PL2319581T3 - Kompozycje zawierające ornitynę i fenylooctan lub fenylomaślan do leczenia encefalopatii wątrobowej - Google Patents

Kompozycje zawierające ornitynę i fenylooctan lub fenylomaślan do leczenia encefalopatii wątrobowej

Info

Publication number
PL2319581T3
PL2319581T3 PL10014283T PL10014283T PL2319581T3 PL 2319581 T3 PL2319581 T3 PL 2319581T3 PL 10014283 T PL10014283 T PL 10014283T PL 10014283 T PL10014283 T PL 10014283T PL 2319581 T3 PL2319581 T3 PL 2319581T3
Authority
PL
Poland
Prior art keywords
phenylbutyrate
phenylacetate
ornithine
compositions
hepatic encephalopathy
Prior art date
Application number
PL10014283T
Other languages
English (en)
Polish (pl)
Inventor
Kamal Nayan Jalan
Rajiv Jalan
Original Assignee
Ucl Business Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0426141A external-priority patent/GB0426141D0/en
Priority claimed from GB0426142A external-priority patent/GB0426142D0/en
Application filed by Ucl Business Plc filed Critical Ucl Business Plc
Publication of PL2319581T3 publication Critical patent/PL2319581T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL10014283T 2004-11-26 2005-11-28 Kompozycje zawierające ornitynę i fenylooctan lub fenylomaślan do leczenia encefalopatii wątrobowej PL2319581T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0426141A GB0426141D0 (en) 2004-11-26 2004-11-26 Treatment
GB0426142A GB0426142D0 (en) 2004-11-26 2004-11-26 Formulation
EP09013613.6A EP2153870B1 (en) 2004-11-26 2005-11-28 Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy
EP10014283.5A EP2319581B1 (en) 2004-11-26 2005-11-28 Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy
EP05808837A EP1824563B1 (en) 2004-11-26 2005-11-28 Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy

Publications (1)

Publication Number Publication Date
PL2319581T3 true PL2319581T3 (pl) 2015-10-30

Family

ID=35559327

Family Applications (3)

Application Number Title Priority Date Filing Date
PL10014283T PL2319581T3 (pl) 2004-11-26 2005-11-28 Kompozycje zawierające ornitynę i fenylooctan lub fenylomaślan do leczenia encefalopatii wątrobowej
PL09013613T PL2153870T3 (pl) 2004-11-26 2005-11-28 Kompozycje zawierające ornitynę oraz fenylooctan lub fenylomaślan do leczenia encefalopatii wątrobowej
PL05808837T PL1824563T3 (pl) 2004-11-26 2005-11-28 Kompozycje zawierające ornitynę i fenylooctan lub fenylomaślan do leczenia encefalopatii wątrobowej

Family Applications After (2)

Application Number Title Priority Date Filing Date
PL09013613T PL2153870T3 (pl) 2004-11-26 2005-11-28 Kompozycje zawierające ornitynę oraz fenylooctan lub fenylomaślan do leczenia encefalopatii wątrobowej
PL05808837T PL1824563T3 (pl) 2004-11-26 2005-11-28 Kompozycje zawierające ornitynę i fenylooctan lub fenylomaślan do leczenia encefalopatii wątrobowej

Country Status (22)

Country Link
US (3) US8389576B2 (enExample)
EP (3) EP1824563B1 (enExample)
JP (2) JP5116479B2 (enExample)
KR (1) KR101380446B1 (enExample)
CN (1) CN102512408B (enExample)
AT (1) ATE457187T1 (enExample)
AU (1) AU2005308622B2 (enExample)
CA (1) CA2589261C (enExample)
CY (3) CY1112259T1 (enExample)
DE (1) DE602005019319D1 (enExample)
DK (3) DK2153870T3 (enExample)
EA (2) EA011716B1 (enExample)
ES (3) ES2448549T3 (enExample)
IL (1) IL183401A (enExample)
MX (1) MX2007006171A (enExample)
NO (2) NO342198B1 (enExample)
NZ (1) NZ555870A (enExample)
PL (3) PL2319581T3 (enExample)
PT (3) PT2319581E (enExample)
SG (1) SG158073A1 (enExample)
SI (3) SI2319581T1 (enExample)
WO (1) WO2006056794A1 (enExample)

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PL3133396T3 (pl) 2008-04-29 2019-03-29 Horizon Therapeutics, Llc Sposób leczenia z zastosowaniem leków wychwytujących amoniak
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US12285414B2 (en) 2008-10-02 2025-04-29 Salix Pharmaceuticals, Inc. Methods of treating hepatic encephalopathy
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PL2760479T3 (pl) 2011-09-30 2017-09-29 Horizon Therapeutics, Llc Lek wychwytujący azot do zastosowania w sposobie leczenia zaburzenia retencji azotu
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LT2922576T (lt) 2012-11-21 2018-02-12 Horizon Therapeutics, Llc Azotą surišančių vaistų, skirtų kepenų encefalopatijos gydymui, skyrimo ir įvertinimo būdai
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ME03351B (me) 2014-01-29 2019-10-20 Umecrine Cognition Ab Steroidno jedinjenje za upotrebu u lečenju hepatične encefalopatije
KR20230018526A (ko) * 2014-11-24 2023-02-07 유씨엘 비즈니스 리미티드 암모니아-저감 치료를 이용한 간성상세포 활성화와 연관된 질병의 치료
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KR20180006904A (ko) * 2015-04-20 2018-01-19 오세라 테라퓨틱스, 아이엔씨. L-오르니틴 페닐아세테이트의 제형
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WO2017053613A1 (en) * 2015-09-25 2017-03-30 Ocera Therapeutics, Inc. Treatment and prevention of neuronal cell loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate
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JOP20190146A1 (ar) 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
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WO2018225167A1 (ja) 2017-06-07 2018-12-13 花王株式会社 アンモニア代謝促進剤
CN110709072A (zh) * 2017-06-07 2020-01-17 花王株式会社 氨代谢促进剂
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US10668040B2 (en) 2017-09-11 2020-06-02 Horizon Therapeutics, Llc Treatment of urea cycle disorders in neonates and infants
CN112839643A (zh) 2018-06-20 2021-05-25 胺细拉健康公司 用于治疗肌肉中脂肪浸润的组合物及方法
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JP2022533569A (ja) 2019-05-09 2022-07-25 オセラ セラピューティクス， インコーポレイテッド 肝性脳症を評価および処置する方法
CN113713817B (zh) * 2020-05-26 2023-06-27 中国科学院大连化学物理研究所 一种采用镍基催化剂催化丙醛加氢制正丙醇的方法
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