EA200701146A1 - Композиция, содержащая орнитин и фенилацетат или фенилбутират, для лечения печеночной энцефалопатии - Google Patents

Композиция, содержащая орнитин и фенилацетат или фенилбутират, для лечения печеночной энцефалопатии

Info

Publication number
EA200701146A1
EA200701146A1 EA200701146A EA200701146A EA200701146A1 EA 200701146 A1 EA200701146 A1 EA 200701146A1 EA 200701146 A EA200701146 A EA 200701146A EA 200701146 A EA200701146 A EA 200701146A EA 200701146 A1 EA200701146 A1 EA 200701146A1
Authority
EA
Eurasian Patent Office
Prior art keywords
phenybutirate
ornitin
treatment
composition containing
phenyl acetate
Prior art date
Application number
EA200701146A
Other languages
English (en)
Other versions
EA011716B1 (ru
Inventor
Раджив Джалан
Камал Наян Джалан
Original Assignee
Ю Си Эл БИЗНЕС Пи Эл Си
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0426142A external-priority patent/GB0426142D0/en
Priority claimed from GB0426141A external-priority patent/GB0426141D0/en
Application filed by Ю Си Эл БИЗНЕС Пи Эл Си filed Critical Ю Си Эл БИЗНЕС Пи Эл Си
Publication of EA200701146A1 publication Critical patent/EA200701146A1/ru
Publication of EA011716B1 publication Critical patent/EA011716B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Настоящее изобретение относится к применению орнитина для изготовления лекарственного препарата для применения в комбинации по меньшей мере с одним из фенилацетата и фенилбутирата для профилактики или лечения печеночной декомпенсации или печеночной энцефалопатии. Изобретение также относится к применению по меньшей мере одного из фенилацетата и фенилбутирата для изготовления лекарственного препарата для применения в комбинации с орнитином для профилактики или лечения печеночной декомпенсации или печеночной энцефалопатии.
EA200701146A 2004-11-26 2005-11-28 Композиция, содержащая орнитин и фенилацетат или фенилбутират, для лечения печеночной энцефалопатии EA011716B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0426142A GB0426142D0 (en) 2004-11-26 2004-11-26 Formulation
GB0426141A GB0426141D0 (en) 2004-11-26 2004-11-26 Treatment
PCT/GB2005/004539 WO2006056794A1 (en) 2004-11-26 2005-11-28 Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy

Publications (2)

Publication Number Publication Date
EA200701146A1 true EA200701146A1 (ru) 2008-02-28
EA011716B1 EA011716B1 (ru) 2009-04-28

Family

ID=35559327

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200900105A EA018007B1 (ru) 2004-11-26 2005-11-28 Композиция, содержащая орнитин и фенилацетат или фенилбутират, для лечения печеночной энцефалопатии
EA200701146A EA011716B1 (ru) 2004-11-26 2005-11-28 Композиция, содержащая орнитин и фенилацетат или фенилбутират, для лечения печеночной энцефалопатии

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200900105A EA018007B1 (ru) 2004-11-26 2005-11-28 Композиция, содержащая орнитин и фенилацетат или фенилбутират, для лечения печеночной энцефалопатии

Country Status (23)

Country Link
US (3) US8389576B2 (ru)
EP (3) EP1824563B1 (ru)
JP (2) JP5116479B2 (ru)
KR (1) KR101380446B1 (ru)
CN (1) CN102512408B (ru)
AT (1) ATE457187T1 (ru)
AU (1) AU2005308622B2 (ru)
CA (1) CA2589261C (ru)
CY (3) CY1112259T1 (ru)
DE (1) DE602005019319D1 (ru)
DK (3) DK2319581T3 (ru)
EA (2) EA018007B1 (ru)
ES (3) ES2341120T3 (ru)
HK (1) HK1141471A1 (ru)
IL (1) IL183401A (ru)
MX (1) MX2007006171A (ru)
NO (2) NO342198B1 (ru)
NZ (1) NZ555870A (ru)
PL (3) PL2153870T3 (ru)
PT (3) PT2319581E (ru)
SG (1) SG158073A1 (ru)
SI (3) SI1824563T1 (ru)
WO (1) WO2006056794A1 (ru)

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