JP2008521784A5 - - Google Patents
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- Publication number
- JP2008521784A5 JP2008521784A5 JP2007542118A JP2007542118A JP2008521784A5 JP 2008521784 A5 JP2008521784 A5 JP 2008521784A5 JP 2007542118 A JP2007542118 A JP 2007542118A JP 2007542118 A JP2007542118 A JP 2007542118A JP 2008521784 A5 JP2008521784 A5 JP 2008521784A5
- Authority
- JP
- Japan
- Prior art keywords
- agent
- liver
- phenylbutyrate
- phenylacetate
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 15
- 239000003795 chemical substances by application Substances 0.000 claims 11
- 229940079593 drug Drugs 0.000 claims 8
- 210000004185 liver Anatomy 0.000 claims 7
- OBKXEAXTFZPCHS-UHFFFAOYSA-N 4-phenylbutyric acid Chemical compound OC(=O)CCCC1=CC=CC=C1 OBKXEAXTFZPCHS-UHFFFAOYSA-N 0.000 claims 6
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 6
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 6
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 6
- IPBVNPXQWQGGJP-UHFFFAOYSA-N acetic acid phenyl ester Natural products CC(=O)OC1=CC=CC=C1 IPBVNPXQWQGGJP-UHFFFAOYSA-N 0.000 claims 6
- 208000007386 hepatic encephalopathy Diseases 0.000 claims 6
- 229960003104 ornithine Drugs 0.000 claims 6
- 229940049953 phenylacetate Drugs 0.000 claims 6
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims 6
- 229950009215 phenylbutanoic acid Drugs 0.000 claims 6
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 5
- 229940024606 amino acid Drugs 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 5
- 229960000310 isoleucine Drugs 0.000 claims 5
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 claims 2
- 208000030304 gastrointestinal bleeding Diseases 0.000 claims 2
- 208000019423 liver disease Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 208000007788 Acute Liver Failure Diseases 0.000 claims 1
- 206010000804 Acute hepatic failure Diseases 0.000 claims 1
- ITIONVBQFUNVJV-UHFFFAOYSA-N Etomidoline Chemical compound C12=CC=CC=C2C(=O)N(CC)C1NC(C=C1)=CC=C1OCCN1CCCCC1 ITIONVBQFUNVJV-UHFFFAOYSA-N 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 231100000836 acute liver failure Toxicity 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 230000018044 dehydration Effects 0.000 claims 1
- 238000006297 dehydration reaction Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 230000000763 evoking effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229940006198 sodium phenylacetate Drugs 0.000 claims 1
- 229960002232 sodium phenylbutyrate Drugs 0.000 claims 1
- VPZRWNZGLKXFOE-UHFFFAOYSA-M sodium phenylbutyrate Chemical compound [Na+].[O-]C(=O)CCCC1=CC=CC=C1 VPZRWNZGLKXFOE-UHFFFAOYSA-M 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0426142.6 | 2004-11-26 | ||
| GB0426142A GB0426142D0 (en) | 2004-11-26 | 2004-11-26 | Formulation |
| GB0426141.8 | 2004-11-26 | ||
| GB0426141A GB0426141D0 (en) | 2004-11-26 | 2004-11-26 | Treatment |
| PCT/GB2005/004539 WO2006056794A1 (en) | 2004-11-26 | 2005-11-28 | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012157179A Division JP5612030B2 (ja) | 2004-11-26 | 2012-07-13 | オルニチンならびにフェニルアセテートまたはフェニルブチレートを含む、肝性脳症を治療するための組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008521784A JP2008521784A (ja) | 2008-06-26 |
| JP2008521784A5 true JP2008521784A5 (enExample) | 2009-01-22 |
| JP5116479B2 JP5116479B2 (ja) | 2013-01-09 |
Family
ID=35559327
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007542118A Expired - Fee Related JP5116479B2 (ja) | 2004-11-26 | 2005-11-28 | オルニチンならびにフェニルアセテートまたはフェニルブチレートを含む、肝性脳症を治療するための組成物 |
| JP2012157179A Expired - Fee Related JP5612030B2 (ja) | 2004-11-26 | 2012-07-13 | オルニチンならびにフェニルアセテートまたはフェニルブチレートを含む、肝性脳症を治療するための組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012157179A Expired - Fee Related JP5612030B2 (ja) | 2004-11-26 | 2012-07-13 | オルニチンならびにフェニルアセテートまたはフェニルブチレートを含む、肝性脳症を治療するための組成物 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US8389576B2 (enExample) |
| EP (3) | EP2153870B1 (enExample) |
| JP (2) | JP5116479B2 (enExample) |
| KR (1) | KR101380446B1 (enExample) |
| CN (1) | CN102512408B (enExample) |
| AT (1) | ATE457187T1 (enExample) |
| AU (1) | AU2005308622B2 (enExample) |
| CA (1) | CA2589261C (enExample) |
| CY (3) | CY1112259T1 (enExample) |
| DE (1) | DE602005019319D1 (enExample) |
| DK (3) | DK2153870T3 (enExample) |
| EA (2) | EA011716B1 (enExample) |
| ES (3) | ES2448549T3 (enExample) |
| IL (1) | IL183401A (enExample) |
| MX (1) | MX2007006171A (enExample) |
| NO (2) | NO342198B1 (enExample) |
| NZ (1) | NZ555870A (enExample) |
| PL (3) | PL1824563T3 (enExample) |
| PT (3) | PT2319581E (enExample) |
| SG (1) | SG158073A1 (enExample) |
| SI (3) | SI2319581T1 (enExample) |
| WO (1) | WO2006056794A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2319581E (pt) | 2004-11-26 | 2015-06-30 | Ucl Business Plc | Composições compreendendo ornitina e fenilacetato ou fenilbutirato para tratamento de encefalopatia hepática |
| WO2009134460A1 (en) * | 2008-04-29 | 2009-11-05 | Hyperion Therapeutics | Methods of treatment using ammonia-scavenging drugs |
| GB2465250B (en) * | 2008-08-29 | 2011-01-26 | Ucyclyd Pharma Inc | Dosing and monitoring patients on nitrogen-scavenging drugs |
| US7928115B2 (en) | 2008-10-02 | 2011-04-19 | Salix Pharmaceuticals, Ltd. | Methods of treating travelers diarrhea and hepatic encephalopathy |
| US20110035232A1 (en) | 2008-10-02 | 2011-02-10 | Salix Pharmaceuticals, Ltd. | Methods of treating hepatic encephalopathy |
| US12285414B2 (en) | 2008-10-02 | 2025-04-29 | Salix Pharmaceuticals, Inc. | Methods of treating hepatic encephalopathy |
| BRPI0920465A2 (pt) | 2008-10-02 | 2018-03-20 | Salix Pharmaceuticals, Inc. | metodo de tratamento de encefalopatia hepática |
| CN106810464B (zh) * | 2009-04-03 | 2019-01-22 | 欧塞拉治疗有限公司 | L-鸟氨酸苯乙酸盐及其制备方法 |
| ES2517340T3 (es) * | 2009-06-08 | 2014-11-03 | Ucl Business Plc | Tratamiento de la hipertensión portal usando L-ornitina y fenilacetato |
| EP2397458A1 (en) * | 2010-06-21 | 2011-12-21 | Lunamed AG | Organic salts and co-crystals of phenylbutyric acid |
| EP2625162B1 (en) * | 2010-10-06 | 2019-03-13 | Ocera Therapeutics, Inc. | Methods of making l-ornithine phenyl acetate |
| EP3263102A1 (en) | 2011-09-30 | 2018-01-03 | Horizon Therapeutics, LLC | Methods of therapeutic monitoring of nitrogen scavenging drugs |
| BR112014026138A2 (pt) | 2012-04-20 | 2017-06-27 | Hyperion Therapeutics Inc | métodos de monitoramento terapêutico de pró-fármacos de ácido fenilacético |
| HUE036133T2 (hu) | 2012-11-21 | 2018-06-28 | Horizon Therapeutics Llc | Eljárások hepatikus enkefalopátia kezelésére szolgáló nitrogénelvonó gyógyszerek beadására és értékelésére |
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| EP3019074B1 (en) * | 2013-09-30 | 2018-08-29 | Horizon Therapeutics, LLC | Diagnosing, grading, monitoring, and treating hepatic encephalopathy |
| CN106163528A (zh) | 2014-01-29 | 2016-11-23 | 梅克芳识别有限公司 | 用于治疗肝脑病的甾族化合物 |
| KR20230018526A (ko) | 2014-11-24 | 2023-02-07 | 유씨엘 비즈니스 리미티드 | 암모니아-저감 치료를 이용한 간성상세포 활성화와 연관된 질병의 치료 |
| TWI748936B (zh) | 2015-01-12 | 2021-12-11 | 瑞典商優鎂奎認知Ａｂ公司 | 新穎化合物 |
| HK1251149A1 (zh) * | 2015-04-20 | 2019-01-25 | Ocera Therapeutics, Inc. | L-鸟氨酸苯乙酸盐制剂 |
| JP6990170B2 (ja) * | 2015-08-18 | 2022-01-12 | オセラ セラピューティクス， インコーポレイテッド | Ｌ－オルニチンをフェニルアセテートおよびフェニルブチレートのうちの少なくとも１つと組み合わせて用いる筋肉喪失の治療および予防 |
| JP6989495B2 (ja) * | 2015-09-25 | 2022-01-05 | オセラ セラピューティクス， インコーポレイテッド | Ｌ−オルニチンをフェニルアセテートおよびフェニルブチレートのうちの少なくとも１つと組み合わせて用いる神経細胞喪失の治療および予防 |
| US11219611B2 (en) | 2015-11-13 | 2022-01-11 | Ocera Therapeutics, Inc. | Formulations of L-ornithine phenylacetate |
| WO2017083758A1 (en) * | 2015-11-13 | 2017-05-18 | Ocera Therapeutics, Inc. | Formulation of l-ornithine phenylacetate |
| WO2017090007A1 (en) * | 2015-11-29 | 2017-06-01 | Rao M Surya | Compositions and methods for the treatment of urea cycle disorders and hepatic diseases |
| US9914692B2 (en) | 2016-05-25 | 2018-03-13 | Horizon Therapeutics, Llc | Procedure for the preparation of 4-phenyl butyrate and uses thereof |
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| MX389665B (es) | 2017-05-11 | 2025-03-20 | Ocera Therapeutics Inc | Procesos para producir fenilacetato de l-ornitina |
| WO2018225167A1 (ja) | 2017-06-07 | 2018-12-13 | 花王株式会社 | アンモニア代謝促進剤 |
| JP6469283B2 (ja) | 2017-06-07 | 2019-02-13 | 花王株式会社 | アンモニア代謝促進剤 |
| WO2019036471A1 (en) | 2017-08-14 | 2019-02-21 | Axcella Health Inc. | AMINO ACIDS BRANCHED FOR THE TREATMENT OF LIVER DISEASE |
| US10668040B2 (en) | 2017-09-11 | 2020-06-02 | Horizon Therapeutics, Llc | Treatment of urea cycle disorders in neonates and infants |
| EP3810123A1 (en) | 2018-06-20 | 2021-04-28 | Axcella Health Inc. | Compositions and methods for the treatment of fat infiltration in muscle |
| JP7197340B2 (ja) * | 2018-12-06 | 2022-12-27 | 花王株式会社 | 認知機能改善剤 |
| CA3138914A1 (en) | 2019-05-09 | 2020-11-12 | Ocera Therapeutics, Inc. | Methods of assessing and treating hepatic encephalopathy |
| US12697317B2 (en) | 2019-10-16 | 2026-08-04 | Amalive Limited | Dosages and uses of ornithine phenylacetate for treating hyperammonemia |
| CN113713817B (zh) * | 2020-05-26 | 2023-06-27 | 中国科学院大连化学物理研究所 | 一种采用镍基催化剂催化丙醛加氢制正丙醇的方法 |
| ES3060948T3 (en) | 2020-09-14 | 2026-03-30 | Pharma Cinq Llc | 2',3'-diacetyluridine substituted with acetoacetyl at the 5' position |
| DK4255563T3 (da) | 2020-12-01 | 2026-03-16 | Pharma Cinq Llc | 5´-o-phenylacetyluridin og terapeutisk anvendelse |
| EP4294405A4 (en) | 2021-02-21 | 2025-01-29 | Pharma Cinq, LLC | COMPOSITIONS AND COMPOUNDS FOR CO-ADMINISTRATION OF URIDINE AND KETOLEUCINE |
| WO2024261477A1 (en) | 2023-06-20 | 2024-12-26 | Yaqrit Limited | Combination of tlr4 antagonist, ornithine and phenylacetate or phenylbutyrate |
| WO2025137400A1 (en) * | 2023-12-20 | 2025-06-26 | Cedars-Sinai Medical Center | Use of tenapanor for the treatment or prevention of hepatic encephalopathy |
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