血友病の治療方法
JP2013520441A (ja) * 2010-02-21 2013-06-06 バイエル・ヘルスケア・エルエルシー 生体分子を活性化およびコンジュゲートする方法
JP2013525414A (ja) * 2010-04-30 2013-06-20 カンタブ バイオファーマシューティカルズ パテンツ リミテッド 共役血液凝固第viii因子
JP2014520094A (ja) * 2011-05-27 2014-08-21 バクスター・インターナショナル・インコーポレイテッド 増加した半減期を有する治療用タンパク質およびそれを調製する方法
JP2015509365A (ja) * 2012-02-15 2015-03-30 バイオジェン・アイデック・エムエイ・インコーポレイテ 組換え第viii因子タンパク質
JP2016518321A (ja) * 2013-03-15 2016-06-23 バイエル・ヘルスケア・エルエルシーBayer HealthCare LLC 組み換え因子viii配合物
JP2016519120A (ja) * 2013-04-28 2016-06-30 バイエル・ヘルスケア・エルエルシーBayer HealthCare LLC 凝固因子タンパク質に対する免疫寛容を誘導するための組成物
US12030925B2 (en) 2018-05-18 2024-07-09 Bioverativ Therapeutics Inc. Methods of treating hemophilia A
US12161696B2 (en) 2016-12-02 2024-12-10 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
US12617839B2 (en) 2014-01-10 2026-05-05 Bioverativ Therapeutics Inc. Factor VIII chimeric proteins and uses thereof

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US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
JP2008505119A (ja) * 2004-06-30 2008-02-21 ネクター セラピューティクス アラバマ,コーポレイション 高分子−第ix因子部分の抱合体
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US9187546B2 (en) 2005-04-08 2015-11-17 Novo Nordisk A/S Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
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